130 results about "Electrospun fiber" patented technology

The present invention relates to an electrospun fiber, a process for preparing the same, a nonwoven fabric comprising the electrospun fiber, as well as corresponding uses and articles. The inventive electrospun fiber comprises a polymer, a surface-reacted calcium carbonate and a pharmaceutically or nutraceutically active ingredient, wherein at least a part of the pharmaceutically or nutraceutically active ingredient is present within the pores of the surface-reacted calcium carbonate. The inventive fibers may be used e.g. in yarns, transdermal patches, intrabuccal patches, implantable textiles, wound dressings and / or medical tapes.

Aspects of the disclosure relate to synthetic tissue or organ scaffolds and methods and compositions for promoting or maintaining their structural integrity. Aspects of the disclosure are useful to prevent scaffold damage (e.g., delamination) during or after implantation into a host. Aspects of the disclosure are useful to stabilize tissue or organ scaffolds that include electrospun fibers.

The invention relates to the field of textile fabrics, and particularly discloses an antibacterial and crease-resistant garment fabric and a preparation process thereof. The antibacterial and crease-resistant garment fabric is prepared from modified cotton fibers and electrospun fibers of polyacrylonitrile and polyurethane according to the mass ratio of 1: (0.1-0.3): (0.3-0.5), and a preparation method of the polylactic acid fiber modified cotton fibers containing silver nanowires comprises the following steps that the cotton fibers are padded in finishing liquid and then dried and shaped, and pretreated cotton fibers are prepared; the pretreated cotton fibers are padded in the treating fluid and then dried and baked, and modified cotton fibers are prepared; the finishing liquid is prepared from the following raw materials: citric acid modified titanium dioxide sol, sodium hypophosphite, triethanolamine and deionized water; the treating fluid is prepared from the following raw materials: nylon waste silk, chitosan quaternary ammonium salt, N, N-dimethylformamide and alkaline silica sol. The garment fabric has the advantages of being good in antibacterial and crease-resistant effect, lasting in antibacterial effect and high in breaking strength.

The invention discloses a bimetal MOFs-loaded electrostatic spinning fiber membrane for oil-water separation and a preparation method thereof, and belongs to the technical field of membrane separation, and the preparation method comprises the following steps: (1) preparing a hydroxyl-modified metal organic framework material MIL-53 (Al)-OH through a solvothermal reaction; (2) preparing an MIL-53 (Fe) precursor solution by using ferric salt, terephthalic acid, polyvinylpyrrolidone and an organic solvent, ultrasonically dispersing MIL-53 (Al)-OH in the MIL-53 (Fe) precursor solution, uniformly mixing, and soaking the electrostatic spinning fiber membrane in the MIL-53 (Fe) precursor solution for 1-3 hours; and (3) transferring the system in the step (2) into a reaction kettle, reacting at 130-150 DEG C for 10-15 hours to enable the bimetallic MOFs to grow on the surface of the electrostatic spinning fiber membrane, washing, and drying to obtain the bimetallic MOFs-loaded electrostatic spinning fiber membrane for oil-water separation. The bimetal MOFs-loaded electrostatic spinning fiber membrane has the advantages of good oil-water separation performance, strong antifouling ability and strong dye degradation ability.

A dry drug delivery system comprising a middle layer encased in two outer layers, the middle layer and the two outer layers each comprising a mixture of electrospun fibers. Also disclosed is a water-dissolvable dry device containing a physical mixture of a first fiber and a second fiber in which the first fiber and the second fiber are configured to react with each other and with a biological tissue upon hydration, and the device transforms into a hydrogel upon contact with the biological tissue. Further provided is a method for delivering a bioactive substance to a soft tissue using the system or device.

The invention discloses a solid electrolyte using an electrostatic spinning fiber membrane as a matrix and a preparation method and application thereof, and the preparation method of the solid electrolyte specifically comprises the following steps: (1) sequentially dissolving PVDF powder and commercial tetragonal phase BaTiO3 (BTO) powder in a mixed solvent of DMF and THF, and uniformly stirring with a magnetic stirrer to obtain a PVDF / BTO solution; and (2) carrying out electrostatic spinning on the PVDF / BTO solution to prepare a fiber membrane, drying, and carrying out a solution pouring method to prepare the composite solid electrolyte film. Compared with the prior art, the prepared solid electrolyte has excellent cycle performance, the ion transference number of the solid electrolyte is greatly increased, and the solid electrolyte has good lithium metal negative electrode compatibility.

The invention belongs to the technical field of flexible electronic materials and sensing, and particularly relates to a PVDF (polyvinylidene fluoride) fiber membrane doped with a surface modified boron nitride nano material and a preparation method of the PVDF fiber membrane. The PVDF fiber membrane is prepared by adopting an electrostatic spinning method, and a surface-modified boron nitride (BN) nano material is doped during spinning, so that the electrospun PVDF / BN composite fiber membrane is prepared. The piezoelectric property of the electrospun PVDF fiber membrane can be effectively improved by adding the boron nitride, the dispersity of the boron nitride nano material in PVDF can be improved after the boron nitride nano material is subjected to surface modification, and the piezoelectric property of the composite fiber membrane is further enhanced. The electrospinning PVDF / BN flexible piezoelectric fiber membrane provided by the invention can be widely applied to the fields of human health monitoring, intelligent wearable equipment, biomedical treatment and the like.

The invention provides a pH response type self-repairing electrostatic spinning fiber material and a synthesis method and application thereof.According to the method, pH response type micro / nano containers are evenly distributed in a polymer matrix through the electrostatic spinning technology, so that the self-repairing function of a coating is achieved, and the method is particularly suitable for the field of anticorrosive coatings.

The invention relates to a eugenol liposome / chitosan / polyoxyethylene hydrophobic electrospun fibrous membrane and a preparation method thereof, and the method comprises the following steps: based on soybean lecithin and cholesterol, adding eugenol and Tween 80, preparing a lipid solution, injecting the lipid solution into water or a phosphate buffer solution, and preparing an eugenol liposome suspension with the eugenol embedding rate greater than 88%; preparing a cross-linked chitosan acetic acid solution based on chitosan and a cross-linking agent; preparing a polyoxyethylene acetic acid solution, and mixing the cross-linked chitosan acetic acid solution with the polyoxyethylene acetic acid solution to obtain a base material spinning solution; mixing the eugenol liposome suspension with a base material spinning solution to prepare a final spinning solution, and preparing the eugenol liposome / chitosan / polyoxyethylene hydrophobic electrospinning fiber membrane by adopting an electrostatic spinning method. The embedding rate of eugenol is high, the water contact angle of the fiber membrane can reach 90 degrees or above, the slow release effect on eugenol is good, and the antibacterial and fresh-keeping effects are improved.

This invention discloses a multifunctional composite flexible fabric with multiple functions including radiative cooling, energy harvesting, hydrophobicity, and antibacterial properties. The composite flexible fabric consists of several electrospun fiber layers, each formed sequentially by electrospinning in a top-to-bottom order. It includes at least two polymer electrospun fiber layers and at least one nanofunctional electrospun fiber layer, wherein the nanofunctional electrospun fiber layer serves as an intermediate sandwich layer, forming a sandwich structure with the polymer electrospun fiber layers located on the upper and lower surfaces. This invention also discloses a method for preparing this flexible fabric, using electrospinning to prepare it by electrospinning a PVDF or related polymer solution and a polymer solution modified with functional nanoparticles. This preparation method can effectively control the morphology of the nanofibers and the functions of the nanoparticles, enabling a synergistic effect between the functional nano-scattering particles and the nanofibers, resulting in an integrated functional fabric with thermal management, energy harvesting, and antibacterial properties.

The invention provides a genetically engineered oriented electrostatic spinning fiber as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. Gene TSPAN9 is packaged in liposome through a micro-fluidic chip technology, then oriented electrostatic spinning fibers of a shell-core structure are prepared through an oriented micro-sol electrostatic spinning technology, and the liposome containing the TSPAN9 is protected on a core layer by hyaluronic acid; and the polylactic acid fibers are arranged in an oriented manner to form a shell layer. An in-vitro experiment shows that the oriented fiber closely simulates a fascia oriented arrangement structure, and the cell migration rate is remarkably improved through contact guidance; by slowly releasing lipidosome loaded with genes into cells and maintaining the mitochondrial steady state, mitochondrial respiration is effectively recovered, the active oxygen level is reduced, and the mitochondrial membrane potential function is maintained. In-vivo experiments show that the genetically engineered fiber can effectively inhibit inflammatory response and promote fascia tissue regeneration by promoting mitochondrial exocytosis to discharge damaged mitochondria.

The invention discloses a multifunctional wound patch combined with electrical stimulation therapy and a preparation method and application thereof, and relates to the technical field of medical materials, and the multifunctional wound patch comprises a double-layer electrostatic spinning fiber membrane, a conductive ink layer and a conductive hydrogel layer. S-shaped concentric circle conductive electrode pairs written by conductive ink are integrated on the surface (directly in contact with the wound) of the hydrophobic fiber layer, and square conductive ports with corresponding sizes can be drawn at the tail ends of the two electrodes as required. And the surface of the conductive electrode pair is packaged by conductive hydrogel with an antibacterial function. An external electric signal can be transmitted to the electrode pair of the patch through the conductive port of the electrode pair, and then acts on a wound through the conductive hydrogel layer, so that on-demand electrical stimulation treatment on the wound is realized. According to the multifunctional wound patch combined with the electrical stimulation therapy, discharge of redundant seepage can be achieved, and it is guaranteed that the wound environment is good; the curcumin-loaded medicine has the effects of resisting bacteria, resisting oxidation and promoting healing on wounds.

The disclosed concept includes systems and methods for the delivery of magnesium to a patient to modulate the human immune system and create an anti-inflammatory periodontal environment to support tissue regeneration. Various mechanisms for the delivery of magnesium include magnesium-polymer (PLGA) microparticles, magnesium-polymer (PLGA) electrospun fibers, and / or magnesium-polymer (PLGA) implant devices, e.g., scaffolds, constructed of the magnesium-polymer (PLGA) electrospun fibers. These mechanisms provide a controlled- and / or sustained-release of magnesium for the treatment of one or more of periodontitis, peri-implantitis, and bone defects. The magnesium-polymer (PLGA) microparticles include magnesium metal nanopowder that is coated with a fatty acid or lipid.

The application belongs to the field of functional material preparation, and particularly relates to a preparation method of a super-light high-nucleic-acid-absorption electrospun fiber sponge material and application thereof. The SiO2 electrospun fiber is used as a framework, a three-dimensional monolithic structure assembled by fragmented electrospun nanofiber membranes is used, the interconnected nanofiber cell structures of which endow the three-dimensional monolithic structure with high porosity and excellent structural flexibility and stability. Meanwhile, the amino-rich polyethylene imine and chitosan are chemically crosslinked by using epichlorohydrin as a crosslinking agent, and finally during freeze-drying, the ice crystals are partially sublimated, leaving a pore structure, and a porous sponge material is obtained. The material has a high nucleic acid adsorption capacity, and makes nucleic acid extraction more simple, rapid and sensitive.

A flexible barrier laminate comprising a cellulose fiber-based substrate layer (1), a barrier layer (2) comprising an electrospun fiber web, deposited on one side of the substrate layer.

The invention relates to the technical field of composite membranes, in particular to a PLLA / DFSCs composite membrane and a preparation method thereof.DFSCs are cultured after being separated, then the DFSCs are inoculated to a PLLA electrostatic spinning fiber membrane to be cultured, and the final PLLA / DFSCs composite cell membrane is obtained. The method comprises the following steps: inoculating DFSCs to a PLLA bracket, and carrying out flat culture for 3 days to construct a P-CS composite cell sheet; compared with a traditional membrane (the culture period is 14-28 days), the P-CS composite membrane only needs to be cultured for 3 days, so that the culture time of the cell membrane is greatly shortened; compared with a traditional diaphragm (CS), the P-CS composite diaphragm has excellent mechanical strength and plasticity and is suitable for different defect surface plasticity.

This application discloses a photodynamic antibacterial fiber membrane and its preparation method and application, which relates to the field of functional materials, including: dissolving aggregation-induced luminescence photosensitive molecules in a first solvent to obtain a photosensitive molecule solution; dissolving the purified polymer in a second solvent and adding the photosensitive molecule solution to obtain a spinning precursor; regulating the orientation of the spinning precursor by electrospinning to obtain a fiber membrane; and regulating the crystallinity of the fiber membrane to obtain a photodynamic antibacterial fiber membrane. The preparation method provided in this application combines the polymer condensed state structure with aggregation-induced luminescence photosensitive molecules, using the polymer crystallization and orientation structure to provide a rigid confined domain for the photosensitive molecules; at the same time, the nanoscale of the electrospun fiber membrane is used to increase the contact area between the material and oxygen, synergistically improving the material's active oxygen yield.

The invention relates to the technical field of material engineering, in particular to a lignocellulose-based amphiphilic polymer, an electrospun fiber film and a preparation method thereof. The preparation method comprises the following steps: pre-treating agricultural product processing byproducts by adopting a chemical method and / or a biological method to obtain lignocellulose; the method comprises the following steps: taking lignocellulose as a raw material, carrying out high-pressure homogenization treatment to obtain lignocellulose nanofibers, mixing the lignocellulose nanofibers, an aliphatic monomer and a catalyst, and carrying out high-temperature polymerization to obtain the lignocellulose-based amphiphilic polymer. The invention further provides a porous electrospun fiber film which is converted from a mixture of the lignocellulose-based amphiphilic polymer and the aliphatic polymer and has excellent mechanical strength, flexibility and biocompatibility, and the porous electrospun fiber film can be widely applied to the biomedical fields of wound dressing, tissue engineering and the like. And optimal regulation and control of material performance and efficient utilization of agricultural product processing byproducts are realized.

The application provides a preparation method of a down-like heat storage and preservation material, and comprises the following steps: dissolving polylactic acid in a mixed solution of chloroform / acetone to obtain a polylactic acid solution; dissolving composite hollow spheres in a mixed solution of chloroform / acetone to obtain a composite hollow sphere solution; using the polylactic acid solution as a shell layer solution and the composite hollow sphere solution as a core layer solution, adopting a coaxial conjugate electrospinning instrument to prepare a fiber bundle, the spinning voltage is 12-14 kV, the distance between composite spinnerets is 25-30 cm, the flow rate of the shell layer solution is 0.5-3 mL / h, and the flow rate of the core layer solution is 0.5-3 mL / h, to obtain an electrospun fiber bundle; using the electrospun fiber bundle as a covering yarn and polylactic acid filaments as core yarns, the down-like heat storage and preservation material is obtained by covering. The application adopts the electrospinning method to prepare the fiber bundle, and adds the composite hollow spheres in the core layer of the fiber bundle, uses the electrospun fiber bundle as the covering layer and the ordinary filaments as the core layer, so that a heat storage and preservation effect of the down-like heat storage and preservation material is better than that of ordinary air long down material.

A barrier laminate comprising a substrate layer (1), a connection layer (2) comprising an electrospun fiber network, and a non-fiber-based sealing layer (3), adjacent to the connection layer (2) and facing the outside of the laminate.

A porous membrane can include a first plurality of near-field electrospun fibers that are substantially parallel one to another. A second plurality of near-field electrospun fibers can be deposited over the first plurality of fibers. The second plurality of fibers can also be substantially parallel one to another. The second plurality of fibers can be transverse to the first plurality of fibers, such that the second plurality of fibers cross the first plurality of fibers to form pores between adjacent fibers of the first plurality of fibers and adjacent fibers of the second plurality of fibers.

This invention provides a medical repair membrane with an orthogonal crack-limiting structure and its preparation method. This invention relates to the field of biomedical materials technology. The medical repair membrane of this invention comprises at least two electrospun fiber layers, which intersect to form an orthogonal fiber structure. Layer B, facing tissue integration, adopts a coaxial core-shell structure. The shell layer contains biodegradable polymers and bioactive components, while the core layer is a biodegradable polymer. The structure of this invention effectively inhibits crack propagation and improves the structural stability of the material. Simultaneously, the core-shell structure enables controlled release of active components and tissue-selective induction, balancing mechanical properties and biocompatibility. The medical repair membrane is suitable for soft tissue defect repair, such as dura mater repair, fascia repair, pericardial repair, and hernia repair.

The invention discloses a special adsorption dressing used after a laparoscopic surgery, and belongs to the technical field of medical dressings. The dressing is of a layered composite structure and sequentially comprises a hydrophilic guide layer, an absorption foam layer and a hydrophobic protective layer from inside to outside, the hydrophilic guide layer is an electrospun fibrous membrane formed by micro / nano fibers oriented along a specific direction; the absorption foam layer is made of a foam material with high aperture ratio; the hydrophobic protective layer is a breathable hydrophobic film; the preparation method mainly comprises the steps of preparation of each functional layer and composite molding through a low-temperature hot pressing process. According to the dressing, through the synergistic effect of the three layers of materials, directional and rapid absorption and storage of percolation of a postoperative puncture hole are achieved, tissue regeneration guidance is provided, the skin around a wound is effectively prevented from being hardened, and the dressing is antibacterial, anti-inflammatory, good in fitting performance and beneficial to wound healing.

The invention belongs to the field of filter materials, and relates to a composite microfiber filter material as well as a preparation method and application thereof. The material comprises a polylactic acid electrostatic spinning fiber layer and a polylactic acid melt-blown fiber layer which are compounded together, the polylactic acid electrostatic spinning fiber layer is prepared from an electret polylactic acid composition through electrostatic spinning, and the polylactic acid melt-blown fiber layer is prepared from the electret polylactic acid composition through melt-blown molding; the electret polylactic acid composition is prepared from the following components in parts by weight: 100 parts of polylactic acid, 0.2 to 4 parts of a composite electret, 0.2 to 2.5 parts of a plasticizer, 0.05 to 0.5 part of a dispersing agent and 0.01 to 0.5 part of an antioxidant. The composite microfiber filtering material comprises the melt-blown layer and the electrostatic spinning superfine fiber layer, the melt-blown layer is used for coarse filtration, the electrostatic spinning superfine fiber layer is used for fine filtration, the problems that the filtering performance of a single melt-blown layer is insufficient and the filtering resistance of a single electrostatic spinning layer is too large can be solved, and the effects of high efficiency and low resistance are achieved.

The present invention provides an electrospun fiber mat, a preparation method thereof and an application thereof, relating to the technical field of composite materials. The preparation method of the electrospun fiber mat provided by the present invention comprises the following steps: mixing L-lactic acid, D-lactic acid, divalent metal oxide and an organic solvent to obtain a spinning solution; performing electrospinning on the spinning solution to obtain an electrospun fiber mat. The present invention can control the crystallinity of the electrospun fiber mat and improve the mechanical properties of the electrospun fiber mat.

According to the high-waterproofness fiber membrane and the preparation method thereof, the hydrophobic component is uniformly dispersed in the hydrophobic polymer solution, then the fiber membrane is prepared in an electrostatic spinning mode, and the hydrophobic component can be attached to the surface of the fiber, so that the fiber has super-hydrophobicity. By adopting the preparation method, the in-situ efficient electrospun fiber membrane can be obtained, the hydrophobic polymer and the hydrophobic component are dual-hydrophobic, the waterproofness is greatly improved, the fiber membrane has the function of a physical barrier due to high porosity and high air permeability, the fiber membrane is antifouling and waterproof, and the super-hydrophobic fiber membrane is soft and ultrathin and can be used as a super-hydrophobic membrane. And a certain bacterium isolation capability is achieved. The preparation method can be customized as required, and is high in safety, convenient and fast.

The invention discloses a double-bionic wound dressing with seepage management and self-power generation functions as well as a preparation method and application of the double-bionic wound dressing. The double-bionic wound dressing comprises a first electrode layer, a blocking layer, a moisture absorption power generation layer, a diffusion antibacterial layer, an evaporation power generation layer and a second electrode layer which are sequentially stacked from bottom to top. The electrostatic spinning fiber membrane with high biocompatibility is adopted, a liquid transport mechanism of plant transpiration and an ion active transport principle of electric ray power generation cells are combined through bionic design, the triple functions of wound surface antibiosis, efficient seepage management and stable power generation are achieved, the wound surface microenvironment is regulated and controlled, and the wound surface antibacterial effect is achieved. Excessive inflammation caused by seepage accumulation is effectively avoided, fibroblast migration, angiogenesis and skin appendage regeneration are remarkably promoted, wound healing is accelerated, skin function recovery is facilitated, and a new treatment mode is provided for burn wound repair.

The present invention provides a silicon-carbon negative electrode, a preparation method thereof and an application. The preparation method comprises the following steps: mixing an organosilicon source, a polymer and a solvent to obtain a spinning solution, subjecting the spinning solution to electrospinning to obtain electrospun fibers; mixing a coating solution and the electrospun fibers and carbonizing them to obtain the silicon-carbon negative electrode. The preparation method can avoid the problem that the agglomeration of silicon materials during the preparation process causes the coating layer to break, thereby being unable to inhibit the expansion of silicon materials, and can obtain a silicon-carbon negative electrode with a stably coated carbon layer, effectively inhibiting the expansion of silicon materials, improving the cycle performance of the battery. At the same time, the prepared silicon-carbon negative electrode can be directly used as a self-supporting negative electrode, improving the volume energy density of the battery.

The present invention relates to, inter alia, various scaffold materials including a scaffold material comprising: i) platelet-rich plasma and / or platelet lysate and / or bone marrow concentrate; and ii) electrospun fibres comprising silk protein.

The invention discloses an ibuprofen transdermal patch based on core-shell structure viscous electrostatic spinning fibers and a preparation method of the ibuprofen transdermal patch, and belongs to the technical field of external transdermal patches. A viscous fiber membrane constructed based on core-shell structure electrospun fibers is used as a functional layer; a shell layer of the fibers is formed by curing a spinning solution formed by dissolving a thermoplastic elastomer and natural resin in an organic solvent B, and provides stable viscosity; the core layer is formed by curing a spinning solution formed by dissolving ibuprofen, a hydrophobic polymer and a penetration enhancer in an organic solvent A, and efficient loading and controllable release of drugs are achieved. By optimizing the shell-core flow rate ratio, spinning voltage and other key process parameters, the patch has the characteristics of strong adhesion in the initial stage and easy stripping in the later stage, and meanwhile, it is ensured that the transdermal permeation amount and release rate of the medicine meet the treatment requirements. The patch has the characteristics of high porosity and biphasic drug release which takes effect quickly in the initial stage and is maintained slowly in the subsequent stage, effectively avoids the first-pass effect and the skin irritation risk, and is particularly suitable for local treatment of inflammatory diseases such as acute gouty arthritis and the like.