61 results about "Injury blood vessel" patented technology

An intravascular catheter for peri-vascular and / or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and / or nerve fibers in the outer layer or deep to the outer layer of the vessel. A method of treating hypertension involves injecting an ablative fluid such as ethanol deep into zones in the wall of the renal artery such that the zones of fluid merge to form a circumferential ablation ring at a depth which ablates sympathetic nerves while minimizing injury to interior layers of the vessel wall.

A blood vessel extroverting instrument used to turn an end of a blood vessel inside out. The instrument has a contact portion to be brought into contact with an end of a blood vessel, a supporting portion on which the contact portion is supported, and an operating mechanism for increasing and reducing the diameter of the contact portion. At least two portions of the end of the blood vessel in the radial direction can be simultaneously expanded and / or reversed by operating the operating mechanism. Therefore the blood vessel extroverting instrument provided by the present invention is capable of easily turning an end of a blood vessel inside out in a short time without damaging the blood vessel.

The invention discloses a thrombectomy bracket system which comprises a thrombectomy bracket. The far end of the thrombectomy bracket is in an opening state. Preferably, the thrombectomy bracket is shaped like a winding drum; the cross section of the thrombectomy bracket is of an open-loop structure, so that the bracket has proper support force and very good flexibility, and the bracket can better reach an intracranial bent blood vessel. The thrombectomy bracket has the proper support force, fusion of the thrombectomy bracket and thrombus is improved, the blood vessel is not damaged, and the thrombus grasping capacity is improved. Furthermore, by means of special thrombectomy bracket cutting design, the flexibility of the thrombectomy bracket is guaranteed, and meanwhile the very good thrombus grasping capacity is achieved; effective thrombus attaching can be achieved, and the phenomenon that the thrombus gets away from the thrombectomy bracket in the thrombectomy process is avoided.

The invention discloses a shock wave generation system applied to angioplasty. The shock wave generation system applied to angioplasty is provided with an axially extending elongated member with an outer surface; a plurality of wired electrodes arranged in series; at least one non-conductive gap; and a non-conductive member arranged on the at least one non-conductive gap, wherein each of the wireelectrodes is connected to an output terminal of a high-voltage source by a wire extending from one terminal on an outer surface of the elongated member to the wire electrode; and each non-conductivemember has a shape, the configuration of which affects the direction and / or intensity of shock waves generated by arc discharge from the first electrode to the second electrode, or affects the direction and / or intensity of shock waves generated by arc discharge from the second electrode to the first electrode. Calcified plaques in arteries can be effectively crushed, vascular tissue is not damaged, further interventional treatment of the calcified arteries is facilitated, and occurrence of interlayers and restenosis can be reduced.

The invention relates to a third generation PCI therapeutic saccule support system, a preparation method and application, and belongs to the field of biomedical engineering. The therapeutic saccule support treatment system comprises a catheter and a saccule, and is characterized in that the support is a naked support, and a therapeutic medicament and / or a cell coat are attached to the surface of the saccule. After the saccule expansion support is placed into a coronary artery through the catheter, the saccule is expanded through transient pressure so that the medicament or the cell coat on the saccule can tightly cling to the inner wall of a blood vessel so as to repair the blood vessel intima injured by saccule expansion. The system well combines the advantages of the first generation support system and the second generation support system so that the saccule carries the medicament to enter the blood vessel once, and the support is the naked support and only plays a role in supporting the blood vessel so as to well solve the problem of long-term non healing of the injured blood vessel caused by the sustainable medicament of the second generation support system, effectively prevent the formation of thrombus and restrain the occurrence of restenosis.

A kind of medicinal elution cardiovascular frame, comprises frame and biological degradation layer, which is made of biological degradation material that embeds the drug and covered in the frame. The characteristic is: the biological degradation material includes glycolide, L-lactide, homopolymers or one of the copolymer and the copolymer with polyfunctional group amino acid of Epsilon-caprolactone; the biological degradation layer contains the drug is a kind of macromolecule graft heparin. After the frame is implanted, the drug is deliveried to limit the endometrial hyperplasia sufficiently, and the heparin is exist continuously and steadily. It can prevent the occurrence of acute or subacute thrombus, and can promote the healing of the injury vessel wall, prevent the occurrence of late thrombus. Compare to the traditional heparin frame, it overcomes the defects like intolerance by the humor erosion and interceding poison substance in the progress of chemical binding.

The invention provides a coronary stent containing a recombinant human cellular repressor of E1 A-stimulated genes (hCREG) glycoprotein. The surface of the coronary stent is uniformly coated with the recombinant hCREG glycoprotein. After the coronary stent is implanted into a human body, the proliferation of vascular smooth muscle cells is restrained by the sustained release of hCREG glycoprotein components carried by the stent, the re-endothelialization of a vascular wall is promoted, and the damaged vascular wall is quickly cured, so that intraluminal thrombi caused by medical equipment are prevented, and the time used by a patient to take anti-thrombotic medicaments and blood platelet medicaments postoperatively is shortened.

A blood vessel metal stent coating of amidoglucosan polysaccharide loaded with antibody comprises carrier material composed of chitosan and inartificial degradable acidic amidoglucosan polysaccharide and the effective dose of CD133 antibody loaded in the carrier material. The blood vessel metal stent coating is manufactured with self-assemble method to fix the CD133 antibody in the carrier material of the coating. The coating has good biocompatibility, water retention property, flexibility, flush resistance and bio-stability, and can specifically capture the vascular endothelial progenitor cells in human peripheral blood, and differentiate into vascular endothelial cells. The process would accelerate endothelialization to repair injured vessel caused and prevent restenosis and thrombosis efficiently.

The invention discloses a medical guide wire, and belongs to the technical field of machinery. The invention provides a guide wire. The guide wire comprises a proximal isodiametric core wire section and a distal diameter-variable core wire section. The diameter-variable core wire section comprises a proximal cutting section and a distal tip. A plurality of pairs of recesses formed by cutting are uniformly distributed on the cutting section along the axial direction. The two recesses in the same pair are symmetrically arranged relative to the axis of the diameter-variable core wire section. Dueto every two adjacent pairs of recesses in staggered arrangement, the cutting section is set to enable the entire guide wire of the present invention to have stable support force and excellent torquetransmission capacity. Therefore the guide wire has the capacity of passing through tortuous blood vessels and is unlikely to injure blood vessels. According to the guide wire provided by the invention, a sharpened end is arranged on the tip of the guide wire, and a spring is sleeved on the the tip of the guide wire. An elastic sheath is wrapped outside the spring. Due to the arrangement of the tip and the elastic sheath, the optimal contact part between the guide wire and the inner walls of blood vessels is soft enough, so that the guide wire of the present invention is unlikely to injure the blood vessels.

A kind of medicinal elution cardiovascular frame, comprises saccule expansion frame and biological degradation layer, which is made of biological degradation material that embeds the drug and covered in the frame. Wherein, the biological degradation material includes glycolide, L-lactide, homopolymers or one of the copolymer and the copolymer with polyfunctional group amino acid of Epsilon-caprolactone. The biological degradation layer is a kind of macromolecule graft heparin, the drug contains rhubarb horsetails and one or more of the emodin. The biological degredation macromolecule graft heparin opposes being more narrow is covered in the frame. After the frame is implanted, the drug is deliveried to limit the endometrial hyperplasia sufficiently, and the heparin is exist continuously and steadily. It can prevent the occurrence of acute or subacute thrombus, and can promote the healing of the injury vessel wall, prevent the occurrence of late thrombus. Compare to the traditional heparin frame, it overcomes the defects like intolerance by the humor erosion and interceding poison substance in the progress of chemical binding.

The invention relates to a medical instrument, in particular to an inflatable type zero-damage blood vessel occlusion tractor which is an auxiliary operation instrument used for stopping blood and exposing operation view without damage in surgical operation. The inflatable type zero-damage blood vessel occlusion tractor comprises a blood vessel clamp pipeline comprising an upper wall and a lower wall. The upper wall is movably connected with the lower wall through a clamping groove and a lock catch which are matched with each other, an air bag is arranged on the inner wall of the upper wall, and rubber is embedded on the inner wall of the lower wall. The inflatable type zero-damage blood vessel occlusion tractor further comprises an air flow control device for controlling air amount in the air bag, and the air flow control device comprises an air inflation device, a vent pipe and an air flow controller arranged on the vent pipe. The air inflation device is a needle cylinder with a pushing handle or a hand air pump, the vent pipe is a high-temperature-resisting rubber pipe, the air flow controller is a clamp or forceps with lock catches, and the vent pipe is communicated with the air bag on the inner wall of the upper wall. The inflatable type zero-damage blood vessel occlusion tractor has the advantages of being small in size, low in weight, convenient to carry, simple and feasible in operation, strong in pertinence, and wide in practicability.

The invention discloses an adhesive self-repairing hemostatic membrane and a preparation method thereof. The hemostatic membrane is prepared by the following steps od fully reacting dopamine grafted oxidized alginic acid, acrylamide, acrylic acid N-hydroxysuccinimide ester and N, N'-methylene bisacrylamide, adding a coagulation crosslinking agent, acrylic acid and a first part of a photoinitiator,carrying out pre-polymerizing, and adding a mixed solution of acrylate PEG-N hydroxyl succinimide ester, dopamine, acrylamide, acrylic acid N-hydroxyl succinimide ester and a second part of photoinitiator, fully polymerizing, and carrying out programmed vacuum drying to obtain the product. The hemostatic membrane prepared by the invention can quickly absorb interface moisture, so that the interface of the hemostatic membrane is in full contact with a tissue interface, strong adhesion is formed to tissues through covalent bonds and intermolecular forces, mechanical compression is caused to injured blood vessels, and hemostasis is promoted. After the hemostatic membrane absorbs blood or tissue fluid, dynamic bonds can be formed, and a certain self-repairing function is achieved. Therefore,the hemostatic membrane has the effects of rapid and efficient hemostasis, adhesion and self-repairing.

The invention discloses a vascular interventional radiography guide wire and a preparation method thereof. The vascular interventional radiography guide wire comprises an internal strong developing metal core, a head end internal spring ring sleeve, an external far end spring ring sheath and an external near end polymer sheath, and the surface of the guide wire is coated with a hydrophilic coating. The head end of the radiography guide wire provided by the invention is preformed into a J-shaped elbow, so that the radiography guide wire does not easily enter a branch blood vessel, and the condition that head end of the guide wire damages the inner wall of the blood vessel can be effectively avoided. The J-shaped elbow can adjust the bending shape of the head end when the external far end spring ring sheath is acted by axial extrusion stress until the J-shaped elbow is adjusted to be straight, so that the radiography guide wire can enter a matched instrument conveniently. Due to the design of external far end spring ring sheath, the tactile feedback of an operator is improved. Due to the design of the spring ring sleeve in the head end, the torque transmissibility and safety of the guide wire are improved, and the head end of the radiography guide wire cannot be wound. Besides, the hydrophilic coating on the surface of the radiography guide wire improves the lubricity of the radiography guide wire, so that the radiography guide wire can easily reach a target part in a blood vessel.

The invention discloses a visual pelvic floor puncture device and auxiliary equipment thereof in the field of medical instruments, and aims to reduce the risk that blood vessels, nerves and surrounding important organs are damaged by blind puncture in the current vaginal pelvic floor reconstruction (TVM) operation process. The device comprises a cylindrical transparent sleeve for supporting a lacuna space, an internal camera shooting component and a visual system connected with the outside for observation, wherein the outer surface of the sleeve is divided into a plurality of fine hollow grids; a mirror sheath of a visual operation kit is fixed in the center of a base in the sleeve; and the visual operation kit comprises an endoscope positioned in the mirror sheath and a high-definition display screen for displaying an endoscope image. Compared with the traditional TVM operation process, the visual pelvic floor puncture device has the advantages that blind puncture is converted into visual puncture, so that the puncture part is more accurate, the operation effect is more exact, and the risk of damage to blood vessels, nerves and surrounding important organ tissues caused by blind puncture can be greatly reduced; and the device is integrally designed, is simple and convenient to operate, does not need carbon dioxide to establish pneumoperitoneum, is low in cost and can be disinfected and repeatedly used.

The invention discloses a thrombolysis device promoting absorption of medicine by using ultrasonic waves, and belongs to the technical field of medical instruments. The thrombolysis device promoting absorption of medicine by using ultrasonic waves comprises an operating handle, a medicine release catheter and an ultrasonic guide wire, wherein the operating handle is fixedly connected with the medicine release catheter through a Ruhr joint; and the operating handle consists of a casing, an ultrasonic generator, an ultrasonic transducer, a battery, an ultrasonic switch and an ultrasonic adjusting knob. The thrombolysis device promoting absorption of medicine by using ultrasonic waves performs continuous ultrasonic cavitation treatment on the thrombolysis medicine at a thrombus part, and greatly promotes penetration and dissolution of thrombus by the thrombolysis medicine; the ultrasonic guide wire is located in a medicine release catheter, and does not make contact with blood vessel walls or damage blood vessel walls and surrounding tissue. When used for clearing thrombus, the thrombolysis device promoting absorption of medicine by using ultrasonic waves has the advantages of good thrombolysis effects, short treatment time, simple operation, safety, reliability and the like.

The invention relates to the technical field of medical instruments, and in particular relates to a postcava filter being capable of being placed for a long term and provided with an anti-proliferation and antithrombus medicine coating. The postcava filter comprises a branch pipe, a pipe sleeve and a plurality of metal filtering wires, wherein two ends of the metal filtering wires are respectivelyconnected in the branch pipe and the pipe sleeve, and the metal filtering wires are convex outwards, so that a filtering cage is formed; the branch pipe and the pipe sleeve are made of a soft material; a first medicine coating used for resisting thrombus coats each metal filtering wire. According to the postcava filter, the thrombus can be intercepted through the metal filtering wires, so that embolism seldom occurs, due to the first medicine coatings on the metal filtering wires, the taking-out time of the filter can be prolonged, meanwhile, the occurrence rate of a series of complications including the difficulty in taking out, the injuries or tearing of the blood vessels, and the like which are caused by too late taking out can be reduced, the branch pipe and the pipe sleeve sleeve twoends of the metal filtering wires, so that the blood vessels are seldom injured. The postcava filter is strong in practicability and convenient to operate.

The invention provides a cutting balloon with a flexible cutting device. The cutting balloon comprises a balloon body; a flexible cutting device longitudinally arranged along the outer surface of the balloon body, wherein the flexible cutting device comprises a cutting function structure and a flexible functional structure wrapping or semi-wrapping the cutting function structure; the mechanical property of the cutting functional structure is higher than that of the flexible functional structure. Compared with the prior art, the cutting balloon provided by the invention has higher flexibility, can smoothly pass through a complex tortuous blood vessel, quickly reach a preset part, prevent a blood vessel wall from being damaged and improve the instrument safety, and after pressurization, the flexible cutting device is in contact with tissues, and the flexible functional structure is extruded to enable the cutting structure to protrude. Therefore, the cutting balloon has good cutting performance, the cutting structure can be effectively fixed to the balloon through the flexible functional structure, and the phenomenon that the cutting functional structure loses efficacy or falls off in a using process of the balloon is avoided.

The invention discloses an adhesive repair-promoting hemostatic sponge and a preparation method thereof. The hemostatic sponge is prepared according to the following steps: subjecting N-maleinized gelatin, exosome, acrylate-PEG-N-hydroxysuccinimide ester, N,N'-methylenebisacrylamide to full reaction, adding maleic anhydride, acrylic acid and a first part of photoinitiator, performing neutralizingwith a neutralizer, carrying out prepolymerization, adding a mixed solution of acrylic acid N-hydroxysuccinimide ester and a second part of photoinitiator, fully performing polymerizing, and carryingout programmed freeze-drying. The hemostatic sponge prepared by the invention not only can quickly absorb blood or tissue fluid to form gel, form mechanical compression on damaged blood vessels on the surface of a cavity and promote hemostasis, but also can be adhered to the surface of the cavity, so that displacement is prevented while hemostasis is further promoted. The hemostatic sponge disclosed by the invention can slowly release gelatin and exosome, and has a long-acting repair promoting function. Therefore, the hemostatic sponge has the effects of quickly and efficiently stopping bleeding, achieving adhering and promoting repair.

The invention discloses a blood vessel puncture outfit comprising a conduit sheath and an expander. The expander comprises an expander straight section; the conduit sheath is formed by a conduit sheath straight section and an interference part connected with the conduit sheath; the diameter of the external edge of the interference part is smaller than the external diameter of the expander straight section; and when the expander is inserted into the conduit sheath, the interference part is in interference cooperation with the expander. A gap cannot be formed when the blood vessel puncture outfit is bent; resistance of the conduit sheath inserted into the blood vessel can be reduced, so projected or continuous folding can be avoided; and risk of damage to the blood vessel can be avoided.

The invention discloses a blood capillaryligation clamp. The clamp structurally comprises an upper clamping arm, clamping teeth, an upper clamping block, a clamping hook, a lower clamping arm, a lowerclamping block, a clamping groove, teeth grooves, a fastening device and a protecting layer, the top of the upper clamping arm is provided with the clamping teeth, so that the problem of the droppingof the ligation clamp caused by the failure of stable fixing in subsequent restoring process is solved, the fastening device is arranged on the top of the lower clamping arm to insert a clamping member into a clamping groove, so that the effect of preventing the falling of the ligation clamp is achieved by the inserting fixing which is achieved through a protruding block and a block, so that theproblem of the secondary damage on blood vessels caused by the failure of protecting the blood vessels is solved, the protecting layer is arranged on the top of the upper clamping arm, the blood vessels are protected through flexible harmless materials of a soft glue layer, water gel and protecting cottons, the secondary damage of the blood vessels caused by the excessive clamping performed by theupper and lower clamping arms is prevented, and the effect of protecting the blood vessels is achieved.

The invention discloses an adhesive healing-promoting hemostatic sponge and a preparation method thereof. The hemostatic sponge is prepared by neutralizing dopamine-grafted oxidized sodium hyaluronate, exosome, acrylic acid and N,N'-methylene bisacrylamide, adding a redox initiator for cross-linking, and performing freeze-drying according to a program. The hemostatic sponge prepared by the methodnot only can quickly absorb blood or tissue fluid to form gel, form mechanical compression on damaged blood vessels on the surface of a cavity and promote hemostasis, but also can be adhered to the surface of the cavity, so that displacement is prevented while hemostasis is further promoted. After the hemostatic sponge absorbs the blood or tissue fluid, dynamic bonds can be formed, and the hemostatic sponge has a certain self-repairing function. In addition, sodium hyaluronate and exosome with specific molecular weights can be continuously released while efficient hemostasis is achieved, and wound healing is promoted. Therefore, the hemostatic sponge has the effects of rapid and efficient hemostasis, adhesion, self-repairing and healing promotion.

The invention provides a medical appliance containing recombinant hCREG glycoprotein. The recombinant hCREG glycoprotein is uniformly applied to the surface of the medical appliance, and can be combined with multiple drugs for using. After the medical appliance is implanted in a human body, by means of constant release of the hCREG glycoprotein carried by the appliance, cell proliferation of vascular smooth muscle can be inhibited, re-endothelialization of vascular walls can be promoted, and injured vascular wall can be quickly cured, so that occurrence of thrombus in the cavity of the medical appliance can be prevented, and the time of taking anti-thrombus and blood platelet medicines after a patient is operated can be reduced.

The invention relates to a medical instrument, in particular to an inflatable type zero-damage blood vessel occlusion tractor which is an auxiliary operation instrument used for stopping blood and exposing operation view without damage in surgical operation. The inflatable type zero-damage blood vessel occlusion tractor comprises a blood vessel clamp pipeline comprising an upper wall and a lower wall. The upper wall is movably connected with the lower wall through a clamping groove and a lock catch which are matched with each other, an air bag is arranged on the inner wall of the upper wall, and rubber is embedded on the inner wall of the lower wall. The inflatable type zero-damage blood vessel occlusion tractor further comprises an air flow control device for controlling air amount in the air bag, and the air flow control device comprises an air inflation device, a vent pipe and an air flow controller arranged on the vent pipe. The air inflation device is a needle cylinder with a pushing handle or a hand air pump, the vent pipe is a high-temperature-resisting rubber pipe, the air flow controller is a clamp or forceps with lock catches, and the vent pipe is communicated with the air bag on the inner wall of the upper wall. The inflatable type zero-damage blood vessel occlusion tractor has the advantages of being small in size, low in weight, convenient to carry, simple and feasible in operation, strong in pertinence, and wide in practicability.

The invention discloses a surgical system, an ultrasonic suction knife system and a control method thereof, and the method comprises the steps: obtaining the imaging data of a target tissue to be removed and the imaging data of a blood vessel, constructing a three-dimensional model of the target tissue to be removed and the blood vessel to be removed, carrying out the overlapping positioning of the three-dimensional model and the positioning data of a to-be-operated part, determining the positioning data of the blood vessel, according to the positioning data of the blood vessel and the positioning data of the ultrasonic suction knife, the relative positions of the ultrasonic suction knife, determining the target tissue and the blood vessel, that is, the relative positions of the ultrasonic suction knife and the blood vessel are positioned, and obtaining the corresponding control parameters according to the relative positions in combination with the diameter of the blood vessel. The control parameters are determined according to the relative position of the ultrasonic suction knife and the blood vessel and the diameter of the blood vessel, so that the blood vessel can be prevented from being damaged while the tumor is removed.

The invention discloses a multi-net-bag type thrombus-retrieving bracket, which includes a traction guide wire and a net bag unit, and the number of the net bag units from the proximal end to the distal end is at least two; The connecting ribs are connected; and each net bag unit and its corresponding connecting ribs are cut on the pipe with a laser cutting machine to obtain an integrated multi-net bag type thrombus removal bracket during manufacture. The multi-net thrombectomy system includes the above-mentioned multi-net thrombectomy bracket. The thrombectomy bracket and system of the present invention have simple body structure, laser integrated molding, and simple preparation process; multiple mesh pocket units capture thrombus to the greatest extent, and are equipped with mesh holes of different sizes and different forms of structures: large mesh penetration , converging and fixing thrombus, small mesh cuts and captures thrombus fragments; the distal covering prevents broken thrombus from escaping during the withdrawal process; the imaging structure is inside, which will not damage the vessel wall, and has good adherence, which improves the stent's ability to capture thrombus and Velocity of thrombus fragments.

The invention discloses an advanced high-twist control conduction guide wire and a preparation method thereof, which belong to the technical field of medical devices and include a guide wire body, which includes a stainless steel core wire, a hollow rope, a safety rope, an interwoven rope and TPU Containing tungsten tube, the thinnest grinding section of the stainless steel core wire is 0.009mm, and the hollow rope is set in the middle of the stainless steel core wire. The wire diameter is very thin 0.0002‑0.04mm. The safety rope is located beside the stainless steel core wire and inside the hollow rope. The safety rope is twisted from 2‑20 strands of stainless steel 304 ultra-fine wire into a strand like a twist. The interwoven rope is set on the safety wire. Rope, hollow rope, stainless steel core wire, interwoven rope is two 304 stainless steel wires coaxially interwoven and twisted into a spring shape, TPU tungsten tube is sleeved on the interwoven rope, and the inner diameter of TPU tungsten tube is 0.2‑0.4mm , the outer diameter is 0.4‑0.6mm, the thinnest on one side is 0.05mm, and contains 60% tungsten, which solves the problem that the weight of the tip of the guide wire is too hard and the blood vessels are easily damaged when entering complex CTO lesions.

The invention relates to a left ventricular volume reduction mechanism, which includes a support frame and a base connected to the support frame. The support frame is composed of a plurality of support rods, and the proximal ends of the support rods are gathered to form a gathering of the support frame. The bottom end has a distal end that is adaptively opened along the inner wall of the left ventricle in a direction away from the apex. The base includes a central end connected to the gathered bottom end, and a plurality of spirals extending from the central end toward the apex. Branches, a plurality of the spiral branches are rotationally symmetrical along the central axis of the base, and the entire body forms a trumpet shape with the opening facing the apex direction. The support frame is made of shape memory material and its surface is covered with a film. The base is made of Made of elastic material, the base adaptively fits the inner wall of the apex. The invention reduces the risk of instrument displacement and breakage, has good fatigue strength, and reduces the risk of damaging blood vessels and heart valves.

The invention discloses an apocynum venetum tea compound functional beverage capable of preventing and treating cardiovascular and cerebrovascular diseases by targeting vascular endothelial cells. Theamount of a stock solution is calculated according to a final concentration of total flavonoids of 3-100 mg / L, and components of 5-hydroxytryptophan (with a final concentration of 4-200 mg / L), dihydrolipoic acid (with a final concentration of 4-100 mg / L), pantothenic acid (with a final concentration of 1-10 mg / L) and nicotinic acid (with a final concentration of 2-20 mg / L) are additionally added.The formula has a good synergistic effect, with NADPH oxidase inhibited by apocynum venetum tea, the nicotinic acid is added, thus reactive oxygen species (ROS) injuries are not liable to be generated, moreover, the situation that nitric oxide and ROS form active nitrogen to induce nitrative stress, so as to injure vascular endothelial cells is prevented, and by inducing a state of the endothelial cells with a high nitric oxide content and a low ROS content, the added components enhance a physiological effect of the apocynum venetum tea, and reduce side effects. Moreover, in the aspect of developing the formula, by means of high-throughput standardized cell experiments and double-blind randomized controlled multicenter volunteer trials, action ranges and toxicity thresholds of the components of the formula are precisely verified, and the formula has certain tolerance in dosage, and has very high safety, so that the formula is suitable for being used as a core formula for product development.

The invention discloses a stent sleeve for treating injury and bleeding in a blood vessel cavity and a preparation method thereof. The stent cover utilizes the degradability of polylactide, and uses the polylactide as a degradable basic stent to obtain a stent cover for treating intravascular injury and bleeding. A developing belt is arranged in the middle of the outer surface of the stent cover, which is convenient for determining the release position of the stent cover, and ensures that the bleeding site is covered after the stent cover is released. At the same time, the development belt is located in the middle position so that the development belt is not easy to fall off during the transportation process; the surface of the stent sleeve contains growth factors, which can slowly release the growth factors, effectively block the damaged blood vessels, and at the same time promote the tissue at the damaged site to the greatest extent. heal. The stent sleeve provided by the present invention has good biocompatibility, does not cause thrombus or inflammation after being implanted in blood vessels, is easy to operate, can be implanted without special equipment, and has high drug loading capacity, Good hemostatic effect and other advantages.

The invention discloses a porta hepatis blocker. The porta hepatis blocker comprises a sleeve, a blocking hose, a folding assembly and a pressing device. The blocking hose is mounted at the lower end of the sleeve; the folding assembly is installed in the blocking hose and comprises a plurality of connecting assemblies which are arranged in sequence, and any connecting assembly is provided with two connecting units which are rotatably connected; the two connecting units of any connecting assembly are correspondingly and rotationally connected with the two connecting units of the adjacent connecting assembly respectively, and the line included angle theta 1 formed by the two rotating axes of the two adjacent connecting assemblies is smaller than 180 degrees; the pressing device is installed in the sleeve and connected with the two connecting units at the head end of the folding assembly, and when the pressing device is subjected to pressing force, the pressing device drives the tail end of the folding assembly to be wound to the wall of the sleeve. According to the porta hepatis blocking sleeve, blood vessels can be bound together under the condition that the blood vessels are not damaged.