Methods and compositions concerning poxviruses and cancer

a technology of poxvirus and cancer, applied in the field of poxviruses, can solve the problems of ineffective clearing of attenuated virus, reduced antiviral response, inability to counter, etc., and achieve the effect of increasing the antitumoral efficacy of attenuated vaccinia virus and increasing the antitumoral efficacy
US20060099224A1Inactive Publication Date: 2006-05-11JENNEREX BIOTHERAPEUTICS ULC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
JENNEREX BIOTHERAPEUTICS ULC
Publication Date
2006-05-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention concerns methods and compositions for the treatment of cancer and cancer cells using altered poxviruses, including a vaccinia virus that has been altered to generate a more effective therapeutic agent. Such poxviruses are engineered to be attenuated or weakened in their ability to affect normal cells. In some embodiments, methods and compositions involve poxviruses that possess mutations that result in poxviruses with diminished or eliminated capability to implement an antiviral response in a host. Poxviruses with these mutations in combination with other mutations can be employed for more effective treatment of cancer.
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Description

BACKGROUND OF THE INVENTION

[0001] 1. Field of the Invention

[0002] The present invention relates generally to the fields of oncology and virology. More particularly, it concerns poxviruses, specifically including vaccinia viruses, that comprise one or more mutations rendering them particularly suitable for the treatment of cancer.

[0003] 2. Description of Related Art

[0004] Normal tissue homeostasis is a highly regulated process of cell proliferation and cell death. An imbalance of either cell proliferation or cell death can develop into a cancerous state (Solyanik et al., 1995; Stokke et al., 1997; Mumby and Walter, 1991; Natoli et al., 1998; Magi-Galluzzi et al., 1998). For example, cervical, kidney, lung, pancreatic, colorectal and brain cancer are just a few examples of the many cancers that can result (Erlandsson, 1998; Kolmel, 1998; Mangray and King, 1998; Gertig and Hunter, 1997; Mougin et al., 1998). In fact, the occurrence of cancer is so high that over 500,000 deaths per ...

Claims

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