2 results about "Release pattern" patented technology

The application discloses a kind of hierarchical response intelligent drug-loading units and its controlled-release system, including A type drug-loading microbubble and B type phase change droplet, A type drug-loading microbubble includes gas core and rigid shell, the first drug active substance is loaded in the rigid shell, and the A type drug-loading microbubble has first burst threshold;B type phase change droplet includes low-boiling liquid perfluorocarbon core and phospholipid shell, the second drug active substance is loaded in the phospholipid shell, and the B type phase change droplet has phase transition threshold and second burst threshold;Wherein, first burst threshold>Second burst threshold>Phase transition threshold.The application realizes the precision and intelligent controlled-release of drug, significantly improves curative effect and reduces toxic side effect, benefits from the core structure design of hierarchical response drug-loading unit and programmable ultrasonic excitation sequence, and the application completely changes the extensive release mode of traditional one-time blasting.