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Application of artemisia leaf extract in medicament for treating pulmonary heart diseases and preparation method of artemisia leaf extract

A technology of Artemisia argyi leaf extract and cor pulmonale, applied in the field of the use of Artemisia argyi leaf extract in the treatment of cor pulmonale and its preparation

Inactive Publication Date: 2014-01-22
TONGDE HOSPITAL OF ZHEJIANG PROVINCE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, there are no relevant research reports on lung tissue changes and right ventricular remodeling, so it is meaningful to study the pharmacodynamics of Artemisia argyi leaf extract in the treatment of cor pulmonale, pulmonary hypertension and right ventricular remodeling

Method used

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  • Application of artemisia leaf extract in medicament for treating pulmonary heart diseases and preparation method of artemisia leaf extract
  • Application of artemisia leaf extract in medicament for treating pulmonary heart diseases and preparation method of artemisia leaf extract
  • Application of artemisia leaf extract in medicament for treating pulmonary heart diseases and preparation method of artemisia leaf extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: Preparation of Folium Artemisiae Argyi Extract

[0014] Take 100g of dried mugwort leaves, crush them, put them in a flask, add 8 times the amount of pure water, soak them for 2 hours, and then extract them by steam distillation to obtain volatile oil.

[0015] The Artemisia argyi extract prepared in the above examples can be further prepared into pharmaceutical preparations of the Artemisia argyi extract, such as tablets, capsules, granules and other pharmaceutically acceptable pharmaceutical dosage forms.

Embodiment 2

[0016] Embodiment 2: Preparation of Folium Artemisiae Argyi Extract

[0017] Take 1000g dried Artemisia argyi, put it into the extraction kettle after crushing, seal it, pressurize to an appropriate pressure for CO2 supercritical extraction after the temperature of the extraction kettle and the separation tank reaches 40°C, and obtain the Artemisia argyi leaf extract, the supercritical extraction pressure is 15MPa , the temperature is 35°C, the flow rate is 20kg / h, and the extraction time is 100min.

Embodiment 3

[0018] Example 3: Preparation of Artemisia argyi Extract β-cyclodextrin Inclusion Compound

[0019] 1) Take the mugwort extract prepared in Examples 1 and 2 and dissolve it in ethanol with a mass volume ratio of 1:1 to prepare a solution; at 40°C water temperature, dissolve β-cyclodextrin in water to prepare β-cyclodextrin Saturated aqueous solution of dextrin. Then use a dropper to slowly drop the ethanol solution of volatile oil into the saturated aqueous solution of β-cyclodextrin, keep it warm, and keep stirring for 10 minutes. The dropping speed is 1ml / min. :20. The inclusion solution was refrigerated overnight in the refrigerator, filtered with suction, washed with a small amount of ether, and dried in a constant temperature oven at 40°C to obtain the product.

[0020] 2) Take β-cyclodextrin and add water to make a saturated aqueous solution; dissolve the Artemisia argyi leaf extract prepared in Examples 1 and 2 in a small amount of ethanol to make an ethanol solution,...

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Abstract

The invention relates to application of an artemisia leaf extract, and in particular relates to application of an artemisia leaf extract in a medicament for treating pulmonary heart diseases and a preparation method of the artemisia leaf extract. The invention discloses the application of the artemisia leaf extract in preparing the medicament for treating the pulmonary heart diseases. The pulmonary heart diseases have the characteristics of high epidemicity, high morbidity rate, high death rate and high cost, and surveys show that the morbidity rate of people living in rural areas in northern China is 0.44%, therefore, the development of a pulmonary heart disease Chinese traditional medicine treatment medicament with a definite curative effect, a reasonable cost and sufficient supply of goods is of great significance. Meanwhile, the traditional Chinese medicament namely artemisia leaf is further developed and studied, and is finally pushed to the market, which also is one of important paths of realizing modernization of Chinese medicaments.

Description

technical field [0001] The present invention relates to the use of Artemisia argyi extract, in particular to the use of Artemisia argyi extract in medicine for treating cor pulmonale and its preparation method. Background technique [0002] Cor pulmonale (pulmonary heart disease) is a change in the structure and (or) function of the lung tissue caused by chronic disease of the lung tissue, pulmonary vessels, or thorax, resulting in increased pulmonary vascular resistance, increased pulmonary artery pressure, and dilated or (hypertrophic) right ventricle ), with or without right heart failure. The main pathological changes of cor pulmonale include pulmonary arterial hypertension (PAH) and heart disease, among which PAH is the central link and prerequisite in the pathogenesis of cor pulmonale, and the final destination and concentrated manifestation of cor pulmonale in heart disease. The main treatment measures include improvement of respiratory function, correction of hypoxi...

Claims

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Application Information

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IPC IPC(8): A61K36/282A61K47/48A61K9/127A61P11/00A61P9/04A61P9/00
Inventor 应茵黄萍张美玲杨秀丽羊波韩冰叶佐武
Owner TONGDE HOSPITAL OF ZHEJIANG PROVINCE
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