59 results about "Injury blood vessel" patented technology

A blood vessel extroverting instrument used to turn an end of a blood vessel inside out. The instrument has a contact portion to be brought into contact with an end of a blood vessel, a supporting portion on which the contact portion is supported, and an operating mechanism for increasing and reducing the diameter of the contact portion. At least two portions of the end of the blood vessel in the radial direction can be simultaneously expanded and/or reversed by operating the operating mechanism. Therefore the blood vessel extroverting instrument provided by the present invention is capable of easily turning an end of a blood vessel inside out in a short time without damaging the blood vessel.

The invention discloses a thrombectomy bracket system, which comprises the thrombectomy bracket, and the distal end of the thrombectomy bracket is in an open state. Preferably, the thrombectomy stent is in the shape of a roll; the cross section of the thrombectomy stent is an open-loop structure, so that the stent has a suitable supporting force and also has very good flexibility, and can better reach curved blood vessels in the cranium. The thrombectomy stent has a suitable supporting force, which is beneficial to improve the fusion between the thrombus retrieval stent and the thrombus without damaging the blood vessel and increasing the grasping ability of the thrombus. Furthermore, the special cutting design of the thrombectomy stent ensures the flexibility of the thrombectomy stent and has a suitable and good thrombus grasping ability, and can effectively attach the thrombus to avoid the thrombus from falling off from the thrombus retrieval stent during the thrombectomy process.

The invention relates to a third generation PCI therapeutic saccule support system, a preparation method and application, and belongs to the field of biomedical engineering. The therapeutic saccule support treatment system comprises a catheter and a saccule, and is characterized in that the support is a naked support, and a therapeutic medicament and/or a cell coat are attached to the surface of the saccule. After the saccule expansion support is placed into a coronary artery through the catheter, the saccule is expanded through transient pressure so that the medicament or the cell coat on the saccule can tightly cling to the inner wall of a blood vessel so as to repair the blood vessel intima injured by saccule expansion. The system well combines the advantages of the first generation support system and the second generation support system so that the saccule carries the medicament to enter the blood vessel once, and the support is the naked support and only plays a role in supporting the blood vessel so as to well solve the problem of long-term non healing of the injured blood vessel caused by the sustainable medicament of the second generation support system, effectively prevent the formation of thrombus and restrain the occurrence of restenosis.

A kind of medicinal elution cardiovascular frame, comprises frame and biological degradation layer, which is made of biological degradation material that embeds the drug and covered in the frame. The characteristic is: the biological degradation material includes glycolide, L-lactide, homopolymers or one of the copolymer and the copolymer with polyfunctional group amino acid of Epsilon-caprolactone; the biological degradation layer contains the drug is a kind of macromolecule graft heparin. After the frame is implanted, the drug is deliveried to limit the endometrial hyperplasia sufficiently, and the heparin is exist continuously and steadily. It can prevent the occurrence of acute or subacute thrombus, and can promote the healing of the injury vessel wall, prevent the occurrence of late thrombus. Compare to the traditional heparin frame, it overcomes the defects like intolerance by the humor erosion and interceding poison substance in the progress of chemical binding.

The invention provides a coronary stent containing a recombinant human cellular repressor of E1 A-stimulated genes (hCREG) glycoprotein. The surface of the coronary stent is uniformly coated with the recombinant hCREG glycoprotein. After the coronary stent is implanted into a human body, the proliferation of vascular smooth muscle cells is restrained by the sustained release of hCREG glycoprotein components carried by the stent, the re-endothelialization of a vascular wall is promoted, and the damaged vascular wall is quickly cured, so that intraluminal thrombi caused by medical equipment are prevented, and the time used by a patient to take anti-thrombotic medicaments and blood platelet medicaments postoperatively is shortened.

The invention discloses a medical guide wire, and belongs to the technical field of machinery. The invention provides a guide wire. The guide wire comprises a proximal isodiametric core wire section and a distal diameter-variable core wire section. The diameter-variable core wire section comprises a proximal cutting section and a distal tip. A plurality of pairs of recesses formed by cutting are uniformly distributed on the cutting section along the axial direction. The two recesses in the same pair are symmetrically arranged relative to the axis of the diameter-variable core wire section. Dueto every two adjacent pairs of recesses in staggered arrangement, the cutting section is set to enable the entire guide wire of the present invention to have stable support force and excellent torquetransmission capacity. Therefore the guide wire has the capacity of passing through tortuous blood vessels and is unlikely to injure blood vessels. According to the guide wire provided by the invention, a sharpened end is arranged on the tip of the guide wire, and a spring is sleeved on the the tip of the guide wire. An elastic sheath is wrapped outside the spring. Due to the arrangement of the tip and the elastic sheath, the optimal contact part between the guide wire and the inner walls of blood vessels is soft enough, so that the guide wire of the present invention is unlikely to injure the blood vessels.

A kind of medicinal elution cardiovascular frame, comprises saccule expansion frame and biological degradation layer, which is made of biological degradation material that embeds the drug and covered in the frame. Wherein, the biological degradation material includes glycolide, L-lactide, homopolymers or one of the copolymer and the copolymer with polyfunctional group amino acid of Epsilon-caprolactone. The biological degradation layer is a kind of macromolecule graft heparin, the drug contains rhubarb horsetails and one or more of the emodin. The biological degredation macromolecule graft heparin opposes being more narrow is covered in the frame. After the frame is implanted, the drug is deliveried to limit the endometrial hyperplasia sufficiently, and the heparin is exist continuously and steadily. It can prevent the occurrence of acute or subacute thrombus, and can promote the healing of the injury vessel wall, prevent the occurrence of late thrombus. Compare to the traditional heparin frame, it overcomes the defects like intolerance by the humor erosion and interceding poison substance in the progress of chemical binding.

The invention relates to a medical instrument, in particular to an inflatable type zero-damage blood vessel occlusion tractor which is an auxiliary operation instrument used for stopping blood and exposing operation view without damage in surgical operation. The inflatable type zero-damage blood vessel occlusion tractor comprises a blood vessel clamp pipeline comprising an upper wall and a lower wall. The upper wall is movably connected with the lower wall through a clamping groove and a lock catch which are matched with each other, an air bag is arranged on the inner wall of the upper wall, and rubber is embedded on the inner wall of the lower wall. The inflatable type zero-damage blood vessel occlusion tractor further comprises an air flow control device for controlling air amount in the air bag, and the air flow control device comprises an air inflation device, a vent pipe and an air flow controller arranged on the vent pipe. The air inflation device is a needle cylinder with a pushing handle or a hand air pump, the vent pipe is a high-temperature-resisting rubber pipe, the air flow controller is a clamp or forceps with lock catches, and the vent pipe is communicated with the air bag on the inner wall of the upper wall. The inflatable type zero-damage blood vessel occlusion tractor has the advantages of being small in size, low in weight, convenient to carry, simple and feasible in operation, strong in pertinence, and wide in practicability.

The invention discloses an adhesive self-repairing hemostatic membrane and a preparation method thereof. The hemostatic membrane is prepared by the following steps od fully reacting dopamine grafted oxidized alginic acid, acrylamide, acrylic acid N-hydroxysuccinimide ester and N, N'-methylene bisacrylamide, adding a coagulation crosslinking agent, acrylic acid and a first part of a photoinitiator,carrying out pre-polymerizing, and adding a mixed solution of acrylate PEG-N hydroxyl succinimide ester, dopamine, acrylamide, acrylic acid N-hydroxyl succinimide ester and a second part of photoinitiator, fully polymerizing, and carrying out programmed vacuum drying to obtain the product. The hemostatic membrane prepared by the invention can quickly absorb interface moisture, so that the interface of the hemostatic membrane is in full contact with a tissue interface, strong adhesion is formed to tissues through covalent bonds and intermolecular forces, mechanical compression is caused to injured blood vessels, and hemostasis is promoted. After the hemostatic membrane absorbs blood or tissue fluid, dynamic bonds can be formed, and a certain self-repairing function is achieved. Therefore,the hemostatic membrane has the effects of rapid and efficient hemostasis, adhesion and self-repairing.

The invention discloses a vascular interventional radiography guide wire and a preparation method thereof. The vascular interventional radiography guide wire comprises an internal strong developing metal core, a head end internal spring ring sleeve, an external far end spring ring sheath and an external near end polymer sheath, and the surface of the guide wire is coated with a hydrophilic coating. The head end of the radiography guide wire provided by the invention is preformed into a J-shaped elbow, so that the radiography guide wire does not easily enter a branch blood vessel, and the condition that head end of the guide wire damages the inner wall of the blood vessel can be effectively avoided. The J-shaped elbow can adjust the bending shape of the head end when the external far end spring ring sheath is acted by axial extrusion stress until the J-shaped elbow is adjusted to be straight, so that the radiography guide wire can enter a matched instrument conveniently. Due to the design of external far end spring ring sheath, the tactile feedback of an operator is improved. Due to the design of the spring ring sleeve in the head end, the torque transmissibility and safety of the guide wire are improved, and the head end of the radiography guide wire cannot be wound. Besides, the hydrophilic coating on the surface of the radiography guide wire improves the lubricity of the radiography guide wire, so that the radiography guide wire can easily reach a target part in a blood vessel.

The invention relates to the technical field of medical instruments, and in particular relates to a postcava filter being capable of being placed for a long term and provided with an anti-proliferation and antithrombus medicine coating. The postcava filter comprises a branch pipe, a pipe sleeve and a plurality of metal filtering wires, wherein two ends of the metal filtering wires are respectivelyconnected in the branch pipe and the pipe sleeve, and the metal filtering wires are convex outwards, so that a filtering cage is formed; the branch pipe and the pipe sleeve are made of a soft material; a first medicine coating used for resisting thrombus coats each metal filtering wire. According to the postcava filter, the thrombus can be intercepted through the metal filtering wires, so that embolism seldom occurs, due to the first medicine coatings on the metal filtering wires, the taking-out time of the filter can be prolonged, meanwhile, the occurrence rate of a series of complications including the difficulty in taking out, the injuries or tearing of the blood vessels, and the like which are caused by too late taking out can be reduced, the branch pipe and the pipe sleeve sleeve twoends of the metal filtering wires, so that the blood vessels are seldom injured. The postcava filter is strong in practicability and convenient to operate.

The invention provides a cutting balloon with a flexible cutting device. The cutting balloon comprises a balloon body; a flexible cutting device longitudinally arranged along the outer surface of the balloon body, wherein the flexible cutting device comprises a cutting function structure and a flexible functional structure wrapping or semi-wrapping the cutting function structure; the mechanical property of the cutting functional structure is higher than that of the flexible functional structure. Compared with the prior art, the cutting balloon provided by the invention has higher flexibility, can smoothly pass through a complex tortuous blood vessel, quickly reach a preset part, prevent a blood vessel wall from being damaged and improve the instrument safety, and after pressurization, the flexible cutting device is in contact with tissues, and the flexible functional structure is extruded to enable the cutting structure to protrude. Therefore, the cutting balloon has good cutting performance, the cutting structure can be effectively fixed to the balloon through the flexible functional structure, and the phenomenon that the cutting functional structure loses efficacy or falls off in a using process of the balloon is avoided.

The invention discloses an adhesive repair-promoting hemostatic sponge and a preparation method thereof. The hemostatic sponge is prepared according to the following steps: subjecting N-maleinized gelatin, exosome, acrylate-PEG-N-hydroxysuccinimide ester, N,N'-methylenebisacrylamide to full reaction, adding maleic anhydride, acrylic acid and a first part of photoinitiator, performing neutralizingwith a neutralizer, carrying out prepolymerization, adding a mixed solution of acrylic acid N-hydroxysuccinimide ester and a second part of photoinitiator, fully performing polymerizing, and carryingout programmed freeze-drying. The hemostatic sponge prepared by the invention not only can quickly absorb blood or tissue fluid to form gel, form mechanical compression on damaged blood vessels on the surface of a cavity and promote hemostasis, but also can be adhered to the surface of the cavity, so that displacement is prevented while hemostasis is further promoted. The hemostatic sponge disclosed by the invention can slowly release gelatin and exosome, and has a long-acting repair promoting function. Therefore, the hemostatic sponge has the effects of quickly and efficiently stopping bleeding, achieving adhering and promoting repair.

The invention discloses a surgical system, an ultrasonic suction knife system and a control method thereof, and the method comprises the steps: obtaining the imaging data of a target tissue to be removed and the imaging data of a blood vessel, constructing a three-dimensional model of the target tissue to be removed and the blood vessel to be removed, carrying out the overlapping positioning of the three-dimensional model and the positioning data of a to-be-operated part, determining the positioning data of the blood vessel, according to the positioning data of the blood vessel and the positioning data of the ultrasonic suction knife, the relative positions of the ultrasonic suction knife, determining the target tissue and the blood vessel, that is, the relative positions of the ultrasonic suction knife and the blood vessel are positioned, and obtaining the corresponding control parameters according to the relative positions in combination with the diameter of the blood vessel. The control parameters are determined according to the relative position of the ultrasonic suction knife and the blood vessel and the diameter of the blood vessel, so that the blood vessel can be prevented from being damaged while the tumor is removed.

The invention discloses an apocynum venetum tea compound functional beverage capable of preventing and treating cardiovascular and cerebrovascular diseases by targeting vascular endothelial cells. Theamount of a stock solution is calculated according to a final concentration of total flavonoids of 3-100 mg/L, and components of 5-hydroxytryptophan (with a final concentration of 4-200 mg/L), dihydrolipoic acid (with a final concentration of 4-100 mg/L), pantothenic acid (with a final concentration of 1-10 mg/L) and nicotinic acid (with a final concentration of 2-20 mg/L) are additionally added.The formula has a good synergistic effect, with NADPH oxidase inhibited by apocynum venetum tea, the nicotinic acid is added, thus reactive oxygen species (ROS) injuries are not liable to be generated, moreover, the situation that nitric oxide and ROS form active nitrogen to induce nitrative stress, so as to injure vascular endothelial cells is prevented, and by inducing a state of the endothelial cells with a high nitric oxide content and a low ROS content, the added components enhance a physiological effect of the apocynum venetum tea, and reduce side effects. Moreover, in the aspect of developing the formula, by means of high-throughput standardized cell experiments and double-blind randomized controlled multicenter volunteer trials, action ranges and toxicity thresholds of the components of the formula are precisely verified, and the formula has certain tolerance in dosage, and has very high safety, so that the formula is suitable for being used as a core formula for product development.

The invention discloses a porta hepatis blocker. The porta hepatis blocker comprises a sleeve, a blocking hose, a folding assembly and a pressing device. The blocking hose is mounted at the lower end of the sleeve; the folding assembly is installed in the blocking hose and comprises a plurality of connecting assemblies which are arranged in sequence, and any connecting assembly is provided with two connecting units which are rotatably connected; the two connecting units of any connecting assembly are correspondingly and rotationally connected with the two connecting units of the adjacent connecting assembly respectively, and the line included angle theta 1 formed by the two rotating axes of the two adjacent connecting assemblies is smaller than 180 degrees; the pressing device is installed in the sleeve and connected with the two connecting units at the head end of the folding assembly, and when the pressing device is subjected to pressing force, the pressing device drives the tail end of the folding assembly to be wound to the wall of the sleeve. According to the porta hepatis blocking sleeve, blood vessels can be bound together under the condition that the blood vessels are not damaged.