23 results about "Niacin" patented technology

The invention relates to the technical field of biological medicines, in particular to a preparation containing mesenchymal stem cell-derived insulin-secreting cells and application of the preparation in preparation of blood sugar regulating products. The insulin-secreting cell is derived from mesenchymal stem cells, and the preparation method of the insulin-secreting cell adopts a four-stage directional induced differentiation strategy: in the first stage, all-trans retinoic acid, LDN-193189 and cyclopamine are combined, an endoderm program is started, non-target differentiation is specifically inhibited, and pedigree locking is realized; in the second stage and the third stage, a high-glucose environment and GLP-1 are utilized to promote the cells to differentiate into endocrine precursors and terminal insulin secreting cells; in the fourth stage, GLP-1, PTHrP and nicotinic acid are added for function strengthening, and the glucose responsiveness, maturity and stress resistance of the cells are synergistically improved. The method is accurate in differentiation path and economic in factor, and the obtained cells are high in insulin positive rate and mature in function. A preparation containing the cell can be used for preparing a medicine for treating diabetes mellitus.

The present invention relates to a nutritional vitamin complex for pets intended to improve the fur and skin quality of pets such as dogs and cats. The composition of the complex contains omega-3, curcumin, piperine, biotin (vitamin H or vitamin B7), vitamin B2 (riboflavin), vitamin B3 (nicotinic acid or niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), folic acid (vitamin B9), vitamin E (alpha-tocopherol), vitamin C, zinc (zinc glycine chelate), coenzyme Q10, hydrolysed type II collagen, astaxanthin, DL-methionine, selenium, L-glycine, L-proline, L-phenylalanine, L-leucine, L-isoleucine, L-histidine, L-arginine, L-lysine, L-tyrosine, resveratrol, and a flavouring agent.

Providing a cosmetic that is not sticky, has excellent skin affinity, and has a smooth feeling. 【Solution means】The cosmetic according to the present disclosure contains (A) 0.1% by mass to 5% by mass of a glycine derivative represented by formula (1) or a salt thereof, (B) niacin or a derivative thereof, (C) a higher alcohol having 14 to 22 carbon atoms, (D) a hydrophilic polyoxyethylene alkyl ether, and (E) a glycerin monoalkyl ether. TIFF2026105749000006.tif43169 (In the formula, R 1 and R 2 each independently represents H, an alkyl group, an alkenyl group, an aryl group, an aralkyl group, an aminomethylcarbonyl group, an amidino group, an alkylcarbonyl group, an alkenylcarbonyl group, etc., and R 3 represents H, an alkyl group, an alkenyl group, an aryl group, or an aralkyl group. However, R 1 , R 2 , R 3 do not simultaneously become H.)

A composition comprising an amino acid component selected from L-Arginine, Citrulline Malate, L-Theanine, or any combination thereof, and an herbal and / or vitamin component selected from at least two of Niacin, Panax Ginseng, Lepidium Meyenii, Turnera Diffusa, Ptychopetalum Olacoides, Zinc, or any combination thereof.

The present invention relates to a nutritional vitamin complex for pets intended to improve the fur and skin quality of pets such as dogs and cats. The composition of the complex contains omega-3, curcumin, piperine, biotin (vitamin H or vitamin B7), vitamin B2 (riboflavin), vitamin B3 (nicotinic acid or niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), folic acid (vitamin B9), vitamin E (alpha-tocopherol), vitamin C, zinc (zinc glycine chelate), coenzyme Q10, hydrolysed type II collagen, astaxanthin, DL-methionine, selenium, L-glycine, L-proline, L-phenylalanine, L-leucine, L-isoleucine, L-histidine, L-arginine, L-lysine, L-tyrosine, resveratrol, and a flavouring agent.

The present disclosure provides compositions and methods for providing a health benefit to a growing animal comprising administering a food composition to the animal, wherein the food composition includes a brain development blend. The brain development blend generally comprises DHA, EPA, taurine, choline, thiamine, riboflavin, pantothenic acid, niacin, pyridoxine, vitamin B12, and folic acid.

To provide a topical skin preparation that has excellent effects in preventing and improving wrinkles, anti-aging, anti-inflammatory, pore tightening, whitening, and improving firmness and elasticity, while reducing skin stickiness and being easily absorbed by the skin. [Solution] A topical skin preparation containing specific plant materials, niacin, and glycyrrhizic acid.

The invention belongs to the technical field of coffee products, and particularly relates to a coffee composition for relieving depressive symptoms and a preparation method thereof. 25-30 parts of coffee beans, 6-10 parts of fructus rosae laevigatae, 6-10 parts of semen boitae, 8-12 parts of cortex albiziae and 1-3 parts of seaweed are limited, and different raw materials are extracted, decocted or subjected to enzymolysis, so that separation and retention of active ingredients of the raw materials are facilitated, and the active ingredients in fructus rosae laevigatae, semen boitae, cortex albiziae and seaweed have a protection effect on brain cells; the traditional Chinese medicine composition is beneficial to recovering the balance of a nervous system, relieving the inflammatory response in the brain, reducing the generation of oxygen free radicals, reducing the activity of xanthine oxidase in the cerebral cortex and improving the symptom of depression; and chlorogenic acid, nicotinic acid and the like in coffee can generate positive influence on depression symptoms. Therefore, the coffee composition provided by the invention can be used for relieving depression symptoms and provides a basis for adjuvant therapy of depression.

The present invention relates to use of a personal care composition comprising a heteroaromatic compound selected from nicotinic acid, picolinic acid, niacin, niacinamide, picolinamide and mixtures thereof, a retinoic acid precursor selected from retinyl esters, retinol, retinal, retinoic acid and mixtures thereof, a resorcinol compound; and an oil-soluble sunscreen, for improving the barrier function of skin.

The application discloses application of a nitrilase in selective catalysis of 6-chloronicotinonitrile to synthesize 6-chloronicotinic acid and a mutant, wherein the nitrilase mutant is obtained by mutating alanine at the 55th position of the amino acid shown in SEQ ID NO. 2 into serine. In an optimal system, the hydrolysis activity of the nitrilase to 6-chloronicotinonitrile reaches 450 U / g (WCW), 300 g / L 6-chloronicotinonitrile can be catalyzed to synthesize 6-chloronicotinic acid, the yield reaches 92%, and the catalysis synthesizes 2-chloronicotinamide with a concentration of up to 4.8 g / L; when the nitrilase mutant is used to catalyze 6-chloronicotinonitrile, the activity reaches 580 U / g (WCW), 300 g / L 6-chloronicotinonitrile can be catalyzed to synthesize 6-chloronicotinic acid, the yield reaches 99%, and the hydration activity of 2-chloronicotinonitrile is eliminated, and 2-chloronicotinamide is not generated.

The invention discloses an application of an HCAR2 receptor stimulant in preparation of a medicine for treating esophageal squamous cell carcinoma. A mechanism of the HCAR2 receptor stimulant in playing an anti-tumor role in molecules, cells and animals is clarified through a nab-PTX + alphaPD-1 animal model. Further experiments in animal bodies prove that supplement of intestinal colonization of nicotinic acid or Prevotella copri can further enhance the anti-ESCC effect of chemotherapy combined with immunotherapy, has clinical transformation potential and plays an important role in treatment of esophageal squamous cell carcinoma.

This invention provides a fermenting *Lactobacillus mucinus* strain that can accelerate alcohol metabolism and improve hangover symptoms, along with its applications. This strain exhibits high safety, lacking resistance genes and pathogenic virulence genes, and demonstrates strong tolerance to bile salts, artificial gastric juice, and artificial intestinal juice. The bacterium possesses strong antioxidant capabilities, exhibiting potent scavenging abilities against ABTS, DPPH, and hydroxyl radicals. This fermenting *Lactobacillus mucinus* can increase the alcohol dehydrogenase content in a mouse model of alcoholic liver disease, demonstrating significant application value in antioxidation, alcohol detoxification, and hangover prevention. Furthermore, this bacterium can produce melatonin and convert NR to niacin.

The disclosure provides methods to reverse or regress fibrosis and / or liver cirrhosis in a subject in need thereof, using high-dose (pharmacologic) niacin, or a niacin analog thereof.

Disclosed herein is a method for enhancing molecular brightness of a near infrared (NIR) dye in aqueous solution, the method including at least the step of contacting the dye with a biocompatible ionic liquid (IL). In one aspect, the IL includes an organic cation such as, for example, choline, and an organic anion selected from decanoate, ethylenediamine tetraacetate, urocanate, nicotinate, pyridoxinate, orotate, citrate, hexadecanoate, biotinate, and deoxycholate, wherein the cation and anion are present in a ratio of from about 4:1 to about 1:1. Also disclosed are compositions containing the NIR dye and IL as well as methods of using the compositions for immunohistochemical staining, photothermal treatment, and medical imaging.

To provide a cosmetic that contains beauty ingredients such as niacin and has good usability such as lightness in elongation and quick adaptability. 【Solution means】The cosmetic contains (a) niacin or its derivative, (b) at least one selected from the group consisting of polyoxyethylene dialkyl esters and polyoxyethylene dialkyl ethers represented by the general formula (1) R A —O—〔CH2—CH2—O〕 n —R B (In the formula, R A and R B are independently a linear aliphatic acid residue or a linear aliphatic alcohol residue having 16 to 24 carbon atoms, and n is an integer of 4 to 15), and (c) at least one selected from the group consisting of polyoxyethylene alkyl esters and polyoxyethylene alkyl ethers represented by the general formula (2) R C —〔O—CH2—CH2〕 n —OH (In the formula, R C is a linear aliphatic residue, a linear aliphatic acid residue, or a linear aliphatic alcohol residue having 16 to 24 carbon atoms, and n is an integer of 5 to 30).

The invention belongs to the technical field of microorganism application and the like, and particularly relates to application of nicotinic acid or lactobacillus sake LZ217 in preparation of a medicine for treating gastritis. The invention discloses application of nicotinic acid in preparation of a medicine for treating / relieving helicobacter pylori induced gastritis. The invention also provides an application of the lactobacillus sake LZ217 in preparation of a medicine for treating / relieving the helicobacter pylori induced gastritis, and the effect of treating / relieving the helicobacter pylori induced gastritis is achieved by improving the nicotinic acid level in a host body.

The application discloses 2-hydroxynicotinic acid-3-bromobenzyl ester as well as a preparation method and application thereof, and a structural formula of the 2-hydroxynicotinic acid-3-bromobenzyl ester is shown in the specification. The 2-hydroxynicotinic acid-3-bromobenzyl ester with a novel structure is obtained by using 2-hydroxynicotinic acid as raw material through an esterification reaction. The 2-hydroxynicotinic acid-3-bromobenzyl esters have low cytotoxicity, can remove active oxygen, have good anti-UVB-induced HaCaT cell oxidative damage activity, and can be used in cosmetics or medicines for resisting skin damage, resisting oxidation and / or resisting aging.

To provide an emulsifying composition that is free from stickiness and squeaky feeling, has good skin compatibility, provides a moist feeling, and has excellent emulsification stability. To provide. [Solution] The emulsified composition according to this disclosure contains (A) niacin or a derivative thereof in an amount of 1% to 10% by mass, (B) phospholipid or a derivative thereof, (C) stearyl glycyrrhetinate in an amount of 0.06% to 3% by mass, (D) oil, and (E) water.

The present disclosure provides an antibody and a polypeptide that specifically bind to nicotinate phosphoribosyltransferase (NAPRT). Additionally, a nucleic acid encoding such an antibody, an expression vector and a host cell for producing such an antibody, a method for detecting NAPRT in a sample from a subject requiring such an antibody using such an antibody, and a method for diagnosing a subject having cancer or sepsis using such an antibody are provided. Additionally, a composition comprising such an antibody is provided. Additionally, a composition comprising a nicotinamide phosphoribosyltransferase inhibitor (NAMPTi) and a method for treating cancer using NAMPTi after diagnosis using the NAPRT antibody are provided.

Therapeutic methods including the coadministration of niacin or niacin-related compound and tranexamic acid are provided. Typically, the treated subject have a hemorrhage (i.e., hemorrhagic injury) and may suffer from hemorrhagic shock. The methods typically include administering the subject an effective amount of niacin or niacin-related compound and tranexamic acid to reduce one or more symptoms of the hemorrhage. Symptoms include those associated with hemorrhagic injuries and shock such as death. The niacin or niacin-related compound and tranexamic acid can be administered in an effective amount to increase the subject's survival. Compositions and kits are also provided. The kits can include the niacin or niacin-related compound and tranexamic acid in the same or separate containers. In some forms, the kit includes a syringe, optionally an autoinjector syringe. For example, the kits can include an autoinjector syringe loaded with an effective amount of niacin or niacin-related compound and tranexamic acid.

This disclosure relates generally to compositions, and / or methods of use thereof regarding compositions for increasing energy and calcium levels in cows. In various aspects, a composition for increasing calcium levels in a cow includes calcium propionate provided in a concentration ranging from about 80% to about 88% by weight. The calcium propionate may be both a glucose precursor and a source of calcium to increase calcium levels in the cow. The composition may also include at least one probiotic component provided in a concentration ranging from about 6% to about 10% by weight and niacin provided in a concentration ranging from about 6% to about 10% by weight. The niacin may be a glucose precursor to increase energy levels in the cow. The composition may be administered orally.

This invention belongs to the field of bioengineering technology, specifically relating to a nutritional composition, its preparation method, and its application. By weight, the nutritional composition comprises 80-98 parts yeast extract and 1-15 parts free methionine. It also includes 0.1-6 parts choline chloride, 0.1-2 parts niacin, 0.01-0.15 parts vitamin B2, 0.01-0.2 parts vitamin B6, 0.01-0.25 parts vitamin B5, 0.001-0.05 parts vitamin B1, 0.001-0.06 parts vitamin C, and 0.0001-0.0008 parts biotin. The peptides with a molecular weight of 1000 Da or less account for at least 70% of the total peptides in the nutritional composition. The nutritional composition provided by this invention can be efficiently utilized by the producing strains during the production of amino acid fermentation broth, resulting in fewer impurities in the fermentation broth and facilitating the extraction of fermentation products. Simultaneously, it shortens the fermentation cycle of the amino acid fermentation broth, increases the amino acid concentration, and improves the sugar-acid conversion rate.

The method for confirming nutrient attenuation in frozen food according to the present invention is characterized by comprising: a step for performing an accelerated test on frozen food at a temperature of 0 DEG C or more and a high pressure of 90 MPa or more; and a step for analyzing the nutrients contained in the frozen food after the accelerated test. The method is also characterized in that the nutrient to be confirmed is at least one of the following: retinol, alpha-carotene, beta-carotene, beta-cryptoxanthin, vitamin D, alpha-tocopherol, vitamin K, vitamin B1, vitamin B2, nicotinic acid, vitamin B6, vitamin B12, folic acid, pantothenic acid, biotin, vitamin C, n-3 polyunsaturated fatty acids and n-6 polyunsaturated fatty acids.