47 results about "High morbidity" patented technology

The invention discloses a preparation method of rice bran protein peptide with ACE inhibitory activity. The method is characterized in that rice bran is adopted as a raw material, and comprises the following steps: firstly extracting rice bran protein, then preparing rice bran protein hydrolysate by adopting an enzyme hydrolysis method, and separating and purifying the rice bran ACE inhibitory peptide by adopting a hyperfiltration method, sephadex G-15 and a RP-HPLC method. According to the preparation method, the rich and cheap rice bran resource is effectively utilized to prepare the rice bran protein peptide with the high ACE inhibitory activity. The decompression function of the rice bran ACE inhibitory peptide can be maximally utilized, so that on one hand, the additional value of the rice bran is increased, and the good economic benefit and market value can be created; on the other hand, the morbidity of the hypertension can be effectively reduced, the high morbidity can be controlled, the human beings can be protected from the harm of the hypertension, the application value and social benefit are good, and the theoretical foundation and the experiment evidence can be provided for researching the structure and decompression mechanism of the rice bran protein ACE inhibitory peptide.

The invention discloses an application of enniatine compound for preparing anti-drug-resistant tubercle bacillus drugs; the enniatine compound has a general formula showed by a formula (I); aiming atthe conditions that tuberculosis has high morbidity at present, mycobacterium tuberculosis has multiple drug-resistant strains and human immune deficiency virus is infected doubly, so as to lead the tuberculosis morbidity and mortality to be on the rise, the invention provides a new application of the enniatine compound on the anti-drug-resistant tubercle bacillus by finding that the enniatine compound has strong anti-drug-resistant tubercle bacillus activity, thereby not only providing a new beneficial tool for the treatment of the drug-resistant tubercle bacillus, but also expanding the application range of the enniatine compound. In addition, the enniatine compound is derived from ocean mangrove endophytic fungi, the raw material is plentiful, and the collection and cultivation of the raw material are easy, the purification is easy and the cost is low, and the breeding cycle is short, thereby being large-scale industrial production.

The invention discloses application of Cyanogramide to preparation of medicine for resisting mycobacterium tuberculosis. Targeting the current situation that high morbidity of tuberculosis and appearance of mycobacterium tuberculosis multi-drug-resistant strains lead to a rising trend of the tuberculosis morbidity and the death rate, it is found that Cyanogramide has remarkable activity in inhibiting mycobacterium tuberculosis and then has a very good application prospect. The usage of Cyanogramide in preparing the medicine for treating and resisting mycobacterium tuberculosis is disclosed for the first time; due to the fact that the framework type is brand new and the activity of Cyanogramide in inhibiting mycobacterium tuberculosis is too strong to imagine, it is impossible to give any revelation by other compounds, and Cyanogramide has outstanding substantive characteristics; meanwhile, Cyanogramide apparently has remarkable progress when applied to prevention and treatment of mycobacterium tuberculosis infection.

The invention relates to application of an artemisia leaf extract, and in particular relates to application of an artemisia leaf extract in a medicament for treating pulmonary heart diseases and a preparation method of the artemisia leaf extract. The invention discloses the application of the artemisia leaf extract in preparing the medicament for treating the pulmonary heart diseases. The pulmonary heart diseases have the characteristics of high epidemicity, high morbidity rate, high death rate and high cost, and surveys show that the morbidity rate of people living in rural areas in northern China is 0.44%, therefore, the development of a pulmonary heart disease Chinese traditional medicine treatment medicament with a definite curative effect, a reasonable cost and sufficient supply of goods is of great significance. Meanwhile, the traditional Chinese medicament namely artemisia leaf is further developed and studied, and is finally pushed to the market, which also is one of important paths of realizing modernization of Chinese medicaments.

The invention discloses an application of a quinine compound in preparing anti-tubercle bacillus drugs. A structure general formula of the quinine compound of the invention is shown in a formula (1), wherein R is H or OH. In the invention, aiming to current situations that the current tuberculosis has high morbidity, and multidrug-resistant tuberculosis (TB) strains of tubercle bacillus occur so that the morbidity and mortality of the tuberculosis are in a rising trend, and according to characteristics of anti-tubercle bacillus and tolerance tubercle bacillus activities of the quinine compound, the quinine compound is used for preparing the anti-tubercle bacillus drugs. The quinine compound of the invention is derived from marine microorganisms, is easy to be extracted, has low cost and wide application prospect, and can be used for preparing the anti-tubercle bacillus drugs.

Cardiovascular and cerebrovascular diseases have high morbidity, mortality and disability rate and can bring heavy burdens for the society and families. Occurrence of dangerous cardiovascular and cerebrovascular events can be prevented through early prevention. The invention provides a drug composition containing one of small dosage of folic acid or methyltetrahydrofolic acid, medicinal content of aspirin and a medicinal carrier and application of the drug composition for preparing the drugs for preventing or treating the cardiovascular and cerebrovascular diseases. The invention belongs to the pharmaceutical field.

The invention provides a tomato planting method, and relates to the technical field of vegetable planting. The tomato planting method includes steps of (1), soil selection; (2), variety selection; (3), seed drying; (4), seed immersion by medicament; (5), germination treatment; (6), soil preparation; (7), sowing; (8), seedling management; (9), fixed planting; (10) field management; (11) harvesting. The tomato planting method solves the problems of high morbidity, low output and poor quality of the tomato planted by the existing tomato planting method.

The invention discloses a method for establishing a model of oral cancer and lymphatic metastasis of mice, which is characterized by including mouse selection and grouping, reagent preparation, mouse feeding, experimental observation and conclusion drawing. The method specifically includes: using 200mg/L 4-nitroquinoline-1-oxide to feed Balb/c (Bagg albino/c) mice for 20 weeks by a drinking method; continuously using tap water to feed the mice to the fortieth week and observing to the fortieth week; obtaining the model of oral cancer and lymphatic metastasis of the mice which have development metastasis extremely similar to human oral cancer, namely location diversification, a full metastasis process of normal mucosa, dysplasia, carcinoma in situ, squamous carcinoma and cervical lymph nodes. The method is simple, natural and ideal in effect, guarantees high morbidity, diversified disease locations (lip, palate, gum, tongue and mouth floor) and high submandibular lymph node metastasis rate, and a novel powerful tool for preventing and treating human oral cancer is provided.

Osteoarthritis and rheumatoid arthritis are common chronic diseases, which have high morbidity and hard to heal, therefore a long period medicine treatment is required. Life of the patient can be threatened if the long period medicine treatment is not well insisted. Currently, among medicine for arthritis, nonsteroidal anti-inflammatory drugs are most important. But currently oral preparation account for the most portions, which has more side effects. Etodolac belongs to the indole nonsteroidal anti-inflammatory drugs, which play an important role in arthritis treatment. But the current oral preparation has a plurality of side effects, which brings trouble to the long period treatment in patients. Therefore the present invention develops an external preparation of Etodolac, which not only greatly reduces side effects of the drugs, but also applicable for long period treatment of arthritis particularly.

The invention provides hydrogen-selenium rice, composition of the hydrogen-selenium rice and a preparation method of the hydrogen-selenium rice. The hydrogen-selenium rice is composed of rice, and resistant starch, selenium-enriched yeast and ethylenediaminetetraacetic acid ferric sodium salt which can generate hydrogen gas in large intestines, so that the rice is named as the hydrogen-selenium rice. The hydrogen gas can be used for neutralizing free radicals in bodies. Selenium is a necessary microelement for human bodies and can be used for preventing and inhibiting tumors and resisting ageing; and China is a selenium-deficiency country so that a manner of enriching selenium in the rice is the best way for supplementing selenium. Iron deficiency anemia is one of nutrition deficiency diseases with the high morbidity in China; in estimation of Global Burden of Diseases in 2004, disability-adjusted life years (DALYs) caused by iron deficiency in every 100,000 people in China are 189 and rank 99th in 192 member countries; and the total loss of the whole country is 247.9 billion and ranks second last in the member countries. When people supplement iron through drugs, about 2000 yuan needs to be paid every year; 400-600 yuan needs to be paid when people eat health-care products to supplement iron; and the ideal effect can be realized by only spending additional 2-3 yuan when people eat iron-enriched rice.

The invention discloses a traditional Chinese medicine for treating lumbar disc herniation and a preparation method of the traditional Chinese medicine. The lumbar disc herniation has the characteristics of high morbidity, long treatment time, extreme easiness for recurrence after treatment and the like. The traditional Chinese medicine is prepared from 40-60 parts of safflower, 40-60 parts of red paeony roots, 20-40 parts of olibanum, 20-40 parts of ground beetle, 20-40 parts of angelica sinensis, 20-40 parts of rhizoma chuanxiong, 40-60 parts of pseudo-ginseng, 20-40 parts of rhizoma corydalis, 20-40 parts of rheum officinale, 20-40 parts of earthworms, 20-40 parts of radix angelicae pubescentis, 20-40 parts of eucommia ulmoides, 20-40 parts of radix aconiti agrestis, 20-40 parts of spina gleditsiae, 20-40 parts of radix achyranthis bidentatae, 1-3 parts of centipedes, 20-40 parts of dragon blood, 20-40 parts of liquorice, 20-40 parts of pangolin and 40-60 parts of dragon bone. The traditional Chinese medicine is used for treating lumbar disc herniation.

The invention provides an anti-head-smut corn auxiliary breeding method, which mainly adopts a seedling culture disc for seedling inoculation. The infection of head smut germs on plants is promoted through three measures of transplanting young seedlings, watering little water on survival plants and manually inhabiting the growth of the plants, and the disease incidence is improved for assisting the anti-head-smut plant breeding. When the method of the invention is adopted, the seedling culture disc is adopted for seedling culture in the early breeding period, and the culture conditions are manually controlled, so the infection chances of head smut germs on the seed and the seed infection degrees are identical, and at the same time, the outbreak of the disease is promoted through transplanting and breaking the normal growing conditions by drying treatment after the plants are survived, so the disease outbreak rate of the plants is improved by 30 to 50 percent, and the disease resistance breeding cost in the later period is greatly saved.

The invention provides a high-yield disease-resistant potato cultivation method, relating to the technical field of vegetable cultivation. The high-yield disease-resistant potato cultivation method comprises the following steps: (1) species selection; (2) seed treatment; (3) selection and preparation of land; (4) seed sowing; (5) field management; and (6) harvesting. The method solves the problems of high morbidity rate, poor quality and low yield of potatoes cultivated by the existing potato cultivation processes.

The invention relates to duplex egg yolk antibody freeze-drying powder for duck virus hepatitis and duck plague, which comprises each following component according to weight percent: 30 to 60 percent of egg yolk antibody for duck plague, 30 to 55 percent of egg yolk antibody for duck virus hepatitis, 0.2 to 0.3 percent of formaldehyde, 0.01 to 0.02 percent of thiomersalate, 4 to 5 percent of glucose, 1 to 2 percent of sorbitol, 2 to 3 percent of glycocoll and 2 to 3 percent of mannitol. The invention discloses a preparation method of the duplex egg yolk antibody freeze-drying powder for the duck virus hepatitis and the duck plague simultaneously, which comprises the following steps of: separating a strain, preparing a vaccine, immunizing a healthy duck flock, preparing eggs, carrying out acidizing treatment, octoate treatment and refining, extracting and purifying treatment after separating egg yolks, preparing and freeze-drying so as to obtain the duplex egg yolk antibody freeze-drying powder for the duck virus hepatitis and the duck plague. According to the duplex egg yolk antibody freeze-drying powder for the duck virus hepatitis and the duck plague and the preparation method thereof, viruses sampled in regions with high morbidity are separated, the virus strain with wider coverage range is sieved, the vaccine is prepared, the cold/hot acidizing treatment of an egg yolk solution is also carried out, the antibody loss is reduced, and the obtained egg yolk antibody freeze-drying powder has high recovery rate and high purity, can dissolve and act quickly and has no clinical side effect.

The invention belongs to the medical field and relates to the application of vitamin pharmaceuticals and health care, particularly the prevention and health-care function of pteroylglutamic acid for offspring glycometabolism disorder caused by caused by environmental endocrine disruptors (EED) during pregnancy. The pteroylglutamic acid intervention experiment is conducted on female SD rats during pregnancy and during lactation by utilizing animal experimental models. It has been determined that, pteroylglutamic acid can prevent the high morbidity rate of type I diabetes caused by insulin structure and function abnormity under the effect of typical EEDs. The result shows that, the pteroylglutamic acid supplementation during pregnancy can prevent the high morbidity rate of offspring glycometabolism disorder caused by EEDs. The pteroylglutamic acid is harmless to human bodies within the control dosage range and can be safely used. When the pteroylglutamic acid is added in health-care products or used as a food intensifying agent to be administered orally, the pteroylglutamic acid can prevent the offspring glycometabolism disorder caused by EEDs.

The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a medical aquilaria sinensis moxibustion stick for treating a chronic gastric disease. The chronic gastric disease is a major problem affecting human health in nowadays society; almost everybody in life possibly suffers from the chronic stomach disease; the medical proverb of 'nine people out of ten possibly suffer from stomach diseases' proves that the stomach disease has the high morbidity and has the characteristics of being easy in relapse and difficult to cure. The traditional Chinese acupuncture has a definite effect for treating the chronic gastric disease, but a patient feels uncomfortable and a medical worker applying the acupuncture is injured due to the fact that a mugwort stick for acupuncture treatment has the hot and heavy medicine property and a strong and irritative smell during the burning; the traditional Chinese acupuncture cannot obtain an obvious treatment effect. Aquilaria sinensis flocks and traditional Chinese medicine materials comprising radix astragali, ginseng and honewort are combined into medical aquilaria sinensis flocks so as to prepare the medical aquilaria sinensis moxibustion stick for treating the chronic gastric disease according to a public-known method for preparing the medical mugwort stick. The medical aquilaria sinensis moxibustion stick is cauterized on the related acupoints of a human body and has the obvious effect for treating the chronic gastric disease.

The invention relates to a medicament for treating hyperosteogeny by taking Chinese medicinal materials as raw materials, and also relates to a preparation method of the medicament. In modern society, the hyperosteogeny tends to occur in youngsters and has high morbidity rate; and at present, the method for treating the hyperosteogeny in China can only exert a certain relieving function, cannot effect a radical cure, is high in treatment cost, is a temporary solution, and has long treatment time and high relapse rate of the disease. Although the medicament comprises a few of medicinal ingredients, the primary medicinal ingredients are clearly distinguished from the secondary medicinal ingredients, both principal and secondary aspects of the disease are treated, and the medicament is mainly based on the primary medicinal ingredients; thus the theory, the principle, the formula and the medicine are shown in a whole, the tastes and the features of the medicinal ingredients are combined, the special effect of the medicament is exerted and enhanced, the cure rate is up to over 98 percent, and the hyperosteogeny does not relapse.

The invention relates to a dynamic monitoring and data analysis system for patients suffering from spinal cord injury. The system comprises a patient management module for entering and storing patient data, an inquiring and counting module for counting and inquiring the patient information including the basic information and age of patients, injury date and core data, a template management module for designing a data attached table page of the patient management module and the inquiring module, and a system management module for managing the patient management module, the inquiring and counting module and the template management module of the dynamic monitoring and data analysis system for patients suffering from spinal cord injury. The system has the beneficial effect that the later-stage recovery condition of the patients and the condition of spinal cord injury in various areas can be counted, data analysis and statistical treatment can be carried out in areas with high morbidity, and effective monitoring is implemented.

The invention discloses an application of Aspeverin in preparation of medicaments for resisting tubercle bacillus. According to the application disclosed by the invention, Aspeverin is found to have an activity of remarkably inhibiting tubercle bacillus, and a great application prospect, aiming at the current situations that the morbidity and mortality of tuberculosis are on the rise due to the high morbidity of tuberculosis and the occurrence of multi-drug-resistant mycobacterium tuberculosis strains at present. The application of the Aspeverin in preparation of medicaments for resisting tubercle bacillus is disclosed for the first time; the Aspeverin has a new framework type, and an unexpectedly high inhibition activity on tubercle bacillus, so that the possibility of giving any revelation by other compounds is avoided; and the Aspeverin has prominent substantive features, and an obviously remarkable improvement in case of being used for preventing and treating tubercle bacillus infection.

The invention relates to a medicine for treating dysmenorrheal and a preparation method thereof. For primary dysmenorrheal which is quite difficult to be treated due to high morbidity and great recurrence, Western medicines including non-steroidal anti-inflammatory drug, contraceptive, calaium channal blocker and the like are generally adopted, and are not suitable for long-term and wide application in clinical field because of high toxic and side effect. The medicine is prepared into a conventional oral medicine from scutellaria baicalensis, bighead atractylodes rhizome, angelica, ligusticum wallichii, white paeony root and liquorice. The medicine, depending on pathogenic mechanism of dysmenorrheal, is capable of treating both symptom and root cause through a traditional Chinese medicine; the invention provides the medicine for treating the dysmenorrheal, which is above 90% in total effective rate, as well as the preparation method thereof.

The invention discloses the applications of Polyflavanostilbene A in preparing an anti-tubercle bacillus medicine. Aimed at the current situation that the morbidity and mortality of tuberculosis are on the rise due to the high morbidity of tuberculosis and the appearance of multi-drug resistant strain of mycobacterium tuberculosis at present, the invention discovers that Polyflavanostilbene A has obvious activity in suppressing tubercle bacillus, and has good application prospects. The application of Polyflavanostilbene A in preparing an anti-tubercle bacillus medicine is disclosed for the first time; and since the skeleton type is a brand new one and the activity in suppressing tubercle bacillus is unexpectedly high, the possibility of any prompt given by other compounds does not exist, and prominent substantive features are provided and a remarkable progress in preventing and treating tubercle bacillus infection.

The invention discloses a toilet with a natural pigsty environment conditioning function. The toilet is designed according to biological characteristics of pigs and temperature difference laws of pigsties, is based on triangular positioning regulators (with the number of ZL: 2005100102275) and the pigsties with inner rings and outer rings, and is characterized in that heat-insulation and ventilation effects can be realized by upper covers of the inner rings, and toilet cubicles can be closed by the aid of supports, thin films and outer wall panels. The toilet has the advantages that the thickness of ice on the thin films and the outer wall panels can be increased along with decrease of the air temperature, so that temperature difference can be generated between the inner rings and the toilet cubicles, and the temperatures of the inner rings and the toilet cubicles are stable respectively; harmful gas and moisture are continuously naturally condensed by the aid of the toilet cubicles, ventilation rates of the pigsties and the air can be obviously reduced, the preferential temperatures of the inner rings can be maintained by heat dissipated by pig groups without extra heat supply, and obvious energy-saving effects can be realized along with decrease of the air temperature; excellent environments can be created by the aid of the temperatures and the humidity of the inner rings and the quality of the air; the problem of high morbidity and mortality rate of pig groups due to high internal humidity of pigsties and poor quality of air in the north in winter can be solved.