The invention discloses an
apocynum venetum tea compound functional beverage capable of preventing and treating cardiovascular and cerebrovascular diseases by targeting vascular endothelial cells. Theamount of a
stock solution is calculated according to a final concentration of total flavonoids of 3-100 mg / L, and components of 5-hydroxytryptophan (with a final concentration of 4-200 mg / L),
dihydrolipoic acid (with a final concentration of 4-100 mg / L),
pantothenic acid (with a final concentration of 1-10 mg / L) and nicotinic acid (with a final concentration of 2-20 mg / L) are additionally added.The formula has a good synergistic effect, with
NADPH oxidase inhibited by
apocynum venetum tea, the nicotinic acid is added, thus
reactive oxygen species (ROS) injuries are not liable to be generated, moreover, the situation that
nitric oxide and ROS form
active nitrogen to induce nitrative stress, so as to injure vascular endothelial cells is prevented, and by inducing a state of the endothelial cells with a high
nitric oxide content and a low ROS content, the added components enhance a physiological effect of the
apocynum venetum tea, and reduce side effects. Moreover, in the aspect of developing the formula, by means of high-
throughput standardized
cell experiments and double-blind randomized controlled multicenter volunteer trials, action ranges and
toxicity thresholds of the components of the formula are precisely verified, and the formula has certain tolerance in dosage, and has very high safety, so that the formula is suitable for being used as a core formula for product development.