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178 results about "Tissue Adhesion" patented technology

A fibrinous or fibrous connection between two surfaces or tissues, connecting tissues or organs that are not normally attached.

Perianal drug dressing made of multi-layer diversion composite fabric, preparation method and application of perianal drug dressing

The invention relates to the technical field of medical dressings, in particular to a perianal drug dressing of a multi-layer flow guide composite fabric and a preparation method and application of the perianal drug dressing of the multi-layer flow guide composite fabric. The perianal drug dressing is of a four-layer structure, a wet tissue adhesion layer is made of polydopamine modified chitosan / oxidized hyaluronic acid hydrogel, and wet-state adhesion is achieved; the drug sustained-release layer is used for dispersing mesoporous silica loaded with ciprofloxacin hydrochloride / defensin and chitosan microspheres loaded with epidermal growth factors / lonicera japonica into a polycaprolactone fiber membrane to achieve synergistic antibacterial and healing promotion; the directional flow guide layer is of a gradient wettability sandwich structure with a bionic micro-channel, and one-way rapid drainage can be achieved; the high-absorption outer layer is carboxymethyl cellulose / sodium polyacrylate composite sponge, liquid is locked efficiently, the wound surface is kept dry and comfortable, the clinical problem in perianal infection wound treatment can be effectively solved, and the treatment effect and the patient comfort are remarkably improved.
Owner:ZHUHAI JIANLANG DAILY NECESSITIES CO LTD

Double-crosslinking hydrogel loaded with stem cell exosome as well as preparation and application of double-crosslinking hydrogel

The invention relates to the technical field of biomedicine, in particular to stem cell exosome-loaded bi-crosslinked hydrogel as well as preparation and application thereof, and the bi-crosslinked hydrogel comprises the following components in parts by weight: 50-90 parts of a matrix polymer; 0.1 to 5 parts of an active load; 1 to 10 parts of cyclodextrin; 5 to 20 parts of modified chitosan; 0.01 to 1 part of a photoinitiator; and 0.01 to 0.5 part of growth factors. Through double-network design of physical / chemical primary cross-linking and photo-initiation secondary cross-linking, the bottleneck that the mechanical property and the machinability of the traditional single cross-linking hydrogel are difficult to consider at the same time is overcome; meanwhile, the human umbilical vein endothelial cell exosome is introduced, and efficient loading, uniform dispersion and degradation coupling slow release of the exosome are realized by virtue of beta-cyclodextrin inclusion and a double-crosslinking network. Therefore, the problems of mechanics, degradation, cross-linking speed or tissue adhesion of cross-linked hydrogel in the prior art are solved.
Owner:BEIJING UNIV OF CHEM TECH

Composite hydrogel bio-ink with function of space-time delivery of double growth factors as well as preparation method and application of composite hydrogel bio-ink

The invention discloses composite hydrogel bio-ink with a function of space-time delivery of double growth factors as well as a preparation method and application of the composite hydrogel bio-ink, and belongs to the technical field of biomedical materials and tissue engineering. According to the preparation method, imidazolyl-modified methacrylated gelatin and double-bonded PF127 are compounded, and meanwhile, free vascular endothelial growth factors and connective tissue growth factor-loaded PLGA microspheres are entrapped in a system, so that the bio-ink with excellent printability, high adhesion, swelling resistance and space-time delivery function is formed; the bio-ink physically has the advantages of high printing fidelity, low swelling property, high mechanical strength and strong tissue adhesion of a synthetic material; in biology, the system can be used as an intelligent carrier to realize programmed space-time delivery of various growth factors, so that complex cell biological behaviors are accurately arranged, and real regeneration of functional tissues is guided.
Owner:XI AN JIAOTONG UNIV

Seawater soaking wound hydrogel dressing as well as preparation method and application thereof

PendingCN121796672ABroad spectrum antibacterialHas inflammation regulationBandagesWound carePharmaceutical Substances
The invention provides a seawater soaking wound hydrogel dressing and a preparation method thereof, a drug-loaded nano system 4OI (at) ZIF-8 (at) PAD with a core-shell structure is constructed, an anti-inflammatory drug 4-octyl itaconic acid and zinc ions are jointly encapsulated in a ZIF-8 framework, and a polydopamine coating is wrapped, so that synergistic loading and controllable release of the drug and metal ions are realized. According to the dressing, dopamine modified hyaluronic acid is used as a matrix, a temperature-sensitive material and an enzyme catalysis cross-linking system are combined, stable gel can be rapidly formed in situ within 5 seconds, and the dressing has excellent tissue adhesion performance (the adhesion strength reaches 6.7 kPa). Experiments prove that the hydrogel dressing has the characteristics of broad-spectrum antibiosis, inflammation regulation and control and long-acting release. Animal experiments prove that the healing rate of seawater soaking wounds treated by the dressing on the twelfth day is as high as 95.7% and is remarkably superior to that of a commercial silver ion gel control group, scars are less after healing, and an efficient, safe and easy-to-implement scheme is provided for marine environment wound nursing.
Owner:CHINESE PEOPLES LIBERATION ARMY ARMY SPECIAL MEDICAL CENTER

Biological patch material with dry-state adhesion and wet-state easy stripping characteristics and application thereof

PendingCN121197500ABandagesBurned skinIrritation
The invention discloses a biological patch material with dry-state adhesion and wet-state easy stripping characteristics and application thereof, and belongs to the field of biological medicine. The biological patch material is prepared according to the following steps: by taking water-soluble protein as a template and copper ions in water-soluble copper salt as a metal coordination center, carrying out self-assembly on the template and drug molecules with phenolic hydroxyl structures to form nanoflowers; mixing the acrylamide, the sodium alginate, the water-soluble calcium salt and the nano-flowers to obtain the water-soluble calcium-based water-soluble nano-flower fertilizer. The biological patch material is adhered to the skin through electrostatic interaction, covalent bonds, physical interpenetration and topological tissues. The patch has skin adhesion in a dry state, so that the patch is convenient to fix; after the patch is in contact with burnt skin, the patch absorbs water and swells, the adhesive force is obviously reduced, and painless, easy and non-invasive stripping is realized. In addition, the patch has immunoregulation performance, can prevent stimulation and anaphylaxis caused by long-term contact with the skin, and promotes burn repair.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY

Preparation method and application of dynamic borate bond hydrogel loaded with doxorubicin and alphaOX40 antibody

The invention relates to a preparation method and application of dynamic borate bond hydrogel loaded with adriamycin and an alphaOX40 antibody, and belongs to the technical field of tumors. According to the invention, the dynamic borate bond hydrogel loaded with adriamycin and an alphaOX40 antibody is prepared, and the hydrogel is constructed on the basis of dynamic crosslinking of phenylboronic acid modified hyaluronic acid (HA-PBA) and tannic acid (TA) through a borate bond, and has excellent tissue adhesion and programmed drug release characteristics.
Owner:GUANGDONG INST FOR DRUG CONTROL (GUANGDONG INST FOR DRUG QUALITY GUANGDONG PORT DRUG CONTROL INST)

Injectable adhesive carboxylated chitosan / dialdehyde starch hemostatic hydrogel and application thereof

The invention relates to the field of biomedical materials, and particularly provides injectable adhesive carboxylated chitosan / dialdehyde starch hemostatic hydrogel and application thereof.The hemostatic hydrogel is formed by carboxylated chitosan sol and dialdehyde starch size through Schiff base reaction, hydrogen bond construction and in-situ rapid crosslinking by means of a bidirectional pumping and injecting delivery strategy, and the hemostatic hydrogel is prepared through a two-way pumping and injecting delivery strategy, and the injectable adhesive carboxylated chitosan / dialdehyde starch hemostatic hydrogel is prepared from the carboxylated chitosan sol, the dialdehyde starch size and the injectable adhesive carboxylated chitosan / dialdehyde starch hemostatic hydrogel. The hydrogel has the advantages of good biocompatibility, injectability, adhesion, personalized adaptation and the like, integrates multiple hemostasis mechanisms, a physical barrier effect of rapid gelation, an expansion compression effect of water absorption swelling, an electrical neutralization effect of carboxylated chitosan amino and a tissue adhesion effect of dialdehyde starch aldehyde group, realizes multi-scene rapid and efficient hemostasis, and has a wide application prospect. The preparation method of the injectable adhesive hemostatic hydrogel is low in cost, innovative in technology, mild in condition, convenient to store and beneficial to large-scale batch production, and has a wide application prospect in the field of efficient hemostatic hydrogel.
Owner:LANZHOU UNIV

Manganese-based Prussian blue-polyacrylic acid / polyvinyl alcohol hydrogel for preventing and treating allergic rhinitis

The invention discloses manganese-based Prussian blue-polyacrylic acid / polyvinyl alcohol hydrogel for preventing and treating allergic rhinitis. Monodisperse manganese-based Prussian blue nanoparticles synthesized by taking polyacrylic acid as a template are stably immobilized in a polyacrylic acid / polyvinyl alcohol hydrogel matrix. The obtained composite hydrogel membrane has the following prominent advantages: the composite hydrogel membrane has excellent hydrogel characteristics, including controllable membrane thickness, good tissue adhesion and air permeability; reliable biocompatibility and safety are shown; allergen permeation is effectively blocked through a physical barrier effect; prussian blue is continuously released in the slow-release degradation process, active oxygen free radicals are remarkably removed, and the powerful anti-inflammatory effect is achieved. Due to the synergistic effect of double mechanisms of protection and treatment, the material has important clinical application value and development potential in the fields of prevention and treatment of allergic rhinitis.
Owner:NORTHEAST NORMAL UNIVERSITY

Active composite gel sealing material as well as preparation method and application thereof

The invention discloses an active composite gel sealing material as well as a preparation method and application thereof, and belongs to the technical field of medical materials. The active composite gel sealing material based on multiple crosslinking provided by the invention has excellent tissue adhesion and sealing performance; good in-vivo compatibility, biodegradability, low immunogenicity and high safety are achieved; the mechanical strength is high, the self-repairing capability is good, and the anti-hydrolysis stability is high; the adhesive property and the state of the material can be adjusted by adjusting the proportion of the components and adjusting the adhesive property and the state of the material, so that the requirements on different adhesive properties in practical application are met, irregular wounds are filled, and rapid gelation is performed at the body temperature so as to adapt to the form of a surgical site; the effects of stopping bleeding, resisting inflammation, promoting revascularization and repairing nerves are also achieved.
Owner:UNIV OF SCI & TECH BEIJING

Medical tissue adhesive, medical tissue dry adhesive patch and preparation method and application thereof

The present application relates to the field of medical tissue adhesive, in particular to a medical tissue adhesive, a medical tissue dry adhesive patch and a preparation method and application thereof. The present application provides a medical tissue adhesive, a medical tissue dry adhesive patch and a preparation method and application thereof. The medical tissue adhesive provided by the present application comprises: 1wt%-30wt% of acidic polyglutamic acid; 1wt%-30wt% of spherical protein; and the balance of water. The medical tissue adhesive provided by the present application has high tissue adhesion strength and fast hemostatic sealing speed in a wet physiological environment, meets the requirements of rapid and efficient tissue hemostatic sealing, and can be applied to rapid hemostasis of tissue wounds in a wet physiological environment, sealing of wound liquid leakage, healing and repair of wound tissue, and antibacterial of wounds. Experiments show that the dry adhesive patch made of the adhesive provided by the present application has high tissue adhesion strength in a wet physiological environment, and the adhesion strength to a wet pigskin tissue can reach more than 60kPa.
Owner:CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY CHINESE ACADEMY OF SCIENCES

Adhesive compound with adhesive property optimized based on metal hydroxide as well as preparation method and application of adhesive compound

The invention discloses an adhesive compound with an adhesive property optimized based on metal hydroxides as well as a preparation method and application of the adhesive compound, and belongs to the technical field of biological adhesives. The present invention relates to an adhesive composition comprising an adhesive precursor consisting of a protein-polyphenol composite hydrogel and a hydrogen bond destructive small molecule compound capable of network reconstitution comprising beta-folding formation in aqueous phase grafting comprising a metal hydroxide having the characteristics of: (a) a hydration enthalpy value of from-1000 kJ / mol to-4000 kJ / mol; (b) a dissociation constant of from 6 pKa to 13.5 pKa; (c) a water exchange rate of 105 S <-1 > to 10 < 10 > S <-1 >. The adhesion compound can be networked to form an advanced structure when encountering water, not only can generate underwater lap joint shear strength of more than 1MPa, but also can tolerate underwater long-term soaking and temperature change from-196 DEG C to 100 DEG C, and meanwhile, the adhesion compound also has good biocompatibility, can meet the requirement of the environment in a human body on tissue adhesion safety, and has good application prospects. Stability suitable for in vivo tissue repair and industrial applications is exhibited.
Owner:SICHUAN UNIV +1

Hydrogel for promoting healing of diabetic wound as well as preparation method and application of hydrogel

PendingCN121754719ABandagesArginineNitric oxide
The invention relates to hydrogel for promoting healing of diabetic wounds as well as a preparation method and application of the hydrogel, and belongs to the technical field of hydrogel dressings. The invention discloses an exosome hydrogel, which is characterized in that exosome is loaded in crosslinked aldehyde hyaluronic acid and carboxymethyl chitosan, the aldehyde hyaluronic acid is grafted with L-arginine, and the exosome is derived from bone marrow mesenchymal stem cells. L-arginine can release nitric oxide under the action of a diabetic wound surface or an inflammation microenvironment to achieve the effects of resisting bacteria and promoting wound surface recovery, and the exosome successfully avoids the risks of cell survival defects, vascular embolism, immunological rejection and the like while retaining powerful bioactive components. The product has excellent antibacterial activity, degradability, tissue adhesion, injectable performance and self-repairing performance, and can be suitable for wounds in different shapes.
Owner:SHANDONG UNIV QILU HOSPITAL

Mussel mucin-chondroitin sulfate composite hydrogel as well as preparation method and application thereof

The invention relates to the technical field of medical biological materials, and discloses a mussel mucin-chondroitin sulfate composite hydrogel and a preparation method and application thereof, and the preparation method comprises the following steps: respectively preparing a mussel mucin aqueous solution and a chondroitin sulfate aqueous solution; the mass volume concentration of the mussel mucoprotein aqueous solution is 1%-10%, the mass volume concentration of the chondroitin sulfate aqueous solution is 1%-10%, the mass ratio of the mussel mucoprotein to the chondroitin sulfate is 3: 1-1: 3, the two solutions are mixed and stirred or oscillated under the conditions that the temperature is 4-37 DEG C and the pH value is 7.0-9.0, a cross-linking reaction is conducted, and hydrogel is formed; the cross-linking mode is physical cross-linking, chemical cross-linking or physical-chemical dual cross-linking; according to the invention, excellent tissue adhesion, injectability, self-healing property and biodegradability are realized, cell adhesion and proliferation can be effectively promoted, and the gel is suitable for various medical beauty scenes such as skin filling, wound repairing and anti-aging nursing.
Owner:RUIFUXIN (SUZHOU) MEDICAL TECHNOLOGY CO LTD

Core biopsy needle

ActiveUS12544050B2Surgical adhesivesSurgical needlesAspiration biopsyTissue sample
The invention relates to a core biopsy needle (1) for obtaining a tissue sample comprising a hollow outer needle (10) extending along a longitudinal axis (L), and an inner needle (20), which is at least partially arranged or arrangeable within said outer needle along said longitudinal axis (L), wherein said inner needle (20) comprises at least one tissue-holding surface (21), wherein said tissue-holding surface (21) is adapted such that a tissue (3) adheres to the at least one tissue-holding surface (21), when the core biopsy needle (1) is inserted into the tissue (3).
Owner:UNIVERSITY OF BASEL +1

Preparation and application of a microbial alkaline protein and adhesive proteoglycan hydrogel

The application discloses a kind of preparation and application of microbial basic protein and adhesive proteoglycan hydrogel, belong to the field of biomaterials.Basic protein is extracted from microbial cells in the present application, using supramolecular assembly method, basic protein and acidic polysaccharide electrostatic assembly protein glycan gel material with strong tissue adhesion, the method is simple, widely available, and the cost is almost negligible.The tissue adhesive provided by the present application has immediate tissue adhesion performance, excellent biocompatibility and excellent antibacterial ability and hemostatic performance, which is beneficial to cope with different types of bleeding scene and irregular wound healing.Through cell compatibility and blood compatibility test, the results show that the material has excellent biocompatibility, and the basic protein has super strong bacteriostatic ability, avoids the invasion of foreign bacteria in the wound repair process, and has strong healing ability, greatly shortens the healing period of wound.
Owner:JIANGNAN UNIV

ROS / pH dual response type viscous fiber composite hydrogel as well as preparation and application thereof

PendingCN121265843ABandagesFiberDrug release
The invention relates to ROS (reactive oxygen species) / pH (potential of hydrogen) dual response type viscous fiber composite hydrogel as well as preparation and application thereof, amino-modified zeolite-loaded imidazate skeleton-8 (ZIF-8) nanoparticle short fibers and natural polyphenol drugs are introduced into double-dynamic cross-linked network hydrogel containing boric acid ester bonds and Schiff base bonds, and the ROS / pH dual response type viscous fiber composite hydrogel has ROS and pH response drug / Zn < 2 + > release characteristics; good antibacterial performance and DPPH removing performance are realized. The ZIF-8 / fiber composite hydrogel developed by the invention realizes multiple functions of good tissue viscosity, antibiosis and antioxidation, and can effectively regulate the wound microenvironment and promote the healing of rat diabetes infected wound.
Owner:DONGHUA UNIV

Fish-derived acellular dermal matrix and preparation method therefor

PCT designated stageWO2026054593A1ProsthesisCellular componentBiocompatibility
The present invention relates to: a fish-derived acellular dermal matrix having improved tissue-to-tissue adhesion problems while ensuring biocompatibility by removing cellular components from fish-derived by-products; and a preparation method therefor.
Owner:CG BIO CO LTD

A material for preventing tissue adhesion and hemostasis and a method for preparing the same

The application discloses a material for preventing tissue adhesion and hemostasis and a preparation method thereof, and relates to the technical field of medical biomaterials.The carboxymethyl cellulose, chitosan and vancomycin / ceftazidime are synergistically matched, so that the three functions of hemostasis, adhesion prevention and antibiosis are integrated;meanwhile, the water absorption and gelation of the carboxymethyl cellulose and the blood coagulation activation of the chitosan can jointly strengthen the hemostasis effect; the tissue barrier function of the chitosan and the gel isolation of the carboxymethyl cellulose can jointly improve the adhesion prevention performance; the broad-spectrum antibiosis of the vancomycin and the ceftazidime can respond to the infection risk in different surgical scenes; the material preparation process is simple, the dosage form can be adjusted according to different surgical scenes, the material has good biocompatibility and can be completely degraded, the problem that the existing medical materials have single function and are difficult to meet the needs of complex surgical wounds is solved, and the material has significant clinical application value.
Owner:SHANDONG MIANYITONG MEDICAL TECHNOLOGY CO LTD

Natural-based injectable fiber hydrogel as well as preparation method and application thereof

The invention discloses natural-based injectable fiber hydrogel as well as a preparation method and application thereof, the hydrogel is formed by taking gelatin and natural tea hair as raw materials and carrying out cross-linking reaction on polyphenol substances in the tea hair and gelatin molecules under the action of an oxidation initiator, the hydrogel has excellent biocompatibility, mechanical strength, oxidation resistance, self-healing performance and tissue adhesion performance, and has good injectability, rapid gelation characteristics and the like. The preparation method comprises the following steps: dissolving gelatin in a water phase to form a solution, adding tea hair, uniformly dispersing to form a pre-polymerized solution, adding an oxidation initiator to trigger oxidation of the tea hair, and forming the natural-based injectable fiber hydrogel with the gelatin. The natural-based injectable fiber hydrogel is wide in raw material source, low in cost, simple in process, safe and environmentally friendly, and the prepared natural-based injectable fiber hydrogel has wide application prospects in the biomedical fields of wound repair, bone tissue regeneration and the like.
Owner:YANGZHOU UNIV

Anti-inflammatory and healing-promoting hemostatic powder and preparation method thereof

PendingCN121130149ASurgical adhesivesHEMOSTATIC POWDERPolyvinyl alcohol
The invention provides anti-inflammatory and healing-promoting hemostatic powder and a preparation method thereof. The rapid hemostatic powder is prepared from the following components in percentage by mass: 10 to 15 percent of cannabidiol, 4 to 8 percent of polyvinyl alcohol, 18 to 24 percent of polyacrylamide and the balance of quaternary ammonium salt-based chitosan. All the components are synergistically matched in proper mass percent, so that the effects of good blood compatibility and cell compatibility, fast gelling, high tissue adhesion and rapid hemostasis can be achieved. Meanwhile, the hemostatic powder has the advantages of good inflammation resistance and healing promotion. The hemostatic powder is suitable for accidents, operations and other scenes. In addition, the preparation method of the hemostatic material is simple and easy to implement, does not need to depend on complex processes and equipment, and is convenient for large-scale popularization.
Owner:GUANGDONG YUNZHAO MEDICAL TECH CO LTD

Self-adhesive hydrogel photoelectrodes, arrays, devices, applications, and methods of evaluation

This invention discloses a self-adhesive hydrogel photoelectrode, array, device, application, and evaluation method. The self-adhesive hydrogel photoelectrode comprises a self-adhesive hydrogel optical fiber and at least one flexible fiber electrode. The optical fiber has a core-skin structure; the skin is composed of adhesive polymers such as polyvinyl alcohol, polyacrylic acid, and polydopamine, while the core is a transparent hydrogel. The flexible fiber electrode comprises conductive materials such as graphene oxide, carbon nanotubes, and polypyrrole. The flexible fiber electrode is directly integrated onto the surface of the optical fiber through the adhesion of the fiber skin, forming a heterogeneous structural unit integrating optical transmission and electrical conduction. This technology relies on a dynamic interface bonding mechanism to achieve stable and reconfigurable heterogeneous integration in a humid environment. The device simultaneously possesses low optical loss, high conductivity, strong tissue adhesion, and excellent biocompatibility, making it suitable for implantable neural modulation and signal acquisition, in vitro testing, and interface reliability assessment.
Owner:DONGHUA UNIV

Venous closed radiofrequency ablation assembly

The utility model discloses a vein closure radiofrequency ablation component, including handle, catheter and ablation electrode that connect in proper order, the ablation electrode is provided at the front end of catheter, the rear end of catheter extends to handle rear end and is connected with joint, the inside of catheter is hollow structure, joint and the inside of catheter are communicated and are used for the leading wire to pass through before the operation. The ablation electrode is reliable in structure, simple in structure, stable, reliable and convenient to operate, normal saline is instilled to the ablation electrode in an operation to conduct the electrode tip and the outer tube, low-temperature plasma is generated under excitation of radio-frequency current to ablate varicose blood vessels, meanwhile, the high-resistance metal electrode tip is powered on to emit heat, the blood vessels are secondarily heated, and the ablation effect of the high-resistance metal electrode tip is improved. Compared with a coil type catheter, the ablation temperature is not too high, the ablation range is relatively small, tissues are not prone to adhesion, and the vein ablation closing effect is improved.
Owner:JIANGSU BONSS MEDICAL TECH

Recombinant collagen type iii, hydrogel, preparation method and application

ActiveCN121895437BCelluloseTissue repair
The application discloses recombinant collagen type III, a hydrogel, a preparation method and application, and belongs to the technical field of medical materials. The protein has an amino acid sequence as shown in SEQ ID No. 2 or 3, and has excellent biocompatibility and cell activity. The hydrogel based on the protein is formed by mixing a solution of the protein with a solution containing oxidized sodium alginate and hydroxypropyl methyl cellulose, adjusting pH, sequentially introducing an EDC / NHS crosslinking system and calcium ions, and standing. The process constructs a stable double-network structure of EDC / NHS catalyzed covalent crosslinking network and OSA-Ca 2+ ion crosslinking network synergistic effect. The obtained hydrogel has high mechanical strength, excellent toughness, long-lasting wet tissue adhesion and suitable swelling performance, can effectively adapt to the complex stress changes of dynamic wounds, and provides an active matrix for cells, and promotes tissue repair.
Owner:SHANDONG YITENON BIOTECHNOLOGY CO LTD

Levan-catechol composite, and tissue adhesion composition and nanocluster including same

The present invention relates to a levan-catechol composite, and a tissue adhesion composition and nanocluster, including same. In particular, the levan-catechol composite is prepared by the conjugation of levan and catechol and is applicable, by hydrogelation or nanoclustering thereof, for use in tissue adhesion in wet environments, wound healing, hemostasis, or drug delivery.
Owner:POSTECH ACADEMY INDUSTRY FOUNDATION +1

Surgical robot OCT (optical coherence tomography) guided anterior retinal membrane self-adaptive stripping system

The invention relates to the technical field of medical robots and intelligent surgical equipment, and particularly discloses a surgical robot OCT (optical coherence tomography) guided anterior retinal membrane self-adaptive stripping system. A tail end stripping instrument is driven by a surgical robot, and a biomechanical original vibration signal is generated by a micro-pulse exciter; further, a prospective ductile impedance fingerprint is generated to predict the tissue adhesion strength; meanwhile, a high-risk adhesion area is positioned according to the fingerprint, and the image is verified by obtaining a local microstructure; and finally, in combination with mechanical and morphological information, generating a comprehensive evaluation report of the peeling risk, and generating a composite self-adaptive regulation and control instruction according to the comprehensive evaluation report so as to realize intelligent adjustment of surgical parameters. According to the invention, the problem of iatrogenic retina injury caused by large adhesion strength difference in the anterior retina dissection operation is solved, the operation is converted from a reaction mode to a feedforward intelligent control mode, and the safety and success rate of the operation are improved.
Owner:THE SECOND HOSPITAL OF HEBEI MEDICAL UNIV

Chitosan-based in-situ self-gel powder as well as preparation method and application thereof

The invention relates to the technical field of hemostatic materials, and provides chitosan-based in-situ self-gel powder as well as a preparation method and application thereof. The chitosan-based in-situ self-gel powder provided by the invention comprises modified chitosan-based powder and oxidized polysaccharide powder, the modified chitosan-based powder is prepared from poly (3-sulfopropyl methacrylate potassium salt) grafted chitosan and poly [2-(methylacryloyloxy)-ethyltrimethyl ammonium chloride] grafted chitosan. The chitosan-based in-situ self-gelling powder provided by the invention has an in-situ self-gelling function, can quickly absorb water to realize self-gelling under the triggering of body fluid or blood, has excellent wet tissue adhesion performance, is high in water absorption speed and good in hemostatic effect, is not influenced by a normal blood coagulation mechanism in a hemostatic process, and has good postoperative anti-adhesion performance; no chemical cross-linking agent is used in the preparation process of the chitosan-based in-situ self-gel powder, the chitosan-based in-situ self-gel powder has good biocompatibility and biodegradability, raw materials are easy to obtain, synthesis is simple, and the chitosan-based in-situ self-gel powder is economical and safe.
Owner:YANTAI ZHONGKE RES INST OF ADVANCED MATERIALS & GREEN CHEM ENG +1

Temperature-sensitive hydrogel dressing as well as preparation method and application thereof

PendingCN122005903ABandagesClick chemistryRos responsive
The invention discloses a temperature-sensitive hydrogel dressing as well as a preparation method and application thereof. The method comprises the following steps: preparing an alkynylation temperature-sensitive block copolymer, azidated mussel protein, an alkynylation MOF (at) QK nano-enzyme compound, an ROS responsive HA-ss-RGD compound and a traditional Chinese medicine yellow wine extract; the components are covalently assembled through click chemistry to obtain a precursor solution. The dressing forms gel in situ at the body temperature, powerful wet tissue adhesion is achieved through mussel protein, long-acting ROS removal and QK peptide continuous release are achieved through MOF (at) QK, RGD peptide on-demand release is achieved through phenylboronic acid ester bond ROS responsive breakage of HA-ss-RGD, and multi-target-point coordinated regulation is achieved through traditional Chinese medicine extracts. Nano-enzyme catalysis, ROS responsive drug release and traditional Chinese medicine multi-target regulation are combined, all the characteristics have a synergistic effect, chronic wound healing is remarkably promoted, and the ROS responsive drug release nano-enzyme is used for preparing oxidative stress related chronic wound repair materials.
Owner:TAIHE HOSPITAL OF SHIYAN CITY (AFFILIATED HOSPITAL OF HUBEI UNIVERSITY OF MEDECINE)

Method for preparing a self-fixing patch and use thereof

The present application relates to the field of medical devices, in particular to a preparation method of a self-fixing patch and application thereof. The present application provides a self-fixing patch, the self-fixing biological patch comprising a patch material layer, the patch material layer being loaded or coated with a glue film layer. The micropores on the surface of the glue film layer of the self-fixing patch of the present application are spaced apart from each other by tens of microns, and a uniform micropore array can be regularly formed on the surface of the glue film layer. Due to the existence of the micropore array, the surface roughness and specific surface area of the tissue-adhesive glue film layer are improved, the tissue-adhesive glue film layer is more easily combined with the tissue, and has a positive influence on the adhesion, migration and differentiation of cells. The various micropore structures can adapt to complex tissue surfaces. The tissue-adhesive glue film layer maintains stability by dissipating the matrix through the micropore structure, and the micropore structure is beneficial to strengthening the tissue adhesion performance.
Owner:SHANGHAI EXCELLENCE MEDICAL TECH CO LTD +1

Surgical planer and planing system

The invention provides a surgical planer and a planing system, and relates to the technical field of medical instruments. The surgical planer comprises a handle, a driving motor, a vibration device, a tool bit component and a suction device. The driving motor is connected with the vibration device, the cutter head part is connected with the vibration device and comprises an outer pipe and an inner pipe arranged in the outer pipe, the side face of the head end of the outer pipe is provided with an outer cutter edge, the side face of the inner pipe is provided with an inner cutter edge corresponding to the outer cutter edge, a suction channel is formed in the inner pipe, and the cutter head part is connected with the vibration device. And the suction channel is communicated with the inner knife edge and the through hole. The vibration device is used for driving the inner pipe and / or the outer pipe to vibrate, and the driving motor is used for driving the vibration device to rotate so as to drive the inner pipe to rotate. The inner tube is driven to vibrate and rotate through the vibration device and the driving motor, suction is performed while tissue cutting is performed, the cutting efficiency is high, tissue adhesion is avoided, and the tissue is prevented from being clamped between the inner tube and the outer tube.
Owner:SHANGHAI RAYKEEN LASER TECH CO LTD