30 results about "Vitamin K3" patented technology

The invention discloses a vitamin K3 oxidation waste liquid recovery device based on glucose reduction, and relates to the technical field of waste liquid recovery, the recovery device comprises a tank body, a stirring device, a detection device, a comparison device, a medicament adding pipe, a glucose adding pipe and a waste liquid adding pipe, the tank body is connected with the stirring device, the tank body is connected with the detection device, and the tank body is connected with the comparison device. The tank body is connected with the comparison device, the comparison device is connected with the stirring device, the tank body is communicated with the agent feeding pipe, the tank body is communicated with the glucose feeding pipe, the tank body is communicated with the waste liquid feeding pipe, the comparison device is connected with the agent feeding pipe, the stirring device is arranged in the tank body, the detection devices and the comparison devices are arranged on the tank body, and a discharging pipe is arranged on the tank body. And the detection device is connected with the medicament adding pipe and the comparison device.

The invention belongs to the technical field of biological medicines, and discloses application of vitamin K3 in preparation of a medicine for treating psoriasis. The invention finds that the compound vitamin K3 can obviously inhibit the activation of the STING downstream immune pathway and has an inhibition effect on the activation of the STING pathway. A mouse psoriasis model is formulated according to the absorption and metabolism characteristics of the inhibitor VK3, and it is proved that the VK3 can significantly inhibit the process of psoriasis and up-regulation of an STING pathway at an affected part in a transdermal drug delivery mode. The STING pathway does not belong to a main pathway affecting the course of disease in most non-immunodeficient inflammatory diseases, so that a better treatment effect may be generated by using the STING pathway in combination with a direct treatment drug (such as an IL-17A antibody for psoriasis). The vitamin K3 is simple in chemical structure, mature in production process and low in preparation cost, has more remarkable price advantage compared with biological agents and small-molecule targeting drugs, and has high popularization value and application prospects.

The invention relates to the field of nutritional compositions for young animals, such as milk with a high vitamin content for puppies and kittens. More particularly, the invention relates to a method for obtaining a milk-type nutritional composition characterised by a high vitamin K3 content.

The invention relates to the technical field of vitamin K3 preparation, in particular to a waste liquid recovery device for vitamin K3 preparation and a recovery method thereof. The device comprises a filtering box body, a supporting column is arranged at the bottom of the filtering box body, a feeding pipe is arranged at the top of the filtering box body, the feeding pipe is arranged in an L shape, one end of the feeding pipe penetrates through the filtering box body and extends into the filtering box body, a filtering mechanism is arranged in the filtering box body, and the other end of the feeding pipe penetrates through the filtering box body. A clamping mechanism is arranged on the side face of the filtering box body, a reduction mechanism is arranged below the filtering mechanism, and a precipitation mechanism is arranged below the reduction mechanism. According to the vitamin K3 filtering device, the filtering mechanism can be conveniently replaced, the problem that the filtering effect is reduced due to the fact that a filtering assembly is difficult to replace is solved, chromium compounds in vitamin K3 can be reduced, precipitated and recycled, and pollution to the environment is avoided.

The invention discloses a method for improving the synthesis yield of vitamin K3, which comprises the following steps: S1, adding beta-menadione and sodium pyrosulfite into a container, adding ethanol as a solvent, stirring to react for 1-2 hours at the reaction temperature of 30-50 DEG C, heating to 40-70 DEG C, keeping the temperature for 10-60 minutes, and filtering while hot after the reaction is completed to obtain filtrate; and S2, adding sodium pyrosulfite into the filtrate, and then freezing, crystallizing, filtering, washing and drying to obtain a vitamin K3 finished product. When the vitamin K3 is prepared through cooling crystallization, the sodium pyrosulfite is added into the filtrate to be crystallized, so that the crystallization yield of the vitamin K3 can be effectively improved.

The invention belongs to the technical field of experimental animal nutriology and sterile animal culture, and particularly relates to a vitamin compound for prolonging the survival time of sterile zebra fish and a preparation method of the vitamin compound. The vitamin compound is prepared from the following components in parts by mass: 600 to 1000 parts of vitamin A, 4000 to 6000 parts of vitamin C, 10 to 30 parts of vitamin D3, 1500 to 2200 parts of vitamin E, 80 to 120 parts of vitamin K3, 15000 to 25000 parts of compound B vitamins and sterile culture water. The preparation method comprises the following steps: dissolving the vitamin raw materials in sterile culture water, performing ultrasonic assisted dissolution, and then filtering and sterilizing to obtain the vitamin supplement. When the vitamin supplement is used for feeding the sterile zebra fish, the survival time of the sterile zebra fish can be obviously prolonged, and the expression level of growth hormone genes and insulin-like growth factor genes can be up-regulated. The application value of the sterile zebrafish in scientific research is further expanded.

The invention discloses a compound immunopotentiator and application thereof in prevention and control of aquatic diseases, and belongs to the technical field of aquaculture. The compound immunopotentiator is prepared by scientifically compounding eucommia ulmoides, astragalus membranaceus, curcumin, vitamin A, vitamin D3, vitamin E and vitamin K3. According to the compound immunopotentiator, through the synergistic effect of the Chinese herbal medicine extract and the compound vitamins, the autoimmunity of aquaculture animal bodies can be remarkably improved, the resistance of the aquaculture animal bodies to pathogenic microorganisms and bad environments is enhanced, the compound immunopotentiator further has a good pathogen removing effect, and damage of pathogens to the aquaculture animals can be effectively reduced. The compound immunopotentiator provided by the invention is used as a combination of a plant-derived drug and multivitamins, has no problems of environmental pollution and drug resistance, and is good in safety and effectiveness.

The utility model discloses a cooling tower for vitamin K3 production. The cooling tower comprises a cooling tower main body, the cooling tower main body comprises a main box body, a cooling box is arranged at the top end of the main box body, a production conveying pipeline is arranged in the cooling box, and a built-in cooling stirring barrel is fixed at the bottom end in the main box body; by designing the rapid cooling and cleaning mechanism, when the cooling tower body is cooled, the production conveying pipeline is heated for a long time and makes contact with water substances, a movable frame moves on the outer surface of a lead screw, and the movable frame moves to drive a movable plate and a scraping ring to stably move on the outer surface of the production conveying pipeline to scrape water scale and dirt on the outer surface; the cooling tower is simple in structure and convenient to clean, the outer surface of the production conveying pipeline makes full contact with water to be quickly and effectively cooled, the protection plate is opened to clean dirt accumulated at the bottom end of the interior, and the convenience and the cooling effect of the cooling tower for cleaning the outer surface of the production conveying pipeline during vitamin K3 processing production are improved.

The invention discloses a formula and a processing method for ecological culture of crustacean aquatic products, and the formula comprises the following medicines by weight: glycine / methionine chelated trace elements: by taking glycine as an example, not less than 13% of magnesium citrate, 9-20 g of magnesium citrate, not less than 21% of zinc glycinate, 5-9.5 g of zinc glycinate, not less than 15% of manganese glycinate, 3.5-6.5 g of manganese glycinate, not less than 15% of copper glycinate, and 1-2.5 g of copper glycinate; 6-11g of ferrous glycinate with the concentration of more than or equal to 17%; the selenium content of the yeast is 2,000 PPM, and is 1-1.5 g; per kilogram of the vitamin compound comprises 550000-8000000 IU of vitamin A, 150000-45000000 IU of vitamin D3, more than or equal to 3500 milligrams of vitamin E, more than or equal to 1200 milligrams of vitamin K3, more than or equal to 800 milligrams of vitamin B1, more than or equal to 5000 milligrams of vitamin B2, more than or equal to 800 milligrams of vitamin B6, more than or equal to 2000 micrograms of vitamin B12 and more than or equal to 15000 milligrams of vitamin C; the invention relates to the technical field of aquaculture, the formula realizes the virtuous cycle of efficient absorption, sedimentation, slow release, decomposition and supply of trace elements through artificial and natural synergistic nutrition chain design, and achieves the ecological breeding target of'zero emission 'of nutrient substances and'zero addition' of chemical agents.

The application is a method for quantitatively detecting vitamin K3, characterized in that: a "HCHO NaHSO3-Na2SO3" pH clock reaction system is used as a detection solution, and different responses of the system to different concentrations of vitamin K3, namely different induction times, are used to realize quantitative analysis of vitamin K3. The quantitative analysis method for vitamin K3 disclosed by the application has the characteristics of high accuracy, easy operation, and convenience and rapidness.

The invention discloses a vitamin K3 waste liquid recycling device with a multi-stage filtering function, and relates to the technical field of waste liquid recycling, the waste liquid recycling device comprises a main body mechanism, a multi-stage filtering mechanism, a path adjusting mechanism and a separating mechanism, the main body mechanism is connected with the multi-stage filtering mechanism, and the main body mechanism is connected with the separating mechanism; the multi-stage filtering mechanism is connected with the path adjusting mechanism, the multi-stage filtering mechanism is connected with the separating mechanism, the path adjusting mechanism is connected with the separating mechanism, the main body mechanism comprises a mounting base, a waste liquid storage tank and a waste liquid output pipe, the waste liquid storage tank is arranged on the mounting base, and one end of the waste liquid output pipe is communicated with the bottom of the waste liquid storage tank; the waste liquid output pipe is connected with a self-priming pump, the mounting base is connected with the multi-stage filtering mechanism, the waste liquid output pipe is connected with the multi-stage filtering mechanism, and the mounting base is connected with the separating mechanism.

The invention discloses a pharmaceutical composition for resisting NQO1 high-expression malignant tumors and application of the pharmaceutical composition, and relates to the technical field of medicines. When the vitamin K3, the vitamin K4 or the pharmaceutically acceptable salts thereof are combined with the quinone compounds for use, the killing sensitivity of NQO1 high-expression malignant tumor cells to the quinone compounds is obviously enhanced, and an explosive synergistic or synergistic anti-tumor effect is initiated; the killing effect of various quinone compounds on NQO1 high-expression malignant tumor cells is remarkably improved, so that the application dosage of the quinone compounds is reduced to reduce side effects, and the effect of killing NQO1 high-expression tumor cells with low dosage and high efficiency is achieved.

The invention discloses application of a combination of a copper ion carrier ilisemox carrying copper ions and vitamin K3 in preparation of a medicine for treating liver cancer. Through high-throughput screening of metabolites having a synergistic effect with copper death (copper ion carrier ES combined with copper ions), preliminary screening shows that vitamin K3 can cooperatively kill liver cancer cells with ES + Cu < 2 + >, and further in-vivo and in-vitro various experiments prove that vitamin K3 can obviously promote liver cancer cell copper death, so that the vitamin K3 can obviously promote liver cancer cell copper death. Vitamin K3 and ES + Cu < 2 + > are combined for use, so that liver cancer can be effectively inhibited, and a remarkable synergistic killing effect on liver cancer is achieved. Therefore, the invention provides a strategy for synergistically treating the liver cancer by jointly using the vitamin K3 and the ES + Cu < 2 + >, and the strategy can be used for manufacturing liver cancer biological medicines, liver cancer chemical medicine raw material medicines and preparations.

The invention discloses a method for efficiently preparing a chrome tanning agent with high quality from vitamin K3 chromium-containing waste liquid, and relates to the technical field of industrial waste liquid resource utilization. The method comprises the following steps: reacting sodium dichromate, concentrated sulfuric acid and the vitamin K3 chromium-containing waste liquid, completely oxidizing organic matters which are difficult to oxidize in the waste liquid by adopting a high-concentration hexavalent chromium oxidizing agent, reducing the content of the organic matters in the product, and increasing the content of chromium. The conventional pure glucose reduction is changed into oxidation of glucose to form a micromolecular reducing agent alcohol aldehyde acid, so that the organic matters in the waste liquid can be thoroughly eliminated. And key parameters are controlled through DCS control pipeline reaction, so that insoluble substances are reduced to the maximum extent, and the chromium content in the sugar reduction chromium powder is maximized and organic matters are minimized. The main quality index of the prepared chrome tanning agent exceeds the original national standard.

The invention relates to the technical field of preparation of modified milk powder, and discloses formula camel milk powder with a function of assisting teenagers to grow tall, and the formula camel milk powder comprises the following raw materials: camel milk powder, compound minerals, compound vitamins and a compound active composition, the compound mineral substances comprise magnesium oxide, ferrous fumarate and zinc gluconate; the compound vitamins comprise vitamin B5, vitamin K2 and vitamin K3; the compound active composition comprises radix puerariae polypeptide, fructus gardeniae polypeptide and poria cocos polypeptide; the kudzuvine root polypeptide, the gardenia polypeptide and the poria cocos polypeptide are respectively small molecular peptides obtained by performing enzymolysis on natural kudzuvine root protein, natural gardenia protein and natural poria cocos protein; all the components are from camel milk, trace elements, vitamins and medicinal and edible natural plants which are harmless to a human body, so that the safety is high; all the components have a synergistic effect, so that children and teenagers are supplemented and helped to improve bone health, linear growth is improved, and growth and development are promoted.

The present invention relates to the technical field of vitamin K3 preparation, and particularly to a waste liquid recovery device and a recovery method for vitamin K3 preparation. The present invention includes a filtration box body, the bottom of the filtration box body is provided with support columns, the top of the filtration box is provided with a feed pipe, the feed pipe is arranged in an L shape, and one end of the feed pipe passes through the filtration box body and extends into the interior of the filtration box body. A filtration mechanism is arranged inside the filtration box body, a clamping mechanism is arranged on the side of the filtration box body, a reduction mechanism is arranged below the filtration mechanism, and a precipitation mechanism is arranged below the reduction mechanism. The present invention can conveniently replace the filtration mechanism, solves the problem of reduced filtration effect caused by the difficulty in replacing the filtration components, and can reduce and precipitate and recover the chromate in vitamin K3, avoiding environmental pollution.

The invention discloses a bifidobacterium improved culture medium and a culture method and application thereof, and belongs to the technical field of culture media and biological culture methods. The improved culture medium comprises a basic culture medium, a barnacle extract, a growth promoter and a selective inhibitor; the addition amount of the barnacle extract is 2-5% of the mass of the basic culture medium; the addition amount of the growth promoter is 0.1-0.3% of the mass of the basic culture medium; the addition amount of the selective inhibitor is 0.01-0.03% of the mass of the basic culture medium; the growth promoter is prepared from vitamin K3, N-acetylneuraminic acid and glutamine; the selective inhibitor comprises vancomycin and neomycin. The basic culture medium is reasonably prepared, and the barnacle extract, the growth promoter and the selective inhibitor are added, so that proliferation of bifidobacterium can be well promoted, and the culture purity is improved.

The invention discloses a rosa roxburghii tratt pomace powder feed for improving immunity of green-shelled egg-laying hens and a preparation method thereof, and the green-shelled egg-laying hen feed is prepared from corn, soybean meal, corn protein powder, soybean oil, stone powder, a premix and rosa roxburghii tratt pomace powder. The premix contains vitamin A, vitamin D, vitamin E, vitamin K3, vitamin B1, vitamin B2, vitamin B6, vitamin B7, vitamin B12, nicotinamide, pantothenic acid, folic acid, copper, iron, manganese, zinc, iodine, selenium, methionine, calcium, total phosphorus, available phosphorus and sodium chloride. According to the present invention, with the feed, the lipid metabolism of the green-shell laying hen body can be effectively improved, and the oxidation resistance and the immunocompetence of the body can be improved.

The application discloses application of an E3 ubiquitin ligase SIAH2 inhibitor in preparation of a lupus nephritis kidney protection drug. Researches of the application show that the SIAH2-LATS2 axis participates in the pathogenic process of kidney fibrosis of lupus nephritis, and it is confirmed that LATS2 can be used as a target point for preventing fibrosis progression in lupus nephritis. It is shown that LATS2 is abnormally down-regulated in lupus nephritis, and the use of an E3 ubiquitin ligase SIAH2 inhibitor can restore the LATS2 level, reduce the production of a LATS2 downstream gene CTGF, reduce the occurrence of interstitial fibrosis, reduce the proteinuria effect of lupus nephritis, thereby protecting the kidney function and delaying the progression of lupus nephritis. The application uses the SIAH2 inhibitor vitamin K3, which can prevent the conversion of lupus nephritis to ESRD, and can be used as an effective drug for treating and preventing kidney fibrosis, and provides a new selection for lupus nephritis treatment drugs and fibrosis prevention and treatment drugs.

The invention discloses a pharmaceutical composition for inhibiting gram-negative bacteria and application of the pharmaceutical composition, and belongs to the technical field of biological medicines. The medicine composition is prepared from vitamin K3 and polymyxin. A chessboard method minimum inhibitory concentration test proves that the vitamin K3 can obviously enhance the antibacterial efficiency of the polymyxin, and especially has obvious effects on resisting mcr-1 positive polymyxin drug-resistant escherichia coli, high-level polymyxin drug-resistant escherichia coli and acinetobacter baumannii. In addition, an in-vitro bacterial growth curve experiment is also utilized to further verify the time-dependent bactericidal dynamic characteristics of the pharmaceutical composition. The vitamin K3 disclosed by the invention can recover the antibacterial effect of the polymyxin on drug-resistant strains, and the drug resistance of bacteria to the polymyxin is reversed while the use amount of the polymyxin is reduced. The invention is helpful to alleviate the increasingly serious bacterial drug resistance problem, provides a new treatment strategy for clinical treatment of bacterial infectious diseases, and has important application value.

To provide a vitamin D eutectic crystal excellent in chemical stability, a method for preparing the same, and applications thereof.SOLUTION: Vitamin D and a eutectic ligand are comprised, wherein the Vitamin D is vitamin D2 or vitamin D3, and the eutectic ligand is idebenone or vitamin K3. The vitamin D cocrystal according to the present invention not only can significantly improve the chemical stability of vitamin D under light and heat conditions, but also can avoid the problems caused by physically mixing vitamin D with other APIs.SELECTED DRAWING: Figure 1

The invention relates to the field of nutritional compositions for young animals, such as high-vitamin-content milk for puppies and kittens. More particularly, the invention concerns a method for obtaining a milk-like nutritional composition characterized by a high vitamin K3 content.

The invention discloses a method for improving the synthesis yield of vitamin K3, which comprises the following steps: S1, adding beta-menadione and sodium pyrosulfite into a container, adding ethanol as a solvent, stirring to react for 1-2 hours at the reaction temperature of 30-50 DEG C, heating to 40-70 DEG C, keeping the temperature for 10-60 minutes, and filtering while hot after the reaction is completed to obtain filtrate; and S2, adding sodium pyrosulfite into the filtrate, and then freezing, crystallizing, filtering, washing and drying to obtain a vitamin K3 finished product. When the vitamin K3 is prepared through cooling crystallization, the sodium pyrosulfite is added into the filtrate to be crystallized, so that the crystallization yield of the vitamin K3 can be effectively improved.

The invention discloses application of quinone compounds in preparation of antituberculous drugs, and relates to the technical field of biological medicines. According to the invention, an inhibitor targeting a prokaryotic ubiquitin-proteasome degradation system is screened out by constructing a Dop protein inhibitor high-throughput screening technology model, i.e., a quinone compound 2-methoxy-1, 4-naphthoquinone and a derivative 2-bromo-1, 4-naphthoquinone and vitamin K3 of the quinone compound 2-methoxy-1, 4-naphthoquinone are screened out. Wherein the 2-methoxy-1, 4-naphthoquinone serving as an inhibitor has a remarkable effect of inhibiting the combination of Dop and Pup, and IC50 (half maximal inhibitory concentration) ranges from 17.93 mu M to 34.55 mu M. The quinone compound 2-methoxy-1, 4-naphthoquinone and the derivative 2-bromo-1, 4-naphthoquinone and vitamin K3 thereof have a remarkable inhibition effect on mycobacterium tuberculosis, and can be applied to the development of antituberculosis drugs.

The invention discloses a method for synthesizing high-value chemicals through enzyme catalysis aromatic hydrocarbon dearomatization. According to the method, in a water phase system, 2-methylnaphthalene is taken as a substrate, hydrogen peroxide is taken as an oxidant, ascorbic acid is taken as a free radical scavenger, and a non-specific peroxygenase mutant is taken as a catalyst, so that an efficient catalytic synthesis way is established. The non-specific peroxygenase mutant is obtained by carrying out rational design modification on the non-specific peroxygenase, including mutation on a 99th or 119th amino acid residue point or truncation on a C terminal, so that the tolerance and catalytic efficiency of the enzyme to a high-concentration aromatic hydrocarbon substrate are improved. Efficient synthesis of menadione can be achieved through a green and mild biological enzyme method, and a key enzyme tool is provided for industrial biological manufacturing of vitamin K3.

The invention discloses application of zinc combined with vitamin K3 in inhibiting bacteria, and belongs to the technical field of medical biology. According to the invention, zinc with a safe concentration and vitamin K3 with a low concentration are used in a combined manner, so that an efficient antibacterial effect on bacteria such as escherichia coli, klebsiella pneumoniae and the like is realized. Zinc specifically inhibits iron-sulfur cluster assembly of SoxR protein in bacteria, so that expression of soxS is reduced, the superoxide dismutase level is reduced, the resistance of the bacteria to superoxide anions is weakened, and the antibacterial effect is enhanced. Therefore, a novel antibacterial strategy is provided on the basis of combination of zinc and vitamin K3, the concentration is low, certain clinical application value is achieved, the zinc-vitamin K3 can be used for improving the antibacterial effect and overcoming the defects in an existing antibacterial method, and a new thought and theoretical basis are provided for development of an efficient and safe antibacterial method.

The invention belongs to the technical field of biological medicine, and particularly relates to application of vitamin K3 in preparation of a medicine for tumor radiotherapy sensitization and / or radiotherapy resistance reversal. According to the application of the vitamin K3 in preparation of the medicine for enhancing sensitivity of tumor radiotherapy and / or reversing radiotherapy resistance, cell and animal experiments find that the vitamin K3 can obviously enhance the sensitivity of esophageal cancer radiotherapy at the cell level and the animal level, and the esophageal cancer radiotherapy resistance is effectively reversed. It is further found through action mechanism research that vitamin K3 reverses esophageal cancer radiotherapy resistance through targeting SKP2; meanwhile, the vitamin K3 inhibits tumor proliferation and reverses radiotherapy resistance by targeting an SKP2-MAZ-PIF1 axis. Therefore, a new research thought and direction can be provided for reversing esophageal cancer radiotherapy resistance, meanwhile, a new treatment strategy can be provided for patients suffering from esophageal cancer radiotherapy resistance, and good medicine development potential is shown.

The present invention provides a water-soluble dimethylnidazole composition, a preparation method thereof, and an application thereof, belonging to the technical field of veterinary drug preparation. The composition comprises dimethylnidazole 10-20%, tremella oligosaccharide 2-4%, vitamin K3 2%, hydroxypropyl methylcellulose HPMC E5 0.4-1.2%, xanthan gum 0.1-0.4%, a cosolvent 15-25%, a stabilizer 5-10%, Tween 20 2%, and a water-soluble carrier as the remainder. The composition can reach 8000ppm water-soluble, 12000ppm suspension, uniform dispersion without stratification for 4 hours, and convenient drinking water administration. The combination of dimethylnidazole and tremella oligosaccharide enhances the preventive and therapeutic effect on pathogens such as Escherichia coli and Salmonella, reduces the usage of antibiotics and traditional Chinese medicine extracts, and improves drug bioavailability and efficacy. The composition has a definite therapeutic effect on poultry enteritis and salpingitis caused by such pathogens and is suitable for application in intensive scale farms.

The utility model discloses an oxidation liquid preparation device for vitamin K3 production, which comprises an oxidation liquid preparation device main body, the oxidation liquid preparation device main body comprises a liquid preparation stirring tank, a liquid preparation stirrer is arranged in the middle of the interior of the liquid preparation stirring tank, and quantitative liquid preparation cylinders are mounted at two ends of the upper surface of the liquid preparation stirring tank; by designing a uniform mixing liquid preparation mechanism, when an oxidation liquid preparation device main body is used for preparing liquid and a liquid preparation stirrer is used for stirring and mixing at the middle position in a liquid preparation stirring tank, a motor is electrified to operate to drive a driving gear to rotate, and the driving gear is meshed with the outer surface of a gear ring to drive the gear ring to rotate when rotating; when the gear ring rotates, the connecting rod and the mounting plate are driven to rotate stably, and the mounting plate drives the connecting shaft and the mixing rod to rotate at the edge of the inner surface of the prepared liquid stirring tank for mixing treatment, so that the prepared liquid is uniformly mixed and stirred in the prepared liquid stirring tank, and the prepared liquid is more uniform.

The present invention relates to the use of vitamin K3 in the preparation of plant pathogen inhibitors. The vitamin K3 of the present invention can inhibit the growth of various plant pathogens, including tobacco bacterial wilt pathogen, citrus canker pathogen, rice bacterial leaf streak, cucumber Rhizoctonia solani, Alternaria alternata, Fusarium solani, Fusarium oxysporum, Fusarium graminearum, cucumber Botrytis cinerea, Aspergillus niger, Verticillium foetida, Colletotrichum gloeosporioides, Corynespora multilocus, and Pseudomonas aeruginosa. The vitamin K3 can be used in the development of biopesticides and has broad application prospects.