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Self-microemulsifying nanocombination comprising lucid ganoderma total triterpene and jobstears seed oil and preparation method and application thereof

A technology of Ganoderma lucidum total triterpenes and nano-composites, which is applied in the directions of medical preparations containing active ingredients, drug combinations, oil/fat/wax non-active ingredients, etc., can solve the problems of poor water solubility, poor water solubility, Affecting oral absorption and drug efficacy, etc., to avoid safety problems, enhance compliance, and take safety effects

Inactive Publication Date: 2013-02-27
陈彦
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the compound is still used in patients by the traditional method of decocting in water, but the water solubility of the total triterpenoids of Ganoderma lucidum and coix seed oil is poor, which affects its oral absorption and efficacy

Method used

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  • Self-microemulsifying nanocombination comprising lucid ganoderma total triterpene and jobstears seed oil and preparation method and application thereof
  • Self-microemulsifying nanocombination comprising lucid ganoderma total triterpene and jobstears seed oil and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Prescription: Ganoderma lucidum total triterpenes 4.5g, coix seed oil 22.5g, polyoxyethylene hydrogenated castor oil 24g, polyethylene glycol 400 12g.

[0075]Put the total triterpenoids of Ganoderma lucidum and coix seed oil in a container, and mix well with a magnetic stirrer to dissolve the drug completely, then add polyoxyethylene hydrogenated castor oil and polyethylene glycol 400, and then stir magnetically for 10 minutes. The multi-component self-microemulsified nanometer composition of Ganoderma lucidum total triterpenes and Coix seed oil can be obtained.

Embodiment 2

[0077] Prescription: Ganoderma lucidum total triterpenes 9g, coix seed oil 90g, Tween 80 120g, polyethylene glycol 300 60g.

[0078] The preparation method is the same as in Example 1.

Embodiment 3

[0080] Prescription: Ganoderma lucidum total triterpenes 6g, coix seed oil 20g, OP emulsifier 24g, ethanol 400 13g.

[0081] The preparation method is the same as in Example 1.

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Abstract

The invention relates to a self-microemulsifying nanocombination comprising lucid ganoderma total triterpene and jobstears seed oil and a preparation method and application thereof. The lucid ganoderma total triterpene and the jobstears seed oil are adopted as medicinal materials, the jobstears seed oil doubles as the oil phase, the mixture of surfactant and cosurfactant is adopted as medicine carrier, and the parts by weight are as follows: 15 parts of lucid ganoderma total triterpene, 45 to 150 parts of jobstears seed oil, 45 to 200 parts of surfactant and 20 to 100 parts of cosurfactant. The invention also discloses the preparation method and application of the self-microemulsifying nanocombination. The invention prepares the self-microemulsifying nanocombination with the water-insoluble medicinal lucid ganoderma total triterpene and the jobstears seed oil, wherein the jobstears seed oil has the effects of both medicine and adjuvant, so that the dosage of preparation adjuvant, and moreover, the jobstears seed oil and the lucid ganoderma total triterpene which are compatible have a synergistic antitumor effect. Meanwhile, the self-microemulsifying nanocombination can promote the absorption of medicines, so that the antitumor effect can be enhanced.

Description

technical field [0001] The invention relates to a self-microemulsifying nanocomposite composed of ganoderma total triterpenes and coix seed oil. The nanocomposition prepares water-insoluble drugs ganoderma total triterpenes and coix seed oil into a self-microemulsifying preparation. The invention also relates to a preparation method of the self-microemulsion nano composition. The present invention also includes the application of the self-microemulsified nano composition composed of total ganoderma triterpenes and coix seed oil in the preparation of anti-lung cancer oral medicine. Background technique [0002] At present, lung cancer has become a major killer threatening human health. According to the latest domestic and foreign literature reports, new cases of lung cancer in the world account for about 14% of new cases of various tumors in the world. It has the characteristics of high morbidity and high mortality. With the increase in the number of young people smoking, lu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61K9/107A61K47/44A61P35/00
Inventor 陈彦贺俊杰袁菱曹伟王莹
Owner 陈彦
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