59 results about "Electrospun fiber" patented technology

This invention discloses a multifunctional composite flexible fabric with multiple functions including radiative cooling, energy harvesting, hydrophobicity, and antibacterial properties. The composite flexible fabric consists of several electrospun fiber layers, each formed sequentially by electrospinning in a top-to-bottom order. It includes at least two polymer electrospun fiber layers and at least one nanofunctional electrospun fiber layer, wherein the nanofunctional electrospun fiber layer serves as an intermediate sandwich layer, forming a sandwich structure with the polymer electrospun fiber layers located on the upper and lower surfaces. This invention also discloses a method for preparing this flexible fabric, using electrospinning to prepare it by electrospinning a PVDF or related polymer solution and a polymer solution modified with functional nanoparticles. This preparation method can effectively control the morphology of the nanofibers and the functions of the nanoparticles, enabling a synergistic effect between the functional nano-scattering particles and the nanofibers, resulting in an integrated functional fabric with thermal management, energy harvesting, and antibacterial properties.

The application belongs to the field of functional material preparation, and particularly relates to a preparation method of a super-light high-nucleic-acid-absorption electrospun fiber sponge material and application thereof. The SiO2 electrospun fiber is used as a framework, a three-dimensional monolithic structure assembled by fragmented electrospun nanofiber membranes is used, the interconnected nanofiber cell structures of which endow the three-dimensional monolithic structure with high porosity and excellent structural flexibility and stability. Meanwhile, the amino-rich polyethylene imine and chitosan are chemically crosslinked by using epichlorohydrin as a crosslinking agent, and finally during freeze-drying, the ice crystals are partially sublimated, leaving a pore structure, and a porous sponge material is obtained. The material has a high nucleic acid adsorption capacity, and makes nucleic acid extraction more simple, rapid and sensitive.

The invention relates to the technical field of composite membranes, in particular to a PLLA / DFSCs composite membrane and a preparation method thereof.DFSCs are cultured after being separated, then the DFSCs are inoculated to a PLLA electrostatic spinning fiber membrane to be cultured, and the final PLLA / DFSCs composite cell membrane is obtained. The method comprises the following steps: inoculating DFSCs to a PLLA bracket, and carrying out flat culture for 3 days to construct a P-CS composite cell sheet; compared with a traditional membrane (the culture period is 14-28 days), the P-CS composite membrane only needs to be cultured for 3 days, so that the culture time of the cell membrane is greatly shortened; compared with a traditional diaphragm (CS), the P-CS composite diaphragm has excellent mechanical strength and plasticity and is suitable for different defect surface plasticity.

The application provides a preparation method of a down-like heat storage and preservation material, and comprises the following steps: dissolving polylactic acid in a mixed solution of chloroform / acetone to obtain a polylactic acid solution; dissolving composite hollow spheres in a mixed solution of chloroform / acetone to obtain a composite hollow sphere solution; using the polylactic acid solution as a shell layer solution and the composite hollow sphere solution as a core layer solution, adopting a coaxial conjugate electrospinning instrument to prepare a fiber bundle, the spinning voltage is 12-14 kV, the distance between composite spinnerets is 25-30 cm, the flow rate of the shell layer solution is 0.5-3 mL / h, and the flow rate of the core layer solution is 0.5-3 mL / h, to obtain an electrospun fiber bundle; using the electrospun fiber bundle as a covering yarn and polylactic acid filaments as core yarns, the down-like heat storage and preservation material is obtained by covering. The application adopts the electrospinning method to prepare the fiber bundle, and adds the composite hollow spheres in the core layer of the fiber bundle, uses the electrospun fiber bundle as the covering layer and the ordinary filaments as the core layer, so that a heat storage and preservation effect of the down-like heat storage and preservation material is better than that of ordinary air long down material.

This invention provides a medical repair membrane with an orthogonal crack-limiting structure and its preparation method. This invention relates to the field of biomedical materials technology. The medical repair membrane of this invention comprises at least two electrospun fiber layers, which intersect to form an orthogonal fiber structure. Layer B, facing tissue integration, adopts a coaxial core-shell structure. The shell layer contains biodegradable polymers and bioactive components, while the core layer is a biodegradable polymer. The structure of this invention effectively inhibits crack propagation and improves the structural stability of the material. Simultaneously, the core-shell structure enables controlled release of active components and tissue-selective induction, balancing mechanical properties and biocompatibility. The medical repair membrane is suitable for soft tissue defect repair, such as dura mater repair, fascia repair, pericardial repair, and hernia repair.

The invention discloses a special adsorption dressing used after a laparoscopic surgery, and belongs to the technical field of medical dressings. The dressing is of a layered composite structure and sequentially comprises a hydrophilic guide layer, an absorption foam layer and a hydrophobic protective layer from inside to outside, the hydrophilic guide layer is an electrospun fibrous membrane formed by micro / nano fibers oriented along a specific direction; the absorption foam layer is made of a foam material with high aperture ratio; the hydrophobic protective layer is a breathable hydrophobic film; the preparation method mainly comprises the steps of preparation of each functional layer and composite molding through a low-temperature hot pressing process. According to the dressing, through the synergistic effect of the three layers of materials, directional and rapid absorption and storage of percolation of a postoperative puncture hole are achieved, tissue regeneration guidance is provided, the skin around a wound is effectively prevented from being hardened, and the dressing is antibacterial, anti-inflammatory, good in fitting performance and beneficial to wound healing.

The invention belongs to the field of filter materials, and relates to a composite microfiber filter material as well as a preparation method and application thereof. The material comprises a polylactic acid electrostatic spinning fiber layer and a polylactic acid melt-blown fiber layer which are compounded together, the polylactic acid electrostatic spinning fiber layer is prepared from an electret polylactic acid composition through electrostatic spinning, and the polylactic acid melt-blown fiber layer is prepared from the electret polylactic acid composition through melt-blown molding; the electret polylactic acid composition is prepared from the following components in parts by weight: 100 parts of polylactic acid, 0.2 to 4 parts of a composite electret, 0.2 to 2.5 parts of a plasticizer, 0.05 to 0.5 part of a dispersing agent and 0.01 to 0.5 part of an antioxidant. The composite microfiber filtering material comprises the melt-blown layer and the electrostatic spinning superfine fiber layer, the melt-blown layer is used for coarse filtration, the electrostatic spinning superfine fiber layer is used for fine filtration, the problems that the filtering performance of a single melt-blown layer is insufficient and the filtering resistance of a single electrostatic spinning layer is too large can be solved, and the effects of high efficiency and low resistance are achieved.

According to the high-waterproofness fiber membrane and the preparation method thereof, the hydrophobic component is uniformly dispersed in the hydrophobic polymer solution, then the fiber membrane is prepared in an electrostatic spinning mode, and the hydrophobic component can be attached to the surface of the fiber, so that the fiber has super-hydrophobicity. By adopting the preparation method, the in-situ efficient electrospun fiber membrane can be obtained, the hydrophobic polymer and the hydrophobic component are dual-hydrophobic, the waterproofness is greatly improved, the fiber membrane has the function of a physical barrier due to high porosity and high air permeability, the fiber membrane is antifouling and waterproof, and the super-hydrophobic fiber membrane is soft and ultrathin and can be used as a super-hydrophobic membrane. And a certain bacterium isolation capability is achieved. The preparation method can be customized as required, and is high in safety, convenient and fast.

The invention discloses an ibuprofen transdermal patch based on core-shell structure viscous electrostatic spinning fibers and a preparation method of the ibuprofen transdermal patch, and belongs to the technical field of external transdermal patches. A viscous fiber membrane constructed based on core-shell structure electrospun fibers is used as a functional layer; a shell layer of the fibers is formed by curing a spinning solution formed by dissolving a thermoplastic elastomer and natural resin in an organic solvent B, and provides stable viscosity; the core layer is formed by curing a spinning solution formed by dissolving ibuprofen, a hydrophobic polymer and a penetration enhancer in an organic solvent A, and efficient loading and controllable release of drugs are achieved. By optimizing the shell-core flow rate ratio, spinning voltage and other key process parameters, the patch has the characteristics of strong adhesion in the initial stage and easy stripping in the later stage, and meanwhile, it is ensured that the transdermal permeation amount and release rate of the medicine meet the treatment requirements. The patch has the characteristics of high porosity and biphasic drug release which takes effect quickly in the initial stage and is maintained slowly in the subsequent stage, effectively avoids the first-pass effect and the skin irritation risk, and is particularly suitable for local treatment of inflammatory diseases such as acute gouty arthritis and the like.

The invention discloses a polybenzoxazine-based mesoporous active carbon nanofiber as well as a preparation method and application thereof, and belongs to the technical field of carbon nanofiber material preparation. Silica particles are taken as a template, polybenzoxazine is taken as a carbon source, polyvinyl butyral is taken as a spinning polymer, and an electrostatic spinning fiber membrane is prepared by proportioning metal salt and anhydrous stannous chloride; carrying out carbonization treatment to obtain a PBZ-based carbon nanofiber membrane; the preparation method comprises the following steps: putting a carbon nanofiber membrane into a hydrofluoric acid solution, carrying out chemical activation on the carbon membrane, melting a SiO2 template, washing the membrane to be neutral by using deionized water, and putting a polybenzoxazine-based active carbon nanofiber membrane into a blast drying oven to remove moisture, so as to prepare the active carbon nanofiber with high mesoporous rate, which has the advantages of a carbon material and a nano material. The polybenzoxazine-based carbon nanofiber membrane prepared by a template method can effectively increase the mesoporous rate, the high porosity can provide a channel for molecular transport, and potential application prospects are provided for active carbon nanofibers.

The invention belongs to the technical field of biomedical materials, and particularly relates to ultrasonic-excited piezoelectric delivery exosome electrostatic spinning and a preparation method thereof.The piezoelectric delivery exosome electrostatic spinning comprises piezoelectric electrostatic spinning prepared by embedding barium titanate nanoparticles into polylactic acid, the surface of the piezoelectric electrostatic spinning is modified by chitosan and then loaded with exosome, and the surface of the piezoelectric electrostatic spinning is loaded with the exosome. The preparation method comprises the following steps: preparation of piezoelectric electrostatic spinning: dissolving polylactic acid in hexafluoroisopropanol, adding barium titanate nanoparticles, and carrying out ultrasonic dispersion to form a uniform precursor solution; piezoelectric electrostatic spinning containing barium titanate is prepared through high-voltage electrostatic spinning; piezoelectric electrostatic spinning surface modification: immersing the piezoelectric electrostatic spinning into a chitosan solution for incubation, and modifying the piezoelectric electrostatic spinning to form piezoelectric electrostatic spinning with positive electricity on the surface; the modified piezoelectric electrostatic spinning is soaked in an exosome suspension to be incubated, and piezoelectric exosome delivery electrostatic spinning is prepared and has the self-energy-supply function, the space-time response function and the biological delivery function, the defects of traditional biological medicine materials are hopefully overcome, and the piezoelectric exosome delivery electrostatic spinning can be applied to the field of biological medicine materials. The clinical transformation application of the intelligent biological material in the chronic wound repair of diabetes mellitus is promoted.

The present invention provides a fibrous mat comprising a plurality of electrospun fibers wherein each electrospun fiber comprises a shell and a core comprising a water-soluble polymer and a plurality of cells, e.g., dormant cells. The invention further provides methods of activating dormant cells and methods of use thereof, such as for supplementing cosmeceutical ingredients to the skin of a subject.

The invention relates to lithium-based battery systems and, more particularly, to electro-spinable solution compositions, electro-spun sulfur-polymer fibers, e.g., wires and yarns, and their use in preparing high performance sulfur mattes, e.g., electrodes, for lithium-sulfur batteries with potential applications in small-scale mobile devices. The sulfur-polymer fibers have nanoscale dimensions and yarn-like morphology. The sulfur-polymer fibers can be prepared by co-dissolving sulfur and polymer in a solvent for forming the electro-spinable solution, and electrospinning the solution. The electrospun fibers can be used to form a composite that includes alternating layers of the electrospun fibers and polymer on a current collector.

The invention relates to a magnetic induction curing fiber reinforced composite material as well as a preparation method and application thereof, and belongs to the technical field of fiber reinforced composite materials. In order to solve the problem of weak interlayer performance of the existing fiber reinforced resin-based composite material, the invention provides a method for magnetically inducing and curing the fiber reinforced composite material, which comprises the following steps of: preparing an electrostatic spinning fiber membrane containing nano magnetic powder as an interlayer, and paving the electrostatic spinning fiber membrane between prepreg or other fiber reinforced body layers to form a composite material blank; in the resin gel stage in the composite material curing process, a strong magnetic field is applied in the thickness direction, so that the magnetic particles in the interlayer film are oriented and arranged along the magnetic field direction to form a reinforced chain. The interlayer magnetic powder is induced to be directionally arranged through a magnetic field, an effective reinforcing structure is formed in the thickness direction of the composite material, and the interlayer shear strength and the layering resistance of the composite material are remarkably improved. The method is simple in process, remarkable in effect and suitable for manufacturing high-performance composite materials in the fields of aerospace, transportation and the like.

The present disclosure provides a PI-in-situ functionalized bimetallic MOF / phosphoric acid proton exchange membrane and a preparation method and an aqueous organic flow battery. The preparation method comprises: sequentially adding diamine monomers and dianhydride monomers in a polar solvent and stirring to form a viscous polyamide acid spinning solution; electrospinning the spinning solution to obtain a PAA fiber membrane; gradient temperature imidization of the PAA fiber membrane to obtain a PI electrospun fiber membrane; plasma pretreatment of the PI electrospun fiber membrane to obtain a surface-activated PI electrospun fiber membrane; placing a sulfonated modified bimetallic MOF reaction solution and the PI electrospun fiber membrane in a reaction kettle by a solvothermal in-situ growth method to obtain a PI@ sulfonated modified bimetallic MOF composite fiber membrane; soaking the PI@ sulfonated modified bimetallic MOF composite fiber membrane in a phosphoric acid solution containing a silane coupling agent for soaking treatment, and then performing heat pressing densification and drying treatment to obtain a PI-in-situ functionalized bimetallic MOF / phosphoric acid composite proton exchange membrane.

- 98 - Abstract The invention relates to new electrospun fiber materials of a biodegradable polymer loaded with antimicrobial peptides. At least about 50% of the electrospun 5 antimicrobial peptides are trapped within the fibers allowing the materials to maintain an antibacterial and an antibiofilm activity during at least 3-days after application. The materials of the invention may be used to treat mucosa and skin conditions such as infected wounds.

The invention relates to the field of fuel cells and technologies, in particular to an electrospun composite proton exchange membrane based on polysulfonated dopamine modification and a preparation method thereof. The composite proton exchange membrane comprises a porous electrospinning fiber substrate which is coated and modified by self-polymerization of a sulfonated dopamine monomer, wherein the sulfonated dopamine monomer is any one of aromatic ring sulfonated dopamine, terminal sulfonated dopamine and amino sulfonylated dopamine; the porous electrospinning fiber substrate is filled with the trivalent cerium salt and the sulfonated polymer. By introducing the poly-sulfonated dopamine coating, the wettability and binding force of the sulfonated polymer can be remarkably improved, and uniform dispersion and fixation of Ce < 3 + > are promoted, so that the proton conductivity and chemical stability of the membrane are improved. The preparation method of the composite proton exchange membrane is simple and convenient, the composite proton exchange membrane has good interface compatibility, free radical degradation resistance and long-term operation stability, and the composite proton exchange membrane has good application prospects in proton exchange membrane fuel cells and water electrolysis devices.

This invention discloses a silicon carbon fiber material, its preparation method, applications, and batteries. The preparation method includes the following steps: electrospun fibers are obtained by coaxial electrospinning of a core layer spinning solution and a shell layer spinning solution; the electrospun fibers are then subjected to pre-oxidation and carbonization to obtain the silicon carbon fiber material. The core layer spinning solution comprises Si nanoparticles and a hard carbon precursor A, with a mass ratio of Si nanoparticles to hard carbon precursor A of (0.25-0.5):1; the shell layer spinning solution comprises a soft carbon precursor C and a hard carbon precursor B, with a mass ratio of soft carbon precursor C to hard carbon precursor B of (0.1-0.4):1; during the coaxial electrospinning process, the core layer spinning solution is encapsulated by the shell layer spinning solution. The silicon carbon fiber material prepared by this invention possesses excellent flexibility, mechanical strength, and electrical conductivity, and can be used alone as a negative electrode.

This invention relates to the field of bio-tissue engineering technology, and particularly to an injectable amniotic membrane compound gel, its preparation method, and its application. It addresses the problems of degradation and unadjustable mechanical properties of existing materials, easy displacement and sedimentation of amniotic membrane particles, insufficient cell loading, and short-lasting repair effects. The gel comprises a composite scaffold membrane and an aldehyde-based hyaluronic acid gel in a mass ratio of 1:3 to 10. The membrane is formed by freeze-drying and grinding the composite scaffold. The scaffold comprises a sequentially stacked upper electrospun fiber membrane layer, a decellularized amniotic membrane matrix intermediate layer, and a lower electrospun fiber membrane layer, cross-linked and bonded together. The electrospun fibers in the upper and lower electrospun fiber membrane layers have a core-shell structure. The shell layer raw material components include natural polymer materials, and the core raw material components include synthetic polymer materials. The preparation method includes preparing a decellularized amniotic membrane matrix, constructing a gradient fiber membrane layer through coaxial electrospinning, cross-linking with tannic acid, freeze-drying and grinding, and preparing and compounding the aldehyde-based hyaluronic acid gel.

The application provides a preparation method of an anti-ultraviolet / super-hydrophobic multifunctional silk cashmere fabric, comprising the following steps: S1, adding polylactic acid powder into dichloromethane to obtain a polylactic acid solution; S2, covering the silk cashmere fabric on a receiving plate, smearing a layer of silk fibroin protein solution on the surface of the silk cashmere fabric, and preparing an electrospun fiber layer on one side of the surface of the silk cashmere fabric on which the silk fibroin protein solution is smeared through electrospinning; S3, adding raspberry-shaped CeO2 / SiO2 composite microspheres into an N, N-dimethylformamide solution, ultrasonic dispersion, then adding polylactic acid and dichloromethane into the above solution, stirring and dissolving to obtain a composite microsphere / polylactic acid precursor solution; and S4, taking the electrospun fiber layer prepared in step S2 as a receiving surface, and performing electrostatic spraying to obtain the anti-ultraviolet / super-hydrophobic multifunctional silk cashmere fabric. Through cooperation of the electrospinning and electrostatic spraying methods, the dispersibility and the bonding strength of nanometer cerium dioxide are improved.

The present application relates to a kind of multifunctional medical fiber membrane and its preparation method and application, the multifunctional medical fiber membrane is with including poly high molecular material, material with anionic group, collagen and ε-polylysine in it Material is raw material, using the electrospun fiber membrane prepared by conjugated electrospinning technology.This medical fiber membrane has the advantages of electrospun membrane and self-assembly membrane simultaneously, close to the structure of extracellular matrix, can provide a large number of cell contact points, provide better microenvironment for cell adhesion, proliferation, physiological function;It contains collagen and ε-polylysine in composition, can make it have good hydrophilicity and antibacterial property, the addition of material with anionic group makes collagen and ε-polylysine more stably combined on fiber membrane, so that it slowly releases, while its own good characteristics make product can be directly attached in clinical use, more effectively induce cell growth and tissue regeneration, and then effectively promote the repair of wound surface.

The application discloses a kind of CS@ZIF-8 / PLA composite electrostatic spinning fiber membranes with fast degradation in water, high antibacterial and filtration efficiency, by in-situ growth method synthesis MOFs composite material with positive electricity, namely CS@ZIF-8;It is mixed with polylactic acid to make spinning fluid, electrostatic spinning is carried out, so as to obtain composite electrostatic spinning fiber membrane.Because the fiber membrane of the application contains polylactic acid and chitosan, it has the characteristics of simple preparation process, easy degradation, green environmental protection, the self-charge of MOFs composite material not only makes the application have excellent bactericidal effect, and it also has better adsorption to PM pollutants in air;Its chemical property is stable, can adapt to different temperature and humidity environment, has wide practical application prospect in medical material, antibacterial filter material field.

An article comprising a multilayer matrix is provided, the matrix comprising a viscoelastic polymer film sandwiched between two or more layers of an elastic polymeric material; wherein each of the two or more layers of the elastic polymeric material is in the form of a fibrous mat; the fibrous mat (i) comprising a plurality of electrospun fibers characterized by an average cross-sectional dimension of between about 1 and about 5 microns, and (ii) characterized by an average pore size of between about 5 and about 50 microns; the viscoelastic polymer film characterized by a thickness of between about 10 and about 60 um; the viscoelastic polymer film characterized by a melting peak temperature of between 30 and about 45 °C; and the two or more layers of the elastic polymeric material comprising PLCL characterized by a Mw of between 78 and about 100 kDa. Methods of making the article are also provided.

The application provides an asymmetric anti-adhesion composite film and a preparation method and application thereof. The composite film comprises a bioactive layer and an electrospun fiber layer, and the electrospun fiber layer comprises a first fiber layer and a second fiber layer. The first fiber layer comprises fibers with a first diameter. The second fiber layer comprises fibers with the first diameter and fibers with a second diameter, and the first diameter is larger than the second diameter. The composite film has strong mechanical and degradation resistance properties, and is suitable for anti-adhesion applications of various moving organoids or tissues, so that the composite film still has structural integrity and functional integrity for a long time in these environments. One side of the composite film has adhesive fibers, and has stronger adhesion in a wet state, so that the composite film cannot be easily displaced when applied to moving organoids or tissues.

The invention provides a visual in-vivo medical electrostatic spinning device and system, and relates to the field of medical instruments. The device comprises an in-vitro injection control mechanism, a visualization mechanism and a solution injection mechanism, the solution injection mechanism comprises an insulation protection sleeve, an injection assembly is arranged in an inner cavity of the insulation protection sleeve, and a circumferential conducting strip is further arranged between the insulation protection sleeve and the injection assembly and used for being connected with a high-voltage power source; the visualization mechanism comprises a camera shooting sleeve, the side wall of the camera shooting sleeve is connected with the side wall of the insulation protection sleeve, and an illumination light source and a camera shooting module are arranged in an inner cavity of the camera shooting sleeve; the in-vitro injection mechanism comprises a liquid storage cavity, an air cavity, and push injection assemblies and valve bodies for respective cavities; the liquid storage cavity and the air cavity are connected with the tail end of the injection assembly. According to the invention, the fiber deposition process of the target part can be monitored in real time, and the treatment precision and safety are obviously improved, so that the treatment effect is enhanced, and the clinical application boundary of the micro-nano electrostatic spinning fiber material is expanded.

The invention provides mineralized hydrogel as well as a preparation method and application thereof. The preparation method of the mineralized hydrogel provided by the invention comprises the following steps: firstly, preparing a calcium salt-loaded electrostatic spinning fiber by using a calcium salt, polylactic acid and polyoxyethylene; secondly, mixing the electrostatic spinning fibers loaded with the calcium salt with a hydrogel precursor solution containing phosphate, initiating the hydrogel precursor solution to generate a cross-linking reaction, and combining calcium ions released from the electrostatic spinning fibers with phosphate ions in the hydrogel in a network to form a mineralized core; finally, the pre-mineralized hydrogel is sequentially subjected to mineralization treatment in a solution containing calcium ions and a solution containing phosphate ions, a large number of mineralized particles are formed, and the mineralized hydrogel is obtained. The preparation method provided by the invention is beneficial to improving the Young modulus of the hydrogel and balancing the relationship between the rigidity of the hydrogel and the mineralization speed, and provides a solution thought for taking the rigidity-enhanced hydrogel as a bone defect repair material.

The application discloses a preparation method of a magnetically controlled piezoelectric short fiber oriented microsphere scaffold, and comprises the following steps: 1) preparing a biomaterial electrospun fiber membrane containing magnetic nanoparticles and piezoelectric particles; 2) grinding the treated fiber membrane into short fibers; 3) dispersing the short fibers in a microsphere preparation solution to prepare magnetically controlled piezoelectric microspheres; 4) dispersing the prepared microspheres in a solution after being treated with a washing liquid to obtain magnetically controlled piezoelectric microspheres wrapped with short fibers; and 5) applying an external magnetic field to the magnetically controlled piezoelectric microspheres to obtain a piezoelectric short fiber oriented microsphere scaffold. The magnetically controlled piezoelectric short fiber oriented microsphere scaffold prepared by the application has good biocompatibility and in-vivo degradability; under the regulation of an external magnetic field, the mechanical force acting on the magnetic nanoparticles in the internal magnetically controlled piezoelectric short fiber oriented microsphere scaffold is applied to the piezoelectric nanoparticles, so that the piezoelectric nanoparticles generate a piezoelectric effect and act on cells and tissues in contact with the piezoelectric nanoparticles, thereby realizing non-invasive and precise regulation of the piezoelectric effect.

The application discloses a kind of gold nanometer double-cone functionalized electrospun fiber membrane and its preparation method and visual analysis application, the application is by gold nanometer double-cone load in the surface of electrospun fiber membrane and mobile phone chroma identification technology two combinations, finally develops a kind of acetylcholinesterase and its inhibitor visual POCT technology;The functionalized electrospun membrane overcomes the defect that the quantitative effect of vision is not good in the single color of visual effect, the resolution is not high in traditional visual equipment, shows higher level in the quantitative and qualitative analysis detection of acetylcholinesterase, with good visual signal effect, high sensitivity, good reproducibility, multicolor high efficiency and the like advantages.

This invention belongs to the field of biomaterials technology, specifically relating to a bioactive scaffold, its preparation method, and its applications. This invention incorporates functionalized mesoporous silica nanoparticles loaded with aminoguanidine into the skin secretions of the giant salamander and polycaprolactone electrospun fibers to construct a bioactive composite scaffold (SPMA). This scaffold enables the sustained release of AG and osteogenic factors, effectively inhibiting free radical generation, AGEs toxicity, and inflammatory responses. Furthermore, it significantly improves the survival rate, osteogenic differentiation, and mineralization capacity of bone marrow mesenchymal stem cells in a high-glucose microenvironment. In vivo experiments further demonstrate that in a streptozotocin-induced diabetic mouse model of skull defects, the SPMA scaffold can alleviate local inflammation, promote angiogenesis, and significantly accelerate new bone formation and defect repair.