32 results about "Pulmonary vessels" patented technology

The invention belongs to the technical field of medicine, and particularly relates to a method and application for evaluating the respiratory muscle movement function of an IPF patient based on dynamic MRI. Performing dynamic MRI processing on the to-be-tested person to obtain a lung dynamic MRI image; manually marking and segmenting an end-expiratory image and an end-inspiratory image on the lung dynamic MRI image along the inner edge of the thoracic cavity outline, and checking and correcting; obtaining evaluation parameters of chest wall movement and evaluation parameters of diaphragm movement and form by using the images; measuring parameters are analyzed, and the pulmonary fibrosis degree and pulmonary vessel and chest wall muscle parameters of the HRCT image are quantified; and comparing and statistically analyzing the parameters of different to-be-tested persons so as to evaluate the respiratory muscle movement function of the IPF patient. The dynamic MRI technology is adopted, and a quantitative basis is provided for evaluating the respiratory muscle dysfunction and severity of the IPF patient.

The utility model relates to the technical field of medical instruments, in particular to a pulmonary artery multistage conveying catheter. The pulmonary artery multistage conveying catheter comprises an outer sheath tube, a middle catheter and a working catheter, a first balloon is arranged on the outer wall of one end of the outer sheath tube, a first airflow cavity channel penetrating out of the side wall of the other end of the outer sheath tube is formed in the outer sheath tube, one end of the first airflow cavity channel is communicated with the first balloon, and the other end of the first airflow cavity channel is communicated with the working catheter. The middle catheter penetrates through one end of the outer sheath tube, a second balloon is arranged on the outer wall of one end of the middle catheter, a second airflow cavity channel penetrating out of the side wall of the other end of the middle catheter is formed in the middle catheter, one end of the second airflow cavity channel is communicated with the second balloon, and the working catheter penetrates through one end of the middle catheter. The utility model has the advantages of simple and reasonable structural design, can be specially used for the vast majority of operations of pulmonary vessels, greatly saves the operation time, and reduces the consumable cost of patients.

A lung CT blood vessel image segmentation and reconstruction system based on multiple interpretable features performs further fine-grained segmentation on the basis of main airway features through a feature extraction module to obtain a plurality of connected domains, performs multi-stage feature extraction on the connected domains, and outputs multi-scale feature information; the blood vessel segmentation module generates an information matrix according to the indexes and the pulmonary parenchyma mask, generates a blood vessel network segmentation result through an adversarial network and performs post-processing; and the model reconstruction module performs three-dimensional reconstruction on the blood vessel network segmentation result and the pulmonary parenchyma mask to obtain a 3D model. According to the method, on the basis of anatomical priori knowledge of pulmonary vessels and airways, a large amount of multi-scale feature information is utilized, the information loss of the two-stage segmentation network is reduced, and the network adaptability and the learning ability of the relation between pixels under the complex condition are improved. In the aspect of system design, a modular design and management mode is adopted, efficient resource access is achieved, and meanwhile the operability and usability of the system are improved through end-to-end process design.

The utility model relates to the technical field of medical instruments, in particular to a pulmonary artery wedge pressure balloon. The pulmonary artery wedge pressure balloon comprises a catheter and a balloon body, one end of the catheter is provided with an inclined and elastic bent section, the balloon body is arranged on the outer wall of the end of the bent section, an airflow cavity channel communicated with an inner cavity of the balloon body is formed in the catheter, and the airflow cavity channel penetrates out of the side wall of the other end of the catheter. The pulmonary artery pressure detector has the advantages that the structural design is simple and reasonable, the use cost is low, and the pulmonary vessel pressure information of a pulmonary artery hypertension patient can be effectively detected, so that medical staff can judge the drug effect of administration according to the information or accurately evaluate the interventional operation of the patient.

The invention discloses an application of rhBMP9 in preparation of a medicine for treating idiopathic pulmonary fibrosis related pulmonary arterial hypertension, the rhBMP9 protects pulmonary vascular endothelial cells, inhibits endothelial cell apoptosis and improves pulmonary vascular remodeling by up-regulating BMP9 / BMPR2 / SMAD signal pathways so as to treat IPF-PH, the invention further provides various dosage forms and administration routes of the rhBMP9 medicine, and the rhBMP9 medicine can be used for preparing the medicine for treating the idiopathic pulmonary fibrosis related pulmonary arterial hypertension. According to the application of the rhBMP9 and the drug combination scheme of the rhBMP9 and other IPF treatment drugs, animal experiments show that the rhBMP9 can remarkably improve hemodynamic parameters and lung tissue pathological changes of an IPF-PH model, and a new strategy is provided for clinical treatment of IPF-PH.

A lightweight 3D attention-based dual-path U-Net segmentation method for lung CT vessels, belonging to the field of medical image processing technology, solves the problems of low accuracy and poor segmentation of small vessels due to loss of key information when using existing techniques for vessel segmentation. The key technical points of this invention are: acquiring the image to be segmented, labeling and preprocessing the image, extracting the largest connected region of the image, constructing a DS-ResUNet network, training the DS-ResUNet network, inputting the image into the trained DS-ResUNet network, and outputting a predicted image, which is the result of dual-path U-Net segmentation of lung CT vessels. This invention is applicable to the segmentation of lung CT vessels.

The application provides a chest plain CT image lung artery and vein automatic extraction method, and relates to the technical field of CT image processing. The method first acquires lung airway, lung blood vessel and lung external artery and vein data, and performs data preprocessing and unifies layer thickness; then, based on the reconstructed CT scan image, lung blood vessel skeletonization is performed; and a lung internal artery and vein growth algorithm is used to classify the lung blood vessel skeleton; then, the lung artery and vein are reconstructed according to the artery and vein marked by the lung blood vessel skeleton; finally, the classified lung blood vessel is evaluated according to the blood vessel skeleton of the marked lung internal artery and vein and the blood vessel voxel point after the lung internal artery and vein reconstruction. The method uses multiple features to classify the lung internal artery and vein, does not require the imaging mode of the input data, is an automatic algorithm, does not require manual parameter adjustment or seed point setting, has strong generalization ability, and proposes two new evaluation methods, so that the classification effect of the lung artery and vein is checked and evaluated from multiple angles.

The invention belongs to the technical field of medical treatment, particularly discloses an application of allicin in preparation of a medicine for improving right heart dysfunction caused by pulmonary arterial hypertension, and discloses an effect of the allicin in treatment of the right heart dysfunction caused by the pulmonary arterial hypertension. Compared with existing medicines (mainly for reducing pulmonary arterial pressure) for treating pulmonary arterial hypertension, allicin not only can reduce the pulmonary arterial pressure and relieve the symptoms of pulmonary arterial hypertension, but also can remarkably improve right heart dysfunction caused by pulmonary arterial hypertension, and the allicin is specifically shown as follows: (a) average pulmonary arterial pressure, pulmonary artery ejection time and pulmonary artery end diastolic inner diameter are reduced; the pulmonary artery acceleration time is prolonged; (b) the right ventricular systolic pressure, the right ventricular end-of-systolic free wall thickness, the right ventricular end-of-systolic free wall thickness, the right ventricular end-of-systolic inner diameter and the right heart hypertrophy index are reduced, and tricuspid valve displacement, stroke output and right heart discharge are increased; and (c) improving right ventricular and pulmonary vascular remodeling.

The application provides application of levosulpiride in preparation of a medicine for treating pulmonary arterial hypertension, and the medicine comprises levosulpiride as an active ingredient. Through a pulmonary arterial hypertension model of a rat, the application gives an intervention treatment of levosulpiride, and the effect of levosulpiride on pulmonary vessels is determined: the levosulpiride can reduce the mean pulmonary arterial pressure of a pulmonary arterial hypertension rat, reduce pulmonary vascular resistance, and improve right ventricle and pulmonary vessel remodeling, thereby providing a strategy for developing the medicine for treating the pulmonary arterial hypertension.

This invention discloses a three-dimensional visualization method for pulmonary vessels based on light-sheet fluorescence microscopy, belonging to the field of three-dimensional imaging technology. It solves the problem of low spatial resolution in existing imaging and ultrasound examination equipment. The method includes endotracheal intubation of mice, subcutaneous injection of Cy7 solution for staining, dehydration of mouse lung tissue using gradient concentration tetrahydrofuran solution, and defatting with dichloromethane to make the sample nearly transparent. A light-sheet fluorescence microscopy system is then used to perform three-dimensional imaging of the lung tissue. This invention, through fluorescence excitation and acquisition in the infrared II band, can achieve higher imaging depth of the pulmonary vascular system, and deeper imaging offers better axial resolution, signal-to-background ratio, and contrast. Numerous two-dimensional image slices can be integrated and reconstructed to form an intuitive and complete three-dimensional visualization model of the pulmonary vessels. By quantifying the three-dimensional model, the fine structural changes of the pulmonary vessels can be observed more accurately.

The utility model belongs to the technical field of interventional instruments, and discloses a double-cavity micro catheter capable of accurately positioning the position of a pulmonary vessel working guide wire, which comprises a catheter body and a guide guide wire, and the catheter body is provided with a guide cavity and a working cavity; the guide cavity channel is used for introducing the catheter body into an operation area; the working cavity channel is used for guiding a working guide wire to enter a target blood vessel, two ends are provided with an inlet II and an outlet II, and the outlet II is provided with a developing mark; and the end part of the guide wire is provided with a developing belt with a plurality of strong and weak developing areas with alternate strong and weak developing areas. A mark developing area corresponding to a target blood vessel opening is found through one-time contrast agent injection by arranging a plurality of developing belts with strong and weak developing areas and a developing mark at the position of an outlet II, and then the developing mark at the position of the outlet II corresponds to the mark developing area through X-ray developing, so that working guide wire positioning is realized. The purposes that positioning is completed through one-time radiography and small-amount X-ray development, and the working guide wire is guided to enter a target blood vessel which is difficult to enter are achieved.

This invention belongs to the field of medical image processing technology, specifically relating to a method and apparatus for quantitative analysis of microvessels in pulmonary nodules in chest CT images. The analysis method of this invention includes the following steps: Step 1, preprocessing the chest CT image; Step 2, segmenting the chest CT image using a convolutional neural network model to obtain images of the pulmonary airways, pulmonary vessels, and lung tissue; Step 3, detecting pulmonary nodules in the chest CT image using the convolutional neural network model, extracting lesions, and extracting microvessels around the lesions and within the pulmonary nodules; Step 4, calculating the microvessel density value based on the extraction results of Step 3. This invention also provides an apparatus suitable for the above analysis method. This invention can non-invasively, rapidly, and accurately display the microvessel density value in pulmonary nodules and around lesions in three dimensions, and provide precise quantitative data. It has significant clinical and socioeconomic value.

The present invention discloses the application of Nrf2 in the auxiliary diagnosis of fetal lung hypoplasia caused by intrauterine growth restriction, belonging to the field of biotechnology. This study found that the knockout of the Nrf2 gene in mice with intrauterine growth restriction led to a decrease in the live birth rate compared with wild-type mice, a decrease in the birth weight of fetal mice and the appearance of catch-up growth, an exacerbation of asymmetric development, and an obstruction in the development of pulmonary blood vessels; the oxidative stress index in lung tissue was aggravated; the pyroptosis index GSDMD in lung tissue increased. Overexpression of Nrf2 can effectively inhibit the expression of GSDMD and inhibit cell pyroptosis. The above results indicate that Nrf2 plays an important protective role in the lung hypoplasia of IUGR. Overexpression of Nrf2 can play a role in preventing and / or alleviating fetal lung hypoplasia caused by intrauterine growth restriction, and detecting the content of Nrf2 can predict the development of the fetal lung.

The present disclosure belongs to the technical field of biomedicine, and specifically relates to use of a malic enzyme 1 (ME1) inhibitor in preparation of a drug for preventing and treating pulmonary hypertension (PH) and as a marker for detecting and / or treating the PH. Since a protein level and / or an enzymatic activity are significantly increased in a lung tissue, the ME1 can be used as a marker for detecting or treating the PH. Meanwhile, the ME1 inhibitor can ameliorate pulmonary vascular resistance (PVR) and right ventricular involvement / right heart failure in PH patients by reducing a right ventricular systolic pressure (RVSP) and a right ventricular hypertrophy index (RVHI). Therefore, the ME1 inhibitor can be used as a therapeutic target for treating the PH, thereby increasing a medical utility of the ME1 and the ME1 inhibitor.

A method for improving an ejection fraction of a patient in need thereof, including positioning a pulmonary artery manipulation device in a target blood vessel, within the pulmonary vasculature of the patient; and impairing the activity of at least one sympathetic nerve, nerve fiber or neuron, using the pulmonary artery manipulation device, to denervate the target blood vessel, thereby improving the ejection fraction of the patient.

This invention relates to the field of image enhancement processing technology, specifically to an image enhancement method for chest X-rays used to assess heart failure. The invention first obtains the occluded region of the lung area from an orthogonal X-ray and projects it onto a target image to obtain the occluded portion. Further, based on the similarity between the skeleton lines of the foreground connected components and the edge lines of the occluded portion, combined with the edge blurring features of the connected components and local gray-level differences, the pulmonary vascular information of each pixel is obtained, and the pulmonary vascular region is acquired. Further, based on the similarity of gray-level changes in the vertical direction, pixels in the pulmonary vascular region of left and right anterior oblique X-rays are matched. Finally, based on the overlapping pixel groups and the pulmonary vascular information, the left and right anterior oblique X-rays are translated and superimposed, and the fused pulmonary vascular portion is fitted to the occluded portion to obtain a pulmonary vascular X-ray image. Matching, translation, and superimposition repair the occluded area, overcomes oblique distortion, and improves the display effect of pulmonary vessels.

The invention provides a traditional Chinese medicine composition for treating pulmonary arterial hypertension and application thereof, and belongs to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine composition for treating pulmonary arterial hypertension is prepared from the following components in parts by weight: 5-7 parts of herba ephedrae, 7-9 parts of semen armeniacae amarae, 20-24 parts of gypsum, 5-7 parts of liquorice root, 9-11 parts of radix salviae miltiorrhizae, 0.8-1.2 parts of leech and 2.5-3.5 parts of radix notoginseng. According to the treatment principle of freeing lung, relieving asthma and promoting blood circulation to remove blood stasis, ephedra, apricot kernel, gypsum and licorice granules with the effects of freeing lung, clearing heat and relieving asthma are used as monarch drugs, and salvia miltiorrhiza, leech and pseudo-ginseng with the effects of promoting blood circulation to remove blood stasis are used as ministerial drugs for compatibility; the prepared traditional Chinese medicine composition can reduce the length ratio of the right ventricle to the left ventricle plus ventricular septum and the length ratio of the right ventricle to the tibia, inhibit right ventricular hypertrophy, repair pulmonary vascular injury and improve the pulmonary ventilation function, the cardio-pulmonary function and pulmonary arterial hypertension.

The invention discloses application of mesenchymal stem cell spheres in preparation of medicines for treating pulmonary arterial hypertension, and relates to the technical field of biological medicines. According to the application of the mesenchymal stem cell spheres in preparation of the medicine for treating pulmonary arterial hypertension, the pulmonary arterial pressure of mice can be reduced, lung tissue collagen deposition can be reduced to relieve pulmonary fibrosis, myocardial hypertrophy and right ventricular remodeling are inhibited, pulmonary vascular endothelial injury is improved, and integrity is enhanced; meanwhile, infiltration of inflammatory cells such as macrophages, mononuclear cells and neutrophils in lung tissues is inhibited, and circulating inflammatory response is regulated. The invention provides a novel therapeutic scheme for repairing blood vessels, regulating immunity and improving pathological remodeling for pulmonary arterial hypertension, and has clinical application potential.

The present application relates to medical image processing technical field, more specifically, it relates to a lung blood vessel motion compensation method based on space-time sequence, based on three-dimensional CT image sequence and monitoring data, four-dimensional space-time data set is constructed;Based on the four-dimensional space-time data set, the motion field between adjacent data frames is calculated, and the continuous motion field based on pixels is obtained;According to the continuous motion field based on pixels, the blood vessel motion is decomposed, and the separated heart and lung motion is obtained;Based on the separated heart and lung motion, the prediction field and the local prediction field of the blood vessel motion are calculated;According to the local prediction field, the imaging parameter of the angiography system is adjusted;Based on the separated heart and lung motion and the adjusted imaging parameter, the non-rigid motion field between images is estimated through frame registration method;According to the non-rigid motion field, the motion compensated image is generated through multi-frame image fusion method, through the construction of four-dimensional space-time data set, combined with the innovative blood vessel motion decomposition model, the high-precision compensation of complex lung blood vessel motion is realized.

The invention relates to application of eosinophilic granulocyte cationic protein in preparation of a medicine for preventing and treating pulmonary arterial hypertension, and belongs to the technical field of biological medicine. The invention finds that the ECP level in the plasma of a PAH patient and the ECP level combined with the endothelial surface of the lung far-end arteriole are obviously reduced for the first time, which prompts that the reduction of the ECP level is possibly closely related to the pulmonary vascular remodeling process, and further animal experiments prove that the ECP deficiency has a promoting effect on the generation and development of PAH. The invention also proves that the ECP can be specifically combined with the BMPR-1A / BMPR-2 receptor of the pulmonary artery endothelial cell. Besides, the invention also proves that the exogenous recombinant ECP can inhibit pulmonary vascular remodeling, relieve the occurrence and development of pulmonary arterial hypertension, including reducing vascular wall thickening and collagenous fiber deposition and relieving right heart function, and provides a new therapeutic target and a potential therapeutic strategy for PAH treatment.

The present invention relates to the field of medical device technology, specifically a thrombus stripping and collection net bag and a venous thrombectomy device. The thrombus stripping and collection net bag comprises a proximal stripping net tube and a distal dense net bag. The dense net bag comprises a front bell mouth, a middle waist tube, and a rear retention net. The bell mouth is connected to the stripping net tube. The stripping net tube and the dense net bag are both elastic, self-expanding structures. After expansion, the outer diameters of the bell mouth and the retention net are both larger than the outer diameter of the waist tube. The stripping net tube can separate thrombi and allow thrombi to penetrate, while the dense net bag can filter and collect thrombi. The venous thrombectomy device comprises a thrombus stripping and collection net bag, a blocking net umbrella, an inner sheath, and an outer sheath. The blocking net umbrella is an elastic, self-expanding umbrella-shaped structure with the umbrella mouth facing the distal end. The thrombus stripping and collection net bag and venous thrombectomy device provided by this patent do not block blood flow during thrombus removal, effectively prevent thrombi from escaping and flowing back into the cardiovascular and pulmonary vessels, and can completely collect and remove thrombi without easily damaging the inner wall of the blood vessel.

The utility model belongs to the technical field of medical instruments, and particularly relates to a pulmonary vessel balloon dilatation catheter. The pulmonary vessel balloon dilatation catheter comprises a balloon, and the balloon comprises a balloon body, a far-end cone-shaped body and a near-end cone-shaped body, wherein the far-end cone-shaped body and the near-end cone-shaped body are arranged at the two ends of the balloon body respectively. Wherein the balloon body is of a conical structure, and the diameter of the near end of the balloon body is larger than that of the far end of the balloon body. The pulmonary blood vessel balloon dilatation catheter is designed according to the characteristics of pulmonary artery anatomy, the balloon body can be well attached to the wall of a pulmonary artery when dilated under working pressure, and therefore the occurrence rate of blood vessel injuries can be reduced; and the diameter of the far end part of the balloon body is smaller, so that the balloon body can pass through the vascular lesion part more easily, the interventional operation is simplified, and the operation safety and effect are improved.

The invention discloses a dry powder inhaler of a GLP-1 receptor stimulant and a preparation method and application of the dry powder inhaler, and belongs to the technical field of biological medicine, the dry powder inhaler comprises the following raw materials in percentage by mass: 0.01%-10% of GLP-1 drugs, 10%-99% of carriers and 0-80% of auxiliary materials, the carrier is at least two of first lactose, second lactose, mannitol, xylitol, cyclodextrin, a cyclodextrin derivative, trehalose, trehalose hydrate, dipalmitoyl lecithin, distearoyl phosphatidylcholine, glucose, amino acid and an amino acid derivative, and the prepared dry powder inhalant of the GLP-1 receptor agonist is used for pulmonary administration, has the advantages of high bioavailability and high bioavailability, and can be used for preparing the dry powder inhalant of the GLP-1 receptor agonist. The medicine can be directly inhaled into the end bronchus or alveolus of the respiratory tract in the form of particles and absorbed by the lung, and the medicine can be rapidly absorbed into blood by utilizing the characteristics of short pulmonary circulation path, thin pulmonary artery wall, multiple pulmonary vessel branches and the like, so that the medicine takes effect more rapidly.

The application discloses a lung multi-anatomy analysis and three-dimensional reconstruction method, which comprises the following steps: acquiring and preprocessing chest CT scan images to obtain input tensors; identifying and outputting airway masks and lung blood vessel masks in the input tensors by using a connected structure segmentation network; identifying and outputing lung nodule masks in the input tensors by using a micro-lesion analysis network; determining spatial physical coordinates of foreground voxels of each mask in the chest CT scan images, and determining unique anatomy class labels of each voxel by using a dynamic clinical risk priority conflict resolution strategy to obtain a multi-anatomy voxel set; and sampling and reconstructing each anatomy based on an adaptive manifold sampling strategy based on morphological characteristics to obtain reconstructed lung multi-anatomy. The method can clearly show the spatial relationship among airways, blood vessels and lesions in a unified three-dimensional coordinate system, and provides an intuitive and accurate digital model for clinical diagnosis and treatment.

The utility model belongs to the technical field of pulmonary vessel guiding catheters, and particularly relates to a pulmonary vessel guiding catheter which can be used for right heart function examination. The technology comprises a guiding catheter, and a floating catheter is arranged in the guiding catheter in a penetrating mode. According to the technical scheme, the functions of an existing right heart floating catheter and an existing pulmonary vessel guiding catheter are organically combined, and the function effects of the original right heart floating catheter and the original pulmonary vessel guiding catheter are achieved through one set of technical scheme. Specifically, a guiding catheter in the prior art is adopted, and physical characteristics such as proper flexibility and strength are utilized to adapt to various bends and steers in a blood vessel; a floating catheter in the prior art is adopted to realize pulmonary vessel intervention operation; the floating catheter is arranged in the guiding catheter, so that the guiding catheter can be used for right heart function examination and pulmonary vessel intervention operation, and clinical diversified requirements are met.

The application is suitable for the technical field of image processing, and provides a lung blood vessel segmentation method and device in a CT image, a terminal equipment and a medium. The method comprises the following steps: acquiring a lung CT image to be segmented, and inputting the lung CT image to a pre-trained lung blood vessel segmentation model to output a segmentation result of lung blood vessels in the lung CT image; the lung blood vessel segmentation model comprises an encoder and a decoder; the encoder comprises a depth separable convolution module and a Swin Transformer module, and the two modules are respectively used for acquiring local feature information and global feature information of the lung CT image to be segmented; the decoder comprises a residual module, a multi-dimensional feature calibration module, an up-sampling path and a channel splicing module; the residual module, the multi-dimensional feature calibration module, the up-sampling path and the channel splicing module are used for fusing the local feature information and the global feature information. The application can improve the segmentation accuracy of small branches of lung blood vessels.

The invention belongs to the technical field of biomedicine, and particularly relates to a method for evaluating the elastic contraction function of lung tissue and application thereof.The method for evaluating the elastic contraction function of the lung tissue comprises the following steps that (1) a semi-automatic segmentation module of ITK-SNAP software is adopted for lung area recognition, and an initial lung segmentation mask is generated; performing 10 voxel morphological expansion on the mask to generate an inspiration sequence mask and an expiration sequence mask; (2) outputting to obtain a shape transformation matrix; the method comprises the following steps: quantitatively analyzing lung elastic contraction characteristics of an IPF patient by using an elastic registration algorithm, and analyzing the correlation between elastic contraction parameters and lung function parameters, dyspnea degree, exercise tolerance, health-related life indexes and the correlation between pulmonary fibrosis degree and pulmonary blood vessel related parameters quantified based on HRCT (High Resolution Computed Tomography); mRI-based lung elastic contraction quantitative analysis is expected to become a novel image marker and is used for noninvasive evaluation of lung tissue elasticity of an IPF patient.

The invention discloses a Myo9b inhibitor and application thereof in prevention and treatment of pulmonary arterial hypertension diseases, the Myo9b inhibitor is used for prevention and / or treatment of individual pulmonary arterial hypertension diseases, and the application comprises preparation of a pharmaceutical composition. The Myo9b inhibitor inhibits abnormal proliferation and migration of hypoxia-induced pulmonary artery smooth muscle cells, so that the pulmonary vascular remodeling process is slowed down, a novel Myo9b-targeted treatment strategy is provided for the pulmonary hypertension disease, and a foundation is further laid for developing a novel high-safety medicine capable of effectively treating the pulmonary hypertension disease.

The invention belongs to the field of intelligent medical treatment, and particularly relates to a construction method and equipment of an intractable mycoplasma pneumonia prediction model. The method comprises the following steps: acquiring a data set of baseline time and a follow-up time label of a mycoplasma pneumoniae patient; inputting the image data set into a pulmonary blood vessel segmentation model to obtain a pulmonary blood vessel network, obtaining a total pulmonary blood vessel volume based on the pulmonary blood vessel network, and obtaining blood vessel volumes of different cross section areas based on the blood vessel cross section areas in the pulmonary blood vessel network; and inputting the ratio of the blood vessel volume of different cross section areas to the total pulmonary blood vessel volume into a machine learning model to obtain a prediction label, and iteratively optimizing the machine learning model based on the difference between the prediction label and the follow-up time label to obtain an intractable mycoplasma pneumonia prediction model. According to the method, the lung CT image is segmented to obtain the blood vessel network graph, the percentage of the volume of blood vessels with different thicknesses in the total lung blood vessel volume is obtained through quantification, and the refractory pneumonia prediction model is constructed based on an innovative feature extraction mode.

The invention relates to the technical field of medicines, provides novel application of enoxaparin combined with sivelestat, and particularly relates to application of enoxaparin combined with sivelestat in preparation of medicines and systems for preventing or treating decompression sickness. The application of enoxaparin combined with sivelestat preventive administration in combination with hyperbaric oxygen therapy in prevention and treatment of decompression sickness lung injury caused by rapid buoyant escape can significantly reduce the death rate of decompression sickness caused by rapid buoyant escape, alleviate lung tissue pathological conditions and inflammatory cell infiltration, reduce pulmonary vascular leakage caused by rapid buoyant escape, and improve the clinical application value of decompression sickness lung injury caused by rapid buoyant escape and decompression sickness, and the application of enoxaparin combined with sivelestat in prevention and treatment of decompression sickness lung injury caused by rapid buoyant escape. The levels of lung tissue inflammatory factors and chemotactic factors are reduced.