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A complex coacervation - spray drying method for preparing idebenone microcapsules

A spray-drying and idebenone technology, applied in the field of preparing microcapsules, can solve the problems of easily causing oxidation, fragile wall membranes of microcapsules, short shelf life, etc. The effect of onset time

Inactive Publication Date: 2013-08-07
广州保税区雅兰国际化妆品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But this method has its defect again: (1) core material material can be adsorbed on the surface of microcapsule, easily causes oxidation; It has a porous structure and cannot prevent the entry of oxygen, and the shelf life of the product is short; (3) the microcapsule wall membrane is fragile and porous, which is not suitable for the preparation or controlled release of microcapsules
[0012] However, the bright orange appearance and water insoluble properties of IDBN make it difficult to evenly add to water-based products, which greatly limits the application of IDBN in the cosmetics industry

Method used

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  • A complex coacervation - spray drying method for preparing idebenone microcapsules

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Experimental program
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Effect test

Embodiment 1

[0060] After mixing 1% sodium alginate and 1% gelatin at a weight ratio of 1:1 to form a composite wall material solution, add the core material IDBN powder according to the core wall mass ratio of 1:3, mix and stir evenly, and then homogeneously emulsify for 5 minutes to obtain an emulsion, and then Put the emulsion at a feed temperature of 70°C, an inlet air temperature of 170°C, and an air flow rate of 30m 3 / h under the condition of spray-drying to powder, that is, IDBN microcapsules, the inclusion rate of 82.5%.

Embodiment 2

[0062] After mixing 1% sodium alginate and 2% gelatin at a weight ratio of 1:2 to form a composite wall material solution, add core material IDBN powder at a core-wall mass ratio of 1:1, mix and stir evenly, and homogeneously emulsify for 5 minutes to obtain an emulsion, then Put the emulsion at a feed temperature of 60°C, an inlet air temperature of 160°C, and an air flow rate of 20m 3 / h under the condition of spray-drying into powder, that is, IDBN microcapsules, the inclusion rate of 84.3%.

Embodiment 3

[0064] After mixing 1% sodium alginate and 2.5% gelatin at a weight ratio of 1:2.5 to form a composite wall material solution, add core material IDBN powder at a core-wall mass ratio of 1:2, mix and stir evenly, and then homogeneously emulsify for 5 minutes to obtain an emulsion. Then the emulsion is heated at a feed temperature of 70°C, an inlet air temperature of 170°C, and an air flow rate of 30m 3 / h under the condition of spray-drying to powder, that is, IDBN microcapsules, the inclusion rate of 86.3%.

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Abstract

The present invention discloses a complex coacervation - spray drying method for preparing idebenone (IDBQ) microcapsules. The method comprises the steps of: dissolving wall materials separately in deionized water by heating, mixing according to a ratio to a wall material solution, adding in a core material idebenone, mixing and stirring uniformly for homogeneous emulsification to obtain an emulsion; and then spray drying the emulsion to be powder to obtain the idebenone microcapsules. Particles of the idebenone microcapsules provided by the invention have characteristics such as smooth outer walls, an uniform particle size, and few air holes and fissures, and have good hydrophilicity; the core material is completely wrapped in the wall materials, thereby diluting the original color of IDBN and solving problems such as water-solubility in the application of the IDBN in cosmetics; and the preparation method is simple and feasible, easy for industrial production.

Description

【Technical field】 [0001] The invention relates to a method for preparing microcapsules, in particular to a method for preparing idebenone microcapsules by a composite coacervation-spray drying method, and belongs to the technical field of microencapsulation of bioactive functional substances to change physical properties and appearance. 【Background technique】 [0002] Microcapsule technology is a technology that wraps solid or liquid with easy-to-film-forming materials to form tiny particles. The resulting tiny particles are called microcapsules, and the diameter of the particles is generally in the order of microns or millimeters. The substance wrapped inside the microcapsule is called the core material, or clathrate, capsule core, etc. The core material can be solid, liquid or gaseous. The outer membrane of the microcapsule formed by a material that is easy to form a film is called the wall material, or outer membrane, capsule wall. According to the nature, state and us...

Claims

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Application Information

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IPC IPC(8): A61K8/11A61K8/35A61K8/73A61K8/65A61Q19/08A61Q19/00A61Q17/04
Inventor 朱杰连程传深梁娟陈意平
Owner 广州保税区雅兰国际化妆品有限公司
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