Wound nursing dressing containing hyaluronic acid

Abstract

The invention discloses a wound nursing dressing containing hyaluronic acid. The dressing comprises hyaluronic acid and salt thereof, and soluble silver salt effective ingredients, wherein the hyaluronic acid comprises high molecular weight hyaluronic acid and low molecular weight hyaluronic acid or oligomeric hyaluronic acid, wherein the high molecular weight hyaluronic acid is excellent in viscoelasticity, moisture retention and hydroscopicity, and the low molecular weight has a remarkable effect of promoting angiogenesis; the hyaluronic acids with two molecular weights both have multiple effects to wound healing, and have the effect of playing quick response and long action; and the soluble silver salt is stable in quality, has a good bacteriostatic effect, and plays a synergetic effect when being compounded with hyaluronic acids with high and low molecular weights. The dressing can be used for disinfection, anti-infection and healing acceleration of various skin wounds, ulcer and the like, and has a remarkable effect.

Description

technical field

[0001] The invention relates to a dressing for wound care, in particular to a dressing for wound care containing hyaluronic acid (abbreviated as HA) and suitable for disinfection, anti-infection and accelerated healing of various skin wounds and ulcers. Background technique

[0002] Wound healing is a process involving the reconstruction and regeneration of extracellular matrix by various cells and their secreted products. Hyaluronic acid is the main component of extracellular matrix, and a large amount of hyaluronic acid participates in the early stage of matrix formation. As early as 1968, Bentley discovered that after tissue damage, the initial change was a significant increase in the content of HA in the damaged area. Weigel et al. believed that when the wound began to heal, an activating factor could be produced by platelets or surrounding cells to promote the blood cells in the clot to synthesize hyaluronic acid, combine with fibrin, and fill it into t...

Examples

Embodiment 1

[0034] Preparation of gel: under rapid stirring, slowly add 1.5 g of low molecular weight (molecular weight: 8,000 daltons) sodium hyaluronate into an appropriate amount of purified water, and then add high molecular weight (molecular weight: 2,000,000 daltons) hyaluronic acid Slowly add 1.0 g of sodium, and after fully dissolving, add 0.1 g of silver nitrate and stir to dissolve it. Add 5.0 g of polyethylene glycol, supplement with purified water to 100 g, and mix well. Filling, sterilization processing products.

Embodiment 2

[0036] Preparation of gel: under rapid stirring, slowly add 1.5 g of low molecular weight (molecular weight: 50,000 daltons) sodium hyaluronate into an appropriate amount of purified water, and then add high molecular weight (molecular weight: 1.5 million daltons) hyaluronic acid Slowly add 1.0 g of sodium, and after fully dissolving, add 0.05 g of silver nitrate and stir to dissolve it. Add 5.0 g of polyethylene glycol, supplement with purified water to 100 g, and mix well. Filling, sterilization processing products.

Embodiment 3

[0038] Preparation of gel: under rapid stirring, slowly add 1.0 g of low molecular weight (molecular weight: 300,000 daltons) sodium hyaluronate into an appropriate amount of purified water, and then add high molecular weight (molecular weight: 1,200,000 daltons) hyaluronic acid Slowly add 1.5 g of sodium, and after fully dissolving, add 0.01 g of silver nitrate and stir to dissolve it. Add 5.0 g of polyethylene glycol, supplement with purified water to 100 g, and mix well. Filling, sterilization processing products.

technical field

[0001] The invention relates to a dressing for wound care, in particular to a dressing for wound care containing hyaluronic acid (abbreviated as HA) and suitable for disinfection, anti-infection and accelerated healing of various skin wounds and ulcers. Background technique

[0002] Wound healing is a process involving the reconstruction and regeneration of extracellular matrix by various cells and their secreted products. Hyaluronic acid is the main component of extracellular matrix, and a large amount of hyaluronic acid participates in the early stage of matrix formation. As early as 1968, Bentley discovered that after tissue damage, the initial change was a significant increase in the content of HA in the damaged area. Weigel et al. believed that when the wound began to heal, an activating factor could be produced by platelets or surrounding cells to promote the blood cells in the clot to synthesize hyaluronic acid, combine with fibrin, and fill it into t...

Examples

Embodiment 1

[0034] Preparation of gel: under rapid stirring, slowly add 1.5 g of low molecular weight (molecular weight: 8,000 daltons) sodium hyaluronate into an appropriate amount of purified water, and then add high molecular weight (molecular weight: 2,000,000 daltons) hyaluronic acid Slowly add 1.0 g of sodium, and after fully dissolving, add 0.1 g of silver nitrate and stir to dissolve it. Add 5.0 g of polyethylene glycol, supplement with purified water to 100 g, and mix well. Filling, sterilization processing products.

Embodiment 2

[0036] Preparation of gel: under rapid stirring, slowly add 1.5 g of low molecular weight (molecular weight: 50,000 daltons) sodium hyaluronate into an appropriate amount of purified water, and then add high molecular weight (molecular weight: 1.5 million daltons) hyaluronic acid Slowly add 1.0 g of sodium, and after fully dissolving, add 0.05 g of silver nitrate and stir to dissolve it. Add 5.0 g of polyethylene glycol, supplement with purified water to 100 g, and mix well. Filling, sterilization processing products.

Embodiment 3

[0038] Preparation of gel: under rapid stirring, slowly add 1.0 g of low molecular weight (molecular weight: 300,000 daltons) sodium hyaluronate into an appropriate amount of purified water, and then add high molecular weight (molecular weight: 1,200,000 daltons) hyaluronic acid Slowly add 1.5 g of sodium, and after fully dissolving, add 0.01 g of silver nitrate and stir to dissolve it. Add 5.0 g of polyethylene glycol, supplement with purified water to 100 g, and mix well. Filling, sterilization processing products.

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