12 results about "Idebenone" patented technology

The invention provides a preparation process of a soothing and repairing type mask, and belongs to the technical field of cosmetics, an intelligent response type cell bionic delivery system is adopted, macrophage membrane vesicles serve as a carrier, a composite repairing kernel, epicatechin gallate, a neuropeptide P substance antagonist and idebenone are wrapped, and by means of the inflammation chemotaxis of a macrophage membrane, the soothing and repairing type mask is prepared. According to the present invention, the active component can actively target the inflammation region, the phase change release core is provided in the weakly acidic microenvironment with the pH value of 5.0-6.0, the targeting property and the permeation efficiency of the active component can be improved, the bottleneck of the traditional passive diffusion can be broken through, and compared with the conventional liposome or nanoparticle, the active component can be accurately delivered to the inflammation core region, the permeation rate can be improved by several times, and the carrier can directly reach the problem core region; according to the method, the utilization rate of effective components is greatly increased, a micro-ecology-immunity-nerve-physical barrier multi-dimensional and systematic synergistic repair network is constructed, full-path fundamental repair from immediate relieving to root strengthening is achieved, and immediate relieving and long-term barrier repair effects are provided.

The present invention provides a bacterial strain that possesses higher free radical scavenging ability and idebenone production ability. [Solution] The Oceanobacillus Y-3 strain of the present invention was obtained by screening from black mud of Yuncheng Salt Lake in Shanxi Province. It possesses high free radical scavenging ability and strong iron ion reduction ability, exhibits high antioxidant activity, and has the ability to produce idebenone. The strain of the present invention has great potential for application in the fields of health foods and cosmetics.

The invention relates to the technical field of drugs for acute organ injury, and particularly discloses idebenone-modified platelet membrane-coated mitochondria as well as a preparation method and application thereof, aiming at the problems of low drug delivery efficiency, insufficient targeting and the like of ROS (reactive oxygen species) removal drugs for acute organ injury at present. The in-vitro mitochondria-modified platelet membrane comprises in-vitro mitochondria and an idebenone-modified platelet membrane coating the in-vitro mitochondria, the preparation method comprises the following steps: S1, extracting a platelet membrane; s2, extracting mitochondria; s3, mixing the platelet membrane with mitochondria, and centrifuging for multiple times to obtain platelet membrane coated mitochondria; and S4, incubating and combining the platelet membrane-coated mitochondria with idebenone, carrying out centrifugal washing for multiple times, adding a lysis solution, and carrying out lysis, ultrasonication and separation to obtain the idebenone-modified platelet membrane-coated mitochondria. A platelet membrane is modified by idebenone, a mitochondrial targeting delivery system is constructed and directly acts on active oxygen in cells, and the pertinence and efficiency of therapeutic drugs are improved.

The application provides application of idebenone in preparation of a medicine for treating osteosarcoma. The application of idebenone or a pharmaceutically acceptable salt thereof in preparation of the medicine for treating osteosarcoma is achieved by carrying out proliferation experiments (CCK8 method) and invasion experiments (transwell invasion experiment) of osteosarcoma cell lines in vitro, quantitative analysis of cell viability in the CCK8 method proliferation experiment and quantitative analysis of the number of penetrated cells in the transwell invasion experiment; and constructing a nude mouse CDX (cell-derived xenograft) model, a PDX (human-derived xenograft) model and a tibial orthotopic / metastatic tumor model, intraperitoneally injecting idebenone, and quantitatively analyzing the tumor volume and tumor weight in the CDX model, the tumor volume and tumor weight in the PDX model and the tumor volume, the weight of the affected limb and the number of lung metastases in the tibial orthotopic / metastatic tumor model, which fully indicates that idebenone can inhibit the proliferation, invasion and metastasis of osteosarcoma.

To provide a vitamin D eutectic crystal excellent in chemical stability, a method for preparing the same, and applications thereof.SOLUTION: Vitamin D and a eutectic ligand are comprised, wherein the Vitamin D is vitamin D2 or vitamin D3, and the eutectic ligand is idebenone or vitamin K3. The vitamin D cocrystal according to the present invention not only can significantly improve the chemical stability of vitamin D under light and heat conditions, but also can avoid the problems caused by physically mixing vitamin D with other APIs.SELECTED DRAWING: Figure 1

According to the method, coenzyme Q0 and 10-bromocapraldehyde are taken as initial raw materials, selective alkylation reaction, catalytic hydrogenation reaction and oxidation reaction are carried out step by step, and specific catalyst combination and reaction condition control are adopted to obtain idebene. The method has the advantages that the catalyst is stable in activity, the yield and the purity of a target product are remarkably improved, and the method is simple in reaction step, environment-friendly and suitable for industrial production.

The invention provides a method of promoting weight management in a mammal comprising administering to the mammal a composition comprising at least one weight loss agent and at least one mitochondrial enhancer. The weight loss agent can be selected from the group consisting of psyllium, guar gum, capsaicin, chitosan, caffeine, gamboge, mume, capsaicin, yohimbine, butterfly pea, glucomannan, African mango, guarana, pyruvate, carnitine, beta-glucan, fucoxanthin, raspberry ketone, white kidney bean, kola nut, chromium, ginseng, psyllium, St. John's wort, dandelion, hydroxycitric acid, conjugated linoleic acid, green tea, black tea, coffee bean extract, forskolin, and bitter orange. The mitochondrial enhancer can be selected from the group consisting of beetroot extract, nitrate, idebenone, nicotinamide riboside, elamipretide, vitamin C, vitamin D, vitamin E, thiamine, riboflavin, magnesium, calcium, phosphate, phospholipid, creatine, pyruvate, coenzyme Q10, NADH, niacin, L-carnitine, dichloroacetate, curcumin, schisandrin, and resveratrol. Compositions for weight management are also provided.

The invention discloses an Ectoine-containing anti-aging composition and a preparation method and application thereof, and belongs to the technical field of cosmetics. Every 100 parts by weight of the Ectoine-containing anti-aging composition is prepared from the following raw materials in parts by weight: 10 to 30 parts of polyol, 2 to 4 parts of alkyl glycoside modified silicon dioxide, 3 to 10 parts of a skin conditioner, 2 to 6 parts of phospholipid, 2 to 5 parts of an oil phase, 2 to 4 parts of an emulsifier and the balance of deionized water, through the synergistic compatibility of the two active ingredients of Ectoine and idebenone, the composition has strong antioxidant ability, can effectively neutralize the oxidative stress of the environment and relieve oxidative damage, and further delays the photoaging process of the skin; the composition has an excellent anti-inflammatory effect and can effectively reduce inflammatory response; besides, through the innovative design of the nano carrier-alkyl glycoside modified silicon dioxide, the physical stability of the system is improved, the composition has excellent long-acting moisturizing capacity, meanwhile, the transdermal absorption and efficacy exertion of the active ingredients are enhanced, and the composition has wide application prospects in the field of external cosmetics.

The application discloses a bacillus megaterium with the ability of producing aediron and high antioxidant capacity, and belongs to the field of microbial strains. The bacillus megaterium Y-3 is screened from black mud in a salt lake in Yuncheng, Shanxi, has high free radical scavenging capacity and strong iron ion reduction capacity, shows high antioxidant activity, and has the ability of producing aediron. The strain has great application potential in the fields of health products and cosmetics.

The present disclosure provides methods and compositions for improving cell viability, mitochondrial function and / or frataxin expression or treating Friedreich's ataxia (FRDA) comprising two or more of monomethyl fumarate (MMF) or a MMF prodrug such as dimethyl fumarate (DMF), nicotinamide (NAM), idebenone (IDB) and nitisinone (NTS).

The present disclosure relates to a composition for promoting hair growth or preventing hair loss, and more particularly, the composition comprises idebenone, a salt thereof, a hydrate thereof, or a solvate thereof as an active ingredient, thereby being able to exhibit a hair follicle growth and / or hair (e.g., hair, eyebrows, eyelashes, etc.) growth effect, and ultimately being able to exhibit a hair growth promoting and / or hair loss preventing effect.

This invention discloses a bioactive nanomicelle based on idebenone. By designing idebenone molecules with hydrophobic ends and functionalized hydrophilic polyethylene glycol, it exhibits excellent responsiveness, antioxidant properties, and cellular safety, making it suitable as a carrier for delivering drugs, genes, or other bioactive molecules for therapeutic and diagnostic applications. This invention also discloses a method for preparing this idebenone-based bioactive nanomicelle. The method for synthesizing the amphiphilic polymer of IDBP is simple, with mild reaction conditions, easy synthesis, convenient post-processing, high yield, and easy industrial production. The prepared amphiphilic polymer exhibits spontaneous assembly behavior in aqueous solution, forming a stable nanomicelle structure. This demonstrates the great potential of idebenone-based bioactive nanomicelles in drug delivery, potentially improving drug stability, bioavailability, and targeting.