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Adhesive self-repairing hemostatic membrane and preparation method thereof

A self-healing, hemostatic membrane technology, applied in pharmaceutical formulations, pharmaceutical sciences, absorbent pads, etc., can solve the problems of high swelling rate, low mechanical properties, and non-degradable electrospun fiber membranes, and achieve the effect of high mechanical strength

Active Publication Date: 2020-12-04
SHANDONG BRANDEN MEDICAL DEVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the electrospun fiber membrane still has the disadvantages of not being easy to degrade and having poor adhesion to wounds.
[0006] The common Daqing absorbable hemostatic film on the market has the disadvantages of high swelling rate after absorbing blood, low mechanical properties, and poor adhesion

Method used

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  • Adhesive self-repairing hemostatic membrane and preparation method thereof
  • Adhesive self-repairing hemostatic membrane and preparation method thereof
  • Adhesive self-repairing hemostatic membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1 2.5% dopamine grafted oxidized alginic acid (oxidation degree is 85%, dopamine grafting rate is 15%, viscosity is 300mPa·s), 30% acrylamide, 5% N- hydroxysuccinimide acrylate, 0.015%N,N'- methylene bisacrylamide are added into purified water at a temperature of 100-20min Add 1.6% 2- hydroxy -2- methyl -1-[4-(2- hydroxyethoxy) phenyl ]-1- acetone, 20% acrylic acid and 0.6% calcium chloride, stir at 100-200rpm until the solution is uniform, and prepolymerize for 30min under ultraviolet lamp with power of 150W and wavelength of 365nm. Spray the mixture of 150W% acrylic ester PEG-N hydroxysuccinimide ester, 0.6% dopamine, 0.4% acrylamide, 3% acrylic ester N- hydroxysuccinimide ester and 0.018%2- hydroxy -2- methyl -1-[4-(2- hydroxyethoxy) phenyl ]-1- acetone on the surface, and spray it on the surface. The finished gel-like product was put in a mold and placed in a programmed vacuum drying oven. First, it was dried at 4℃ for 1.5h with a vacuum of 100Pa, then at 10℃ wi...

Embodiment 2

[0052]Example 2: 3.5% dopamine grafted oxidized alginic acid (oxidation degree is 80%, dopamine grafting rate is 10%, viscosity is 200mPa·s), 25% acrylamide, 3% N- hydroxysuccinimide acrylate, 0.020%N,N'- methylene bisacrylamide are added into purified water at the temperature of 100-200 Adding 1.6% 2- hydroxy -2- methyl -1-[4-(2- hydroxyethoxy) phenyl ]-1- acetone, 25% acrylic acid and 0.4% calcium chloride, stirring at 100-200rpm until the solution is uniform, prepolymerizing under ultraviolet lamp at power of 150W and wavelength of 365nm for 20 minutes, and Spray the mixture of 1.5% acrylate PEG-N hydroxysuccinimide, 1.25% dopamine, 0.6% acrylamide, 4% acrylate N- hydroxysuccinimide and 0.028%2- hydroxy -2- methyl -1-[4-(2- hydroxyethoxy) phenyl ]-1- acetone on the surface, and The finished gel-like product was put in a mold and placed in a programmed vacuum drying oven. First, it was dried at a vacuum of 100Pa at 4℃ for 2 hours, then at a vacuum of 50Pa at 10℃ for 1 hour, and ...

Embodiment 3

[0053] Example 3 1.5% dopamine grafted oxidized alginic acid (oxidation degree is 90%, dopamine grafting rate is 20%, viscosity is 500mPa·s), 35% acrylamide, 7% N- hydroxysuccinimide acrylate, 0.010%N,N'- methylene bisacrylamide are added into purified water at a temperature of 100-200 Add 1.6% 2- hydroxy -2- methyl -1-[4-(2- hydroxyethoxy) phenyl ]-1- acetone, 15% acrylic acid and 0.5% calcium chloride, stir at 100-200rpm until the solution is uniform, and prepolymerize for 40min under ultraviolet lamp with power of 150W and wavelength of 365nm. Spray the mixture of 0.5% acrylate PEG-N hydroxysuccinimide ester, 0.25% dopamine, 0.2% acrylamide, 2% acrylate N- hydroxysuccinimide ester and 0.009%2- hydroxy -2- methyl -1-[4-(2- hydroxyethoxy) phenyl ]-1- acetone on the surface, and The finished gel-like product was put in a mold and placed in a programmed vacuum drying oven. First, it was dried at a vacuum of 100Pa at 4℃ for 1h, then at a vacuum of 50Pa at 10℃ for 0.5h, and finally a...

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Abstract

The invention discloses an adhesive self-repairing hemostatic membrane and a preparation method thereof. The hemostatic membrane is prepared by the following steps od fully reacting dopamine grafted oxidized alginic acid, acrylamide, acrylic acid N-hydroxysuccinimide ester and N, N'-methylene bisacrylamide, adding a coagulation crosslinking agent, acrylic acid and a first part of a photoinitiator,carrying out pre-polymerizing, and adding a mixed solution of acrylate PEG-N hydroxyl succinimide ester, dopamine, acrylamide, acrylic acid N-hydroxyl succinimide ester and a second part of photoinitiator, fully polymerizing, and carrying out programmed vacuum drying to obtain the product. The hemostatic membrane prepared by the invention can quickly absorb interface moisture, so that the interface of the hemostatic membrane is in full contact with a tissue interface, strong adhesion is formed to tissues through covalent bonds and intermolecular forces, mechanical compression is caused to injured blood vessels, and hemostasis is promoted. After the hemostatic membrane absorbs blood or tissue fluid, dynamic bonds can be formed, and a certain self-repairing function is achieved. Therefore,the hemostatic membrane has the effects of rapid and efficient hemostasis, adhesion and self-repairing.

Description

Technical field [0001] The invention belong to that technical field of biomedical materials, and relate to an adhesive self-repairing hemostatic film and a preparation method thereof. The medical hemostatic film provided by the invention can quickly stop bleeding and has the effects of adhesion, displacement prevention and self-repair. technical background [0002] In emergency treatment, surgery and war, 50% of deaths are caused by massive bleeding. Some traditional hemostatic materials, such as hemostatic gauze, hemostatic bandage, hemostatic cotton yarn, etc., have limited hemostatic ability and the hemostatic effect is not very ideal. Therefore, it is one of the main goals of the research and development of hemostatic materials to develop efficient and fast absorbable hemostatic materials and products, which can effectively and quickly stop bleeding within 1-2 minutes or even less after bleeding occurs. Hemostatic membrane is a kind of material used to stop bleeding in surgic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/24A61L15/28A61L15/42C08F285/00C08F220/36C08F220/56C08L51/00C08J5/18
CPCA61L15/24A61L15/28A61L15/42A61L2400/04C08F285/00C08J5/18C08J2351/00C08F220/36C08F220/56C08L51/00C08L5/04
Inventor 张海军袁坤山张淑欣车超越侯文博尹玉霞鲁守涛段翠海
Owner SHANDONG BRANDEN MEDICAL DEVICE
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