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3 results about "Release pattern" patented technology

A smart drug-loaded unit with graded response and a controlled release system thereof

The application discloses a kind of hierarchical response intelligent drug-loading units and its controlled-release system, including A type drug-loading microbubble and B type phase change droplet, A type drug-loading microbubble includes gas core and rigid shell, the first drug active substance is loaded in the rigid shell, and the A type drug-loading microbubble has first burst threshold;B type phase change droplet includes low-boiling liquid perfluorocarbon core and phospholipid shell, the second drug active substance is loaded in the phospholipid shell, and the B type phase change droplet has phase transition threshold and second burst threshold;Wherein, first burst threshold>Second burst threshold>Phase transition threshold.The application realizes the precision and intelligent controlled-release of drug, significantly improves curative effect and reduces toxic side effect, benefits from the core structure design of hierarchical response drug-loading unit and programmable ultrasonic excitation sequence, and the application completely changes the extensive release mode of traditional one-time blasting.
Owner:TIANJIN MEDICAL UNIVERSITY GENERAL HOSPITAL

Medicinal capsule structure

The invention relates to the technical field of capsule preparations, in particular to a medicinal capsule structure, which comprises a mother capsule and a sub-capsule filled in the mother capsule, and two working modes are realized through filling switching of the mother capsule: under the mode A (time sequence release), the mother capsule is filled with a quick-release medicine and the sub-capsule filled with a slow-release medicine at the same time, and under the mode B (time sequence release), the sub-capsule is filled with a slow-release medicine; multi-component off-peak release is realized by utilizing the quick release characteristic of the mother capsule and the slow release characteristic of the ascomycetes; and in the mode B (split swallowing), the mother capsule is only filled with the ascoid to adapt to people with dysphagia, and the ascoid can be taken in a mixed manner after the mother capsule is split, and the function of a medicine coating is reserved. The ascus is composed of a medicine containing cavity, a targeting layer and an anchoring layer, the targeting layer can be made of an arabinoxylan-chitosan compound (colon targeting) or a methacrylic acid copolymer (esophageal targeting), the anchoring layer is made of a hyaluronic acid-chitosan compound, and it is ensured that the ascus is anchored at the focus position. The preparation has multiple functions of sequential release, targeted drug delivery, adaptation to people with dysphagia and the like.
Owner:XIAN ZHENGHAO BIOLOGICAL PHARMA

Modified release composition of orlistat and acarbose for the treatment of obesity and related metabolic disorders

The present invention relates to a modified-release composition comprising orlistat and acarbose, comprising individually distinct parts with different release patterns:a) a first part, G1, comprising from about 5 to about 70% w / w of the total dose of acarbose,b) a second part, G2A, comprising from about 30 to about 95% w / w of the total dose of acarbose,c) a third part, G2B, comprising from about 10 to about 90% w / w of the total dose of orlistat, andd) a fourth part, G3, comprising from about 10 to about 80% w / w of the total dose of orlistat, and the total concentration of acarbose and orlistat, respectively, in the composition is 100% w / w.
Owner:EMPROS PHARMA AB