47 results about "Pulmonary vessels" patented technology

A method is provided for treating a cardiovascular disease, such as pulmonary arterial hypertension, an arrhythmia, or heart failure. One step of the method includes providing an apparatus. The apparatus includes an expandable support member having oppositely disposed proximal and distal end portions and a main body portion extending between the end portions. The proximal end portion includes a plurality of wing members extending from the main body portion. At least a portion of the expandable support member is treated with at least one therapeutic agent for eluting into a blood vessel. The expandable support member is inserted into the pulmonary vasculature and then advanced to a bifurcation in the pulmonary vasculature. The bifurcation includes the intersection of a first pulmonary vessel, a second pulmonary vessel, and a third pulmonary vessel. The expandable support member is secured at the bifurcation to treat pulmonary arterial hypertension, for example.

The embodiment of the invention provides a CT image pulmonary vessel segmentation method and system based on deep learning, a used deep learning network model is 3D UNet. The method comprises the following steps: S1, preprocessing; S2, performing three-dimensional sampling; S3, blood vessel segmentation; S4, distinguishing arteries and veins of the blood vessels; and S5, post-processing: combiningthe arteriovenous probability graph obtained by the arteriovenous distinguishing of the blood vessels and the blood vessel preliminary segmentation result obtained by the blood vessel segmentation module. According to the CT image pulmonary vessel segmentation method and system based on deep learning, intrapulmonary small vessels and extrapulmonary large vessels can be segmented, arteries and veins can be completely and automatically distinguished, and the segmentation accuracy is improved.

A method of identifying at least part of a pulmonary artery tree (402) comprises receiving (102) a bronchial tree structure (500) and receiving (104) a pulmonary vessel structure (400). A pair of a first bronchial segment (602) and a first vessel segment (604) is identified (106), wherein the first bronchial segment and the first vessel segment are adjacent with respect to position and orientation. The first vessel segment is identified (108) as arterial segment of the pulmonary artery tree. A spatial transformation is applied (110) such that the first bronchial segment and the first vessel segment substantially coincide (602′). Respective further vessel segments (606, 608) are identified (112) adjacent to bronchial segments (610, 612), wherein the bronchial segments are comprised in the bronchial tree.

The invention relates to a pulmonary vascular tree segmentation method with tubular structure enhancement and an energy function combined. A Pock function is used to calculate the response of a tubular structure, and a potential vascular region is thus detected; a tubular structure enhancement algorithm based on a diffusion tensor is then adopted to enhance the original image, influences on the original image by noise are reduced, and the vascular region is enhanced; and finally, a Pock function calculation result and an image enhancement result are combined to build a region description operator, and a minimum energy segmentation method VRG method is used to finely segment the pulmonary vessel. The segmentation result shows that while the method segments a main pulmonary vessel, a large amount of tiny vessels are also extracted, and the segmentation result is little influenced by the noise. The method is high in specificity, the sensitivity is strong, a vessel and a tracheal wall areacan be distinguished, and the segmentation result accuracy is further improved.

An implantable recyclable pulmonary vessel pressure sensor is characterized in that a group of nickel-titanium hyperelastic alloying metal wires is connected in an end-to-end manner to form a self-expanding oval support, a pressure sensor is arranged on any one of the nickel-titanium hyperelastic alloying metal wires of the self-expanding oval support, and a tail hook is arranged at one end of the self-expanding oval support. The self-expanding oval support with the pressure sensor reaches a lesion site through a press holding type delivery catheter, and after fixation is released, the pressure sensor is capable of sensing pressure signals of monitoring sites continuously; when a reader is implanted on the chest skin, real-time pressure signals and measured values can be monitored and displayed through a pressure sensing system in the reader, the reader can be connected to a pressure analyzer through a needle hole connection jack at the bottom end of the reader, the pressure signals can be printed in real time through the pressure analyzer, all pressure records in the reader are stored, and the self-expanding oval support can be recycled at any time through the tail hook. The implantable recyclable pulmonary vessel pressure sensor and a use method thereof have the advantages of simplicity in operation, small test result errors, no pain on patients, low cost, accurate results, wide application and continuous replacement of existing materials.

A method for distinguishing between pulmonary arteries and pulmonary veins and a method for quantifying blood vessels are disclosed. The method for distinguishing between pulmonary arteries and pulmonary veins includes: forming a set of pulmonary vessels for points corresponding to pulmonary vessels, wherein each of the points of the set of pulmonary vessels has weight information; forming a tree from the points of the set of pulmonary vessels by using the weight information; and distinguishing between the pulmonary arteries and the pulmonary veins by separating the tree into a plurality of regions. The method for quantifying blood vessels includes: extracting blood vessels as a three-dimensional set of voxels based on medical images of an organ; finding the voxels of blood vessels included in a region of interest of the organ; and quantifying length information of the blood vessels by using the found voxels.

The invention relates to a CT image lung vessel segmentation method. The method comprises the steps of S1, acquiring a to-be-segmented image; s2, performing data preprocessing on the to-be-segmented image; s3, sampling a local input image block; s4, inputting the image blocks into a pre-trained segmentation model; s5, post-processing a segmentation result, and constructing a blood vessel tree diagram for refinement; and S6, carrying out three-dimensional visualization on a segmentation result. A segmentation network model is an improved 3D Unet model, and a multi-scale strategy is added to theimproved 3D Unet model to capture rich context information so as to improve the characteristic performance of pulmonary vessels. An attention mechanism is introduced for pulmonary vessel segmentationof pathological lung data, a related region of a target can be highlighted adaptively, and irrelevant features, especially the influence of a lesion region on vessel segmentation, can be inhibited implicitly.

Emerging evidence indicates that diminished activity of the vasoprotective axis of the renin-angiotensin system, constituting angiotensin converting enzyme2 (ACE2) and its enzymatic product, angiotensin-(1-7) [Ang-(1-7)] contribute to pulmonary hypertension (PH). However, clinical success for long-term delivery of ACE2 or Ang-(1-7) would require stability and ease of administration to increase patient compliance. Chloroplast expression of therapeutic proteins enables their bioencapsulation within plant cells to protect from acids and gastric enzymes; fusion to a transmucosal carrier facilitates effective systemic absorption. Oral feeding of rats with bioencapsulated ACE2 or Ang-(1-7) attenuated monocrotaline (MCT)-induced increase in right ventricular systolic pressure, decreased pulmonary vessel wall thickness and improved right heart function in both prevention and reversal protocols. Furthermore, combination of ACE2 and Ang-(1-7) augmented the beneficial effects against cardio-pulmonary pathophysiology induced by MCT administration.

Experiments have also been performed which indicate that this approach is also suitable for the treatment or inhibition of experimental uveitis and autoimmune uveoretinitis These studies provide proof-of-concept for a novel low-cost oral ACE2 or Ang-(1-7) delivery system using transplastomic technology for pulmonary and ocular disease therapeutics.

The embodiment of the invention provides a three-dimensional reconstruction method and device for a blood vessel image. The method comprises the following steps: segmenting a three-dimensional chest image by adopting a level set method to obtain a two-dimensional lung image; obtaining a mask image of a lung blood vessel according to the two-dimensional lung image; performing interpolation calculation on the mask image to obtain a complete lung blood vessel image; and performing volume rendering on the lung blood vessel image to obtain a three-dimensional lung blood vessel image. According to the embodiment of the invention, a pulmonary vessel tree can be established to assist a doctor in avoiding vessels as much as possible when determining an operation scheme, so that damage to the vessels is reduced.

The invention provides application of an aminoadamantane mononitrate compound in preparation of drugs for preventing and treating diseases such as glaucoma, vascular dementia, subarachnoid hemorrhage and pulmonary arterial hypertension. Discovered by experiments, the aminoadamantane mononitrate compound can be combined with an NMDA receptor and release nitric oxide (NO), excitatory toxicity of nerve cells induced by glutamic acid can be lowered, the compound plays a role in dilating cerebral blood vessels, cerebral blood flow can be improved, but peripheral blood pressure is not lowered; retinal ganglion cell injury induced by high intraocular pressure can be reduced, and the intraocular pressure is lowered through releasing the NO; in a vascular dementia model, the cerebral blood flow can be improved, motor behavior disorder is relieved, and learning cognitive ability is improved; behavioral abnormality and cerebrovascular spasm induced by subarachnoid hemorrhage can be relieved; discovered by researches on tissue distribution of the drugs, MN-08 can be gathered in pulmonary tissue, in a pulmonary arterial hypertension model, pulmonary blood vessels can be dilated, right ventricular pressure can be lowered, and plumpness of right ventricle can be reduced.

The invention relates to the fields of medicine chemistry and medicine therapy, in particular to a NO (nitric oxide) donor oleanolic acid derivative. A NO donor can effectively relax blood vessels; a CDDO compound can inhibit the reconstruction of pulmonary arterial vascular. The invention particularly relates to a joint medicine utilization strategy of NO donor on relaxing blood vessels and CDOO and derivative thereof on inhibiting reconstruction of blood vessels, synthesis, and evaluation on pulmonary arterial hypertension-resistant activity. The compound can be used for treating the increasing of pulmonary arterial pressure due to increase of pulmonary vessel resistance. The invention also relates to a preparation method of the compound and a medicine composition containing the compound.

The invention provides a lung tissue dissimilation degree judgment method and device, and the method comprises the following steps: carrying out the pulmonary parenchyma segmentation of all lung CT images, and generating a pulmonary parenchyma segmentation image; performing binarization processing on the pulmonary parenchyma segmentation image to generate a pulmonary parenchyma mask image; carrying out feature enhancement processing on pulmonary vessels in all pulmonary parenchyma segmentation images to generate pulmonary vessel feature enhancement images; carrying out binarization processingon the pulmonary vessel feature enhancement image to generate a pulmonary vessel mask image; counting the number L of pulmonary parenchyma region pixel points in all pulmonary parenchyma mask images to serve as volume parameters of the pulmonary parenchyma region pixel points; counting the number V of pulmonary vessel region pixel points in all the pulmonary vessel mask images as volume parametersof the pulmonary vessel region pixel points; and based on the number L of the pulmonary parenchyma region pixel points in all the pulmonary parenchyma mask images and the number V of the pulmonary vessel region pixel points in all the pulmonary vessel mask images, calculating to obtain a pulmonary effective ventilation function region proportion ELVAR value, and outputting the ELVAR value. The method and the device provided by the invention provide a reliable basis for clinical related lung condition evaluation.

The invention relates to a system for assessing a pulmonary image which allows for an improved assessment with respect to lung nodules detectability. The pulmonary image is smoothed for providing different pulmonary images (20, 21, 22) with different degrees of smoothing, wherein signal values and noise values, which are indicative of the lung vessel detectability and the noise in these images, are determined and used for determining an image quality being indicative of the usability of the pulmonary image to be assessed for detecting lung nodules. Since a pulmonary image shows lung vessels with many different vessel sizes and with many different image values, which cover the respective ranges of potential lung nodules generally very well, the image quality determination based on the different pulmonary images with different degrees of smoothing allows for a reliable assessment of the pulmonary image's usability for detecting lung nodules. The image quality is used to determine a radiation dose level to be applied for generating a next pulmonary image.

The invention relates to weight reducing healthcare essence and a preparation method, and belongs to the technical field of weight reducing essence of healthcare products. The weight reducing healthcare essence is prepared from 16 raw materials such as a rhubarb extract and a lotus leaf extract by seven steps. Seven extracts in a formula are aromatic substances extracted from leaves, stems, roots or fruits of natural plants and are non-irritating to human skins, and abdomen massage fat loss effects are good. Urea, water-soluble azone and phenoxyethanol are common additives in cosmetics and safe to use. PEG-60 hydrogenated castor oil is efficient, soluble, easy to decompose, free from residues and safe to use. Coix seed oil removes dampness, promotes diuresis, stimulates respiration, expands pulmonary vessels and simultaneously has nourishing and anticancer effects. Safflower carthamus distilled oil is rich in linolenic acid content and vitamin E and easily absorbed by human bodies. The preparation process is simple, and cost is low. The shortcomings of the prior art are overcome, and the essence with good abdomen weight reducing fat loss effects is added for office workers and numerous beauty lovers.

The present invention relates to the field of medical imaging in the absence of contrast agents. In one form, the invention relates to the field of imaging vessels, particularly blood vessels such as the pulmonary vasculature and is suitable for use as a technique for detecting pulmonary embolism (PE), such as acute PE. Embodiments of the present invention provide improved image processing techniques having the capability to extract and use image data to overcome the need for contrast agents to distinguish between different types of tissue. Furthermore, it has also been realised that the image data accessed by the improved image processing can be used to identify irregularities in vessels.

The invention provides a pulmonary vessel segmentation method and device, a storage medium and electronic equipment, and relates to the technical field of image processing. The lung blood vessel segmentation method comprises the steps of determining a mediastinal blood vessel image corresponding to a mediastinal region image based on the mediastinal region image corresponding to a to-be-segmented lung three-dimensional image; based on the mediastinal blood vessel image, processing a first lung blood vessel three-dimensional image generated based on the to-be-segmented lung three-dimensional image to obtain a second lung blood vessel three-dimensional image; and processing the second lung blood vessel three-dimensional image based on the lung blood vessel skeleton diagram corresponding to the lung three-dimensional image to be segmented to obtain a lung blood vessel segmentation result of the lung three-dimensional image to be segmented. According to the pulmonary vessel segmentation method, the segmentation result of the mediastinum is optimized, so that the final pulmonary vessel segmentation result is more accurate, and doctors can conveniently diagnose lung-related diseases of patients.

The invention discloses an image processing method and device, which are used for realizing more accurate segmentation of a tiny complex tubular structure in a lung image and obtaining an image which more intuitively displays three-dimensional anatomical structure information of lung parenchyma, a lung tracheal tree and a lung vessel tree. The image processing method provided by the invention comprises the following steps: inputting a to-be-tested sample into a model obtained by training in advance based on a human chest three-dimensional image, and outputting a prediction result, wherein the to-be-tested sample comprises a human chest three-dimensional image of a to-be-tested person; and performing overturning processing on the prediction result to obtain an image including three-dimensional anatomical structure information of the pulmonary parenchyma, the pulmonary tracheal tree and the pulmonary vascular tree.

The invention discloses a preparation method of a rabbit pulmonary vascular model. After the lung and heart tissues of a rabbit are acquired, denture base resin solvents with different colors are infused to the pulmonary vein along the superior vena cava, are infused to the pulmonary artery along the aorta and are infused into the trachea along the main bronchus, and a denture base resin forming part in the lung tissue is left, so that the rabbit pulmonary vascular model is obtained. The method is low in cost, and people can be effectively helped to prepare the pulmonary vascular model for observing specific distribution of the pulmonary artery, the pulmonary vein, the trachea and the main bronchus and more simply and conveniently learning and studying the pulmonary vessels, thereby guiding acquisition of the lung tissue of the rabbit.

The invention discloses a plugging device for an unclosed hole of a patent ductus arteriosus. The perforated plugging device for the unclosed hole of the patent ductus arteriosus comprises a front disk for plugging a gap, a cylindrical barrier part for blocking an unclosed ductus, and a through hole penetrating through the front disk and the cylindrical barrier part; one end of the cylindrical barrier part is connected with the front disk; the other end of the cylindrical barrier part is a closed end; the diameter of the front disk is greater than that of the cylindrical barrier part; the front disk, the cylindrical barrier part and the through hole are all formed by weaving a plurality of memory alloy wires; the memory alloy wires penetrate through the through hole to form the hole wall of the through hole and are wound to form the front disk and the cylindrical barrier part; the two ends of the memory alloy wires are fixed to the same fixing clamp for restricting the memory alloy wires; the memory alloy wires are interwoven to form an elastic mesh; a sealing film is arranged in the elastic mesh. According to the perforated plugging device for the patent ductus arteriosus, the shunt of aorta-pulmonary artery is limited, and the blood flow of the aorta of a high-pressure chamber is also prevented from flowing to the pulmonary artery; the volume overload and the pressure transfer of pulmonary vessels are lightened; serious consequences caused by sudden rise of the pulmonary artery pressure can also be prevented, so that the high pressure of a right heart system has release space.

The invention relates to an isolated culture method for chicken embryo pulmonary arterial smooth muscle cells. The method comprises the following steps that a chicken embryo herringbone pulmonary blood vessel is isolated and kept wet through PBS, tiny connective tissue on the periphery of the vessel is trimmed and removed, the herringbone pulmonary blood vessel is divided into two vessels which are longitudinally cut at a time, a trypsin solution is used for digesting the longitudinally-cut vessels for 1-2 min at 15-37 DEG C, then a complete medium is used for stopping digestion to obtain a digested tissue block, the digested tissue block is cut into small tissue blocks with the size of 0.4-0.6 mm, and primary culture is carried out on the small tissue blocks in the complete medium. According to the isolated culture method for chicken embryo pulmonary arterial smooth muscle cells, operation is easy, the repeatability is good, the cultured cells are high in purity, the growth period is short, cells can climb out at the third day of culture, continuous cell culture can be carried out after 4 days of primary culture, and the cells grow vigorously.

The invention belongs to the technical field of biological medicines, and discloses application of polydatin in preparation of a medicine for treating pulmonary arterial hypertension, and application of the polydatin in preparation of a medicine for inhibiting pulmonary vascular remodeling and right heart hypertrophy to treat pulmonary arterial hypertension. The pulmonary arterial hypertension in the invention is represented by right heart hypertrophy and pulmonary vascular remodeling. The dosage of the polydatin disclosed by the invention is 30 mg/kg to 60 mg/kg. The invention provides pharmaceutical application of the polydatin in treating pulmonary arterial hypertension by improving right heart hypertrophy and pulmonary vascular remodeling. The polydatin has a remarkable inhibiting effect on pulmonary vascular remodeling and right heart hypertrophy, and can remarkably reduce the thickness of a pulmonary artery vascular wall, relieve muscle type thickening of a blood vessel middle layer and enlarge the diameter of a vascular cavity, so that the pulmonary artery pressure is reduced; the weight of the right ventricle can be obviously reduced; the right heart hypertrophy index is obviously reduced; and it is prompted that the polydatin has large potential and distant view in excavating and developing of preparation of the targeted medicine for treating pulmonary vascular remodeling.