4 results about "Idebenone" patented technology

The present invention provides a bacterial strain that possesses higher free radical scavenging ability and idebenone production ability. [Solution] The Oceanobacillus Y-3 strain of the present invention was obtained by screening from black mud of Yuncheng Salt Lake in Shanxi Province. It possesses high free radical scavenging ability and strong iron ion reduction ability, exhibits high antioxidant activity, and has the ability to produce idebenone. The strain of the present invention has great potential for application in the fields of health foods and cosmetics.

The application provides application of idebenone in preparation of a medicine for treating osteosarcoma. The application of idebenone or a pharmaceutically acceptable salt thereof in preparation of the medicine for treating osteosarcoma is achieved by carrying out proliferation experiments (CCK8 method) and invasion experiments (transwell invasion experiment) of osteosarcoma cell lines in vitro, quantitative analysis of cell viability in the CCK8 method proliferation experiment and quantitative analysis of the number of penetrated cells in the transwell invasion experiment; and constructing a nude mouse CDX (cell-derived xenograft) model, a PDX (human-derived xenograft) model and a tibial orthotopic / metastatic tumor model, intraperitoneally injecting idebenone, and quantitatively analyzing the tumor volume and tumor weight in the CDX model, the tumor volume and tumor weight in the PDX model and the tumor volume, the weight of the affected limb and the number of lung metastases in the tibial orthotopic / metastatic tumor model, which fully indicates that idebenone can inhibit the proliferation, invasion and metastasis of osteosarcoma.

The application discloses a bacillus megaterium with the ability of producing aediron and high antioxidant capacity, and belongs to the field of microbial strains. The bacillus megaterium Y-3 is screened from black mud in a salt lake in Yuncheng, Shanxi, has high free radical scavenging capacity and strong iron ion reduction capacity, shows high antioxidant activity, and has the ability of producing aediron. The strain has great application potential in the fields of health products and cosmetics.

This invention discloses a bioactive nanomicelle based on idebenone. By designing idebenone molecules with hydrophobic ends and functionalized hydrophilic polyethylene glycol, it exhibits excellent responsiveness, antioxidant properties, and cellular safety, making it suitable as a carrier for delivering drugs, genes, or other bioactive molecules for therapeutic and diagnostic applications. This invention also discloses a method for preparing this idebenone-based bioactive nanomicelle. The method for synthesizing the amphiphilic polymer of IDBP is simple, with mild reaction conditions, easy synthesis, convenient post-processing, high yield, and easy industrial production. The prepared amphiphilic polymer exhibits spontaneous assembly behavior in aqueous solution, forming a stable nanomicelle structure. This demonstrates the great potential of idebenone-based bioactive nanomicelles in drug delivery, potentially improving drug stability, bioavailability, and targeting.