68 results about "Niacin" patented technology

The invention provides a technical method for improving the anti-aging effect of eurotium cristatum tea compound fermentation liquor, and belongs to the technical field of microorganisms, the Latin name of eurotium cristatum is Eurotium cristatum, the eurotium cristatum is preserved in the China Center for Type Culture Collection, and the preservation number is CCTCC M 2024643. According to the method, the yeast seed solution is inoculated into the tea-sea buckthorn leaf culture solution fermented by the eurotium cristatum, so that the content of anti-aging active components such as procyanidine B2, quercitrin, cyanidin-3-glucoside, nicotinic acid, naringenin and rutin in the fermentation culture solution can be remarkably increased through co-fermentation, and the elastase inhibition rate can be remarkably increased; the anti-aging effect of a component system of the fermentation culture solution is enhanced. The prepared tea-hippophae rhamnoides leaf compound fermentation liquor is suitable for development of anti-aging cosmetics and has a wide market prospect.

Various benefits to intestinal health are made by delivery of an active agent to the colon of an animal, including a human. Active ingredients include of riboflavin, vitamin A, vitamin C, vitamin D, vitamin E, vitamin K, folic acid, β-carotene, vitamin B1, niacin, vitamin B5, vitamin B6, biotin, vitamin B12, omega-3 fatty acids and combinations thereof. Benefits include increased concentration of at least one short-chain fatty acid its salt thereof in the intestine, increased microbiome diversity in the intestine, increased beneficial bacteria in the intestine, increased the butyrate synthesis pathway in the intestine, improved barrier function of the intestine, reduced redox potential of the gut, reduced amount of gas produced in the intestine; and stimulation of intestinal immune responses.

The present invention relates to a composition containing Citrus sinensis (L.) Osbeck fruit and lemon extracts and preferably a trace element, which is preferably a mineral such as Chromium, Calcium, Magnesium, Iron, Copper, Zinc, Iodine, Manganese, Potassium, Sodium, Selenium, Molybdenum, Fluoride, Chloride or Phosphorus or combinations thereof, and their salts and / or a vitamin such as A, D, E, K, B1, B2, C, Niacin, Pantothenic acid, B6, Folic acid, B12 or Biotin or combinations thereof.

Various benefits to intestinal health are made by delivery of an active agent to the colon of an animal, including a human. Active ingredients include of riboflavin, vitamin A, vitamin C, vitamin D, vitamin E, vitamin K, folic acid, β-carotene, vitamin B1, niacin, vitamin B5, vitamin B6, biotin, vitamin B12, omega-3 fatty acids and combinations thereof. Benefits include increased concentration of at least one short-chain fatty acid its salt thereof in the intestine, increased microbiome diversity in the intestine, increased beneficial bacteria in the intestine, increased the butyrate synthesis pathway in the intestine, improved barrier function of the intestine, reduced redox potential of the gut, reduced amount of gas produced in the intestine; and stimulation of intestinal immune responses.

The present invention relates to a nicotinic acid phosphoribosyltransferase mutant and a coding gene, and its application in the biosynthesis of L-phosphinothricin, D-amino acid, L-tert-leucine or L-aminobutyric acid by a multi-enzyme coupling method. The beneficial effects of the present invention are mainly reflected in: (1) the nicotinic acid phosphoribosyltransferase mutant of the present invention improves the intracellular NAD level, brings an efficient, low-cost and environmentally friendly production method for the coenzyme-dependent multi-enzyme catalytic reaction, and does not require the additional addition of coenzymes; (2) the nicotinic acid phosphoribosyltransferase mutant of the present invention has better catalytic efficiency, and when the intermediate product PPO is used as a substrate for catalytic reaction, the conversion rate is much higher than that of the original enzyme, and the L-phosphinothricin yield is also greatly improved; (3) the present invention can directly use PPO to prepare and produce L-phosphinothricin without exogenous addition of coenzymes, without the need for expensive resolution reagents, without the need for synthesizing phosphinothricin derivatives, and without the need for separation, re-racemization, and re-resolution of D-phosphinothricin.

The invention relates to the technical field of biological medicines, in particular to a preparation containing mesenchymal stem cell-derived insulin-secreting cells and application of the preparation in preparation of blood sugar regulating products. The insulin-secreting cell is derived from mesenchymal stem cells, and the preparation method of the insulin-secreting cell adopts a four-stage directional induced differentiation strategy: in the first stage, all-trans retinoic acid, LDN-193189 and cyclopamine are combined, an endoderm program is started, non-target differentiation is specifically inhibited, and pedigree locking is realized; in the second stage and the third stage, a high-glucose environment and GLP-1 are utilized to promote the cells to differentiate into endocrine precursors and terminal insulin secreting cells; in the fourth stage, GLP-1, PTHrP and nicotinic acid are added for function strengthening, and the glucose responsiveness, maturity and stress resistance of the cells are synergistically improved. The method is accurate in differentiation path and economic in factor, and the obtained cells are high in insulin positive rate and mature in function. A preparation containing the cell can be used for preparing a medicine for treating diabetes mellitus.

The present invention relates to a nutritional vitamin complex for pets intended to improve the fur and skin quality of pets such as dogs and cats. The composition of the complex contains omega-3, curcumin, piperine, biotin (vitamin H or vitamin B7), vitamin B2 (riboflavin), vitamin B3 (nicotinic acid or niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), folic acid (vitamin B9), vitamin E (alpha-tocopherol), vitamin C, zinc (zinc glycine chelate), coenzyme Q10, hydrolysed type II collagen, astaxanthin, DL-methionine, selenium, L-glycine, L-proline, L-phenylalanine, L-leucine, L-isoleucine, L-histidine, L-arginine, L-lysine, L-tyrosine, resveratrol, and a flavouring agent.

Providing a cosmetic that is not sticky, has excellent skin affinity, and has a smooth feeling. 【Solution means】The cosmetic according to the present disclosure contains (A) 0.1% by mass to 5% by mass of a glycine derivative represented by formula (1) or a salt thereof, (B) niacin or a derivative thereof, (C) a higher alcohol having 14 to 22 carbon atoms, (D) a hydrophilic polyoxyethylene alkyl ether, and (E) a glycerin monoalkyl ether. TIFF2026105749000006.tif43169 (In the formula, R 1 and R 2 each independently represents H, an alkyl group, an alkenyl group, an aryl group, an aralkyl group, an aminomethylcarbonyl group, an amidino group, an alkylcarbonyl group, an alkenylcarbonyl group, etc., and R 3 represents H, an alkyl group, an alkenyl group, an aryl group, or an aralkyl group. However, R 1 , R 2 , R 3 do not simultaneously become H.)

A composition comprising an amino acid component selected from L-Arginine, Citrulline Malate, L-Theanine, or any combination thereof, and an herbal and / or vitamin component selected from at least two of Niacin, Panax Ginseng, Lepidium Meyenii, Turnera Diffusa, Ptychopetalum Olacoides, Zinc, or any combination thereof.

The present invention relates to a nutritional vitamin complex for pets intended to improve the fur and skin quality of pets such as dogs and cats. The composition of the complex contains omega-3, curcumin, piperine, biotin (vitamin H or vitamin B7), vitamin B2 (riboflavin), vitamin B3 (nicotinic acid or niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), folic acid (vitamin B9), vitamin E (alpha-tocopherol), vitamin C, zinc (zinc glycine chelate), coenzyme Q10, hydrolysed type II collagen, astaxanthin, DL-methionine, selenium, L-glycine, L-proline, L-phenylalanine, L-leucine, L-isoleucine, L-histidine, L-arginine, L-lysine, L-tyrosine, resveratrol, and a flavouring agent.

The present disclosure provides compositions and methods for providing a health benefit to a growing animal comprising administering a food composition to the animal, wherein the food composition includes a brain development blend. The brain development blend generally comprises DHA, EPA, taurine, choline, thiamine, riboflavin, pantothenic acid, niacin, pyridoxine, vitamin B12, and folic acid.

The present invention discloses a nitrilase immobilization technology production equipment for nicotinic acid production, comprising an immobilization box, an immobilization mechanism arranged on the inner wall of the immobilization box, a liquid inlet pipe, the liquid inlet pipe is used to input nitrilase liquid into the immobilization box, a crosslinking agent input pipe, the crosslinking agent input pipe is used to input the crosslinking agent into the immobilization box, a processing mechanism, the processing mechanism is used to purify and discharge the residual liquid, and a storage mechanism. The present invention relates to the technical field of nitrilase immobilization equipment; after the nitrilase enters the immobilization box, the nitrilase can be immobilized and cleaned through the cooperation of a first driving motor, a transmission shaft, a stirring blade, a friction disk, a friction ring plate, a through hole, a heat-insulating ring plate, an electric push rod and a sliding ring, so as to avoid impurities adhering to the solid surface of the nitrilase to affect its storage, and at the same time, the soft pad is arranged to avoid damage to the nitrilase solid when the stirring blade rotates at a high speed.

To provide a topical skin preparation that has excellent effects in preventing and improving wrinkles, anti-aging, anti-inflammatory, pore tightening, whitening, and improving firmness and elasticity, while reducing skin stickiness and being easily absorbed by the skin. [Solution] A topical skin preparation containing specific plant materials, niacin, and glycyrrhizic acid.

The invention belongs to the technical field of coffee products, and particularly relates to a coffee composition for relieving depressive symptoms and a preparation method thereof. 25-30 parts of coffee beans, 6-10 parts of fructus rosae laevigatae, 6-10 parts of semen boitae, 8-12 parts of cortex albiziae and 1-3 parts of seaweed are limited, and different raw materials are extracted, decocted or subjected to enzymolysis, so that separation and retention of active ingredients of the raw materials are facilitated, and the active ingredients in fructus rosae laevigatae, semen boitae, cortex albiziae and seaweed have a protection effect on brain cells; the traditional Chinese medicine composition is beneficial to recovering the balance of a nervous system, relieving the inflammatory response in the brain, reducing the generation of oxygen free radicals, reducing the activity of xanthine oxidase in the cerebral cortex and improving the symptom of depression; and chlorogenic acid, nicotinic acid and the like in coffee can generate positive influence on depression symptoms. Therefore, the coffee composition provided by the invention can be used for relieving depression symptoms and provides a basis for adjuvant therapy of depression.

The present invention relates to use of a personal care composition comprising a heteroaromatic compound selected from nicotinic acid, picolinic acid, niacin, niacinamide, picolinamide and mixtures thereof, a retinoic acid precursor selected from retinyl esters, retinol, retinal, retinoic acid and mixtures thereof, a resorcinol compound; and an oil-soluble sunscreen, for improving the barrier function of skin.

The invention discloses a solid-state fermentation feed additive and a preparation method thereof, and belongs to the technical field of feed additives. The solid-state fermentation feed additive is prepared from sunflower seed shell powder, tangerine pith, an amino acid supplement, a zymophyte solution, magnesium gluconate and chromium nicotinate as raw materials, and the amino acid supplement is composed of ferrous glycinate, methionine, cysteine, threonine, alanine and lysine. The zymophyte liquid is prepared from bifidobacterium longum, bacillus licheniformis and pediococcus acidilactici. The feed additive disclosed by the invention can improve the content of unsaturated fatty acid in pork, regulate the composition of amino acid, balance the content ratio of monounsaturated fatty acid to polyunsaturated fatty acid and promote the synthesis of various different endogenous antioxidants; and the high-quality pork with good taste and long shelf life can be obtained without additionally adding industrial or natural antioxidants.

The application discloses application of a nitrilase in selective catalysis of 6-chloronicotinonitrile to synthesize 6-chloronicotinic acid and a mutant, wherein the nitrilase mutant is obtained by mutating alanine at the 55th position of the amino acid shown in SEQ ID NO. 2 into serine. In an optimal system, the hydrolysis activity of the nitrilase to 6-chloronicotinonitrile reaches 450 U / g (WCW), 300 g / L 6-chloronicotinonitrile can be catalyzed to synthesize 6-chloronicotinic acid, the yield reaches 92%, and the catalysis synthesizes 2-chloronicotinamide with a concentration of up to 4.8 g / L; when the nitrilase mutant is used to catalyze 6-chloronicotinonitrile, the activity reaches 580 U / g (WCW), 300 g / L 6-chloronicotinonitrile can be catalyzed to synthesize 6-chloronicotinic acid, the yield reaches 99%, and the hydration activity of 2-chloronicotinonitrile is eliminated, and 2-chloronicotinamide is not generated.

A composition for eye protection against blue light and for the relief of eye fatigue, which is taken once by a child or adolescent, comprises the ingredients in the amounts of: a) lutein in an amount of about 10.0 to about 15.0 mg; b) zeaxanthin in an amount of about 2.0 to about 3.0 mg; c) blueberry extract (Vaccinium corymbosum) in an amount of about 2.5 to about 3.0 mg; d) bilberry extract (Vaccinium myrtillus L.) in an amount of about 2.5 to about 3.0 mg; e) blackcurrant extract in an amount of about 2.5 to about 3.0 mg; f) blackberry juice concentrate in an amount of about 3.0 to about 3.5 mg; g) chokeberry juice concentrate in an amount of about 2.0 to about 2.5 mg; h) vitamin C in an amount of about 10.0 to about 12.0 mg;i) niacin in an amount of about 8.0 to about 10.0 mg;j) vitamin E in an amount of about 6.0 to about 8.0 mg; andk) zinc in an amount of about 2.5 to about 3.0 mg.

The present invention belongs to the technical field of analytical chemistry, and specifically relates to a mercaptonicotinic acid and gold nanoparticle modified graphene oxide material and its preparation method and application. The present invention obtains a mercaptonicotinic acid and gold nanoparticle modified graphene oxide material with higher selectivity for glycoprotein enrichment by improving the hydrophilicity, ionic interaction force and recognition ability of peptides of the material. The present invention uses graphene oxide as the initial material, and the surface of graphene oxide carries a large number of negatively charged oxygen-containing functional groups (epoxy groups and hydroxyl groups, etc.), so that it is easy to be modified by positively charged polymers through electrostatic interactions, and then the gold nanoparticles are modified by copolymerization, and the mercaptonicotinic acid is modified by gold-sulfur bond reaction. The prepared mercaptonicotinic acid and gold nanoparticle modified graphene oxide material has higher selectivity for glycoprotein enrichment and better hydrophilicity.

The invention relates to the technical field of nutritional agents, and particularly discloses an enteral nutritional agent. The enteral nutritional agent comprises protein, saturated fat, unsaturated fat, carbohydrate, maltodextrin, corn starch, oligosaccharide, vitamin A, vitamin C, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, nicotinic acid, folic acid, calcium, phosphorus, potassium, zinc, magnesium, iron, copper, manganese, selenium, glutamine, dietary fiber nucleotide, choline and the like. According to the invention, whey protein, casein and other high-quality proteins are used as main components, are rich in essential amino acids for human bodies, are high in bioavailability, can fully meet the requirement of mass loss of proteins caused by skin barrier damage of burn patients, and provide a key material basis for wound healing and body repair. Meanwhile, sufficient energy is provided for patients, and the risk of cardiovascular diseases is reduced. And various vitamins and minerals can promote epithelial tissue repair, resist oxidation and enhance immunity.

The invention discloses an application of an HCAR2 receptor stimulant in preparation of a medicine for treating esophageal squamous cell carcinoma. A mechanism of the HCAR2 receptor stimulant in playing an anti-tumor role in molecules, cells and animals is clarified through a nab-PTX + alphaPD-1 animal model. Further experiments in animal bodies prove that supplement of intestinal colonization of nicotinic acid or Prevotella copri can further enhance the anti-ESCC effect of chemotherapy combined with immunotherapy, has clinical transformation potential and plays an important role in treatment of esophageal squamous cell carcinoma.

This invention provides a fermenting *Lactobacillus mucinus* strain that can accelerate alcohol metabolism and improve hangover symptoms, along with its applications. This strain exhibits high safety, lacking resistance genes and pathogenic virulence genes, and demonstrates strong tolerance to bile salts, artificial gastric juice, and artificial intestinal juice. The bacterium possesses strong antioxidant capabilities, exhibiting potent scavenging abilities against ABTS, DPPH, and hydroxyl radicals. This fermenting *Lactobacillus mucinus* can increase the alcohol dehydrogenase content in a mouse model of alcoholic liver disease, demonstrating significant application value in antioxidation, alcohol detoxification, and hangover prevention. Furthermore, this bacterium can produce melatonin and convert NR to niacin.

A supplement formulated to support women's cervical health. Active ingredients include: a combination of Beta-Sitosterol and Beta-Sitosterolin-Beta-D-Glucoside; Calcium D-Glucarate; Curcumin; Indole-3-carinbol; Green tea extract; Diindolyimethane; Sulforaphane; Borage oil; a B vitamin complex including B1, B2, Niacin, B5, B6, B12, and folate; vitamin C; beta glucans 1,3 and 1,6; zinc; vitamin E; selenium; and Beta carotene.

The present invention relates to a deep-fried and braised chicken sauce with improved color and texture and deep-fried and braised chicken prepared by using same. The deep-fried and braised chicken sauce is characterized by containing: 100 parts by weight of starch syrup; 10-90 parts by weight of sugar; 1-60 parts by weight of garlic; 1-10 parts by weight of salt; 1-80 parts by weight of soy sauce; 0.1-3 parts by weight of L-glutamic acid sodium; 0.1-3 parts by weight of a complex seasoning food; and 1-5 parts by weight of a functional enhancer, wherein the functional enhancer contains 100 parts by weight of bamboo shoot powder, 1-30 parts by weight of a bamboo leaf extract, 10-20 parts by weight of adlay powder, and 1-5 parts by weight of at least one additive selected from the group consisting of niacin, salicin, and helicin.

The invention belongs to the field of microorganisms, and particularly relates to a Kazakstein monospora strain, a Kazakstein monospora inoculant, a fermented product and preparation and application of the Kazakstein monospora strain. The Kazakstan monospora yeast provided by the invention has the advantages that the Kazakstan monospora yeast AMCC 30302 (Kazakstan unisporaAMCC 30302) is preserved in the China Center for Type Culture Collection (CCTCC), and the preservation number of the Kazakstan monospora yeast is CCTCC M 20231787. The Kazakstachya monospora AMCC 30302 provided by the invention can be used for effectively degrading the furfural and generating compounds such as the acetoin, the acetic acid and the like which are relatively high in content. The Kazakstachya monospora AMCC 30302 provided by the invention can be used for effectively degrading the furfural and generating the compounds such as the acetoin and the acetic acid and the like. Feed fermented by the Kazakstein monospora strain provided by the invention mainly has the sensory characteristic of mainly generating sour and fragrant flavor, the effects of stimulating the appetite of animals and improving the palatability of the feed are achieved, and the feed can generate organic acid and is beneficial to maintaining the health of the intestinal environment of the animals; meanwhile, a large amount of nicotinic acid is generated, the feed conversion rate can be increased, and growth and development of animals are promoted.

A method for improving skin condition, hair health, anti-inflammation activity, cardiovascular health, anti-oxidation activity, anti-aging activity, and / or relieving body fatigue in a subject in need thereof is provided. The method includes administering to the subject a composition comprising yeast powder having at least 5000 ppm of nicotinamide mononucleotide. The yeast powder is prepared by: preparing a first medium, a second medium and a third medium, wherein components of the first, second, and third media comprise nicotinamide, tryptophan, and niacin; inoculating the first medium with yeast for fermentation to obtain a first fermentation broth; inoculating the second medium with the first fermentation broth for fermentation to obtain a second fermentation broth; inoculating the third medium with the second fermentation broth for fermentation to obtain a third fermentation broth; and centrifuging the third fermentation broth to obtain a fermented product, and drying the fermented product to obtain the yeast powder.

The invention discloses a nutritious food with anti-inflammatory and anti-allergic functions and a preparation method of the nutritious food, and relates to the technical field of functional nutritious foods. 4-7 parts of a licorice extract; 2-4 parts of a dried orange peel extract; 0.2-1 part of a radix puerariae extract; 15 to 20 parts of blueberry powder; 5 to 10 parts of elderberry powder; 10-15 parts of sweet osmanthus powder; 10 to 15 parts of isomaltooligosacharide; 8 to 12 parts of a probiotic material; 0.2 to 1 part of 2-oxoglutaric acid (AKG); 0.01 to 0.2 part of natural menthol; the feed additive is prepared from 7000 [mu] g of vitamin A, 150 [mu] g of vitamin D, 400 mg of vitamin E, 150 mg of vitamin B, 30 mg of vitamin B2, 30 mg of vitamin B6, 60 [mu] g of vitamin B12, 900 mg of vitamin C, 400 mg of nicotinic acid, 4000 [mu] g of folic acid, 100 mg of pantothenic acid, 500 [mu] g of biotin, 860 [mu] g of chromium, 670 [mu] g of selenium and 1000 mg of taurine. The medicinal and edible extract, the probiotics, the anthocyanin-rich fruit powder and the vitamins are coordinated to achieve certain anti-inflammatory and anti-oxidation effects.

The disclosed invention relates to a chemical composition that can be taken orally and supplements an unhealthy diet and lifestyle. In one aspect of the invention the chemical composition includes Retinol Palmitate, Thiamine, Riboflavin, Niacin, Nicotinamide mononucleotide (NMN), Pyridoxal, Folic Acid, Cyanocobalamin, Cholecalciferol, Zinc, Manganese, Copper, Calcium, Magnesium, Iron, L-Selenomethionine, Lysine, Phenylalanine, L-Threonine, L-Methionine, L-Histidine, L-Tryptophan, L-Leucine, L-Isoleucine, L-Valine, Cinnamon Bark Powder, and Curcumin.

The present invention discloses a freeze-dried human rabies vaccine and a preparation method thereof, and belongs to the technical field of virus vaccines. The method comprises the following steps: (1) cell culture; (2) virus inoculation; (3) virus harvesting; (4) concentration and purification: the harvested virus liquid is clarified by a filter, and then ultrafiltration and concentration is performed through an ultrafiltration membrane to obtain a concentrated solution, which is purified by column chromatography to obtain a chromatographic solution; (5) preparation of a stock solution: the chromatographic solution is inactivated and hydrolyzed to obtain a virus inactivation solution, and human serum albumin is added to the virus inactivation solution to obtain a stock solution; (6) preparation of a semi-finished product: the semi-finished product is prepared by diluting with a stabilizer, and the stabilizer includes raw materials such as human serum albumin, arabinoxylan, L-arginine hydrochloride, casein phosphopeptide, α-nicotinic acid tocopherol and solvent; (7) preparation of a finished product. The rabies vaccine of the present invention has excellent quality, stable immune efficacy, and the liquid is clear after redissolution.

The disclosure provides methods to reverse or regress fibrosis and / or liver cirrhosis in a subject in need thereof, using high-dose (pharmacologic) niacin, or a niacin analog thereof.