56results about How to "Improve hemostatic efficiency" patented technology

The invention belongs to the field of biomedical materials, and particularly discloses an alginic acid-chitosan composite fiber for tranma repairing and a preparation method thereof. The alginic acid-chitosan composite fiber for the tranma repairing is characterized by comprising an alginic acid component of which the mass fraction is 50-95%, and a chitosan component of which the mass fraction is 5-50%. The processing technique disclosed by the invention is not involved with an organic reagent or an organic chemical reaction, so that the preparation method is mild in reaction system and controllable in condition; the residue problems of a toxic crosslinking agent or an assistant and the like do not exist; used materials, reagents and the like have good biosecurity; the security risk of clinical applications is greatly reduced. In addition, the technology disclosed by the invention is simple and controllable, and has the good product transformation feasibility; the difficulty of risk management in the preparation process is greatly reduced.

The invention relates to a hemostasis material prepared from Bletilla and a preparation method of the hemostasis material. The hemostasis material in the prior art is used by grinding a traditional Chinese medicine arethusa dry product into powder and has the defects of more defect impurities, low effective substance content and poor hemostasis effect. In the hemostasis material disclosed by the invention, Bletilla polysaccharide is dissolved into water to prepare an aqueous solution of which the concentration is 1-3%, and the aqueous solution is prepared into the hemostasis material at low temperature under the condition of vacuum drying. The hemostasis material prepared from Bletilla has the advantages of simple technology, excellent hemostasis effect and convenience in use, and can be widely applied to medicine and the biomedical engineering.

The invention relates to bleeding-stopping, inflammation-diminishing and pain-relieving nano emulsion for use in minimally invasive beauty treatment therapy and a preparation method thereof. The nano emulsion is prepared from the following raw materials in part by weight: 0.0055 part of thrombase freeze-dried powder, 0.0005 part of epinephrine, 5 parts of calcium chloride, 1 part of sodium chloride, 6 parts of coix seed essence oil, 6 parts of as arum volatile oil, 5 parts of lidocaine hydrochloride, 13.6 parts of isopropyl myristate, 27.6 parts of octoic acid and capric acid polyethylene glycol glyceride, 9.2 parts of polyglycerol-3-dioleate and 26.594 parts of distilled water. The nano emulsion has diversified functions and has bleeding-stopping, inflammation-diminishing and pain-relieving effects, so the complex process of the minimally invasive beauty treatment therapy is simplified. In addition, a nano transdermal technique is adopted to promote the functional components to enterskin effectively, constantly and controllably to produce the bleeding-stopping, inflammation-diminishing and pain-relieving effects; and the toxic and side effects of the nano emulsion can be reducedgreatly.

Disclosed is an ultrasonic haemostatic and cutting system. The ultrasonic haemostatic and cutting system comprises an ultrasonic vibration transmission module, an ultrasonic scalpel bit (101) of the ultrasonic vibration transmission module comprises an ultrasonic scalpel tip (11), a connecting part (13), vibration node bosses (14) and a waveguide unit (15), wherein the ultrasonic scalpel tip (11)is arranged in front of the waveguide unit (15); the connecting part (13) is arranged at the rear of the waveguide unit (15); the vibration node boss (14) is arranged on the waveguide unit (15); the sharp end of the ultrasonic scalpel tip (11) is laterally bent; the ultrasonic scalpel bit (101) is provided with a vibration guide groove (12). By designing the ultrasonic scalpel bit into a bent shape and converting longitudinal ultrasonic vibration into longitudinal and torsional compound vibration, the ultrasonic haemostatic and cutting system can improve temperature uniformity inside of cut orcoagulated tissues and further improve the haemostatic and cutting efficiency and security.

The invention discloses a collagen micro fiber and a preparation method thereof. Provided are the collagen micro fiber and the preparation method thereof. The method comprises the following steps: 1) taking an isolated mammalian dermis and / or subcutaneous tissue layer as a raw material, and removing non-collagen components in the raw material to obtain a crude product; and 2) removing non collagen in the crude product obtained in the step 1), to obtain the collagen micro fiber. The preparation process of the method is simplified, and introduction of complex production equipment is not needed, so that difficult control of microorganisms, heavy metals and other factors in the production process is avoided, and the requirement of industrialized production can be met; the collagen micro fiber is suitable for large-area diffuse hemorrhage, has he advantages of fast hemostatic speed, high hemostatic efficiency, qualified heavy metal content and the like, and has wide application prospects.

The invention provides a hemostatic cross-linking composition, the raw materials of which include gelatin and polysaccharides containing acyl groups or carboxyl groups. The invention also provides the preparation method and application of the hemostatic cross-linking composition. In addition, the present invention also provides a hemostatic and anti-adhesion material comprising the hemostatic crosslinking composition. The hemostatic cross-linked composition provided by the present invention has the characteristics of both gelatin hemostatic products and polysaccharide hemostatic products. Compared with the existing hemostatic products, it has obvious improvements in absorption performance, hemostatic and coagulation performance, and degradation performance. . The hemostatic and anti-adhesion material provided by the invention has the advantages of high hemostatic efficiency and controllable degradation time in vivo, can meet the requirements of hemostatic materials, especially hemostatic and anti-adhesion materials in the medical field, and has broad market application prospects.

The invention provides a blood protein responsive type gamma-PGA (polyglutamic acid) hydrogel hemostasis material as well as a preparation method and an application thereof. The hemostasis material isprepared from a PHPA and DA (dopamine) molecule functionalized gamma-PGA polymer, a solvent with water as a main body, horseradish peroxidase and hydrogen peroxide, the synergetic enhancement effectof gamma-PGA, PHPA and DA on integration of wet high-strength wound is realized and the efficient blocking and hemostasis effect is achieved through Fe<3+> in gamma-PGA complexing blood, adsorption and blood coagulation of blood protein under the inducing action of benzene ring hydrophobic functional groups in PHPA and gel forming through oxidation and crosslinking by catechol groups in DA. The provided gamma-PGA hydrogel hemostasis material can effectively overcome the limitation of conventional pressing hemostasis method in application fields, besides, the problems that numerous hemostasis materials have poor blood responsiveness, poor integration capability for the wet bleeding wound and the like at present are solved, and the blood protein responsive type gamma-PGA hydrogel hemostasismaterial has the advantages of being high in hemostasis efficiency, good in biocompatibility, capable of allowing orthotopic injection of matched complicated wound types and the like and has broad market application prospects.

The invention provides a polyvinyl alcohol sponge with an ordered porous structure prepared on the basis of a 3D printing template and an application thereof. When the sponge with ordered micro-channels makes contact with blood, the sponge can rapidly guide and absorb the blood, and a large number of regularly-arranged red blood cells are gathered in the micro-porous structure at the bottom of the sponge. The sponge prepared by combining structured ordered micro-channels and disordered holes greatly shortens the blood coagulation time and improves the hemostasis efficiency. The used raw materials have excellent biocompatibility, and potential biological safety and side effects are eliminated in the clinical use process. The used raw materials have excellent blood compatibility, do not cause hemolytic reaction and do not affect endogenous and exogenous blood coagulation pathways.

The invention provides a hemostatic device for vascular surgery. The adopted technical solution is that there is a waterproof layer inside the outer layer, a liquid storage bag and an air bag are arranged between the waterproof layer and the inner top surface of the outer layer, and a soft bag is arranged on the liquid storage bag. Tubes and hoses pass through the outer layer and are connected to the bottom of the waterproof layer. There is a pressure sensor on the top of the fluid storage bag and a heating wire inside; there is a gauze fixing block at the inner bottom of the outer layer; there is a control panel and a zipper on the outer layer. By adopting the zipper structure, it is convenient to separate the gauze from the waterproof layer and facilitate the replacement of the gauze; by using the pressure sensor, the pressure of the airbag on the wound can be visualized to avoid secondary damage to the wound caused by excessive pressure; Appropriate heating can increase the activity of coagulation factors and accelerate hemostasis; by using the CaCl2 solution contained in the fluid storage bag to moisten the gauze, Ca2+ can be used to accelerate blood coagulation and improve the hemostasis efficiency; Used to guide above the gauze at the wound site to improve hemostasis.

The invention discloses a rapid hemostasis device for hepatobiliary surgery, and relates to the technical field of medical instruments. The rapid hemostasis device comprises a handle, a medicine hemostasis part and an electrocoagulation hemostasis part, wherein the medicine hemostasis part and the electrocoagulation hemostasis part are fixedly connected with the left end of the handle; the upper part of the medicine hemostasis part is provided with a medicine supply bin; the lower part of the medicine hemostasis part is provided with a restraining bin used for restraining sterile sponge; the medicine supply bin and the restraining bin are separated by a diaphragm made of an elastic material; a plurality of liquid medicine channels are uniformly distributed on the diaphragm; each liquid medicine channel comprises an opening and a valve-shaped structure located at the top part of the opening; and an elastic piece is connected with and arranged between the center of the upper surface of the diaphragm and the center of the surface of the inner wall of the top end of the medicine supply bin, and comprises springs and a balancing weight. The rapid hemostasis device provided by the invention realizes seamless combination of electrocoagulation hemostasis and medicine hemostasis, can automatically supplement a hemostatic medicine into the sterile sponge in the hemostasis process, greatly improves the efficiency of hemostasis, avoids the loss of excessive blood of a patient, reduces the waste of the hemostatic medicine, and relieves the labor intensity of a doctor.

The invention discloses a processing method of degreased human cotton yarns. The method is characterized by comprising the following steps that (1), the degreased human cotton yarns are prepared; (2),seaweed fiber and the degreased human cotton yarns are subjected to plying; (3), the degreased human cotton yarns are subjected to an alkaline bath, after the alkaline bath is conducted multiple times, the degreased human cotton yarns are taken out and naturally dried; (4), after the degreased human cotton yarns subjected to plying are cooled to room temperature, rinsing is conducted again; (5),the degreased human cotton yarns are immersed in liquid medicine, and soaking is conducted for 2-3 hours, wherein the ratio of the degreased human cotton yarns to the liquid medicine is 1:25; (6), heating is conducted during soaking, heating is conducted to reach 60-80 DEG C, and stirring is conducted continuously for 1-1.5 hours; (7), the soaked degreased human cotton yarns are taken out and putin a softening solution, and stirring and cleaning are conducted for 15-30 minutes; (8), the degreased human cotton yarns are taken out and washed with clear water 2-3 times, and then dewatering and drying in the shade are conducted. Compared with the prior art, the technology is simple, operation is facilitated, and the water absorption of the degreased human cotton yarns is effectively improvedthrough the alginate fiber; by means of soaking in the liquid medicine, the degreased human cotton yarns can obtain the property of a medicine.

The invention discloses a convenient-to-adjust intelligent arm hemostasis device and method for the cardiology department and relates to the technical field of medical instruments.The convenient-to-adjust intelligent arm hemostasis device comprises a base, a left backup plate and a right backup plate which are symmetrical are installed at the two ends of the top of the base respectively, and one end of the top of the left backup plate and one end of the top of the right backup plate jointly form a fixed connection structure through a supporting rod; an adjusting assembly is installed on the side face of the right backup plate, the inner side of the adjusting assembly is connected with a disinfecting and hemostasis assembly and a binding assembly, and an arm placing assembly is installed at the position, below the disinfecting and hemostasis assembly and the binding assembly, of the top of the base. In addition, compared with a traditional manual hemostasis mode, due to the intelligent operation design of the structure, the workload of medical staff can be reduced, the labor cost can be reduced, the hemostasis binding efficiency can be improved, the operation accuracy is guaranteed, and the use convenience is improved.

A femoral artery compression hemostasis device at least comprises a hemostasis unit and a fixing unit. The hemostasis unit comprises a pressure knob (1), a sleeve shell (2) connected threadedly with the pressure knob (1) and a compression pad (3) connected with the bottom surface of the pressure knob (1). The fixing unit comprises a support stabilization rod (6), a tail fin (5) fixed on the support stabilization rod (6), a leg support plate (4) positioned below the support stabilization rod (6) and a fixing strap (7), and the support stabilization rod (6) is connected with the leg support plate (4) by the fixing strap (7). The support stabilization rod (6) is perpendicular to the pressure knob (1), one end of the support stabilization rod (6) is connected with the tail fin (5), and the other end of the support stabilization rod (6) is connected threadedly with the sleeve shell (2). The compression pad (3) comprises a base pad (312), a blood vessel compression pad (311) and a hemostatic dressing (32), the blood vessel compression pad (311) and the hemostatic dressing (32) are bilaterally fixed at the bottom of the base pad (312), the blood vessel compression pad (311) is abutted against the hemostatic dressing (32), the area of the hemostatic dressing (32) is larger than that of the blood vessel compression pad (311), and the height of the blood vessel compression pad (311) is not less than that of the hemostatic dressing (32). The hemostasis device is high in hemostatic efficiency, can be fixed stably at a puncture point of a human leg, and can reduce the pressure applied on the leg.

The invention discloses an adhesive self-repairing hemostatic membrane and a preparation method thereof. The hemostatic film is fully reacted by dopamine-grafted oxidized alginic acid, acrylic acid N-hydroxysuccinimide ester, N,N'-methylenebisacrylamide, adding coagulation cross-linking agent, acrylic acid and the first part of photoinitiated agent, after pre-polymerization, add the mixture of acrylate PEG‑N hydroxysuccinimide ester, dopamine, acrylamide, acrylate N‑hydroxysuccinimide ester and the second part of photoinitiator, after sufficient polymerization, the program Prepared by vacuum drying. The hemostatic film prepared by the invention can quickly absorb interface moisture, make the interface of the hemostatic film fully contact with the tissue interface, form strong adhesion to the tissue through covalent bonds and intermolecular forces, cause mechanical compression to damaged blood vessels, and promote hemostasis. After the hemostatic membrane absorbs blood or tissue fluid, it can form a dynamic bond and has a certain self-repair function. Therefore, the hemostatic film has the effects of fast and efficient hemostasis, adhesion and self-repair.