Anti-infection bio-derived hernia and body wall repair material, preparation and application thereof

A repair material and hernia-derived technology, applied in medical science, surgery, etc., to achieve high tissue affinity, fast tissue regeneration, and light adhesion

Inactive Publication Date: 2010-01-13
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, foreign studies have also found that the failure rate of bio-derived material

Method used

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  • Anti-infection bio-derived hernia and body wall repair material, preparation and application thereof
  • Anti-infection bio-derived hernia and body wall repair material, preparation and application thereof
  • Anti-infection bio-derived hernia and body wall repair material, preparation and application thereof

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Embodiment Construction

[0036] Below in conjunction with specific embodiment, further illustrate the present invention. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that after reading the teachings of the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by the appended claims of the present application.

[0037] 1. Preparation of pig small intestinal submucosa-derived biological abdominal wall repair material SIS by using the Abraham method

[0038] The specific process is as follows:

[0039] The first step of mechanical treatment

[0040] ① Necessary medicines

[0041] Peracetic acid, sodium azide, phosphate buffer solution (PBS), ethanol, deionized water.

[0042] ② preparation

[0043] (1) Select a section of fresh porc...

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Abstract

The invention relates to an anti-infection bio-derived hernia and body wall repair material, a preparation and an application thereof, the repair material comprises a small intestinal submucosal acellular matrix (SIS) with the thickness of 80mu m-100mu m and nano-silver particles which are implanted in the SIS. The preparation method comprises the steps of preparing the nano-silver particles into working solution with the concentration of 50ppm-500ppm, carrying out flat immersion into the SIS under the conditions that the volume ratio of working solution/SIS is 100-120:1, the temperature is 37 DEG C and the CO2 concentration is 5% and turning over the SIS at 1 time/30 minutes, thereby obtaining the nano-silver SIS. The repair material has the advantages of safety, no toxicity, anti-infection property, high tissue affinity, absorbability, rapid tissue regeneration, light adhesion, low hernia recurrence rate and the like, the anti-infection property is characterized by high efficiency, durability, broad antibacterial spectrum, no drug resistance and the like, and the composite material can be applied in repair of body wall wounds, fascial defects or hernia accompanied with contamination or infection.

Description

technical field [0001] The invention relates to the hernia and body wall repair material and its preparation and application fields, in particular to an anti-infection biologically derived hernia and body wall repair material as well as its preparation and application. Background technique [0002] In major disasters, the critically wounded are prone to "abdominal compartment syndrome (ACS)". It is difficult to close the abdomen after the initial laparotomy, and the abdominal cavity needs to be closed with repair materials. In the later stage, many wounded are prone to huge incisional hernias, and more suitable artificial materials are needed for repair. In addition, abdominal wall defects are also a common type of trauma in modern warfare. These defects are all accompanied by pollution, and some of them have been seriously infected. At present, there are repair materials in China including silicone membrane, polyester, polypropylene, expanded polytetrafluoroethylene and Com...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/16A61L31/02
Inventor 张剑王强颜荣林王妍妍周海洋王毅阮灿平
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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