1353 results about "Anti infectives" patented technology

Anti-infective foamable composition and kits include a foamable carrier; a therapeutically safe and effective concentration of an anti-infective agent; an augmenting agent selected from the group consisting of a keratolytic agent and a skin penetration enhancer; and a propellant. The composition is housed in a container and upon release is expandable to form a breakable foam. The foamable carrier is selected to generate a foam of good or excellent quality in the presence of the augmenting agent and anti-infective agent. Methods for treating, alleviating or preventing a disorder of the skin, a body cavity or mucosal surface, wherein the disorder involves a fungal, bacterial or viral infection as one of its etiological factors, is described.

Therapeutic formulations adapted for positive-pressure application for controlling biological fluid at a desired site in a subject, absorbent articles comprising therapeutic formulations, and anti-infective devices coated with therapeutic formulations, said formulations comprising about 25% to about 99% by weight liquid-crystal forming compound and 0% to about 75% by weight solvent. In addition, methods of using said formulations including methods for controlling biological fluid at a desired site in a subject, methods for controlling blood loss, and methods for facilitating effective closure of a vascular wound or incision site at a desired site in a subject are disclosed, the methods comprising administering particular formulations comprising liquid-crystal forming compounds and solvents that are described herein.

The present invention relates to a method of treated disordered epithelial tissues such as cold sores and other complications resulting from disorders such as herpes, and the like. The inventive method combines an anti-infective and/or antimicrobial active agent in a carrier, with vigorous agitation of the disordered epithelial tissue for topical treatment thereof under such conditions sufficient to achieve clinically discernable improvement of the disordered epithelial tissue. The preferred anti-infective and/or antimicrobial active agent is an organohalide such as a quaternary ammonium compound, preferably benzalkonium chloride. The inventive method may be used also in connection with a preferred applicator configuration.

Devices are provided which are functionalized to include surface regions having anti-infective agents. Methods are provided for functionalizing various material surfaces to include active surface regions for binding anti-infective agents. Methods are provided by which anti-infective moieties or agents are bonded to functionalized surfaces.

This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.

The present invention is drawn to solidifying adhesive formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug which can treat various skin infections, such as fungal, bacterial, and/or viral skin infections. The formulation can include an anti-infective drug, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent. The non-volatile solvent system can facilitate the delivery of the drug at therapeutically effective rates for sustained period of time. The non-volatile solvent system can also act as a plasticizer for the solidifying agent. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.

A catheter assembly suitable for intermittent catheterization comprising a cylindrical casing composed of two telescopically moveable parts one of which is connectable to and moveable with a piston which is rigidly connected to a urinary catheter. The interior of the cylindrical casing is filled with a lubricating, anesthetic, antiseptic liquid, or the like, which during catheterization is injected into the urethra and urinary bladder through the catheter under the effect of movement of the piston simultaneously with the insertion of the catheter into the urethra. The device is provided with an anti-infective cap which is inserted into the first third of the urethra and is used as a guide for inserting the catheter into the urethra without physical contact with the part if the urethra which is a harbor of infections.

Methods for formulating immediate and sustained release anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.

An apparatus and method for generation of a protective sleeve against infections for a percutaneous lead through human or animal skin. The percutaneous lead (1) includes an extrusion port (7). When the lead extends through a body (3) of a patient, a pump (9) in operative connection with the lead is operative to move biocompatible liquid polymer material from a reservoir (10) through the extrusion port. As the polymer material comes in contact with body tissues of the patient it forms a protective sleeve against infections (5). The protective sleeve must be periodically clipped as it continuously or intermittently grows in an upward direction (6) outside of the body. The continual formation of the protective sleeve prevents the formation of a biofilm on the percutaneous lead that can cause the body tissue to separate from the percutaneous lead.

A patient safety enhancing connection system and method for focusing the mechanical force of the fingers through a cannula to burst and/or wipe off bacteria to thereby mechanically reduce the number of microorganism at the connection interface. The system includes elastomeric septum which is under flow able compression having outer slitted septum face and configured to receive blunt cannula by penetration of the blunt cannula into the compressed septum. The septum face and the distal opening of the cannula are matched such that the edge of the inner wall of the cannula does not engage the septum face during the penetration process to minimize the potential transfer of microorganisms to the interior of the cannula, so that bacteria, if transferred, are preferentially transferred to the outer wall of the cannula where they are compressed, sheared or wiped off by the compressed elastomere and therefore do not reach the bloodstream.

The present invention relates to active bactericidal, antibacterial, anti-infective, antimicrobial, sporicidal, disinfectant, antifungal and antiviral compounds and compositions and to new uses of these compositions in therapy. This specification also describes methods of use for the new compounds and compositions. The specification further describes methods for preparing these compounds.

Methods for formulating immediate and sustained release anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.