49 results about "Niacin" patented technology

Various benefits to intestinal health are made by delivery of an active agent to the colon of an animal, including a human. Active ingredients include of riboflavin, vitamin A, vitamin C, vitamin D, vitamin E, vitamin K, folic acid, β-carotene, vitamin B1, niacin, vitamin B5, vitamin B6, biotin, vitamin B12, omega-3 fatty acids and combinations thereof. Benefits include increased concentration of at least one short-chain fatty acid its salt thereof in the intestine, increased microbiome diversity in the intestine, increased beneficial bacteria in the intestine, increased the butyrate synthesis pathway in the intestine, improved barrier function of the intestine, reduced redox potential of the gut, reduced amount of gas produced in the intestine; and stimulation of intestinal immune responses.

Various benefits to intestinal health are made by delivery of an active agent to the colon of an animal, including a human. Active ingredients include of riboflavin, vitamin A, vitamin C, vitamin D, vitamin E, vitamin K, folic acid, β-carotene, vitamin B1, niacin, vitamin B5, vitamin B6, biotin, vitamin B12, omega-3 fatty acids and combinations thereof. Benefits include increased concentration of at least one short-chain fatty acid its salt thereof in the intestine, increased microbiome diversity in the intestine, increased beneficial bacteria in the intestine, increased the butyrate synthesis pathway in the intestine, improved barrier function of the intestine, reduced redox potential of the gut, reduced amount of gas produced in the intestine; and stimulation of intestinal immune responses.

The invention relates to the technical field of biological medicines, in particular to a preparation containing mesenchymal stem cell-derived insulin-secreting cells and application of the preparation in preparation of blood sugar regulating products. The insulin-secreting cell is derived from mesenchymal stem cells, and the preparation method of the insulin-secreting cell adopts a four-stage directional induced differentiation strategy: in the first stage, all-trans retinoic acid, LDN-193189 and cyclopamine are combined, an endoderm program is started, non-target differentiation is specifically inhibited, and pedigree locking is realized; in the second stage and the third stage, a high-glucose environment and GLP-1 are utilized to promote the cells to differentiate into endocrine precursors and terminal insulin secreting cells; in the fourth stage, GLP-1, PTHrP and nicotinic acid are added for function strengthening, and the glucose responsiveness, maturity and stress resistance of the cells are synergistically improved. The method is accurate in differentiation path and economic in factor, and the obtained cells are high in insulin positive rate and mature in function. A preparation containing the cell can be used for preparing a medicine for treating diabetes mellitus.

The present invention relates to a nutritional vitamin complex for pets intended to improve the fur and skin quality of pets such as dogs and cats. The composition of the complex contains omega-3, curcumin, piperine, biotin (vitamin H or vitamin B7), vitamin B2 (riboflavin), vitamin B3 (nicotinic acid or niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), folic acid (vitamin B9), vitamin E (alpha-tocopherol), vitamin C, zinc (zinc glycine chelate), coenzyme Q10, hydrolysed type II collagen, astaxanthin, DL-methionine, selenium, L-glycine, L-proline, L-phenylalanine, L-leucine, L-isoleucine, L-histidine, L-arginine, L-lysine, L-tyrosine, resveratrol, and a flavouring agent.

Providing a cosmetic that is not sticky, has excellent skin affinity, and has a smooth feeling. 【Solution means】The cosmetic according to the present disclosure contains (A) 0.1% by mass to 5% by mass of a glycine derivative represented by formula (1) or a salt thereof, (B) niacin or a derivative thereof, (C) a higher alcohol having 14 to 22 carbon atoms, (D) a hydrophilic polyoxyethylene alkyl ether, and (E) a glycerin monoalkyl ether. TIFF2026105749000006.tif43169 (In the formula, R 1 and R 2 each independently represents H, an alkyl group, an alkenyl group, an aryl group, an aralkyl group, an aminomethylcarbonyl group, an amidino group, an alkylcarbonyl group, an alkenylcarbonyl group, etc., and R 3 represents H, an alkyl group, an alkenyl group, an aryl group, or an aralkyl group. However, R 1 , R 2 , R 3 do not simultaneously become H.)

A composition comprising an amino acid component selected from L-Arginine, Citrulline Malate, L-Theanine, or any combination thereof, and an herbal and / or vitamin component selected from at least two of Niacin, Panax Ginseng, Lepidium Meyenii, Turnera Diffusa, Ptychopetalum Olacoides, Zinc, or any combination thereof.

The present invention relates to a nutritional vitamin complex for pets intended to improve the fur and skin quality of pets such as dogs and cats. The composition of the complex contains omega-3, curcumin, piperine, biotin (vitamin H or vitamin B7), vitamin B2 (riboflavin), vitamin B3 (nicotinic acid or niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), folic acid (vitamin B9), vitamin E (alpha-tocopherol), vitamin C, zinc (zinc glycine chelate), coenzyme Q10, hydrolysed type II collagen, astaxanthin, DL-methionine, selenium, L-glycine, L-proline, L-phenylalanine, L-leucine, L-isoleucine, L-histidine, L-arginine, L-lysine, L-tyrosine, resveratrol, and a flavouring agent.

The present disclosure provides compositions and methods for providing a health benefit to a growing animal comprising administering a food composition to the animal, wherein the food composition includes a brain development blend. The brain development blend generally comprises DHA, EPA, taurine, choline, thiamine, riboflavin, pantothenic acid, niacin, pyridoxine, vitamin B12, and folic acid.

To provide a topical skin preparation that has excellent effects in preventing and improving wrinkles, anti-aging, anti-inflammatory, pore tightening, whitening, and improving firmness and elasticity, while reducing skin stickiness and being easily absorbed by the skin. [Solution] A topical skin preparation containing specific plant materials, niacin, and glycyrrhizic acid.

The invention belongs to the technical field of coffee products, and particularly relates to a coffee composition for relieving depressive symptoms and a preparation method thereof. 25-30 parts of coffee beans, 6-10 parts of fructus rosae laevigatae, 6-10 parts of semen boitae, 8-12 parts of cortex albiziae and 1-3 parts of seaweed are limited, and different raw materials are extracted, decocted or subjected to enzymolysis, so that separation and retention of active ingredients of the raw materials are facilitated, and the active ingredients in fructus rosae laevigatae, semen boitae, cortex albiziae and seaweed have a protection effect on brain cells; the traditional Chinese medicine composition is beneficial to recovering the balance of a nervous system, relieving the inflammatory response in the brain, reducing the generation of oxygen free radicals, reducing the activity of xanthine oxidase in the cerebral cortex and improving the symptom of depression; and chlorogenic acid, nicotinic acid and the like in coffee can generate positive influence on depression symptoms. Therefore, the coffee composition provided by the invention can be used for relieving depression symptoms and provides a basis for adjuvant therapy of depression.

The present invention relates to use of a personal care composition comprising a heteroaromatic compound selected from nicotinic acid, picolinic acid, niacin, niacinamide, picolinamide and mixtures thereof, a retinoic acid precursor selected from retinyl esters, retinol, retinal, retinoic acid and mixtures thereof, a resorcinol compound; and an oil-soluble sunscreen, for improving the barrier function of skin.

The application discloses application of a nitrilase in selective catalysis of 6-chloronicotinonitrile to synthesize 6-chloronicotinic acid and a mutant, wherein the nitrilase mutant is obtained by mutating alanine at the 55th position of the amino acid shown in SEQ ID NO. 2 into serine. In an optimal system, the hydrolysis activity of the nitrilase to 6-chloronicotinonitrile reaches 450 U / g (WCW), 300 g / L 6-chloronicotinonitrile can be catalyzed to synthesize 6-chloronicotinic acid, the yield reaches 92%, and the catalysis synthesizes 2-chloronicotinamide with a concentration of up to 4.8 g / L; when the nitrilase mutant is used to catalyze 6-chloronicotinonitrile, the activity reaches 580 U / g (WCW), 300 g / L 6-chloronicotinonitrile can be catalyzed to synthesize 6-chloronicotinic acid, the yield reaches 99%, and the hydration activity of 2-chloronicotinonitrile is eliminated, and 2-chloronicotinamide is not generated.

A composition for eye protection against blue light and for the relief of eye fatigue, which is taken once by a child or adolescent, comprises the ingredients in the amounts of: a) lutein in an amount of about 10.0 to about 15.0 mg; b) zeaxanthin in an amount of about 2.0 to about 3.0 mg; c) blueberry extract (Vaccinium corymbosum) in an amount of about 2.5 to about 3.0 mg; d) bilberry extract (Vaccinium myrtillus L.) in an amount of about 2.5 to about 3.0 mg; e) blackcurrant extract in an amount of about 2.5 to about 3.0 mg; f) blackberry juice concentrate in an amount of about 3.0 to about 3.5 mg; g) chokeberry juice concentrate in an amount of about 2.0 to about 2.5 mg; h) vitamin C in an amount of about 10.0 to about 12.0 mg;i) niacin in an amount of about 8.0 to about 10.0 mg;j) vitamin E in an amount of about 6.0 to about 8.0 mg; andk) zinc in an amount of about 2.5 to about 3.0 mg.

The invention discloses an application of an HCAR2 receptor stimulant in preparation of a medicine for treating esophageal squamous cell carcinoma. A mechanism of the HCAR2 receptor stimulant in playing an anti-tumor role in molecules, cells and animals is clarified through a nab-PTX + alphaPD-1 animal model. Further experiments in animal bodies prove that supplement of intestinal colonization of nicotinic acid or Prevotella copri can further enhance the anti-ESCC effect of chemotherapy combined with immunotherapy, has clinical transformation potential and plays an important role in treatment of esophageal squamous cell carcinoma.

This invention provides a fermenting *Lactobacillus mucinus* strain that can accelerate alcohol metabolism and improve hangover symptoms, along with its applications. This strain exhibits high safety, lacking resistance genes and pathogenic virulence genes, and demonstrates strong tolerance to bile salts, artificial gastric juice, and artificial intestinal juice. The bacterium possesses strong antioxidant capabilities, exhibiting potent scavenging abilities against ABTS, DPPH, and hydroxyl radicals. This fermenting *Lactobacillus mucinus* can increase the alcohol dehydrogenase content in a mouse model of alcoholic liver disease, demonstrating significant application value in antioxidation, alcohol detoxification, and hangover prevention. Furthermore, this bacterium can produce melatonin and convert NR to niacin.

A supplement formulated to support women's cervical health. Active ingredients include: a combination of Beta-Sitosterol and Beta-Sitosterolin-Beta-D-Glucoside; Calcium D-Glucarate; Curcumin; Indole-3-carinbol; Green tea extract; Diindolyimethane; Sulforaphane; Borage oil; a B vitamin complex including B1, B2, Niacin, B5, B6, B12, and folate; vitamin C; beta glucans 1,3 and 1,6; zinc; vitamin E; selenium; and Beta carotene.

The invention belongs to the field of microorganisms, and particularly relates to a Kazakstein monospora strain, a Kazakstein monospora inoculant, a fermented product and preparation and application of the Kazakstein monospora strain. The Kazakstan monospora yeast provided by the invention has the advantages that the Kazakstan monospora yeast AMCC 30302 (Kazakstan unisporaAMCC 30302) is preserved in the China Center for Type Culture Collection (CCTCC), and the preservation number of the Kazakstan monospora yeast is CCTCC M 20231787. The Kazakstachya monospora AMCC 30302 provided by the invention can be used for effectively degrading the furfural and generating compounds such as the acetoin, the acetic acid and the like which are relatively high in content. The Kazakstachya monospora AMCC 30302 provided by the invention can be used for effectively degrading the furfural and generating the compounds such as the acetoin and the acetic acid and the like. Feed fermented by the Kazakstein monospora strain provided by the invention mainly has the sensory characteristic of mainly generating sour and fragrant flavor, the effects of stimulating the appetite of animals and improving the palatability of the feed are achieved, and the feed can generate organic acid and is beneficial to maintaining the health of the intestinal environment of the animals; meanwhile, a large amount of nicotinic acid is generated, the feed conversion rate can be increased, and growth and development of animals are promoted.

A method for improving skin condition, hair health, anti-inflammation activity, cardiovascular health, anti-oxidation activity, anti-aging activity, and / or relieving body fatigue in a subject in need thereof is provided. The method includes administering to the subject a composition comprising yeast powder having at least 5000 ppm of nicotinamide mononucleotide. The yeast powder is prepared by: preparing a first medium, a second medium and a third medium, wherein components of the first, second, and third media comprise nicotinamide, tryptophan, and niacin; inoculating the first medium with yeast for fermentation to obtain a first fermentation broth; inoculating the second medium with the first fermentation broth for fermentation to obtain a second fermentation broth; inoculating the third medium with the second fermentation broth for fermentation to obtain a third fermentation broth; and centrifuging the third fermentation broth to obtain a fermented product, and drying the fermented product to obtain the yeast powder.

The invention discloses a nutritious food with anti-inflammatory and anti-allergic functions and a preparation method of the nutritious food, and relates to the technical field of functional nutritious foods. 4-7 parts of a licorice extract; 2-4 parts of a dried orange peel extract; 0.2-1 part of a radix puerariae extract; 15 to 20 parts of blueberry powder; 5 to 10 parts of elderberry powder; 10-15 parts of sweet osmanthus powder; 10 to 15 parts of isomaltooligosacharide; 8 to 12 parts of a probiotic material; 0.2 to 1 part of 2-oxoglutaric acid (AKG); 0.01 to 0.2 part of natural menthol; the feed additive is prepared from 7000 [mu] g of vitamin A, 150 [mu] g of vitamin D, 400 mg of vitamin E, 150 mg of vitamin B, 30 mg of vitamin B2, 30 mg of vitamin B6, 60 [mu] g of vitamin B12, 900 mg of vitamin C, 400 mg of nicotinic acid, 4000 [mu] g of folic acid, 100 mg of pantothenic acid, 500 [mu] g of biotin, 860 [mu] g of chromium, 670 [mu] g of selenium and 1000 mg of taurine. The medicinal and edible extract, the probiotics, the anthocyanin-rich fruit powder and the vitamins are coordinated to achieve certain anti-inflammatory and anti-oxidation effects.

The disclosed invention relates to a chemical composition that can be taken orally and supplements an unhealthy diet and lifestyle. In one aspect of the invention the chemical composition includes Retinol Palmitate, Thiamine, Riboflavin, Niacin, Nicotinamide mononucleotide (NMN), Pyridoxal, Folic Acid, Cyanocobalamin, Cholecalciferol, Zinc, Manganese, Copper, Calcium, Magnesium, Iron, L-Selenomethionine, Lysine, Phenylalanine, L-Threonine, L-Methionine, L-Histidine, L-Tryptophan, L-Leucine, L-Isoleucine, L-Valine, Cinnamon Bark Powder, and Curcumin.

The disclosure provides methods to reverse or regress fibrosis and / or liver cirrhosis in a subject in need thereof, using high-dose (pharmacologic) niacin, or a niacin analog thereof.

Disclosed herein is a method for enhancing molecular brightness of a near infrared (NIR) dye in aqueous solution, the method including at least the step of contacting the dye with a biocompatible ionic liquid (IL). In one aspect, the IL includes an organic cation such as, for example, choline, and an organic anion selected from decanoate, ethylenediamine tetraacetate, urocanate, nicotinate, pyridoxinate, orotate, citrate, hexadecanoate, biotinate, and deoxycholate, wherein the cation and anion are present in a ratio of from about 4:1 to about 1:1. Also disclosed are compositions containing the NIR dye and IL as well as methods of using the compositions for immunohistochemical staining, photothermal treatment, and medical imaging.

The invention discloses compound B vitamin and inositol nutrition fortified flour and a preparation method of fine dried noodles, and relates to the field of food processing, nutrition fortifying and functional staple food. Every 100 g of the flour contains 50 to 100 mg of nicotinic acid (vitamin B3), 5 to 10 mg of pantothenic acid (vitamin B5), 5 to 10 mg of pyridoxine (vitamin B6), 250 to 500 [mu] g of cobalamin (vitamin B12), 100 to 200 [mu] g of biotin (vitamin B7), 500 to 1000 [mu] g of folic acid (vitamin B9), 5 to 10 mg of choline and 5 to 10 mg of inositol. The mass ratio of the riboflavin (vitamin B2) to the pyridoxine (vitamin B6) to the folic acid (vitamin B9) is 1: (0.1-0.2): (0.01-0.02). A sodium alginate-hydroxypropyl methylcellulose double-embedding microcapsule technology and a segmented adding technology are adopted for preparation, and the gastric juice passing rate of the microcapsule is larger than 95%. According to the invention, the vitamin B lost in traditional flour processing is supplemented, a synergistic nutrition system is formed, the bioavailability is improved, the nutrition supplement compliance is improved through the staple food carrier, and the food can be used for preparing food for preventing metabolic syndrome, anemia or neural tube defects.

To provide a cosmetic that contains beauty ingredients such as niacin and has good usability such as lightness in elongation and quick adaptability. 【Solution means】The cosmetic contains (a) niacin or its derivative, (b) at least one selected from the group consisting of polyoxyethylene dialkyl esters and polyoxyethylene dialkyl ethers represented by the general formula (1) R A —O—〔CH2—CH2—O〕 n —R B (In the formula, R A and R B are independently a linear aliphatic acid residue or a linear aliphatic alcohol residue having 16 to 24 carbon atoms, and n is an integer of 4 to 15), and (c) at least one selected from the group consisting of polyoxyethylene alkyl esters and polyoxyethylene alkyl ethers represented by the general formula (2) R C —〔O—CH2—CH2〕 n —OH (In the formula, R C is a linear aliphatic residue, a linear aliphatic acid residue, or a linear aliphatic alcohol residue having 16 to 24 carbon atoms, and n is an integer of 5 to 30).

The invention belongs to the technical field of microorganism application and the like, and particularly relates to application of nicotinic acid or lactobacillus sake LZ217 in preparation of a medicine for treating gastritis. The invention discloses application of nicotinic acid in preparation of a medicine for treating / relieving helicobacter pylori induced gastritis. The invention also provides an application of the lactobacillus sake LZ217 in preparation of a medicine for treating / relieving the helicobacter pylori induced gastritis, and the effect of treating / relieving the helicobacter pylori induced gastritis is achieved by improving the nicotinic acid level in a host body.

This invention discloses a quaternary ammonium salt compound of 3-hydroxyisonicotinic acid dextran ester with the structure shown in Formula I, wherein R is selected from saturated or unsaturated C1-C6 hydrocarbon groups, substituted or unsubstituted benzyl groups, and the substituent of the benzyl group is selected from halogens, C1-C3 alkyl groups, C1-C3 alkoxy groups, C1-C3 halogen-substituted alkyl groups; R1 is selected from NH2, C1-C4 alkyl groups, C1-C4 alkoxy groups, phenyl groups, and phenoxy groups; R2 is selected from H and C1-C3 alkyl groups; and X is selected from bromine and iodine. The compound of this invention has good anti-inflammatory effects and can be used to prepare drugs for treating inflammation-related diseases. This invention also discloses the use of the quaternary ammonium salt compound of 3-hydroxyisonicotinic acid dextran ester in the preparation of drugs for treating inflammation-related diseases.

The invention relates to the technical field of medicines, in particular to a composition with anti-fatigue and anti-oxidation functions for supplementing fundus nerve nutrition. The health-care food is prepared from the following components in parts by weight: 8 to 10 parts of semen cassiae, 6 to 8 parts of fructus lycii, 6 to 8 parts of herba dendrobii, 6 to 8 parts of flos chrysanthemi, 4 to 6 parts of longan, 2 to 3 parts of spirulina platensis, 2 to 3 parts of semen ginkgo, 0.1 to 0.3 part of vitamin A, 0.2 to 0.4 part of vitamin B, 0.2 to 0.5 part of vitamin C, 0.2 to 0.5 part of vitamin E, 0.2 to 0.5 part of zinc, 0.1 to 0.3 part of copper, 0.3 to 0.6 part of nicotinic acid, 0.5 to 1.5 parts of lutein ester, 0.1 to 0.5 part of zeaxanthin, 0.6 to 0.9 part of astaxanthin and 0.3 to 0.5 part of blueberry anthocyanin. The feed additive is prepared from the following components in parts by weight: 0.4-0.6 part of euphausia superba, 0.5-0.7 part of DHA algal oil, 0.1-0.3 part of glutathione and 0.2-0.4 part of The composition can quickly supplement nutrition to the fundus nerves, has anti-fatigue and anti-oxidation functions on the fundus nerves, and solves the problem of eyestrain.

The invention belongs to the technical field of preparation of niacin polyhydroxy alcohol ester, particularly relates to a method for preparing inositol nicotinate in the presence of 1-alkyl imidazole, and particularly relates to a method for preparing niacin polyhydroxy ester by reacting polyhydroxy alcohol and niacin in ionic liquid of 1-alkyl imidazole. The niacin polyhydroxy ester prepared by the method, especially the inositol nicotinate, can be obtained as a colorless product, so that the final purification of the product is greatly simplified. According to the method disclosed by the invention, the inherent strong pungent smell of pyridine in a pyridine process is avoided, and the friendliness of an operation environment is improved. According to the method of the invention, the process can be carried out intermittently, semi-continuously or continuously.

The invention discloses medicinal and edible antihypertensive milk powder and a preparation method thereof, and relates to the technical field of functional milk powder. Comprising 150 to 300 parts of raw milk, 12 to 20 parts of dried skim milk, 24 parts of demineralized whey protein powder, 2 to 2.3 parts of lactose, 2 parts of galactooligosaccharide, 0.05 to 0.1 part of DHA powder, 0.5 to 0.7 part of mixed vitamins, 4.5 to 5.5 parts of mixed minerals, 0.006 part of nicotinic acid, 0.0004 part of folic acid, 0.2 part of choline and 0.24 to 0.3 part of a drug peptide mixture microcapsule preparation. The medicinal and edible antihypertensive milk powder provided by the invention reduces Ang II and ACE2 contents of heart, kidney and thoracic aorta vascular endothelial cells so as to alleviate organ vascular injury, improve antioxidation and anti-inflammatory capabilities of the organ endothelial cells and achieve the purpose of reducing blood pressure by virtue of multiple ways, such as reducing Ang II and ACE2 contents of the heart, kidney and thoracic aorta vascular endothelial cells.