Anti-infection bio-derived hernia and body wall repair material, preparation and application thereof

Abstract

The invention relates to an anti-infection bio-derived hernia and body wall repair material, a preparation and an application thereof, the repair material comprises a small intestinal submucosal acellular matrix (SIS) with the thickness of 80mu m-100mu m and nano-silver particles which are implanted in the SIS. The preparation method comprises the steps of preparing the nano-silver particles into working solution with the concentration of 50ppm-500ppm, carrying out flat immersion into the SIS under the conditions that the volume ratio of working solution / SIS is 100-120:1, the temperature is 37 DEG C and the CO2 concentration is 5% and turning over the SIS at 1 time / 30 minutes, thereby obtaining the nano-silver SIS. The repair material has the advantages of safety, no toxicity, anti-infection property, high tissue affinity, absorbability, rapid tissue regeneration, light adhesion, low hernia recurrence rate and the like, the anti-infection property is characterized by high efficiency, durability, broad antibacterial spectrum, no drug resistance and the like, and the composite material can be applied in repair of body wall wounds, fascial defects or hernia accompanied with contamination or infection.

Description

technical field [0001] The invention relates to the hernia and body wall repair material and its preparation and application fields, in particular to an anti-infection biologically derived hernia and body wall repair material as well as its preparation and application. Background technique [0002] In major disasters, the critically wounded are prone to "abdominal compartment syndrome (ACS)". It is difficult to close the abdomen after the initial laparotomy, and the abdominal cavity needs to be closed with repair materials. In the later stage, many wounded are prone to huge incisional hernias, and more suitable artificial materials are needed for repair. In addition, abdominal wall defects are also a common type of trauma in modern warfare. These defects are all accompanied by pollution, and some of them have been seriously infected. At present, there are repair materials in China including silicone membrane, polyester, polypropylene, expanded polytetrafluoroethylene and Com...

AI Technical Summary

Problems solved by technology

However, foreign studies have also found that the failure rate of bio-derived materials in the repair of contaminated or potentially infected abdominal wall defects is >50%.

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