394 results about "Tissue Adhesion" patented technology

The invention belongs to the technical field of biomedical materials, and relates to ultrasonic response adhesion integrated hydrogel as well as a preparation method and application thereof, the hydrogel comprises a hydrogel matrix, an interface anchoring agent and a functional load component; the preparation method comprises the following steps: 1, preparing a hydrogel precursor solution, and preparing a hydrogel matrix into a solution; 2, carrying out mold molding or injection crosslinking on the solution prepared in the step 1 to form hydrogel; 3, preparing an interface anchoring agent solution, and dissolving or dispersing an interface anchoring agent in a solvent to prepare the interface anchoring agent solution; the ultrasonic responsive adhesive hydrogel platform provided by the invention can provide an efficient, controllable and universal solution for tissue adhesion, targeted therapy, wearable attachment and the like in a complex microenvironment, and is suitable for a plurality of clinical scenes such as chronic wound management, surgical postoperative closure, infection control, adhesive bioelectronic fixation, soft tissue engineering and the like.

The invention belongs to the technical field of biomedical materials, and particularly relates to adipose-derived mesenchymal stem cell loaded conductive hydrogel and a preparation method and application thereof, the preparation method comprises the following steps: step S1, after hyaluronic acid is subjected to oxidation treatment, dopamine is grafted to oxidized hyaluronic acid, and oxidized hyaluronic acid-dopamine is obtained; step S2, carrying out amination treatment on gelatin to obtain aminated gelatin; s3, mixing the oxidized hyaluronic acid-dopamine with the aminated gelatin, and carrying out Schiff base crosslinking, so as to obtain hydrogel; and step S4, loading the adipose tissue-derived stromal cells by using the hydrogel. Dopamine is grafted on an oxidized hyaluronic acid macromolecular chain through amidation reaction, the hydrophilicity and the electrical property of the macromolecular chain are improved, a catechol structure is provided to provide possibility for iron ion coordination, the tissue adhesion, the injectability, the mechanical property and the electrical conductivity of the hydrogel are improved, and the hydrogel can be applied to the field of biomedical materials. After being applied to a spinal cord injury rat model, the functional recovery can be promoted.

The invention belongs to the technical field of hydrogel, and particularly relates to animal glue composite hydrogel as well as a preparation method and application thereof. The animal glue composite hydrogel comprises animal glue, polyvinyl alcohol, glycerol and water. The animal glue composite hydrogel provided by the invention not only has rheological and mechanical properties similar to those of natural nucleus pulposus, adapts to the mechanical environment of intervertebral discs, but also has tissue adhesion, can be adhered to soft tissues and avoid leakage, and also can inhibit lipid peroxidation of nucleus pulposus cells in the reactive oxygen species (ROS) environment, reduce cell ferroptosis and promote nucleus pulposus repair.

The invention relates to the technical field of medical materials, and particularly discloses a biocompatible hydrogel microneedle nursing dressing and a preparation method thereof. A biocompatible hydrogel microneedle nursing dressing comprises a hydrogel substrate, microneedles regularly attached to the side, facing the skin, of the hydrogel substrate, and a breathable film layer attached to the side, back to the skin, of the hydrogel substrate. The micro-needle array tip area of the biocompatible hydrogel micro-needle nursing dressing provides rigid support through silk fibroin, it is ensured that a micro-needle can penetrate through the cuticle, the silk fibroin and hyaluronic acid are compounded through the middle-layer needle body transition area, the mechanical strength and the swelling property are balanced, the flexibility is improved through glycerinum, the needle body is prevented from being broken, and the biocompatibility is improved. The closed area of the top substrate adopts high-concentration hyaluronic acid to achieve rapid water absorption swelling and promote drug diffusion, polydopamine nanoparticles enhance antibacterial property and tissue adhesion, genipin crosslinking improves mechanical strength, and a sealing barrier is formed to prevent drug leakage.

The invention relates to the technical field of medical dressings, in particular to a perianal drug dressing of a multi-layer flow guide composite fabric and a preparation method and application of the perianal drug dressing of the multi-layer flow guide composite fabric. The perianal drug dressing is of a four-layer structure, a wet tissue adhesion layer is made of polydopamine modified chitosan / oxidized hyaluronic acid hydrogel, and wet-state adhesion is achieved; the drug sustained-release layer is used for dispersing mesoporous silica loaded with ciprofloxacin hydrochloride / defensin and chitosan microspheres loaded with epidermal growth factors / lonicera japonica into a polycaprolactone fiber membrane to achieve synergistic antibacterial and healing promotion; the directional flow guide layer is of a gradient wettability sandwich structure with a bionic micro-channel, and one-way rapid drainage can be achieved; the high-absorption outer layer is carboxymethyl cellulose / sodium polyacrylate composite sponge, liquid is locked efficiently, the wound surface is kept dry and comfortable, the clinical problem in perianal infection wound treatment can be effectively solved, and the treatment effect and the patient comfort are remarkably improved.

The degradable breast prosthesis shaping net bag with the heterogeneous hierarchical porous structure is composed of the large-aperture structure layer and the micro-aperture structure layer, the large-aperture structure layer and the micro-aperture structure layer are formed by combining degradable fibers in a staggered mode, the degradable breast prosthesis shaping net bag and the breast prosthesis are perfectly conformal, and the mechanical property and the tissue adhesion property needed by the net bag are provided; the two cooperate to realize the integration function of the prosthesis and the tissue, and an additional suture fixing device is not needed; the overall shape of the net bag is designed to be the hemispherical upper cover and the lower end cover edge, the process of adding the net bag and a prosthesis is simplified, the operation efficiency is improved, the net bag has excellent mechanical performance and shaping capacity, the micropore structure is beneficial to adhesion and immigration of cells, rejection reaction of a body is reduced, the incidence rate of capsular contracture is remarkably reduced, and the net bag is suitable for popularization and application. The invention has the characteristics of hierarchical porous structure design, mechanical shaping capability customization and capsule contracture prevention, and provides an innovative breast prosthesis shaping and biological performance improvement scheme for breast cancer patients.

The invention relates to an antibacterial and hemostatic composite material and a preparation method thereof. The preparation method comprises the following steps: reacting exfoliated graphene oxide with KH560 at 60 DEG C to obtain coupled grafted graphene oxide EGO; then under the condition of intense stirring at 80 DEG C, enabling the kaolin nanotube to react with EGO (Ethylene Gallate Oxide), so as to obtain EGO-EK; and then reacting the chitosan solution with EGO-EK by using a cross-linking agent and a catalyst to obtain a uniform suspension, and freeze-drying. The hemostatic composite material disclosed by the invention has the advantages of bacterial infection resistance, difficulty in tissue adhesion with a wound surface, good mechanical property, photo-thermal effect, excellent biocompatibility and rapid hemostatic capability, and in addition, the hemostatic composite material can accelerate the healing of the bacterial infection wound surface.

The invention discloses an adhesive hydrogel for oral periodontal tissue regeneration and a preparation method thereof, gelatin and polyacrylic acid are used as main raw materials, and a photo-crosslinking method is used as a basis to prepare the adhesive hydrogel; the adhesive hydrogel has good tissue adhesion, can be tightly adhered to wet soft and hard tissue surfaces, and overcomes the defect that the oral periodontal filling material is difficult to fix clinically at present. The adhesive hydrogel has high porosity after completely absorbing water and swelling, and pores in the surface and inside of the adhesive hydrogel are communicated with each other, so that the adhesive hydrogel can provide more space for growth of oral periodontal tissues, and is suitable for ingrowth of cells and regeneration of the oral periodontal tissues.

The invention belongs to the technical field of biological medicines, and particularly discloses a lignin janus hydrogel patch as well as a preparation method and application thereof. The lignin janus hydrogel patch comprises a substrate layer and a tissue adhesion layer, wherein the substrate layer is pre-stretched, one surface of the substrate layer is subjected to hydroxylation treatment, and the tissue adhesion layer is attached to the hydroxylated surface of the substrate layer through lignin-based hydrogel and is subjected to photo-initiated free radical polymerization; the invention also discloses an application of the lignin janus hydrogel patch in preparation of a patch for promoting soft tissue defect or wound healing. In the lignin janus hydrogel patch disclosed by the invention, the lignin janus hydrogel patch has different adhesion properties, and the adhesion surface has excellent adhesion property, mechanical property and antibacterial property; after contacting with wet tissue of a wound, a strain program can be started to perform mechanical self-constriction, thereby effectively helping the wound to be closed and accelerating the repairing speed.

The invention discloses tissue adhesion self-gel powder and a preparation method thereof, and belongs to the field of hydrogel. The preparation method comprises the following steps: firstly, modifying chitosan to obtain quaternized chitosan (QCS), and then grafting urushiol onto the QCS to obtain urushiol-gold quaternized chitosan (US-QCS); the preparation method comprises the following steps: reacting sodium hyaluronate (HA) with calcium salt to obtain calcium hyaluronate (Ca-HA); and mixing the US-QCS and the Ca-HA, so as to obtain US-QCS / Ca-HA self-gel powder. The tissue adhesion self-gel powder prepared by the invention can quickly absorb interface water and then adhere to tissues, various wounds can be blocked, wound healing is promoted, calcium ions in the powder can accelerate blood coagulation, and the powder has the potential ability of promoting bone repair.

The invention belongs to the technical field of biomedical materials, and particularly relates to preparation of a hydrogel ultrasonic coupling patch for long-term stable continuous monitoring. According to the patch, an interpenetrating double-network structure system is formed by an alginate component and a polyacrylic acid component through intermolecular interaction, and the patch has excellent adhesion performance and mechanical performance. Compared with the prior art, by optimizing the components and the preparation process, the obtained hydrogel patch has the following advantages that the excellent acoustic impedance matching characteristic is achieved, and high-fidelity transmission of ultrasonic signals is ensured; the tissue adhesion is strong, and long-term stable attachment can be realized; good mechanical stability and durability are achieved, and the method is suitable for continuous monitoring application. The product effectively solves the technical problems that the traditional liquid coupling agent is easy to lose, the solid coupling patch is insufficient in adhesion and the like, and has important application value in the fields of medical ultrasonic diagnosis and long-term monitoring.

The invention relates to the technical field of biomedicine, in particular to stem cell exosome-loaded bi-crosslinked hydrogel as well as preparation and application thereof, and the bi-crosslinked hydrogel comprises the following components in parts by weight: 50-90 parts of a matrix polymer; 0.1 to 5 parts of an active load; 1 to 10 parts of cyclodextrin; 5 to 20 parts of modified chitosan; 0.01 to 1 part of a photoinitiator; and 0.01 to 0.5 part of growth factors. Through double-network design of physical / chemical primary cross-linking and photo-initiation secondary cross-linking, the bottleneck that the mechanical property and the machinability of the traditional single cross-linking hydrogel are difficult to consider at the same time is overcome; meanwhile, the human umbilical vein endothelial cell exosome is introduced, and efficient loading, uniform dispersion and degradation coupling slow release of the exosome are realized by virtue of beta-cyclodextrin inclusion and a double-crosslinking network. Therefore, the problems of mechanics, degradation, cross-linking speed or tissue adhesion of cross-linked hydrogel in the prior art are solved.

The preparation method specifically comprises the following steps: sequentially adding arginine and lipoic acid into a gelatin solution to obtain a hydrogel pre-polymerized solution; heating the hydrogel prepolymerization liquid to initiate a lipoic acid ring-opening polymerization cross-linking reaction, and adding a poly (3, 4-ethylenedioxythiophene) dispersion liquid modified by polydopamine to obtain gelatin / polylipoic acid conductive hydrogel; the preparation method comprises the following steps: heating and melting a lipoic acid monomer, then adding a cross-linking agent for reaction, then adding metal salt for stirring, and pouring the obtained yellow transparent liquid on the surface of the gelatin / polylipoic acid conductive hydrogel to obtain the double-layer heterogeneous biological adhesive. The invention also discloses an application of the double-layer heterogeneous biological adhesive in a biomedical adhesive. According to the method, strong interface connection between the two layers is achieved through the similar compatibility principle and the hot melting pouring technology, and layering is avoided during use; and the prepared adhesive has good tissue adhesion, self-repairing performance and biocompatibility.

The invention discloses an anti-adhesion conductive ceramic coating and application thereof to a high-frequency electrotome, and relates to the technical field of surface modification. The preparation method of the anti-adhesion conductive ceramic coating at least comprises the following preparation steps: carrying out cleaning and surface sand blasting treatment on a high-frequency electrotome substrate; blending fusible polytetrafluoroethylene powder, hydrophobic nano silicon dioxide particles and modified fluorinated graphene at a high speed to obtain mixed powder; and the mixed powder is sprayed on the surface of the high-frequency electrotome base body subjected to surface sand blasting through a powder electrostatic spraying technology, and after baking and cooling, the anti-adhesion conductive ceramic coating is obtained. The high-frequency electrotome anti-sticking ceramic coating prepared by the invention has good anti-sticking property, tissue adhesion resistance, electrical conductivity and low possibility of falling off.

The invention discloses composite hydrogel bio-ink with a function of space-time delivery of double growth factors as well as a preparation method and application of the composite hydrogel bio-ink, and belongs to the technical field of biomedical materials and tissue engineering. According to the preparation method, imidazolyl-modified methacrylated gelatin and double-bonded PF127 are compounded, and meanwhile, free vascular endothelial growth factors and connective tissue growth factor-loaded PLGA microspheres are entrapped in a system, so that the bio-ink with excellent printability, high adhesion, swelling resistance and space-time delivery function is formed; the bio-ink physically has the advantages of high printing fidelity, low swelling property, high mechanical strength and strong tissue adhesion of a synthetic material; in biology, the system can be used as an intelligent carrier to realize programmed space-time delivery of various growth factors, so that complex cell biological behaviors are accurately arranged, and real regeneration of functional tissues is guided.

The invention discloses a high-adhesion enzymatic hydrogel for promoting vascular intima repair and a preparation method of the high-adhesion enzymatic hydrogel, and belongs to the technical field of hydrogel preparation. The preparation method comprises the following steps: S1, carrying out double-bond modification on hyaluronic acid by utilizing methacrylic anhydride, and then cross-linking with dopamine to prepare dopamine modified double-bond hyaluronic acid; s2, deoxidizing the hyaluronic acid solution, adding a cross-linking agent and tyramine hydrochloride, and reacting in an acidic environment to prepare tyramine modified hyaluronic acid; s3, mixing the dopamine modified double-bond hyaluronic acid, the tyramine modified hyaluronic acid and deionized water to prepare a hydrogel precursor liquid; and S4, carrying out enzymatic reaction to obtain the hydrogel. The method designed by the invention is simple in process, no extra photocuring equipment needs to be added, and the constructed hydrogel is similar to an extracellular matrix. And the coating can be coated into different shapes to adapt to different environments. The gel is formed through enzymatic reaction, and the gel is rapid in gel forming, good in tissue adhesion, good in biocompatibility and suitable for being applied to vascular repair.

The invention relates to the field of biomedical materials, in particular to polyethyleneimine / polyacrylic acid-based hydrogel for wound repair and a preparation method of the polyethyleneimine / polyacrylic acid-based hydrogel. The hydrogel is prepared by the following steps: dissolving polyacrylic acid with a specific polymerization degree, reacting with a cross-linking agent and an initiator, treating to obtain a polyacrylic acid group, and mixing and stirring with a polyethyleneimine aqueous solution. In the preparation process, the raw material proportion, reaction conditions and other parameters are accurately controlled. The hydrogel has a unique microstructure and physicochemical properties, such as appropriate swelling ratio, mechanical strength and surface charge density, and has good tissue adhesion and antibacterial property in wound repair, and degradation products are harmless. The method can also be used for preparing medical dressings, and has a wide application prospect in the field of wound repair of skin, mucous membranes and the like.

The invention provides a modified polyglutamic acid-based tissue adhesive as well as a preparation method and application thereof. The tissue adhesive is composed of the following components: 1-30 wt% of acidic aldehyde polyglutamic acid; 1 to 15 wt% of a linear protein; 1 to 15 wt% of spherical protein; and the balance of water. The tissue adhesive provided by the invention has the advantages of self-healing performance, low underwater swelling rate and stable adhesion to wet tissues in a physiological environment, and can be applied to rapid hemostasis of dynamic wet tissue wounds in the physiological environment and sealing of wound liquid leakage. Experiments show that the tissue adhesive is high in tissue adhesion stability in a wet physiological environment, and the adhesion strength of the tissue adhesive to wet pigskin tissues can reach 37.4 kPa or above after the tissue adhesive is placed for 12 h under the physiological condition.

The invention belongs to the technical field of biomedical materials, and relates to a high-adhesion Janus artificial cornea as well as a preparation method and application thereof. The invention provides an artificial cornea, which is characterized in that a coating containing epsilon-PLL and 4-arm-PEG-NHS is distributed on a collagen skeleton EB-Col, and the functional group ratio of-NHS to-NH2 in the coating is 1: (0.6-1.4), and the molar ratio is 1: (0.6-1.4). The invention also relates to a corresponding high-adhesion Janus artificial cornea, and a preparation method and application thereof. The artificial cornea has instant and stable adhesion capability, gives consideration to optical transparency and mechanical and adhesion properties, can well adapt to the shape of a wound, is convenient to use, high in practical operability and mild in reaction, and is particularly suitable for being applied to cornea repair materials in the ophthalmology department, and the strong wet tissue adhesion property of the artificial cornea can adapt to a dynamic ocular surface moist environment.

The invention discloses a preparation method of a stem cell exosome chitosan compound covered stent. The stem cell exosome chitosan compound comprises a stem cell exosome and a chitosan compound. In the stem cell exosome and chitosan compound, the mass percent of chitosan is 3%-10%, and the number of the stem cell exosomes is 109-1011. Compared with a traditional covered stent, the covered material provided by the invention can resist inflammation, inhibit bacteria, protect vascular endothelial cells covered by the stent, promote tissue repair, prevent tissue adhesion, prevent fibrosis and inhibit exclusion reaction and autoimmunity.

The invention discloses a hydrogel adhesive based on gelatin and a clay material and a preparation method of the hydrogel adhesive. The hydrogel adhesive at least comprises the following preparation raw materials: modified gelatin, a modified clay material and a thiolated cross-linking agent. The hydrogel adhesive prepared by the invention has an excellent tissue adhesion effect in a moist environment, can form gel within 30-60s, has flexibly adjustable adhesion performance, and can meet the application of various surgical scenes. The fibrin glue has the blood coagulation promoting effect, the hemostasis effect is better than that of traditional fibrin glue, the antibacterial effect is achieved, the risk of wound infection is reduced, meanwhile, good elasticity and toughness are achieved, the matching degree with tissue mechanical properties is high, and the fibrin glue cannot lose efficacy during cyclic compression. The biological compatibility is good, the anti-inflammatory and anti-oxidation effects are achieved, and wound healing and regeneration can be accelerated.

The application discloses a mussel-inspired multifunctional double-network crosslinked hydrogel wound dressing. A hydrogel network formed by dynamic covalent crosslinking between carboxymethyl chitosan and oxidized sodium alginate is utilized; further, a natural antioxidant, gallic acid, with a catechol structure is introduced to enhance the tightness of the hydrogel network combination and endow the hydrogel with certain adhesion and antioxidant properties; finally, a mussel adhesive fluid containing catechol and iron is imitated to have strong tissue adhesion behavior under alkaline conditions, which is suitable for dynamic wound treatment, so as to prepare a mussel-inspired multifunctional double-network crosslinked hydrogel wound dressing. In addition, catechol-Fe 3+ Metal coordination also shows strong antibacterial effect, and under the irradiation of near-infrared light, light energy can be converted into heat energy for preventing and treating wound infection, shortening wound closure time and preventing scar formation.

The invention discloses an absorbable tissue adhesion material, a preparation method thereof and an application of the absorbable tissue adhesion material in preparation of a body solid material, a coating material or an injectable liquid material. The preparation method comprises the following steps: heating lipoic acid monomer powder to carry out polymerization reaction, and carrying out ultraviolet polymerization on the obtained polymer in a solution in the presence or absence of polyphenol to obtain a lipoic acid polymer which can absorb the tissue adhesion material, the ultraviolet light intensity of the ultraviolet light polymerization is 20-100W / cm < 2 >, and the ultraviolet light wave band is 250-500nm. The absorbable tissue adhesion material disclosed by the invention is a degradable polymer material with excellent tissue adhesion and anti-inflammatory and anti-oxidation characteristics.

The invention provides a seawater soaking wound hydrogel dressing and a preparation method thereof, a drug-loaded nano system 4OI (at) ZIF-8 (at) PAD with a core-shell structure is constructed, an anti-inflammatory drug 4-octyl itaconic acid and zinc ions are jointly encapsulated in a ZIF-8 framework, and a polydopamine coating is wrapped, so that synergistic loading and controllable release of the drug and metal ions are realized. According to the dressing, dopamine modified hyaluronic acid is used as a matrix, a temperature-sensitive material and an enzyme catalysis cross-linking system are combined, stable gel can be rapidly formed in situ within 5 seconds, and the dressing has excellent tissue adhesion performance (the adhesion strength reaches 6.7 kPa). Experiments prove that the hydrogel dressing has the characteristics of broad-spectrum antibiosis, inflammation regulation and control and long-acting release. Animal experiments prove that the healing rate of seawater soaking wounds treated by the dressing on the twelfth day is as high as 95.7% and is remarkably superior to that of a commercial silver ion gel control group, scars are less after healing, and an efficient, safe and easy-to-implement scheme is provided for marine environment wound nursing.

The invention provides a programmable hydrogel wound dressing with rotation contraction force and application thereof, and belongs to the technical field of biomedical materials, the programmable hydrogel wound dressing comprises a dual-network hydrogel main body, a first hydrogel layer, a second hydrogel layer, a first hydrogel layer and a second hydrogel layer, and the dual-network hydrogel main body is composed of a first network and a second network; the first network is a chemically cross-linked methacrylated hyaluronic acid network and forms a cross-linked network structure through photopolymerization; the second network is a physical cross-linked polyvinyl alcohol network, and forms an instantaneous cross-linking point with a crystal region through a hydrogen bond, so that the hydrogel is endowed with shape memory performance; the surface is modified with an N-hydroxysuccinimide ester functional group, and the N-hydroxysuccinimide ester functional group and amino of wound tissue protein can form a covalent bond; the dual-network hydrogel main body is subjected to pre-stretching or pre-twisting treatment and then is dried and shaped into a preset shape, the initial shape is recovered after moisture is absorbed, and rotary contraction mechanical force is output. Rapid wound healing and scar-free regeneration are achieved by dynamically regulating and controlling wound edge mechanical force and enhancing tissue adhesion, and then application to regulation and control of wound microenvironment to promote scar-free healing is achieved.

The invention relates to a rapid self-gelation modified gelatin-based styptic powder composition as well as a preparation method and application thereof. The styptic powder is composed of phenylboronic acid modified gelatin and a long-chain polymer containing a diol structure, and can be used independently or matched with thrombin or polyethylene glycol active derivative powder to prepare a composition for use. Under physiological conditions, the powder can rapidly absorb blood, settle and self-crosslink to form hydrogel, activate an endogenous hemostasis pathway and perform physical plugging, and rapid hemostasis is realized. When used together with thrombin, the medicine can maintain local high concentration and accelerate blood clot formation, and is suitable for emergency control of massive hemorrhage. When the hydrogel is combined with a polyethylene glycol active derivative, tissue adhesion and a dual-network structure can be realized, the gel strength is improved, and long-acting hemostasis is realized.

The invention discloses a biological patch material with dry-state adhesion and wet-state easy stripping characteristics and application thereof, and belongs to the field of biological medicine. The biological patch material is prepared according to the following steps: by taking water-soluble protein as a template and copper ions in water-soluble copper salt as a metal coordination center, carrying out self-assembly on the template and drug molecules with phenolic hydroxyl structures to form nanoflowers; mixing the acrylamide, the sodium alginate, the water-soluble calcium salt and the nano-flowers to obtain the water-soluble calcium-based water-soluble nano-flower fertilizer. The biological patch material is adhered to the skin through electrostatic interaction, covalent bonds, physical interpenetration and topological tissues. The patch has skin adhesion in a dry state, so that the patch is convenient to fix; after the patch is in contact with burnt skin, the patch absorbs water and swells, the adhesive force is obviously reduced, and painless, easy and non-invasive stripping is realized. In addition, the patch has immunoregulation performance, can prevent stimulation and anaphylaxis caused by long-term contact with the skin, and promotes burn repair.

The invention relates to a preparation method and application of dynamic borate bond hydrogel loaded with adriamycin and an alphaOX40 antibody, and belongs to the technical field of tumors. According to the invention, the dynamic borate bond hydrogel loaded with adriamycin and an alphaOX40 antibody is prepared, and the hydrogel is constructed on the basis of dynamic crosslinking of phenylboronic acid modified hyaluronic acid (HA-PBA) and tannic acid (TA) through a borate bond, and has excellent tissue adhesion and programmed drug release characteristics.

The invention relates to the field of biomedical materials, and particularly provides injectable adhesive carboxylated chitosan / dialdehyde starch hemostatic hydrogel and application thereof.The hemostatic hydrogel is formed by carboxylated chitosan sol and dialdehyde starch size through Schiff base reaction, hydrogen bond construction and in-situ rapid crosslinking by means of a bidirectional pumping and injecting delivery strategy, and the hemostatic hydrogel is prepared through a two-way pumping and injecting delivery strategy, and the injectable adhesive carboxylated chitosan / dialdehyde starch hemostatic hydrogel is prepared from the carboxylated chitosan sol, the dialdehyde starch size and the injectable adhesive carboxylated chitosan / dialdehyde starch hemostatic hydrogel. The hydrogel has the advantages of good biocompatibility, injectability, adhesion, personalized adaptation and the like, integrates multiple hemostasis mechanisms, a physical barrier effect of rapid gelation, an expansion compression effect of water absorption swelling, an electrical neutralization effect of carboxylated chitosan amino and a tissue adhesion effect of dialdehyde starch aldehyde group, realizes multi-scene rapid and efficient hemostasis, and has a wide application prospect. The preparation method of the injectable adhesive hemostatic hydrogel is low in cost, innovative in technology, mild in condition, convenient to store and beneficial to large-scale batch production, and has a wide application prospect in the field of efficient hemostatic hydrogel.

The invention discloses hydrogel for preventing postoperative tissue adhesion and a preparation method thereof, and belongs to the field of medical biological materials. The hydrogel is formed by taking a carboxylated chitin / chitosan derivative with the percentage concentration of 0.5-7% or a low-crosslinking-degree supramolecular derivative of a hydroxyalkylated chitin / chitosan derivative and collagen or gelatin as a solute and water, normal saline, a physiological equilibrium solution, a phosphate buffer solution or a Green's solution as a solvent, the crosslinking degree of the low-crosslinking-degree supramolecular crosslinking derivative is 0.1 to 6 mol percent. The molar ratio of the raw materials to the cross-linking agent is controlled, a small amount of cross-linking agent is used for micro-crosslinking, the prepared low-crosslinking-degree supramolecular derivative can form hydrogel in an aqueous solvent, and the hydrogel has adhesiveness and self-repairing performance, can effectively prolong the residence time and physical barrier time of the hydrogel on the surface of an operative wound, and can be used for preparing the hydrogel. Therefore, the effect of preventing postoperative combined adhesion of the hydrogel is improved, and the hydrogel is an ideal hydrogel material for preventing postoperative abdominal cavity and uterine cavity tissue adhesion.