1012 results about "Anti infectives" patented technology

The invention belongs to the technical field of antibacterial drugs, and discloses a pleuromutilin derivative and a preparation method and application thereof.The pleuromutilin derivative is a compound with the structure shown in the formula I and pharmaceutically acceptable salt of the compound, and in the formula, R1, R2 and R3 are H, OMe, NO2, Me, F, Cl or Br. According to the present invention, the structure is novel, the antibacterial activity is excellent, and the in vitro antibacterial experiment result shows that the antibacterial activity of more than 90% of the compound on the Gram-positive bacteria staphylococcus aureus drug-resistant strains ATCC 33591 and ATCC 43300 and the staphylococcus aureus sensitive strain ATCC 2913 is superior to the antibacterial activity of tiamulin, such that the tiamulin is expected to be used in the treatment of the bacterial infection caused by the staphylococcus aureus, and the application prospect is broad. And a new choice is provided for anti-infection drugs.

The invention belongs to the technical field of antibacterial drugs, and discloses a coumarin thioether pleuromutilin derivative and application thereof.The coumarin thioether pleuromutilin derivative is a compound with the structure shown in the formula I and pharmaceutically acceptable salt of the compound, and in the formula, R1 and R2 are H, OMe, NO2, NH2, Me, F, Cl or Br. The antibacterial agent is novel in structure and has excellent antibacterial activity. In-vitro antibacterial experiment results show that all the compounds have antibacterial effects superior to that of tiamulin, most of the compounds have antibacterial effects equivalent to that of control valnemulin, and the compound has a significant effect on five gram-positive bacteria staphylococcus aureus drug-resistant strains ATCC 33591 and ATCC 43300, staphylococcus aureus sensitive strains ATCC 2913, staphylococcus epidermidis drug-resistant strains ATCC 51625, staphylococcus epidermidis sensitive strains ATCC 12228, staphylococcus aureus drug-resistant strains ATCC 51625, staphylococcus aureus sensitive strains ATCC 12228, staphylococcus aureus drug-resistant strains ATCC 51625 and staphylococcus aureus sensitive strains ATCC 12228. Wherein the bacteriostatic activities of the nine compounds are less than or equal to 0.062 mu g.mL <-1 >. The compound is expected to be applied to treatment of bacterial infection caused by staphylococcus aureus, and a new choice is provided for anti-infection drugs.

The invention discloses a walnut meal-derived antibacterial polypeptide and application thereof, and belongs to the technical field of biology. The amino acid sequence of the walnut meal-derived antibacterial polypeptide disclosed by the invention is shown as any one of SEQ ID NO.1-3. The walnut meal is adopted as the raw material, the antibacterial polypeptide is extracted and separated, the utilization rate of the walnut meal can be effectively increased, resource waste is reduced, a new polypeptide variety is provided for the antibacterial polypeptide field, and new resources are provided for development of novel antibacterial agents, bacterial lysis solutions, food preservatives and anti-infection drugs.

The invention provides lactobacillus crispatus, which is preserved in the general microbiological center of the China Committee for Culture Collection of Microorganisms on February 7, 2023, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) No. 26503. The bacillus subtilis can play a relatively strong role in inhibiting pathogenic bacteria such as gardnerella vaginalis, escherichia coli and staphylococcus aureus at the same time, and also has a certain role in inhibiting candida albicans, two-way proteurella and Atortoria vaginalis. Therefore, the lactobacillus crispatus has the potential of maintaining the environment in the vagina to be faintly acid and improving the mucosal immunity and infection resistance of a host, and can be used for preventing and treating vaginal infection and inflammation, and maintaining, improving or recovering the steady state of the environment in the vagina.

The present invention belongs to the field of biotechnology, and discloses an antimicrobial peptide and a preparation method and use thereof. The antimicrobial peptide of the present invention is a mixture of any one or more of the polypeptides of RcASScGAK, RcASScGAKS, TGMRcASScGAK, and TGMRcASScGAKS. The present invention also provides a method for preparing the antimicrobial peptide by heterologous co-expression of a whole enzyme and a substrate, as well as a purification process of the antimicrobial peptide, which can successfully obtain high-yield and high-purity antimicrobial peptides, the required reagents are low-priced, the operation steps are simple and easy, and it is suitable for large-scale cultivation and purification; the antimicrobial peptide prepared by the present invention has excellent antimicrobial activity, and provides a new choice for the development of antimicrobial and anti-infective drugs.

The invention provides an antibacterial peptide and application thereof, and belongs to the technical field of biological medicine. Based on bioinformatics and an AI technology, a novel broad-spectrum antibacterial peptide is expected to be screened from tick (hard tick shoulder) genomes, and the antibacterial peptide has antibacterial activity on bacteria (including clinical drug-resistant strains) and fungi, does not have obvious cytotoxicity and hemolytic activity, and is an important candidate molecule of anti-infective drugs. In the embodiment of the invention, the minimum inhibitory concentration of the antibacterial peptide on gram-positive bacteria, gram-negative bacteria and fungi is verified, and the antibacterial peptide is proved to have obvious antibacterial activity on the gram-positive bacteria, the gram-negative bacteria and the fungi. The invention also verifies that the minimum inhibitory concentration of the antibacterial peptide to clinical drug-resistant bacteria is equivalent to the minimum inhibitory concentration of the antibacterial peptide to standard strains, and verifies that the antibacterial peptide can be used as a broad-spectrum antibacterial peptide and is named as SL-15.

The invention discloses a titanium-based hydroxyapatite composite coating and a preparation method thereof. The problems that a traditional coating is weak in interface bonding, single in porosity and mismatched in drug sustained release are solved. The composite coating comprises a gradient component layer and a bionic porous outer layer which are sequentially stacked on the surface of a titanium substrate, wherein the gradient component layer comprises a bottom layer (a titanium-based hydroxyapatite transition layer, 70-80% of HA and bonded through Ti-O bonds) and a middle layer (an HA / bioglass composite layer, 50-70% of HA and 10-20% of bioglass); the bionic porous outer layer is a porous HA layer, the porosity is 40-60%, the porosity is gradually increased in a gradient mode in the direction away from the titanium substrate, surface layer pores are loaded with anti-infection drugs, and inner layer pores are loaded with bone growth factors. The method realizes improvement of the interface bonding strength of the coating, consideration of mechanical and biological activity and staged slow release of the medicine, and is suitable for the field of bone joint implantation.

The utility model provides a honeycomb nanofiber-based flexible probe medical dressing, the shape of the medical dressing is a honeycomb formed by closely arranging hexagonal structure units, six edges of each hexagonal structure unit are detection parts, the middle surrounded part is a treatment part, and the detection parts are closely attached to the treatment part; the detection part is used for detecting the high active oxygen concentration of the wound and judging whether the wound is infected or not; the treatment part is used for treatment and infection resistance of wounds after skin tumor excision. The medical dressing is used for wound treatment and infection resistance after skin tumor excision, and meanwhile, the high active oxygen concentration of a wound is detected, and whether the wound is infected or not is judged.

The invention discloses lactobacillus gasseri capable of improving expression of host antibacterial peptide Cathelicidin and secretory immunoglobulin sIgA and enhancing infection resistance by oral administration and external application and a metagen thereof, and belongs to the technical field of microorganisms. The lactobacillus gasseri disclosed by the invention can be used for promoting the generation of a vaginal epithelial cell antibacterial peptide Cathelicidin; the shedding of vaginal epithelial cells is reduced, the fungal load is reduced, and the generation of vaginal tissue antibacterial peptide CRAMP is improved; the pIgR and immune globulin content of the vaginal tissue is increased; the invention also finds that the lactobacillus gasseri for external use can regulate and control TLR2 (Toll-Like Receptor 2), and further has a good balancing effect on body immunity. Therefore, the lactobacillus gasseri has a huge application prospect in a product for improving the pathogenic bacterium infection resistance of a host, enhancing the self-defense capability and inhibiting the vagina inflammation.

The invention discloses an eel antibacterial polypeptide Ajaspkidin and application thereof in preparation of an anti-vibrio composition. The amino acid sequence of the eel antibacterial polypeptide Ajaspkidin is shown as SEQ ID NO.01. The invention further discloses an application of the eel antibacterial polypeptide The zebra fish antibacterial peptide has the characteristics of excellent molecular characteristics, broad-spectrum antibacterial activity, efficient bactericidal ability, high thermal stability, high biological safety, anti-infection effect on zebra fish infected by vibrio vulnificus, capability of remarkably improving the survival rate of bred animals and the like, and has a wide application prospect.

The invention discloses an HSPA8 protein capable of resisting a duck tembusu virus and application of the HSPA8 protein. According to the invention, a prokaryotic expression vector for expressing HSPA8 is constructed, protein expression conditions are optimized, and soluble endotoxin-removed HSPA8 protein, including HSPA8-His protein and GST-HSPA8 protein, is expressed and purified. An in-vitro antiviral experiment shows that the HSPA8 protein disclosed by the invention has a good antiviral effect; in-vivo antiviral experiments show that the HSPA8 protein can significantly weaken pathogenicity caused by DTMUV infection, prevent in-vivo proliferation of viruses, weaken mouse weight loss caused by virus infection and reduce mouse death caused by virus infection. Therefore, the HSPA8 protein disclosed by the invention has a remarkable characteristic of resisting DTMUV infection, can be applied to preparation of drugs for resisting the duck tembusu virus, and provides a new strategy for prevention and control of the duck tembusu virus.

The art does not provide systematic and reproducible methods to personalize dosing of multiple immunosuppressive medications after transplantation. This invention provides a method to systematize multi-drug immuno suppression management in tissue and organ transplantation using an artificial intelligence-based complex systems approach. In embodiments of this invention, immunosuppression drug dose, blood drug concentrations, donor-derived fraction of cell free DNA (dd-cfDNA %), and aspartate aminotransferase are used to indicate allograft status or a proxy for allograft status, to generate a phenotypic response surface to produce individual treatment modalities and dosages using empirically determined unique coefficients. This surface is used to calculate appropriate immunosuppression drug doses associated with the desired outcome for that patient. Embodiments of this disclosure are directed to identifying optimized combinations of inputs for the complex system of the immunosuppressed transplant patient in order to avoid transplant rejection while avoiding unnecessary toxicity and maintaining a robust enough immune response to fight infection.

The invention discloses a preparation method of an in-situ gelation collagen-based biological patch, which comprises the following steps: generating hydrogel in situ on the surface of an acellular matrix material and among internal fiber gaps by introducing various chemical reactivity of dopamine / polydopamine, and combining a hydrogel system and the acellular matrix material into one to construct the in-situ gelation biological patch. The material effectively improves the mechanical support effect, drug loading and cell growth promotion of defective tissues, also has the tissue repair functions of healing promotion, adhesion prevention, infection resistance and the like, and can be widely used for functional modification of acellular matrix materials.

Aiming at the inadequacy of existing hemostatic materials for large-scale trauma and serious bleeding, the present invention provides a silk fibroin complex loaded with a polyhydroxy phenolic compound and a preparation method therefor. The complex is prepared by self-assembly of the polyhydroxy phenolic compound and the silk fibroin. The silk fibroin is subjected to a β-sheet conformation transformation process. The polyhydroxy phenolic compound is preferably an indissoluble compound, most preferably ellagic acid. The feeding ratio of the polyhydroxy phenolic compound to the silk fibroin is a mass ratio of ˂ 1:1, preferably 1:2 to 1:16, more preferably 1:4. The hemostatic ability of the complex is significantly superior to that of the polyhydroxy phenolic compound, the silk fibroin, Yunnan Baiyao, tranexamic acid, chitosan hemostatic powder, and the like. Meanwhile, the complex has a larger particle size and mass than the silk fibroin, and can rapidly settle to a bleeding site in blood. The complex exhibits no cytotoxicity, is blood-insoluble, and is capable of self-degradation in vivo, demonstrating high safety. Meanwhile, the complex has the characteristics of wound healing, antibiosis, infection resistance, adhesion resistance, and the like, and can be applied to the preparation of corresponding formulations.

The invention belongs to the technical field of biological medicines, and relates to application of Ackermann muciniphile or its external vesicles in preparation of a drug for treating schistosomiasis. The anti-infection immunity of a host is enhanced by adjusting intestinal flora balance (recovering diversity and composition) and improving immune response (adjusting macrophage, CD8 + T cell recruitment and Th1 / Th2 balance); meanwhile, the intestinal barrier function is improved, and pathogen invasion and inflammation are reduced; hepatic granuloma and hepatic fibrosis caused by schistosome infection are obviously relieved, and the liver function is improved; the key effect of the MIF gene in immunoregulation is disclosed, and a new direction is provided for schistosomiasis immunotherapy. Besides, the probiotics are high in treatment safety and free of obvious side effects, can be combined with chemotherapy to enhance the curative effect and reduce the side effects and drug resistance of chemical drugs, provides a lasting and comprehensive adjuvant therapy scheme for the schistosomiasis, and has important clinical application potential.

The invention discloses a porcine epidemic diarrhea virus (PEDV) infection resistant Min pig source lactobacillus salivarius LSM231 and application thereof, and belongs to the technical field of microorganisms. The Min pig source lactobacillus salivarius is named as Ligilbacillus salivarius LSM231 and is preserved in the China Center for Type Culture Collection, the preservation number is CCTCC NO: M 20242330, and the preservation time is October 25, 2024. The Min pig source lactobacillus salivarius has the advantages that the Min pig source lactobacillus salivarius is named as Ligilbacillus salivarius LSM231 and is preserved in the China Center for Type Culture Collection (CCTCC); the screened Min pig source lactobacillus salivarius is symbiotic probiotics in intestinal tracts and is high in safety performance, and experimental results show that the Min pig source lactobacillus salivarius LSM231 has relatively good antibacterial, acid-resistant and cholate-resistant characteristics, has a remarkable PEDV (porcine epidemic diarrhea virus) resisting effect, and can relieve clinical symptoms caused by PEDV infection and promote growth of piglets, so that the Min pig source lactobacillus salivarius LSM231 can be used for preventing and treating the porcine epidemic diarrhea. The compound can replace antibiotics to be used for preparing a micro-ecological preparation for resisting PEDV (porcine epidemic diarrhea virus) infection.

The invention relates to a nano-drug delivery system targeting neutrophil and a preparation method and application thereof. The nano-drug delivery system is prepared by the following method: S1, preparing a liposome 1 wrapping a drug 1; s2, preparing a liposome 2 wrapping a medicine 2; and S3, mixing and incubating the liposome 1 wrapping the medicine 1 and the liposome 2 wrapping the medicine 2, and connecting the corresponding ligand and receptor in the liposome 1 and the liposome 2 to obtain the liposome. The ligand and the receptor are respectively biotin and streptavidin. The nano-drug delivery system is obtained by successfully connecting two drug liposomes with different functions through a ligand and a receptor system, so that the chemotaxis of neutrophil to an infected part can be enhanced, the antibacterial property of NETs can be improved, and the nano-drug delivery system has a very good anti-infection effect.

The invention provides lactobacillus gasseri which is preserved in the general microbiological center of the China Committee for Culture Collection of Microorganisms on February 7, 2023, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.26504. The lactobacillus gasseri has the advantages that the lactobacillus gasseri can be used for preparing the lactobacillus gasseri; the lactobacillus gasseri has a relatively strong inhibition effect on pathogenic bacteria such as Gardneria vaginalis, Escherichia coli, staphylococcus aureus and two-way Pleuromycosis, and also has a certain inhibition effect on CA, so that the lactobacillus gasseri has the effects of killing pathogenic bacteria, improving the host mucosal immunity and resisting infection, and has a good application prospect in the field of animal husbandry, animal husbandry, animal husbandry, animal husbandry, animal husbandry, animal husbandry, animal husbandry and animal husbandry. Meanwhile, growth and reproduction of harmful bacteria can be inhibited, vaginal infection is prevented, and inflammation is treated.

The invention provides a marine biological alkali compound. The chemical formula of the marine biological alkali compound is as follows: # imgabs0. The marine biological alkali compound or pharmaceutically acceptable salt thereof can be used for preparing antibacterial drugs or anti-infective drugs. The invention also provides a separation and extraction preparation method or a chemical synthesis preparation method of the marine alkaloid compound or the pharmaceutically acceptable salt thereof, and the preparation method is simple and easy to industrialize. The invention also provides application of the marine biological alkali compound or the pharmaceutically acceptable salt thereof in preparation of antibacterial drugs or anti-infection drugs for human or fish.

The invention relates to the technical field of atomization drug delivery, in particular to an anti-infection drug precise atomization drug delivery system based on respiratory physiological characteristics, comprising a respiratory parameter acquisition module used for acquiring respiratory data of a patient in real time; the breathing mode recognition module is used for classifying breathing modes of the patient and generating breathing mode labels; the dose-parameter cooperative calculation module is used for adjusting the atomization dose and the initial atomization parameter required by the patient at a time; the atomization parameter optimization module is used for monitoring the actual output effect of an atomizer in real time and adjusting dynamic atomization parameters in real time through a PID controller; and the breathing auxiliary intervention module is used for guiding the patient to perform deep and slow breathing through acousto-optic feedback. By collecting the breathing data of the patient in real time and dynamically adjusting the atomization dosage and parameters in combination with breathing mode classification, the limitation of traditional fixed dosage and parameters is broken through, administration is accurately matched with the real-time breathing state of the patient, and the deposition rate and utilization rate of the medicine at the target part are increased.

The invention relates to an intelligent dynamic negative pressure and phototherapy integrated burn wound treatment device, and belongs to the technical field of medical instruments, the device comprises a contact layer, a conduction layer and a honeycomb support layer, the contact layer drains exudate, the conduction layer is integrated with an optical fiber network and a self-adaptive deformation mechanism, and the honeycomb support layer is connected with an intelligent negative pressure chamber and a gradient sterilization system. The pressure of the negative pressure chamber is dynamically adjusted through a corrugated air bag and a rhombic telescopic unit, and the photo-thermal assembly irradiates the wound surface in a time-sharing mode and maintains the constant temperature. And the sterilization system adopts ultraviolet pulse and a multi-stage filter screen to cooperatively purify the percolate. The intelligent regulation and control module optimizes treatment parameters in real time through a multi-mode sensing network, and full-closed-loop cooperation of negative pressure, phototherapy and sterilization is achieved. According to the device, the limitation of traditional treatment is broken through through integrated design, the wound repairing quality and the anti-infection capacity are remarkably improved, meanwhile, the medical care burden is reduced through modular expansion and a non-invasive monitoring function, and an efficient and safe intelligent solution is provided for burn management.

The invention belongs to the field of veterinary drugs, and particularly relates to a medicine for improving immunity of bred animals. The medicine provided by the invention comprises the following active ingredients in parts by weight: 10-20 parts of withered grass 37 peptide and extracts of the following traditional Chinese medicinal materials: 15-30 parts of wintercreeper, 15-30 parts of astragalus membranaceus, 15-30 parts of spirulina, 10-20 parts of silybum marianum and 10-20 parts of herba epimedii. Wherein the withered grass 37 peptide is a biological active peptide with an anti-infection function, is composed of a plurality of amino acids and has broad-spectrum antibacterial activity. The medicine provided by the invention has the functions of inhibiting and sterilizing, regulating immunity and regulating body functions so as to improve the immunity of bred animals, thereby turning pathogenesis and ensuring the health of the bred animals. A curative effect experiment shows that the medicine can improve the growth performance of bred animals and effectively reduce breeding loss, has the advantages of being environmentally friendly, safe and capable of preventing diseases, and has a good market prospect.

The invention discloses a method for in-vitro induction of T cell immune memory differentiation and application, CD8 + T memory differentiation can be enhanced by verifying in-vitro itaconic acid and derivative supplement thereof, and then anti-tumor and anti-infection immune response is enhanced after in-vivo feedback. The invention can be used in malignant tumors and infectious diseases to enhance the curative effect of T cell adoptive therapy.

The invention discloses a filling dressing, and relates to the technical field of medical dressings, the filling dressing is prepared from composite yarn, the composite yarn is of a double-layer composite structure, the two-layer structure of the composite yarn comprises an inner hydrophilic layer and an outer hydrophobic layer, the composite yarn is formed by wrapping inner hydrophilic fibers with outer hydrophobic fibers, and the outer hydrophobic fibers wrap the inner hydrophilic fibers. The outer hydrophobic layer is made of hydrophobic fiber filaments; the composite yarn formed by weaving the outer-layer hydrophobic fibers and the inner-layer hydrophilic fibers in a matched mode is used, then the composite yarn is woven into the complete dressing to be used by a patient, the woven filling dressing has the good liquid absorption and anti-infection functions due to the matching of different materials of the inner layer and the outer layer, and meanwhile due to the hydrophilicity and hydrophobicity of the inner layer and the outer layer, the anti-infection effect is good. Meanwhile, due to the fact that the dressing is formed by weaving the composite yarn, the integrality is good, the good anti-adhesion performance is achieved, and due to the effect of the inner layer material, the dressing further has the effects of stopping bleeding, inhibiting bacteria and the like.

The invention discloses an anti-infection ointment for promoting healing of burns and scalds and other wound surfaces and a preparation method thereof, the anti-infection ointment comprises active components and auxiliary materials, the active components comprise 0.2-3 parts by weight of ganoderma lucidum chitosan, 0.2-5 parts by weight of recombinant III type collagen, 0.1-2 parts by weight of zinc and 0.5-8 parts by weight of a Cur-Mg compound; the Cur-Mg compound is a compound of Cur-Mg (at) PP hydrogel, antibacterial polyphenol and boric acid ester bond hydrogel. Compared with the prior art, the ointment disclosed by the invention has the advantages of good antibacterial property, high wound healing promoting speed, reduction of scar formation and the like through a synergistic effect of multiple components, and realizes slow release of active components and good wound microenvironment regulation through a hydrogel system.

The present invention belongs to the field of biotechnology and specifically relates to the use of a compound AJ2-30 in the preparation of antiviral drugs. The present invention unexpectedly discovered that adding compound AJ2-30 to the culture medium for ASFV can reduce the replication level of ASFV, indicating that compound AJ2-30 has the effect of inhibiting ASFV replication. It can be used to prepare drugs or adjuvants for anti-ASFV infection and inhibit ASFV replication, and has broad application prospects.

The invention relates to the technical field of biomedical materials, in particular to a double-network structure artificial blood vessel with anticoagulation, endothelium promotion and anti-infection functions and a preparation method of the double-network structure artificial blood vessel. The artificial blood vessel comprises a polymer fiber network artificial blood vessel substrate, a microscopic network hydrogel layer penetrating through the polymer fiber network artificial blood vessel substrate, and magnesium-copper alloy particles doped in the hydrogel layer. According to the artificial blood vessel with the double-network structure, the problem that a traditional small-caliber artificial blood vessel is insufficient in mechanical performance is greatly solved, copper ions and magnesium ions are released to the surrounding environment by means of degradation of the magnesium-copper alloy particles in the using process, the microenvironment of the surrounding tissue is adjusted to be alkalescent, nitric oxide is catalytically released, and the mechanical performance of the artificial blood vessel is improved. The artificial blood vessel with the double-network structure is endowed with anticoagulation, endothelium promotion and anti-infection functions. The problems of restenosis and insufficient endothelialization of a small-caliber artificial blood vessel in the prior art are comprehensively solved, and the long-term patency rate of the artificial blood vessel is increased.

The invention belongs to the technical field of anti-infection human body lubricants, and particularly relates to an anti-infection human body lubricant containing plant components as well as a preparation method and application of the anti-infection human body lubricant. The anti-infection human body lubricant is composed of the following components in parts by weight: 1-3 parts of an antibacterial component; 1-4 parts of a lubricating component; 8-10 parts of a solvent component; wherein the antibacterial component is prepared by mixing procyanidine, obaculactone and lotus seed polysaccharide according to a weight part ratio of 5: (0.5-1): (0.5-1). The anti-infection human body lubricant disclosed by the invention contains plant-derived active ingredients, is high in safety, does not need a harsh chemical synthesis process, and also has anti-infection effects, such as bacteria resistance, fungus resistance and trichomonad resistance, while playing a lubricating role.

The invention provides a 3D printing bone scaffold based on a TPMS structure, the bone scaffold is prepared by taking Ti-6Al-4V powder as a building raw material through a 3D printing mode, the bone scaffold is a TPMS G unit structure, the aperture range is 420-630 microns, the inner layer porosity is 55%, the peripheral porosity is 90%, the diameter of the scaffold is 15 mm, and the height of the scaffold is 2 mm. Moxifloxacin / rifampicin PLGA microspheres and BMP-2 are loaded in the bone scaffold and are fixed by hydrogel, so that the 3D printing anti-infection bone scaffold based on the TPMS structure is formed. The prepared 3D printing anti-infection bone scaffold highlights excellent performance in all aspects, has good capacity of resisting infection and promoting bone formation, and provides a new material and thought for treatment of infectious bone defects. In addition, the invention further discloses a preparation method and application of the stent.

In a composition, at least one of TQ and NADH is loaded in a gel. The composition disclosed by the invention is loaded on a gel carrier formed by mixing fibrinogen and thrombin, the gel carrier is smeared on a wound, and then the gel carrier, red light and blue light have a synergistic effect, so that the dual functions of resisting infection and accelerating wound healing are realized under the condition that the illumination time is remarkably shortened. In this way, ramp is used; the combination of bLED and the fibrin gel provides an effective scheme for managing chronic wounds, and is expected to be used for clinical intervention of family chronic diabetic wounds.