The invention relates to the field of biomedical materials, and particularly provides injectable
adhesive carboxylated
chitosan /
dialdehyde starch hemostatic hydrogel and application thereof.The hemostatic hydrogel is formed by carboxylated
chitosan sol and
dialdehyde starch size through
Schiff base reaction,
hydrogen bond construction and in-situ rapid crosslinking by means of a bidirectional pumping and injecting delivery strategy, and the hemostatic hydrogel is prepared through a two-way pumping and injecting delivery strategy, and the injectable
adhesive carboxylated
chitosan /
dialdehyde starch hemostatic hydrogel is prepared from the carboxylated chitosan
sol, the dialdehyde
starch size and the injectable
adhesive carboxylated chitosan / dialdehyde
starch hemostatic hydrogel. The hydrogel has the advantages of good
biocompatibility, injectability, adhesion, personalized
adaptation and the like, integrates multiple
hemostasis mechanisms, a
physical barrier effect of rapid gelation, an expansion compression effect of water absorption swelling, an electrical
neutralization effect of carboxylated chitosan amino and a
tissue adhesion effect of dialdehyde
starch aldehyde group, realizes multi-scene rapid and efficient
hemostasis, and has a wide application prospect. The preparation method of the injectable adhesive hemostatic hydrogel is low in cost, innovative in technology, mild in condition, convenient to store and beneficial to large-scale
batch production, and has a wide application prospect in the field of efficient hemostatic hydrogel.