241 results about "Tissue Adhesion" patented technology

The invention relates to the technical field of medical materials, and particularly discloses a biocompatible hydrogel microneedle nursing dressing and a preparation method thereof. A biocompatible hydrogel microneedle nursing dressing comprises a hydrogel substrate, microneedles regularly attached to the side, facing the skin, of the hydrogel substrate, and a breathable film layer attached to the side, back to the skin, of the hydrogel substrate. The micro-needle array tip area of the biocompatible hydrogel micro-needle nursing dressing provides rigid support through silk fibroin, it is ensured that a micro-needle can penetrate through the cuticle, the silk fibroin and hyaluronic acid are compounded through the middle-layer needle body transition area, the mechanical strength and the swelling property are balanced, the flexibility is improved through glycerinum, the needle body is prevented from being broken, and the biocompatibility is improved. The closed area of the top substrate adopts high-concentration hyaluronic acid to achieve rapid water absorption swelling and promote drug diffusion, polydopamine nanoparticles enhance antibacterial property and tissue adhesion, genipin crosslinking improves mechanical strength, and a sealing barrier is formed to prevent drug leakage.

The invention relates to the technical field of medical dressings, in particular to a perianal drug dressing of a multi-layer flow guide composite fabric and a preparation method and application of the perianal drug dressing of the multi-layer flow guide composite fabric. The perianal drug dressing is of a four-layer structure, a wet tissue adhesion layer is made of polydopamine modified chitosan / oxidized hyaluronic acid hydrogel, and wet-state adhesion is achieved; the drug sustained-release layer is used for dispersing mesoporous silica loaded with ciprofloxacin hydrochloride / defensin and chitosan microspheres loaded with epidermal growth factors / lonicera japonica into a polycaprolactone fiber membrane to achieve synergistic antibacterial and healing promotion; the directional flow guide layer is of a gradient wettability sandwich structure with a bionic micro-channel, and one-way rapid drainage can be achieved; the high-absorption outer layer is carboxymethyl cellulose / sodium polyacrylate composite sponge, liquid is locked efficiently, the wound surface is kept dry and comfortable, the clinical problem in perianal infection wound treatment can be effectively solved, and the treatment effect and the patient comfort are remarkably improved.

The invention belongs to the technical field of biomedical materials, and particularly relates to preparation of a hydrogel ultrasonic coupling patch for long-term stable continuous monitoring. According to the patch, an interpenetrating double-network structure system is formed by an alginate component and a polyacrylic acid component through intermolecular interaction, and the patch has excellent adhesion performance and mechanical performance. Compared with the prior art, by optimizing the components and the preparation process, the obtained hydrogel patch has the following advantages that the excellent acoustic impedance matching characteristic is achieved, and high-fidelity transmission of ultrasonic signals is ensured; the tissue adhesion is strong, and long-term stable attachment can be realized; good mechanical stability and durability are achieved, and the method is suitable for continuous monitoring application. The product effectively solves the technical problems that the traditional liquid coupling agent is easy to lose, the solid coupling patch is insufficient in adhesion and the like, and has important application value in the fields of medical ultrasonic diagnosis and long-term monitoring.

The invention relates to the technical field of biomedicine, in particular to stem cell exosome-loaded bi-crosslinked hydrogel as well as preparation and application thereof, and the bi-crosslinked hydrogel comprises the following components in parts by weight: 50-90 parts of a matrix polymer; 0.1 to 5 parts of an active load; 1 to 10 parts of cyclodextrin; 5 to 20 parts of modified chitosan; 0.01 to 1 part of a photoinitiator; and 0.01 to 0.5 part of growth factors. Through double-network design of physical / chemical primary cross-linking and photo-initiation secondary cross-linking, the bottleneck that the mechanical property and the machinability of the traditional single cross-linking hydrogel are difficult to consider at the same time is overcome; meanwhile, the human umbilical vein endothelial cell exosome is introduced, and efficient loading, uniform dispersion and degradation coupling slow release of the exosome are realized by virtue of beta-cyclodextrin inclusion and a double-crosslinking network. Therefore, the problems of mechanics, degradation, cross-linking speed or tissue adhesion of cross-linked hydrogel in the prior art are solved.

The invention discloses composite hydrogel bio-ink with a function of space-time delivery of double growth factors as well as a preparation method and application of the composite hydrogel bio-ink, and belongs to the technical field of biomedical materials and tissue engineering. According to the preparation method, imidazolyl-modified methacrylated gelatin and double-bonded PF127 are compounded, and meanwhile, free vascular endothelial growth factors and connective tissue growth factor-loaded PLGA microspheres are entrapped in a system, so that the bio-ink with excellent printability, high adhesion, swelling resistance and space-time delivery function is formed; the bio-ink physically has the advantages of high printing fidelity, low swelling property, high mechanical strength and strong tissue adhesion of a synthetic material; in biology, the system can be used as an intelligent carrier to realize programmed space-time delivery of various growth factors, so that complex cell biological behaviors are accurately arranged, and real regeneration of functional tissues is guided.

The application discloses a mussel-inspired multifunctional double-network crosslinked hydrogel wound dressing. A hydrogel network formed by dynamic covalent crosslinking between carboxymethyl chitosan and oxidized sodium alginate is utilized; further, a natural antioxidant, gallic acid, with a catechol structure is introduced to enhance the tightness of the hydrogel network combination and endow the hydrogel with certain adhesion and antioxidant properties; finally, a mussel adhesive fluid containing catechol and iron is imitated to have strong tissue adhesion behavior under alkaline conditions, which is suitable for dynamic wound treatment, so as to prepare a mussel-inspired multifunctional double-network crosslinked hydrogel wound dressing. In addition, catechol-Fe 3+ Metal coordination also shows strong antibacterial effect, and under the irradiation of near-infrared light, light energy can be converted into heat energy for preventing and treating wound infection, shortening wound closure time and preventing scar formation.

The invention provides a seawater soaking wound hydrogel dressing and a preparation method thereof, a drug-loaded nano system 4OI (at) ZIF-8 (at) PAD with a core-shell structure is constructed, an anti-inflammatory drug 4-octyl itaconic acid and zinc ions are jointly encapsulated in a ZIF-8 framework, and a polydopamine coating is wrapped, so that synergistic loading and controllable release of the drug and metal ions are realized. According to the dressing, dopamine modified hyaluronic acid is used as a matrix, a temperature-sensitive material and an enzyme catalysis cross-linking system are combined, stable gel can be rapidly formed in situ within 5 seconds, and the dressing has excellent tissue adhesion performance (the adhesion strength reaches 6.7 kPa). Experiments prove that the hydrogel dressing has the characteristics of broad-spectrum antibiosis, inflammation regulation and control and long-acting release. Animal experiments prove that the healing rate of seawater soaking wounds treated by the dressing on the twelfth day is as high as 95.7% and is remarkably superior to that of a commercial silver ion gel control group, scars are less after healing, and an efficient, safe and easy-to-implement scheme is provided for marine environment wound nursing.

The invention provides a programmable hydrogel wound dressing with rotation contraction force and application thereof, and belongs to the technical field of biomedical materials, the programmable hydrogel wound dressing comprises a dual-network hydrogel main body, a first hydrogel layer, a second hydrogel layer, a first hydrogel layer and a second hydrogel layer, and the dual-network hydrogel main body is composed of a first network and a second network; the first network is a chemically cross-linked methacrylated hyaluronic acid network and forms a cross-linked network structure through photopolymerization; the second network is a physical cross-linked polyvinyl alcohol network, and forms an instantaneous cross-linking point with a crystal region through a hydrogen bond, so that the hydrogel is endowed with shape memory performance; the surface is modified with an N-hydroxysuccinimide ester functional group, and the N-hydroxysuccinimide ester functional group and amino of wound tissue protein can form a covalent bond; the dual-network hydrogel main body is subjected to pre-stretching or pre-twisting treatment and then is dried and shaped into a preset shape, the initial shape is recovered after moisture is absorbed, and rotary contraction mechanical force is output. Rapid wound healing and scar-free regeneration are achieved by dynamically regulating and controlling wound edge mechanical force and enhancing tissue adhesion, and then application to regulation and control of wound microenvironment to promote scar-free healing is achieved.

The invention discloses a biological patch material with dry-state adhesion and wet-state easy stripping characteristics and application thereof, and belongs to the field of biological medicine. The biological patch material is prepared according to the following steps: by taking water-soluble protein as a template and copper ions in water-soluble copper salt as a metal coordination center, carrying out self-assembly on the template and drug molecules with phenolic hydroxyl structures to form nanoflowers; mixing the acrylamide, the sodium alginate, the water-soluble calcium salt and the nano-flowers to obtain the water-soluble calcium-based water-soluble nano-flower fertilizer. The biological patch material is adhered to the skin through electrostatic interaction, covalent bonds, physical interpenetration and topological tissues. The patch has skin adhesion in a dry state, so that the patch is convenient to fix; after the patch is in contact with burnt skin, the patch absorbs water and swells, the adhesive force is obviously reduced, and painless, easy and non-invasive stripping is realized. In addition, the patch has immunoregulation performance, can prevent stimulation and anaphylaxis caused by long-term contact with the skin, and promotes burn repair.

The invention relates to a preparation method and application of dynamic borate bond hydrogel loaded with adriamycin and an alphaOX40 antibody, and belongs to the technical field of tumors. According to the invention, the dynamic borate bond hydrogel loaded with adriamycin and an alphaOX40 antibody is prepared, and the hydrogel is constructed on the basis of dynamic crosslinking of phenylboronic acid modified hyaluronic acid (HA-PBA) and tannic acid (TA) through a borate bond, and has excellent tissue adhesion and programmed drug release characteristics.

The invention relates to the field of biomedical materials, and particularly provides injectable adhesive carboxylated chitosan / dialdehyde starch hemostatic hydrogel and application thereof.The hemostatic hydrogel is formed by carboxylated chitosan sol and dialdehyde starch size through Schiff base reaction, hydrogen bond construction and in-situ rapid crosslinking by means of a bidirectional pumping and injecting delivery strategy, and the hemostatic hydrogel is prepared through a two-way pumping and injecting delivery strategy, and the injectable adhesive carboxylated chitosan / dialdehyde starch hemostatic hydrogel is prepared from the carboxylated chitosan sol, the dialdehyde starch size and the injectable adhesive carboxylated chitosan / dialdehyde starch hemostatic hydrogel. The hydrogel has the advantages of good biocompatibility, injectability, adhesion, personalized adaptation and the like, integrates multiple hemostasis mechanisms, a physical barrier effect of rapid gelation, an expansion compression effect of water absorption swelling, an electrical neutralization effect of carboxylated chitosan amino and a tissue adhesion effect of dialdehyde starch aldehyde group, realizes multi-scene rapid and efficient hemostasis, and has a wide application prospect. The preparation method of the injectable adhesive hemostatic hydrogel is low in cost, innovative in technology, mild in condition, convenient to store and beneficial to large-scale batch production, and has a wide application prospect in the field of efficient hemostatic hydrogel.

The invention discloses manganese-based Prussian blue-polyacrylic acid / polyvinyl alcohol hydrogel for preventing and treating allergic rhinitis. Monodisperse manganese-based Prussian blue nanoparticles synthesized by taking polyacrylic acid as a template are stably immobilized in a polyacrylic acid / polyvinyl alcohol hydrogel matrix. The obtained composite hydrogel membrane has the following prominent advantages: the composite hydrogel membrane has excellent hydrogel characteristics, including controllable membrane thickness, good tissue adhesion and air permeability; reliable biocompatibility and safety are shown; allergen permeation is effectively blocked through a physical barrier effect; prussian blue is continuously released in the slow-release degradation process, active oxygen free radicals are remarkably removed, and the powerful anti-inflammatory effect is achieved. Due to the synergistic effect of double mechanisms of protection and treatment, the material has important clinical application value and development potential in the fields of prevention and treatment of allergic rhinitis.

The invention discloses a near-infrared two-region photosensitive molecule, a preparation method of the near-infrared two-region photosensitive molecule and application of the near-infrared two-region photosensitive molecule in preparation of suture lines, belongs to the technical field of medical materials, and synthesizes an aggregation-induced emission organic photosensitizer molecule T-TBT-P for near-infrared two-region emission. The AIE nano aggregate carrying positive charges is formed by self-assembly of hydrophilic and hydrophobic groups of the molecule in water; preparing a polydopamine nano coating on the surface of the suture line by using a dopamine oxidation auto-polymerization method, so that the surface of the suture line carries negative charges and has super-hydrophilicity; finally, the T-TBT-P nano aggregate is loaded on the surface of the suture line through the electrostatic adsorption effect, finally, the diagnosis and treatment integrated suture line is prepared, and the diagnosis and treatment integrated suture line has good antibacterial, subcutaneous tracing and tissue adhesion resisting performance and has good application prospects.

The invention discloses an active composite gel sealing material as well as a preparation method and application thereof, and belongs to the technical field of medical materials. The active composite gel sealing material based on multiple crosslinking provided by the invention has excellent tissue adhesion and sealing performance; good in-vivo compatibility, biodegradability, low immunogenicity and high safety are achieved; the mechanical strength is high, the self-repairing capability is good, and the anti-hydrolysis stability is high; the adhesive property and the state of the material can be adjusted by adjusting the proportion of the components and adjusting the adhesive property and the state of the material, so that the requirements on different adhesive properties in practical application are met, irregular wounds are filled, and rapid gelation is performed at the body temperature so as to adapt to the form of a surgical site; the effects of stopping bleeding, resisting inflammation, promoting revascularization and repairing nerves are also achieved.

The present application relates to the field of medical tissue adhesive, in particular to a medical tissue adhesive, a medical tissue dry adhesive patch and a preparation method and application thereof. The present application provides a medical tissue adhesive, a medical tissue dry adhesive patch and a preparation method and application thereof. The medical tissue adhesive provided by the present application comprises: 1wt%-30wt% of acidic polyglutamic acid; 1wt%-30wt% of spherical protein; and the balance of water. The medical tissue adhesive provided by the present application has high tissue adhesion strength and fast hemostatic sealing speed in a wet physiological environment, meets the requirements of rapid and efficient tissue hemostatic sealing, and can be applied to rapid hemostasis of tissue wounds in a wet physiological environment, sealing of wound liquid leakage, healing and repair of wound tissue, and antibacterial of wounds. Experiments show that the dry adhesive patch made of the adhesive provided by the present application has high tissue adhesion strength in a wet physiological environment, and the adhesion strength to a wet pigskin tissue can reach more than 60kPa.

The present application relates to a kind of carboxymethylated gellan gum composite hydrogel that can promote the preparation method of infectious skin wound healing, the present application will be a certain concentration of carboxymethylated gellan gum with the solution of active ion (Ca 2+ 、Cu 2+ 、Zn 2+ ) of proper proportion, using ion crosslinking method to prepare carboxymethylated gellan gum hydrogel.The prepared hydrogel has fast gelation, good injectability, self-healing, tissue adhesion performance and excellent bacteriostatic effect, and can effectively promote the healing of infected wound, has potential application prospect in the treatment of wound infection.

The invention discloses an adhesive compound with an adhesive property optimized based on metal hydroxides as well as a preparation method and application of the adhesive compound, and belongs to the technical field of biological adhesives. The present invention relates to an adhesive composition comprising an adhesive precursor consisting of a protein-polyphenol composite hydrogel and a hydrogen bond destructive small molecule compound capable of network reconstitution comprising beta-folding formation in aqueous phase grafting comprising a metal hydroxide having the characteristics of: (a) a hydration enthalpy value of from-1000 kJ / mol to-4000 kJ / mol; (b) a dissociation constant of from 6 pKa to 13.5 pKa; (c) a water exchange rate of 105 S <-1 > to 10 < 10 > S <-1 >. The adhesion compound can be networked to form an advanced structure when encountering water, not only can generate underwater lap joint shear strength of more than 1MPa, but also can tolerate underwater long-term soaking and temperature change from-196 DEG C to 100 DEG C, and meanwhile, the adhesion compound also has good biocompatibility, can meet the requirement of the environment in a human body on tissue adhesion safety, and has good application prospects. Stability suitable for in vivo tissue repair and industrial applications is exhibited.

The invention relates to hydrogel for promoting healing of diabetic wounds as well as a preparation method and application of the hydrogel, and belongs to the technical field of hydrogel dressings. The invention discloses an exosome hydrogel, which is characterized in that exosome is loaded in crosslinked aldehyde hyaluronic acid and carboxymethyl chitosan, the aldehyde hyaluronic acid is grafted with L-arginine, and the exosome is derived from bone marrow mesenchymal stem cells. L-arginine can release nitric oxide under the action of a diabetic wound surface or an inflammation microenvironment to achieve the effects of resisting bacteria and promoting wound surface recovery, and the exosome successfully avoids the risks of cell survival defects, vascular embolism, immunological rejection and the like while retaining powerful bioactive components. The product has excellent antibacterial activity, degradability, tissue adhesion, injectable performance and self-repairing performance, and can be suitable for wounds in different shapes.

The invention relates to the technical field of surgical devices, in particular to a pair of efficient bipolar electrocoagulation forceps for electrocoagulation and electroexcision. Comprising a handle and a grip which are hinged to each other, the grip is connected with a tong head through a connecting rod set, the tong head comprises a first tong head body and a second tong head body which are matched with each other, and opening and closing movement of the first tong head body and the second tong head body can be achieved by adjusting the grip. The working end face of the first clamp head and the working end face of the second clamp head are smooth contact faces without teeth, a cutting rib is arranged at the end of the first clamp head, and a cutting groove matched with the cutting rib is formed in the end of the second clamp head. The inner surfaces of the forceps heads are working end faces and are designed to be smooth contact face structures without teeth, and cutting ribs and cutting grooves are arranged at the ends of the forceps heads, so that the forceps have the functions of efficient electric coagulation hemostasis and accurate electric resection, and tissue adhesion can be better avoided.

The invention relates to the technical field of medical biological materials, and discloses a mussel mucin-chondroitin sulfate composite hydrogel and a preparation method and application thereof, and the preparation method comprises the following steps: respectively preparing a mussel mucin aqueous solution and a chondroitin sulfate aqueous solution; the mass volume concentration of the mussel mucoprotein aqueous solution is 1%-10%, the mass volume concentration of the chondroitin sulfate aqueous solution is 1%-10%, the mass ratio of the mussel mucoprotein to the chondroitin sulfate is 3: 1-1: 3, the two solutions are mixed and stirred or oscillated under the conditions that the temperature is 4-37 DEG C and the pH value is 7.0-9.0, a cross-linking reaction is conducted, and hydrogel is formed; the cross-linking mode is physical cross-linking, chemical cross-linking or physical-chemical dual cross-linking; according to the invention, excellent tissue adhesion, injectability, self-healing property and biodegradability are realized, cell adhesion and proliferation can be effectively promoted, and the gel is suitable for various medical beauty scenes such as skin filling, wound repairing and anti-aging nursing.

The invention relates to a core biopsy needle (1) for obtaining a tissue sample comprising a hollow outer needle (10) extending along a longitudinal axis (L), and an inner needle (20), which is at least partially arranged or arrangeable within said outer needle along said longitudinal axis (L), wherein said inner needle (20) comprises at least one tissue-holding surface (21), wherein said tissue-holding surface (21) is adapted such that a tissue (3) adheres to the at least one tissue-holding surface (21), when the core biopsy needle (1) is inserted into the tissue (3).

The application discloses a kind of preparation and application of microbial basic protein and adhesive proteoglycan hydrogel, belong to the field of biomaterials.Basic protein is extracted from microbial cells in the present application, using supramolecular assembly method, basic protein and acidic polysaccharide electrostatic assembly protein glycan gel material with strong tissue adhesion, the method is simple, widely available, and the cost is almost negligible.The tissue adhesive provided by the present application has immediate tissue adhesion performance, excellent biocompatibility and excellent antibacterial ability and hemostatic performance, which is beneficial to cope with different types of bleeding scene and irregular wound healing.Through cell compatibility and blood compatibility test, the results show that the material has excellent biocompatibility, and the basic protein has super strong bacteriostatic ability, avoids the invasion of foreign bacteria in the wound repair process, and has strong healing ability, greatly shortens the healing period of wound.

The invention relates to ROS (reactive oxygen species) / pH (potential of hydrogen) dual response type viscous fiber composite hydrogel as well as preparation and application thereof, amino-modified zeolite-loaded imidazate skeleton-8 (ZIF-8) nanoparticle short fibers and natural polyphenol drugs are introduced into double-dynamic cross-linked network hydrogel containing boric acid ester bonds and Schiff base bonds, and the ROS / pH dual response type viscous fiber composite hydrogel has ROS and pH response drug / Zn < 2 + > release characteristics; good antibacterial performance and DPPH removing performance are realized. The ZIF-8 / fiber composite hydrogel developed by the invention realizes multiple functions of good tissue viscosity, antibiosis and antioxidation, and can effectively regulate the wound microenvironment and promote the healing of rat diabetes infected wound.

The present invention relates to: a fish-derived acellular dermal matrix having improved tissue-to-tissue adhesion problems while ensuring biocompatibility by removing cellular components from fish-derived by-products; and a preparation method therefor.

This invention belongs to the field of biomaterials technology and discloses a two-component in-situ crosslinking agent, a biodegradable two-component hydrogel, and their applications. The two-component in-situ crosslinking agent disclosed in this invention has injectability and rapid gelation properties. The hydrogel formed after crosslinking has a low self-swelling rate, good elasticity, and is not easily crushed. It also has a suitable metal ion slow-release cycle and degradation cycle for preventing tissue adhesion or tissue repair. It is especially suitable for high-risk areas of postoperative adhesion such as the uterine cavity, abdominal cavity, and joints, and can also promote tissue regeneration.

The invention discloses cefradine supramolecular composite graded gel and a preparation method and application thereof, cefradine and glycosaminoglycan are used as raw materials, and self-assembly of cefradine is controlled through an interface template to form supramolecular hydrogel. And cross-linking and compounding with glycosaminoglycan gel to obtain the double-network supramolecule-polymer graded composite gel. The graded composite gel prepared by the invention has excellent swelling property, tissue adhesion and thixotropy and tensile property similar to that of human skin, so that the graded composite gel can accelerate healing of infected wounds, and due to excellent conductivity, real-time online monitoring of drug release and wound healing conditions can be realized.

The invention belongs to the technical field of biomedical materials and biomedical engineering, and discloses peach gum-based self-repairing moisturizing hydrogel, a preparation method and application of the peach gum-based self-repairing moisturizing hydrogel in hemostasis and moisturizing materials. The preparation method comprises the following steps: carrying out an amide reaction on 3-aminophenylboronic acid hydrochloride (3APBA), and grafting the 3-aminophenylboronic acid hydrochloride (3APBA) on purified peach gum to obtain boronic acid peach gum (PR-3APBA); and adding an efficient humectant sodium pyrrolidone carboxylate, and freeze-drying to obtain the self-repairing hemostatic moisturizing gel. The adhesive has excellent hemostasis, moisturizing and self-repairing functions, is applied to body surface skin wound repair, and particularly has better wound repair performance and tissue adhesion performance when being used as an adhesion hemostasis material.

The application discloses a material for preventing tissue adhesion and hemostasis and a preparation method thereof, and relates to the technical field of medical biomaterials.The carboxymethyl cellulose, chitosan and vancomycin / ceftazidime are synergistically matched, so that the three functions of hemostasis, adhesion prevention and antibiosis are integrated;meanwhile, the water absorption and gelation of the carboxymethyl cellulose and the blood coagulation activation of the chitosan can jointly strengthen the hemostasis effect; the tissue barrier function of the chitosan and the gel isolation of the carboxymethyl cellulose can jointly improve the adhesion prevention performance; the broad-spectrum antibiosis of the vancomycin and the ceftazidime can respond to the infection risk in different surgical scenes; the material preparation process is simple, the dosage form can be adjusted according to different surgical scenes, the material has good biocompatibility and can be completely degraded, the problem that the existing medical materials have single function and are difficult to meet the needs of complex surgical wounds is solved, and the material has significant clinical application value.

The invention discloses natural-based injectable fiber hydrogel as well as a preparation method and application thereof, the hydrogel is formed by taking gelatin and natural tea hair as raw materials and carrying out cross-linking reaction on polyphenol substances in the tea hair and gelatin molecules under the action of an oxidation initiator, the hydrogel has excellent biocompatibility, mechanical strength, oxidation resistance, self-healing performance and tissue adhesion performance, and has good injectability, rapid gelation characteristics and the like. The preparation method comprises the following steps: dissolving gelatin in a water phase to form a solution, adding tea hair, uniformly dispersing to form a pre-polymerized solution, adding an oxidation initiator to trigger oxidation of the tea hair, and forming the natural-based injectable fiber hydrogel with the gelatin. The natural-based injectable fiber hydrogel is wide in raw material source, low in cost, simple in process, safe and environmentally friendly, and the prepared natural-based injectable fiber hydrogel has wide application prospects in the biomedical fields of wound repair, bone tissue regeneration and the like.

A system, a method and a medical apparatus for treatment of body tissue which comprises at least partially one or more electrically conductive element, an energy source configured to provide a DC energy to the medical device and / or the tissue and a first control unit configured to control the energy source, wherein the first control unit causes the energy source to provide DC energy that establishes a direct electroadhesion bonding between the tissue and the medical device when the tissue and the medical device are in a direct contact or that establishes an indirect electroadhesion bonding between the tissue and the medical device via conductive means.