New borneol use and lung cancer treatment drug composition

A composition and technology of borneol, applied in the field of medicine, can solve the problems of not finding borneol and cyclophosphamide, etc., and achieve the effect of improving the trend of action and increasing the tumor inhibition rate

Active Publication Date: 2013-04-03
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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AI Technical Summary

Problems solved by technology

[0003] At present, there is no report on the treatment of lung cancer with borneol alone; there is also no report on the combination of borneol and cyclophosphamide in vivo to improve efficacy and reduce side effects.

Method used

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  • New borneol use and lung cancer treatment drug composition

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Experimental program
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Embodiment Construction

[0010] The following describes but does not limit the present invention through the description of specific embodiments of the present invention.

[0011] Effects of borneol alone and borneol combined with cyclophosphamide on Lewis lung cancer

[0012] 1. Drugs

[0013] The experimental dose of borneol in previous experiments is calculated according to 40 times of the daily dosage of 0.3g for adults (60kg) in the Pharmacopoeia, that is, 0.2g of crude drug / kg. Take an appropriate amount of borneol for grinding, dissolve it with 0.5% Tween, and prepare 10mg / kg. The drug solution of ml concentration was given to mice by intragastric administration.

[0014] Cyclophosphamide, Jiangsu Hengrui Medicine Co., Ltd., batch number 10051521, the dose is 60 mg / kg, prepared with normal saline before use, and administered by intraperitoneal injection.

[0015] The control group was given 0.5% Tween by intragastric administration, and the intragastric administration volume of all mice was 0...

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Abstract

The present invention belongs to the field of medicine, and specifically relates to a new borneol use and a lung cancer treatment drug composition. The first technical problem solved by the present invention is a use of borneol in anticancer drug preparation. The second technical problem solved by the present invention is to provide a completely new lung cancer treatment drug composition, which comprises borneol and cyclophosphamide. Test results show that single use of the borneol provides a lung cancer inhibition effect, combination of the borneol and the cyclophosphamide provides an increased tumor inhibition rate, and improvement of leukocyte inhibition by the cyclophosphamide is further provided. With the present invention, a completely new, safe and efficient selection is provided for clinical lung cancer treatment.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a new application of borneol and a pharmaceutical composition for treating lung cancer. Background technique [0002] Borneol, also known as sliced ​​brain, orange slice, dipterocarp, etc., is the crystallization obtained from the trunk of dipterocarp plant dipterocarp through steam distillation, or synthesized by chemical methods with camphor, turpentine, etc. The former is called natural borneol, also known as dipterocarp; the latter is called synthetic borneol. Borneol is cold in nature, pungent and bitter in the mouth. It has the effects of resuscitating the mind, clearing away heat and relieving pain; it is used for heat pain and coma, convulsions, apoplexy with phlegm, sore throat, red eyes, and mouth sores. [0003] At present, there is no report on the treatment of lung cancer with borneol alone; there is also no report on the in vivo study of borneol combined with c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/045A61K31/675A61P35/00
Inventor 曾南王建夏厚林彭成张廷模李祖伦万德光董晓平吴纯洁马骁刘京伟彭颖王丹丹
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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