248results about How to "Strong anti-infection effect" patented technology

The invention relates to an acellular biological patch, a preparation method and an apparatus thereof. In the invention, small intestines of pigs are taken as raw materials, which are subjected to a series of decellularization treatment by means of an acid, hydrogen peroxide, a mixed solution of high salt and alkali so as to obtain the acellular biological patch. According to the preparation method, after treatment by the hydrogen peroxide, the mixed solution of high salt and alkali can be employed to conduct twice recycling treatment, thus reaching the effects of thorough decellularization and antigen removal. The employment of a transverse and longitudinal alternating laying way maintains uniformity of the patch's mechanical properties, the tensile strength, suture tear force, tear strength and other mechanical indexes can well meet clinical demands, thus facilitating surgical suture operation. The employed drying mode has no need of any adhesive and suture line for fixation, so that a natural three-dimensional support structure of the product is maintained, and after implantation into the human body, no strong inflammatory response and immunological rejection response can occur. The patch has no toxicity on cells, so that infection and adhesion cannot occur in a repair process. The acellular biological patch provided in the invention is suitable for repair of body tissue defects and soft tissue injuries, and also can be used in the bioengineering field to serve as the tissue for reinforcing repair of membranous defects and infected wounds and serve as a biological scaffold material, etc.

The invention provided synthesis and application of a nano-silver antibacterial fiber. The fiber from natural polymer fibers or synthetic polymer fibers, or both portfolio and nano-silver composition, and the silver nano particle size range of 10~80nm. Fiber can be used sausage or PGA fiber. In particular, medical lines or used medical dressings. The nano-silver antibacterial line and bandages have long-lasting and broad-spectrum antibacterial activity, non-toxic, non-stimulating, security features applicable to a variety of medical uses.

The invention relates to a cultivating method of healthcare cassia seed contained coprinus comatus. The cultivating medium is prepared by components: by weight, 50-60 parts of cornstalk, 30-40 parts of cottonseed hull, 5-10 parts of rice bran, 10-15 parts of potato powder, 1-2 parts of land plaster, 1-2 parts bagasse, 0.2-0.3 part of calcium carbonate, 2-3 parts of quick lime, 1-2 parts of sealwort powder, 1-3 parts of immature bitter orange powder, 1-2 parts of radix angelicae powder, 1-2 parts of cassia seed powder, 1-3 parts of caragana microphylia flower, 1-3 parts of momordica grosenori leaves, 2-3 parts of sepiolite powder, and 8-10 parts of bone soup. The cultivating method includes mixing the components according to proportion, adding water to mix, bagging, sterilizing, inoculating, growing fungus in a growing room, replenishing nutrient solution and fruiting to obtain coprinus comatus. The coprinus comatus cultivated is rich in nutrients, high in content of microelements, vitamins and calcium, has healthcare function of the cassia seeds, and is high in anti-infection ability and yield during fruiting of the coprinus comatus.

The invention discloses a nano-silver porous silicone rubber/polyurethane-containing double-layer artificial skin and a preparation method thereof. The nano-silver porous silicone rubber/polyurethane-containing double-layer artificial skin is characterized in that the artificial skin contains a dermis and epidermis double-layer structure; a dermis layer is prepared from loose porous polyurethane; an epidermis layer is prepared from antibacterial agent-containing silicone rubber. A preparation method of the dermis layer comprises the following steps: dissolving the polyurethane, adding a pore-foaming agent, defoaming, carrying out curtain coating so as to form a film, volatilizing a solvent, soaking so as to leach out the pore-foaming agent, and drying so as to obtain a porous polyurethane film. A preparation method of the epidermis layer comprises the following steps: dissolving a silicone rubber precursor, carrying out ultrasonic dispersion on a nano-silver solution, adding the pore-foaming agent, defoaming, carrying out blade coating or curtain coating so as to form a film, volatilizing a solvent, curing so as to obtain an embryonic film, soaking so as to leach out the pore-foaming agent, and drying so as to obtain a silicone rubber microporous film. The preparation method of the double-layer artificial skin comprises the following steps: coating the polyurethane film with polyvinyl alcohol, acid liquor and a crosslinking agent, then covering the polyurethane film by using the silicone rubber film, volatilizing a solvent, and carrying out heat treatment so as to obtain the double-layer artificial skin. The nano-silver porous silicone rubber/polyurethane-containing double-layer artificial skin has the effects of water resistance, air permeability, bacterial inhibition, virus killing and effective absorption of hydrops.

The invention relates to an anti-infection bio-derived hernia and body wall repair material, a preparation and an application thereof, the repair material comprises a small intestinal submucosal acellular matrix (SIS) with the thickness of 80mu m-100mu m and nano-silver particles which are implanted in the SIS. The preparation method comprises the steps of preparing the nano-silver particles into working solution with the concentration of 50ppm-500ppm, carrying out flat immersion into the SIS under the conditions that the volume ratio of working solution/SIS is 100-120:1, the temperature is 37 DEG C and the CO2 concentration is 5% and turning over the SIS at 1 time/30 minutes, thereby obtaining the nano-silver SIS. The repair material has the advantages of safety, no toxicity, anti-infection property, high tissue affinity, absorbability, rapid tissue regeneration, light adhesion, low hernia recurrence rate and the like, the anti-infection property is characterized by high efficiency, durability, broad antibacterial spectrum, no drug resistance and the like, and the composite material can be applied in repair of body wall wounds, fascial defects or hernia accompanied with contamination or infection.

The invention discloses a controlled degradable surgical suture thread and a fabricating method thereof. The innermost part is chitosan fiber core, the middle part is collagen layer, and the outermost part is ethyloic-chitosan layer. From innermost to outermost, the thickness ratio of each layer is 2:X:(3-X), wherein X is larger than 1 and smaller than 3. The value of X is related to degradation velocity of the surgical suture thread: the larger the value, the faster the degradation velocity of the surgical suture thread, and the shorter the healing period of wound suitable to be sutured; andthe smaller the value, the slower the degradation velocity of the surgical suture thread, and the longer the healing period of wound suitable to be sutured. The fabricating method of the surgical suture thread comprises: (1) preparing chitosan fiber core and collagen; (2) covering a layer of collagen outside the chitosan fiber; (3) covering a layer of ethyloic-chitosan outside the collagen cover of the chitosan fiber; (4) processing and polishing the suture thread prepared in (3) by an automatic coreless grinder, connecting with suture needles of different models to prepare into a finish product of surgical suture thread. The technical scheme of the invention has plentiful advantages: controllable degradation velocity, high tension strength, improved biocompatibility and anti-infectious property, quick wound healing, no obvious scars, good biocompatibility, etc.

The invention relates to a medical article, and mainly relates to a chitosan fluid dressing film for accelerating wound healing for skin burn, trauma, and body surface ulcers, and infection treatment. The chitosan fluid dressing film is prepared by using chitosan as a main raw material; the chitosan is dissolved with acids, and mixed with gelatin fully swelled in water; then glycerin and a silver salt solution are added; under the action of ultrasonic wave, simple substance silver exists in the fluid in a form of nanometer colloidal silver so as to obtain nanometer silver sol. The dressing film of the invention adopts chitosan as a main raw material, has wide-spectrum antibacterial properties, and can be used as dressing for skin modification and skin wound. A lot of -NH2 and -OH are contained in the molecules, which can form cage-shaped molecules with a structure like a net with metal ions through hydrogen bonds, and thus stable coordination is provided for silver ions. Chitosan adsorbed with silver ions has more effective bactericidal effect.

The invention relates to a method for preparing a biological polysaccharide self-assembly modificatory chitosan antibacterial biological material, which is characterized by comprising the following steps: (1) preparing a lentinan derivant, i.e. lentinan sulfate; (2) preparing a chitosan membrane base material; (3) preparing a lentinan sulfate solution and a chitosan solution; and (4) carrying outlayer-by-layer self-assembly of the lentinan sulfate and the chitosan on the surface of the base material: respectively carrying out alternative self-assembly on the chitosan membrane base material in the lentinan sulfate solution and the chitosan solution for 5 times to obtain a surface layer-by-layer self-assembly modificatory chitosan mebrane containing 5 bilayers with the outermost layer of the lentinan sulfate, washing and drying to obtain the biological polysaccharide self-assembly modificatory chitosan antibacterial biological material. The chitosan antibacterial biological material prepared by the method has excellent antibacterial activity; and the method has simple preparation process, easy control, mild preparation conditions and low cost.

The invention provides a drug dressing for the burn treatment and a preparing method thereof. The drug dressing comprises the following bulk drugs calculated according to the parts by weight: each 0.6 to 1.5 parts of arnebia root, sanquisorba root, Chinese goldthread, pangolin, dark plum, Chinese gall, giant knotweed, coptis root, corktree bark, dahurian angelica, hyacinth bletilla, bornel, burnt hair and Vaseline, and 1.5 to 2.5 parts of dragon's blood resin; the drug dressing also comprises 20 to 60 parts of vegetable oil calculated according to the parts by weight; the method comprises the following steps that: the pangolin, the bornel, the burnt hair and the dragon's blood resin are ground into four drug powder; the other bulk drugs and the vegetable oil are put into an oil bath to be heated, the other bulk drugs are fired with a slow fire until golden, gruffs are fished out, and then drug oil is achieved; when the drug oil is cooled, the four drug powder are mixed into the drug oil, and is stirred uniformly. The dressing can create a moist and germfree local environment for the wounded area, and has the remarkable advantages that the anti-infection effect is good and the healing of wound surface is quick, so as to be applicable for military first aids, primary hospitals and families.

The invention discloses a keratoprosthesis. The keratoprosthesis has antibacterial activity. The keratoprosthesis comprises a porous peripheral support part and an optical center part. The porous peripheral support part comprises an antibacterial chitosan derivative, polyvinyl alcohol and a nano-phosphate. The optical center part comprises polyvinyl alcohol hydrogel and hydroxyethyl methacrylate hydrogel. The invention also discloses a preparation method of the keratoprosthesis. The keratoprosthesis has good biocompatibility and infection resistance and can promote fast healing of surgical wounds.

The invention discloses a high-efficiency hair care cosmetic and a preparation method thereof, and belongs to the technical field of cosmetic preparation. The cosmetic comprises the following main raw materials: humifuse euphorbia herb, shrubalthea bark, Polygonum aviculare, radix ligustici sinensis, phellodendron bark, Mangnolia officinalis, chrysanthemum flower, gardenia, catechu, chaulmoogra, Cyrtomium fortunei, radix ampelopsis, stemona, pomegranate rind, morning glory seed, southernwood, dark plum, pasqueflower, Lemna minor, tea bran, lysozyme, sericin, hydroxylated soybean lecithin, polyoxyethylene fatty acid ester and modified chitosan. The hair care cosmetic disclosed by the invention has high efficiency and safety, has a remarkable hair care effect, has the favorable effects of sterilization, bacterium resistance and itching relief, improves the infection resistance of hair, can effectively prevent and control phenomena such as head louse appearance and the like on the hair, and exerts favorable hair care action, thereby being worthy of popularization and application.

The invention relates to the technical field of medical dressing, and specifically relates to an external medical dressing for first aid of burns and a preparation method thereof. The medical dressing comprises the following raw materials in parts by weight: 40 to 50 parts of chitosan quaternary ammonium salt, 25 to 35 parts of indigo naturalis powder, 8 to 12 parts of humectant, 3 to 7 parts of bletilla striata extract, 3 to 7 parts of garden burnet extract, and 3 to 7 parts of Japanese eupatorium extract. The provided medical dressing can rapidly stop bleeding, relieve pains, protect wounds, and eliminate scars, at the same time, is capable of inhibiting the growth of bacteria, and can be well attached on the wounds. Moreover, the medical dressing can relieve wound pains, control local infection, maintain the moisture of skins of wounds, protect skins, promote wound healing, and prevent scar formation, and is capable of being widely applied to rapid hemostasis, moisture retention, emergency, and treatment of burns and prevention of scar formation.

The invention provides a wound repair composition. A formula of the wound repair composition comprises the following components in percentage by weight: 10-50 percent of chitosan mucilage, 10-50 percent of an extracting solution of a staphylococcus aureus metabolic product and 0-80 percent of medicament auxiliary materials, wherein the chitosan mucilage is a solution consisting of chitosan and an aqueous solution of an acid; the volume concentration of the acid in the aqueous solution of the acid is 0.8-1.2 percent; and the mass concentration of the chitosan in the chitosan mucilage is 1-3 percent. The invention further provides a preparation method of the wound repair composition and an application thereof as a medicament for treating skin or mucosal injure. The wound repair composition provided by the invention has the advantages of capabilities of promoting tissue repair, promoting wound healing and promoting the growth of epidermal cells, good infection inhibiting effect, high biocompatibility, realization of flat healed wounds, freeness from adverse side reactions, relieving in patient pain, convenience for nursing and using, easiness for storing, and the like.

The invention relates to a preparation method of a silver ion antibacterial medical dressing, and the preparation method comprises the following steps: dyeing, attaching a silver ion antibacterial agent, baking, mixing with viscose, weaving, slitting peritoneum, and preparing patch. Compared with similar products, the product has stronger infection resistance, can be used for remarkably accelerating wound healing, shortening the course of treatment and reducing the formation of scars. Clinical application proves that the silver ion antibacterial medical dressing is applicable to treatment of I-type, II-type and III-type cuts after an operation, has the advantages of safety, reliability, efficiency, no allergy occurrence and the like, and is suitable for clinical popularization and application.

The invention provides an anti-infective medical polymer material, comprising 100 dose of heat curable silicone rubber, 2.5 to 15 dose of Na-montmorillonite, 0.75 to 6.2 dose of quaternary ammonium salt intercalation compounds, 0.3 to 5.6 doses of antibiotics. Preparation method of the materials is: convert the montmorillonite clay to Na-montmorillonite, and then intercalate quaternary ammonium salts to montmorillonite to obtain the organic-montmorillonite with anti-infective drugs attached to it, and compound with heat curable silicone rubber at last. The material has a long anti-infection time, good physical and mechanical properties, and not easy to age. It can be used in the preparation of various medical catheters, such as catheters, deep venous catheters, drainage tubes, trachea intubation and so on.

The invention relates to ainsliaea fragrans champ caffeoylquinic acid extracts and preparation and application thereof. The ainsliaea fragrans champ caffeoylquinic acid extracts are prepared by the following steps of: performing refluxing extraction of the ainsliaea fragrans champ by using ethanol, filtering, concentrating and removing ethanol, adjusting the pH value to 1 to 3 by adding hydrochloric acid, applying macroporous adsorbent resin, water-washing, adding ethanol for gradient elution, and collecting eluent, of which the ethanol concentration is 50 to 70 percent; performing condensation and ethanol removal, adjusting the pH value to 1 to 3 by adding hydrochloric acid, using macroporous adsorbent resin, adding water and ethanol for gradient elution respectively, and collecting the eluent, of which the ethanol concentration is 40 to 70 percent; mixing the eluent, and vacuum drying the eluent to obtain the extracts. The UV content of the ainsliaea fragrans champ caffeoylquinic acid extracts is over 70 percent, the HPLC content is over 50 percent, and the content of 3-caffeoylquinic acid and the content of 3,5-dicaffeoylquinic acid are both over 10 percent. The ainsliaea fragrans champ caffeoylquinic acid extracts have the effects of resisting inflammations, bacteria, medicament-resistant strains, well improves pathologically changed tissues of rat suffering from cervicitis, obviously reduces the uterus index and the number of leukocytes and can be independently prepared into the medicaments for treating cervicitis or combined with other medicaments to prepare the medicaments for treating cervicitis.

The invention discloses a phallic allogeneic accellular patch thickening and lengthening surgery. The surgery comprises the following steps that a V-shaped incision with the length of 4.0 cm is incised from the middle of the symphysis pubis to the two sides of the base of the penis, the skin and the subcutaneous tissue are sequentially incised, blunt dissection is performed to enable the penis, the shallow suspensory ligaments and the deep suspensory ligaments to be completely exposed, and an electrotome is utilized to transversely and downwards incise all the shallow suspensory ligaments and the deep suspensory ligaments to the crural penis; strict blood stopping is performed, a deep wound is washed with a gentamicin aqueous solution and sutured with a NO.7 suture in the mode of double number eight, the superficial fascia is longitudinally and closely sutured with a NO.4 suture, and the subcutaneous tissue and the skin are interruptedly sutured with a NO.1 suture. The phallic allogeneic accellular patch thickening and lengthening surgery has the advantages of being little in surgical trauma, short in surgical time, safe, painless, little in bleeding, rapid in postoperative recovery, high in anti-infection ability and ideal in treatment effect.

The present invention discloses a feed additive for improving the anti-stress ability of livestock and poultry, and a preparation and a use method thereof. The feed additive comprises the following ingredients by weight: 1-5 parts of vitamin C, 10-15 parts of manyprickle acathopanax root, 5-10 parts of silktree albizia bark, 5-12 parts of common anemarrhena rhizome, 4-10 parts of glossy privet fruit, 6-15 parts of baikal skullcap root, 4-10 parts of tree peony root-bark and 4-10 parts of common andrographis herb. According to the present invention, the feed additive for improving the anti-stress ability of livestock and poultry uses a plurality of Chinese herbal ingredients to compound with vitamin C, significantly enhances the immunity, disease resistance and anti-stress ability of livestock and poultry, regulates the excitement of central nervous system, enhances the resistance of livestock and poultry to stress environment and living environment, and increases the appetite of livestock and poultry and the feed conversion ratio. The feed additive for improving the anti-stress ability of livestock and poultry has characteristics that the feed additive has no drug residue, no drug resistance, no pollution, no toxic side effects, and is safe and reliable; and the feed additive can be prepared from raw materials from extensive sources, is simple and feasible in preparation method, low in cost, convenient to use and high in bioavailability, and has wide application prospects.

The invention discloses a specific ointment for treating chilblain, which comprises the following components in part by weight: 10 to 25 parts of Szechuan lovage rhizome, 15 to 25 parts of camphor, 5 to 15 parts of borneol, 15 to 30 parts of prepared common monkshood daughter root, 5 to 10 parts of cassia bark, 10 to 32 parts of Sinkiang arnebia root, 1,000 to 2,500 parts of sesame oil, 5 to 15 parts of root of red-rooted salvia, 12 to 26 parts of aloe vera gel, 10 to 25 parts of safflower, 15 to 25 parts of notoginseng root, 10 to 20 parts of nutgrass galingale rhizome and 60 to 100 parts of yellow wax. The specific ointment has low medicinal cost, is wide in raw material sources, contains high-energy components for activating blood and dissolving stasis, can effectively improve microcirculation, increase epidermal metabolism, expand blood vessels and release cold, can relieve the swelling, fever and pruritus symptoms of skin suffering from the chilblain, has the effects of converging, diminishing inflammation and relieving pain, can clear fester, detoxify and promote tissue regeneration when applied to a wound, has good anti-infection effect and a short treatment period, does not cause pain, and greatly improves the cure rate of patients with the chilblain; and color lump spots or atrophic scars are not left on the skin after the chilblain is cured, and the chilblain cannot be relapsed after being cured.

The invention relates to a method for cultivating rhodiola rosea bag material healthcare pleurotus nebrodensis. A cultivation medium is prepared by, by weight, 20-30 parts of lotus seed hulls, 20-30 parts of cotton stalks, 10-20 parts of sesame stalks, 8-10 parts of bran, 5-6 parts of casava powder, 0.8-1.1 parts of white sugar, 4-5 parts of vinegar residues, 0.5-0.8 part of silkworm excrement, 1-2 parts of salvia miltiorrhizae powder, 2-3 parts of Japanese metaplexis pericarp powder, 1-3 parts of pepper leaf powder, 1-2 parts of rhodiola rosea powder, 2-3 parts of red pine leaf powder, 2-3 parts of Kangxian flower powder, 1-2 parts of bentonite, 1-2 parts of gypsum powder, 2-3 parts of quicklime, 0.2-0.3 part of urea and 10-12 parts of bone soup. The method includes mixing the components according to a proportion, adding water, well mixing, bagging, sterilizing, grafting, producing bacteria in a bacterium producing chamber, replenishing nutrient solution and fruiting pleurotus nebrodensis. The pleurotus nebrodensis cultivated by the method is nutrient-rich and high in content of trace elements, vitamins and calcium and has a rhodiola rosea bag material healthcare function, anti-infection capability is high during pleurotus nebrodensis fruiting, and pleurotus nebrodensis yield is high.

The invention discloses a complex probiotic preparation for treating autistic patients, comprising Lactobacillus helveticus or Lactobacillus fermentum, and a complex microbial preparation containing the Lactobacillus helveticus and Lactobacillus fermentum. The complex probiotic preparation for treating autistic patients has the advantages that: the intervention of JF lactic acid bacteria can remarkably improve the autism symptom and the gastrointestinal symptom of the autistic patient; the bacterial flora structure of the patient can be corrected to be close to that of the normal children, andcan help patients build microbes-Intestine-axonal normal functions. The complex probiotic preparation for treating autistic patients can restore the balance between excitability and inhibition of nervous system, and can significantly improve the immune system function of patients, significantly enhance the ability of patients to fight infection.

The invention relates to a compound biological patch and a preparation method thereof. The compound biological patch comprises a macromolecular material layer and a lower matrix material layer of a mucous membrane of small intestines, wherein the macromolecular material layer comprises a macromolecular material with mesh structures, and the lower matrix material layer of the mucous membrane of the small intestines comprises collagenous fibers and growth factors. By fusing the macromolecular material with animal tissues, the compound biological patch has relatively high mechanical properties, and the animal source portion retains a natural ECM three-dimensional structure, so that the compound biological patch is low in immunogenicity and strong in anti-infection ability.

The invention relates to the technical field of livestock and poultry culture, and concretely relates to an antimicrobial-free laying hen feed. The feed comprises 61.0-65.0% of corn, 16.0-30.0% of soybean meal, 0.0-4.0% of rapeseed meal, 2.0-12.0% of wheat bran, 1.0-8.0% of stone flour, 0.0-1.0% of soybean oil and 1-2% of a premix. The feed containing no antibiotic drugs allows eggs laid by laying hens eating the feed to have no residual problem, so the production safety of the laying hens is guaranteed; and a thyme extract product added in the invention contains various vitamins and mineral elements, such as Mn, Cu, Fe, K, Zn, Ca, Mg, P, vitamin A, vitamin C, vitamin E and carotene, so the feed can prevent Staphylococcus aureus, Bacillus subtilis, Escherichia coli and other pathogens, and has very good bacterium and fungus infection prevention effects.

The invention relates to the field of animal medicines, and particularly provides a Chinese medicine composition for stopping bleeding of sawing antler, a preparation method and application thereof. The Chinese medicine composition for stopping bleeding of sawing antler is mainly prepared from the following various raw materials in parts by mass: 32 to 37 parts of herba agrimoniae, 17 to 22 partsof rhizoma bletillae, 7 to 12 parts of radix notoginseng, 7 to 12 parts of Chinese arborvitae twig, 7 to 12 parts of pollen typhae, 7 to 12 parts of radix sanguisorbae and 4 to 6 parts of camphol. According to the Chinese medicine composition for stopping bleeding of sawing antler, rich traditional Chinese medicine resources and the characteristics of easiness for availability of the traditional Chinese medicines, low cost, greenness, no residues and the like are utilized, through a traditional theory of traditional Chinese medicine, rules of assistance and guide of monarch and minister medicines, dialectical treatment and mutual generation and restriction are conformed, and the characteristics of variety of the traditional herbal medicine components and complexity of the functions are used, and the compatibility is reasonable, so that the obtained Chinese medicine composition for stopping bleeding of sawing antler has the effects of quickly stopping bleeding and resisting bacteria andeliminating inflammation and also no side effect.