118results about How to "Improve tumor inhibition rate" patented technology

The invention discloses an irinotecan or irinotecan hydrochloride lipidosome and a preparation method thereof. The lipidosome contains irinotecan or irinotecan hydrochloride, neutral phospholipid and cholesterol, wherein the weight ratio of the cholesterol to the neutral phospholipid is 1:(3-5), and the irinotecan or irinotecan hydrochloride lipidosome is prepared by an ion gradient method.

The invention discloses a traditional Chinese medicine composition having an anticancer effect and a preparation method thereof. The traditional Chinese medicine composition is a medicament mixture composed of a polyphyllin extract and a turmeric water extract in a mass ratio of 2:3. The preparation process of the traditional Chinese medicine composition comprises the following steps: preparing the polyphyllin extract; preparing the turmeric water extract; and preparing a mixture of the polyphyllin extract and the turmeric water extract. The traditional Chinese medicine composition has the advantages that: the preparation process is simple; the obtained traditional Chinese medicine composition has the anticancer effect, and the anticancer activity of the composition is high and has broad spectrum; and compared with singly applied polyphyllin extract or turmeric water extract, the composition has stronger antitumour activity, smaller toxic and side effects and immunity-enhancing function.

The invention relates to multipiptide protein active substance in a kind of bloody clam (Arca subcrenata Lischke; Scapharca subcrenata), the prepn. method and the uses. The prepn. method is that bloody clam is homogenated to obtain superantant which is treated by chromatography in ion exchange column, desalt, chromatograph separation in gel colum to be combined to several peaks with molecular weight 3-15 KDa which is concentrated and dried to obtain multipeptide protein active substance. Said active substance has 73.72 percent of cancer-inhibiting ratio and can be made as anti-cancer medicine.

The invention discloses a gambogic acid cyclized analog, a preparation method and application thereof. The semi-synthesized gambogic acid cyclized analog is obtained by the extracted and purified gambogic acid through chemical synthesis and has a structural general formula I-III as the right formula, wherein substituent groups of A ring, B ring, C ring, R1, R2, R3, R4, R5, R6, R7, R7, R8, R9, R10, R11 or/and R12 contain glycosyl group, polyhydroxy, amino acid group, acyloxy group, phosphoric acid oxygen group, sulphonic acid oxygen group, alkoxyl group, aromatic oxygen group, heterocyclic oxygen group, mercapto group, substituted mercapto group, primary amine and secondary amines groups or/and substituted primary amine and secondary amines groups, and chain hydrocarbon or and cyclic group containing oxygen, sulphur, nitrogen, carbon or/and phosphor atoms, and one or combination of the substitution groups. The gambogic acid cyclized analog has anti-tumor, antivirus, antibacterial and antifungal pharmacology activities, can be used as anti-tumor, antivirus, immune, antibacterial and antifungal medicaments, and can be applied together with the known anti-tumor, antivirus, immune, antibacterial and antifungal medicaments.

The invention discloses a tumor deoxyribonucleic acid (DNA) vaccine taking mucin 1 and survivin as targets and a viral vector vaccine. The invention relates to the field of tumor DNA vaccines and viral vector vaccines, in particular to recombinant DNA vector VR-S8 and VR-MS, recombinant adenovirus Ad-S8 and Ad-MS, and recombinant poxvirus MVA-MS vaccines, and application of the optimum combination of immune ways between DNA vaccines and viral vector vaccines and between the viral vector vaccines in preparing antitumor vaccines.

The invention relates to isoalantolactone derivatives and salts thereof and provides an isoalantolactone derivative as shown in a formula (I). Salification acids are selected from inorganic acids or organic acids; the inorganic acids are selected from hydrofluoric acid, hydrochloric acid, hydrobromic acid, hydroiodic acid, sulfuric acid, nitric acid, phosphoric acid, carbonic acid, boric acid, seleninic acid, phosphomolybdic acid, phosphorous acid and sulphurous acid; the organic acids are selected from citric acid, maleic acid, D-malic acid, L-malic acid, DL-malic acid, L-lactic acid, D-lactic acid, DL-acid, oxalic acid, methylsulfonic acid, pentanoic acid, oleic acid, lauric acid, p-toluene sulfonic acid, 1-naphthalenesulfonic acid, 2-naphthalenesulfonic acid, phthalic acid, tartaric acid, malonic acid, succinic acid, fumaric acid, glycolic acid, mercaptan acid, glycine, sarcosine, sulfonic acid, nicotinic acid, methylpyridine acid, isonicotinic acid, benzoic acid or substituted benzoic acid.

The invention discloses application of amino-acid-modified metallofullerene water-soluble nanoparticles in the preparation of tumor vascular disrupting agents; the amino-acid-modified metallofullerene water-soluble nanoparticles have a structural general formula: metallofullerene-(OH)x(amino acid)y, wherein metallofullerene is metallic fullerene, with 0</=x</=50 and 0</=y</=50, and amino acid is a water-soluble amino acid. The tumor vascular disrupting agents prepared by applying the amino-acid-modified metallofullerene water-soluble nanoparticles to their preparation have higher biosafety, have zero toxic and side effects for normal biological tissues, are low in dosage and are good in treatment effect.

The invention discloses polyethylene glycol vitamin E succinate and calprotectin modified nanoparticle and a preparation method thereof. The polyethylene glycol vitamin E succinate and calprotectin modified nanoparticle is prepared from the following raw materials in parts by weight: 1 part of active medicine, 20 to 40 parts of phospholipid, 2 to 4 parts of sophorolipid, 1 to 2 parts of calprotectin, and 5 to 10 parts of polyethylene glycol vitamin E succinate. Compared with the prior art, the nanoparticle modified by olyethylene glycol vitamin E succinate, sophorolipid and calprotectin has the advantages that (1) the preparation process is simple and controllable; (2) the stability of the nanoparticle is greatly improved, and the nanoparticle can be stabilized in a solution for up to 6 months; (3) a freeze-drying protective additive is not needed for freezing and drying; the obtained freeze-dried powder dissolved again shows small change on particle size and polydispersity index compared with freeze-dried powder without being dissolved; (4) the targeting for tumor cells is enhanced.

The present invention provides an sgRNA specifically targeting a human DNMT1 gene based on a CRISPR/Cas9 system, a use thereof for guiding the CRISPR/Cas9 system in a drug for treatment and/or prevention of tumors, and a method correspondingly constructing a sgRNA expression vector. The CRISPR/Cas9 system can rapidly, efficiently and specifically knock out the human DNMT1 gene, induces inactivation of the DNMT1 gene in tumor cells, inhibits expression of the DNMT1 and methylation of DNA and thus inhibits tumor cell growth.

The invention relates to biomimetic nanoparticles for gas production and anti-tumor activity catalyzed by bioenzymes and a preparation method thereof. Firstly, MnCO (Manganese carbonyl compounds) areloaded on a PLGA (polylactic acid-glycolic acid) solution, GOX (glucose oxidase) is embedded in the above mentioned system, a MnCO-PLGA nano solution embedded with GOX is prepared through volatilization of an emulsified solvent, GOX-MnCO-PLGA is squeezed into vesicles derived from erythrocyte membranes, and the biomimetic nanoparticles for gas production and anti-tumor activity catalyzed by bioenzymes. The prepared biomimetic nanoparticles provide a novel tumor treatment strategy, a gas therapy and a hunger therapy are synergistically used, and erythrocyte membranes serve as nanoparticle capsids, so that the prepared biomimetic nanoparticles can control formation of carbon monoxide in situ in tumor target tissues and have good anti-tumor effects.

The invention discloses a chickpea sausage and a preparation method thereof. The chickpea sausage is prepared by using beef and chickpeas as raw materials, unfreezing, trimming and secondarily chopping the beef, using 2.5 percent of table salt, 0.03 percent of sodium nitrite and 0.3 percent of sodium hexametaphosphate for curing comminuted meat, adding 1.7 percent of edible spice, 0.3 percent of Kunlun chrysanthemum oil resin and 10 percent of modified starch, then performing secondary chopping, and selecting, soaking and cooking the chickpeas; mixing the treated beef with the chickpeas, adding 0.5 percent of carrageenan and 0.1 percent of gelatin for bonding, and performing steps of filling, baking, cooking, cooling and the like. The chickpea sausage is gentle in flavor, is fine and even in taste, is obvious in sense of meat, is good in elasticity, is moderate in stickiness and has a wide application value.

The invention relates to a self-microemulsifying nanocombination comprising lucid ganoderma total triterpene and jobstears seed oil and a preparation method and application thereof. The lucid ganoderma total triterpene and the jobstears seed oil are adopted as medicinal materials, the jobstears seed oil doubles as the oil phase, the mixture of surfactant and cosurfactant is adopted as medicine carrier, and the parts by weight are as follows: 15 parts of lucid ganoderma total triterpene, 45 to 150 parts of jobstears seed oil, 45 to 200 parts of surfactant and 20 to 100 parts of cosurfactant. The invention also discloses the preparation method and application of the self-microemulsifying nanocombination. The invention prepares the self-microemulsifying nanocombination with the water-insoluble medicinal lucid ganoderma total triterpene and the jobstears seed oil, wherein the jobstears seed oil has the effects of both medicine and adjuvant, so that the dosage of preparation adjuvant, and moreover, the jobstears seed oil and the lucid ganoderma total triterpene which are compatible have a synergistic antitumor effect. Meanwhile, the self-microemulsifying nanocombination can promote the absorption of medicines, so that the antitumor effect can be enhanced.

The invention discloses a probiotic fermented traditional Chinese medicine compound composition for treating liver cancer and preparation and detection methods thereof. The preparation method includes: performing water extraction on traditional Chinese medicine compound medicinal materials; adding nutrient and inorganic salt different in proportion; sterilizing at high temperature, and performing compound intestinal tract probiotic fermentation; stabilizing to obtain the probiotic fermented traditional Chinese medicine compound composition. The traditional Chinese medicine compound medicinal materials include Radix bupleuri, Radix scutellariae, Radix ginseng rubra, Herba hyperici japonici, string stonecrop herb, roasted turtle shell, root of red-rooted salvia, selfheal, raw oyster, Rhizoma corydalis, Radix curcuma piece, polyporus umbellatus and Radix Glycyrrhizae Preparata.The invention further discloses an identification method and a detection method of the probiotic fermented traditional Chinese medicine compound composition. Experiments show that treatment effect of traditional Chinese medicine extract can be improved remarkably, tumor inhibition rate can be increased, and the probiotic fermented traditional Chinese medicine compound composition has remarkable effect on inhibiting liver tumor growth. Taste of the traditional Chinese medicine compound extract can be improved remarkably, irritation of the traditional Chinese medicine extract to intestines and stomach can be reduced, and appetite and physique of patients can be improved.

The invention discloses a preparation method of an abalone mask. The preparation method is characterized in that abalone hydrolysate is prepared from abalone serving as the raw material, and is matched with a traditional Chinese medicine extracting solution taking almonds, Wolfiporia extensa, cucumbers, mint, green tea, peach blossom and roses as the raw materials, then honey is added for mixing, a mask solution is prepared, and a mask sheet is soaked in the mask solution and is packaged in vacuum for preparation. The abalone hydrolysate, the traditional Chinese medicine extracting solution and the honey in the components jointly have a beautifying function, the components are compatible and supplement one another, can supplement skin nutrition, nurse the skin cells to be young and accelerate cell neogenesis, enables the skin to be tender, smooth and anti-aging, can improve local blood circulation and has better toxin expelling, anti-freckle, repairing and beauty maintaining effects.

The invention relates to an IL-12 and TNF-alpha autologous tumor vaccine which is suitable for tolerantable biopsy and operative patients. The vaccine is a composite containing a IL-12 gene, a TNF-alpha gene and a tumor cell, has the characteristics of simple operation, high immunogenicity and target ability, low preparation cost and convenience for clinical application, and is mainly used for anti-tumor immunotherapy which comprises the treatments of residual tumor after operation and unresectable tumor.

The invention discloses a dendritic cell tumor vaccine and a preparation method and application of the dendritic cell tumor vaccine, and belongs to medicine preparations containing antigens or antibodies. According to the dendritic cell tumor vaccine and the preparation method and application of the dendritic cell tumor vaccine, plasmid carrying a GPC3 gene and an eukayotic expression vector pcDNA-DEST53 are recombined, pGFP-GPC3 recombined plasmid is obtained, the recombined plasmid is led into immaturate dendritic cells in a nucleofector mode, the immature dendritic cells are promoted to become mature by cell factors TNE-alpha, and the dendritic cell tumor vaccine DC-GPC3 is obtained. After the obtained dendritic cell tumor vaccine and CIK cells are co-cultured, the tumor killing rate and the tumor restraining rate to high-expression GPC3 liver cancer cells are obviously increased, the good liver cancer resisting effect is presented, and the wide application prospect is achieved.

The invention relates to the field of tumor DNA (Deoxyribose Nucleic Acid) vaccines and virus vector vaccines, and in particular relates to recombinant DNA vectors VR-S8 and VR-MS, recombinant adenoviruses AD-S8 and Ad-MS and a recombinant poxvirus MVA-MS vaccine, as well as application of DNA vaccines and optimized combination of immunization ways between virus vector vaccines to preparation of antitumor vaccines.

The present invention provides an antitumor prodrug, activator thereof, composition thereof and use thereof, the activator being shown as formula (I). The antitumor prodrug in the present invention has unexpectedly high selectivity in the treatment of tumor, and greatly reduces the harm of released cytotoxic drug on the human body.