Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Dairy cow breast injection gel and preparation method thereof

A gel and breast technology, which is applied in the field of cow breast injection gel and its preparation, can solve the problems of low tissue adhesion of liquid medicine, easy dripping and outflow of liquid medicine, poor treatment effect, etc., and achieve easy dispersion and diffusion, high tissue affinity, and easy industrial production

Inactive Publication Date: 2017-12-08
FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, penicillin is often used for treatment, but the effect is not significant, and it has caused great losses to production
[0003] At present, most of the pharmaceutical preparations for the treatment of dairy cow mastitis are suspensions, which are divided into water suspension and oil suspension preparations. The stability of these two dosage forms is relatively poor when stored in a breast injector that is convenient for clinical use. , and the tissue adhesion of the medicinal liquid injected into the breast tissue is low (water suspension is more serious), and the medicinal liquid is easy to drip and flow out, resulting in poor therapeutic effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dairy cow breast injection gel and preparation method thereof
  • Dairy cow breast injection gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0024] On the basis of the dairy cow udder injection gel provided by the above embodiments of the present invention, the embodiment of the present invention further provides a preparation method of the above dairy cow udder injection gel. see figure 1 , figure 1 It is a flowchart of a method for preparing a milk cow udder injection gel according to an embodiment of the present invention. As shown in the figure, the preparation method of the embodiment of the present invention includes the following steps:

[0025] S11: Weighing 0.5-5 parts of antioxidant and 0.1-3 parts of wetting agent respectively and adding them to 46-92.79 parts of dispersion carrier, stirring until dissolved to form a first mixed solution;

[0026] Wherein, the dispersion carrier of the embodiment of the present invention can be selected from soybean oil for injection, tea oil for injection, corn oil for injection, olive oil for injection, ethyl oleate, medium chain triglyceride, cottonseed oil, caprylic...

Embodiment 1

[0041] Weigh 1 part of vitamin E oil + propyl gallate (antioxidant) and 2 parts of Tween-80 (wetting agent) and add it to 70 parts of soybean oil for injection + medium chain triglycerides + cottonseed oil (dispersion carrier), stir until dissolved to form the first mixed solution, add 10 parts of amoxicillin, 2 parts of sulbactam, 0.4 parts of prednisolone, 1 part of lysozyme and 0.3 parts of 1 part of epidermal growth factor, stirred evenly to form a second mixed solution, heated to 42° C., added 7 parts of poloxamer 407 (gel material) and stirred evenly to obtain a cow udder injection gel.

Embodiment 2

[0043] Weigh 5 parts of butyl hydroxyanisole (antioxidant) and 0.5 parts of Span-60+propylene glycol (wetting agent) respectively and add it to 80 parts of corn oil for injection+caprylyl capric acid glyceride (dispersion carrier ), stir until dissolved to form the first mixed solution, add 7 parts of amoxicillin, 1 part of sulbactam, 0.1 part of prednisolone, 3 parts of lysozyme and 0.6 part of epidermal growth factor to the first mixed solution , Stir evenly to form a second mixed solution, heat the second mixed solution to 45° C., add 5 parts of polylactic acid-glycolic acid copolymer+chitosan (gel material) and stir evenly to obtain a cow udder injection gel.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a dairy cow breast injection gel and a preparation method thereof. The dairy cow breast injection gel disclosed by the invention is prepared from the main components of amoxicillin, sulbactam, prednisolone, epidermal growth factors, lysozyme and the like through reasonable matching. The gel disclosed by the invention is a semi-solid that hardly flows at the normal temperature. After being injected into the body of a dairy cow, the gel becomes liquid because of temperature increase, and an added adjuvant has strong lipotropism and high tissue affinity, so as to facilitate drug dispersion and diffusion, and the therapeutic effect is good.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a milk cow udder injection gel and a preparation method thereof. Background technique [0002] In recent years, dairy cow mastitis is the most common disease of dairy cows and one of the diseases that cause the most serious economic losses in the dairy industry, and it is extremely harmful to the dairy farming industry. There are hundreds of millions of dairy cows in the world, and about one-third of them suffer from various types of udder diseases, which lead to changes in milk quality. The incidence of mastitis in dairy cows is generally high in the world, about 5% to 45%, and the economic loss caused by mastitis is as high as 35 billion US dollars every year. Mastitis not only causes a decrease in milk production, but also changes in milk quality. In severe cases, the lactation function is completely lost. There are many kinds of pathogenic microorganisms that cau...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/47A61K9/06A61P15/14A61K38/18A61K31/43A61K31/573
Inventor 焦晓军周淑贞谢志恒孙迎陈静虹
Owner FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com