12 results about "Absorbable polymers" patented technology

The invention relates to the technical field of biological materials, and provides an absorbable self-repairing suture line for maintaining the stability of a mechanical biological microenvironment and a preparation method of the absorbable self-repairing suture line. According to the suture line, an absorbable high polymer material is adopted as a matrix, and PLA microcapsules containing a medical-grade cyanoacrylate n-octyl ester repairing agent are uniformly dispersed in the matrix through a melt blending spinning process. When the suture line generates microcracks at dynamic tissue parts such as cardiovascular and digestive tracts due to periodic stress, the stress at the tip of the cracks enables the microcapsules to be broken to release the repairing agent, rapid in-situ polymerization occurs under triggering of tissue fluid, the self-repairing efficiency of 90% or above is achieved, and the strength retention rate of 95% or above is maintained in the key rehabilitation period of the suture line. The defect that a traditional absorbable suture line is prone to fatigue fracture in a dynamic environment is overcome, the mechanical integrity is actively maintained through an intelligent self-repairing mechanism, all components can be completely degraded and absorbed, and a safer and more reliable solution is provided for dynamic tissue repairing.

The invention discloses a rapid-absorption collagen repair membrane and a preparation method thereof, and relates to the technical field of biological materials. The repairing membrane is of a double-layer structure and comprises a purified collagen layer and an absorbable polymer spinning layer loaded with inorganic nanoparticles. The preparation method comprises the following steps: purifying animal skin to obtain a purified collagen layer; the preparation method comprises the following steps: respectively dispersing akermanite and hydroxyapatite nanoparticles, and mixing; adding the mixed dispersion liquid into the absorbable polymer solution to obtain a composite spinning solution; spinning the composite spinning solution on the surface of the collagen layer by adopting an electrostatic spinning method to form a spinning layer; and drying to obtain the repairing film. According to the invention, by regulating and controlling the variety, proportion, crystallinity and spatial distribution of the inorganic particles, the synergistic enhancement of mechanical properties and biological activity is realized, so that the repair film has pH-responsive graded release ability, can automatically adjust degradation behavior according to inflammation intensity, actively adapts to microenvironment, and has good application prospects. The method can be widely applied to the fields of oral soft tissue repair, periodontal wound covering and the like.

The invention provides a porous cell auxetic material, an absorbable intravascular stent, a preparation device and a preparation method, and belongs to the field of medical instruments, holes in porous cells are dumbbell-shaped structural holes, and the dumbbell-shaped structural holes are transversely and vertically alternately formed in the long axis direction and also transversely and vertically alternately formed in the short axis direction; dumbbell-shaped structure holes in a transverse and vertical alternating array are formed, and the short shafts of the dumbbell-shaped structure holes are provided with anti-springback inserting and pulling abutting supporting structures; the shape of the auxetic material during expansion is maintained, shrinkage is prevented when the auxetic material is axially compressed, and lasting supporting force is provided; when the vascular stent is formed by adopting the structure, radial and axial contraction of the vascular stent is prevented, the shape of the vascular stent is maintained, reliable radial supporting force is provided, the smoothness of the blood vessel is ensured, the mechanical performance of the biological absorbable stent is improved, the use amount of the biological absorbable polymer material is reduced, and the wall thickness is reduced.

This utility model discloses a stretching and shaping device for absorbable polymer materials, relating to the technical field of stretching and shaping equipment. It includes a support box, a movable frame, an air-cooling component, and an angle adjustment component. The support box is installed on the side of an extruder. The movable frame is mounted on the support box via a reciprocating translation component, and an extrusion component is installed on the movable frame to stretch the extruded material in conjunction with the translation of the movable frame. Two air-cooling components are provided, one on the movable frame and the other on the extrusion component, for continuous air cooling of the extruded material. The angle adjustment component is located on the air-cooling components. This utility model, through the above technical solution, solves the problem in the prior art where the cooling fan is fixed and it is difficult to continuously cool the extruded material.

The present application relates to a kind of intelligent color-changing absorbable suture and its preparation method, belong to medical instrument field.The suture includes inner layer support layer, response layer, drug release system and outer layer encapsulation layer.The inner layer support layer is made of absorbable polymer;Response layer includes pH response unit and enzyme response unit, can produce identifiable color change under tissue infection microenvironment;Drug release system is loaded with antibacterial drug by mesoporous nano-carrier and is modified with polyelectrolyte gate layer, triggers drug burst release under microenvironment change;Outer layer encapsulation layer is at least partially degradable, to expose response layer after predetermined time.The suture realizes phased degradation by three-layer structure: outer layer encapsulation layer is preferentially degraded to expose response layer, response layer degradation provides infection monitoring window period, and inner layer support layer is lastly degraded to maintain mechanical support, realizes the synergistic function of infection monitoring, drug release and tissue repair.

The invention discloses a preparation method of an antibacterial coating material based on synergistic interaction of antibiotics and metal ions. The preparation method comprises the following steps: (1) blending antibiotics, soluble salts of metal ions, an absorbable polymer and a mixed solvent to obtain a coating solution; the antibiotics are selected from rifampicin and minocycline hydrochloride; the metal ions are selected from Zn and / or Cu; the mixed solvent is selected from hexafluoroisopropanol and a methanol / aqueous solution, and the volume ratio of hexafluoroisopropanol in the mixed solvent is not less than 25%; and (2) uniformly spraying the coating solution on the surface of the degradable base material through ultrasonic spraying, and then carrying out drying treatment. The preparation method is easy and convenient to operate, the obtained coating is tightly combined with a degradable base material, and the antibacterial rate can still reach 90% or above after 50 times of washing. According to the prepared antibacterial coating material, the synergistic release mode of rapid sterilization and long-acting bacteriostasis is achieved through raw material screening and process optimization, and the short-term and long-acting antibacterial performance can be remarkably improved.

The invention discloses a preparation method of an absorbable antibacterial coating material capable of slowly releasing antibiotics. The preparation method comprises the following steps: step 1, blending antibiotics, an absorbable polymer and a mixed solvent to obtain a coating solution; the antibiotics are selected from rifampicin and minocycline hydrochloride; the absorbable polymer is selected from one or more of polyglycolide, polylactide, polyglycolide-co-lactide, polyglycolide-co-caprolactone and tyrosine polyarylester; the absorbable polymer is selected from one or more of polyglycolide, polylactide, polyglycolide-co-lactide, polyglycolide-co-caprolactone and tyrosine polyarylester; the mixed solvent is selected from hexafluoroisopropanol and acetonitrile, and the volume ratio of the hexafluoroisopropanol in the mixed solvent is not less than 25%; and 2, uniformly spraying the coating solution on the surface of the degradable base material through ultrasonic spraying, and then carrying out drying treatment. According to the preparation method disclosed by the invention, the antibiotic, the absorbable polymer and the organic solvent are blended and dissolved and then are attached to the surface of the absorbable material through ultrasonic spraying, and the release of the antibiotic is regulated and controlled while the stability of the coating is ensured by regulating and controlling the ratio of the antibiotic to the polymer and the swelling characteristic of the solvent to the base material.

This invention discloses a polymer ring-opening polymerization reaction control system based on high-viscosity rheological control, relating to the field of high-viscosity polymerization control technology, and specifically to the reaction control of the high-viscosity final stage of ring-opening polymerization of medical absorbable polymers PPDO or PGLA. A micro-bypass rheological measurement loop is installed alongside the main process to periodically collect fast variables and obtain reference viscosity point, shear consistency index, differential pressure drift, response time, and other health indicators. The bypass is isolated in case of abnormalities. Based on fast variable prediction and combined with health indicator calculations, a confidence weight is performed, and gated correction and parameter updates are executed, outputting a quality status estimate and reliable / suspicious / unusable tags. Trajectory control is performed under constraints such as temperature, torque, and differential pressure, with incremental control limited by tags. A degradation-cleaning-recovery state machine is triggered and an event log is recorded. This scheme can suppress false signal-driven processes, reduce the risk of deviation and loss of control, improve batch pass rate and closed-loop availability, and support continuous production traceability and operation and maintenance management.

This utility model discloses a spinning structure and spinning device for medical absorbable polymer materials, relating to the technical field of spinning structures for medical absorbable polymer materials. It includes a yarn output assembly; a cleaning assembly comprising a water tank, a first roller, and a second roller, both mounted on the inner wall of the water tank; a stirring assembly fixed inside the water tank; a blowing assembly mounted on the top of the water tank, including a blower mounted on the top of the water tank; and a winding assembly mounted on one side of the water tank, including a base plate mounted on one side of the water tank. A support column is fixedly connected to the top of the base plate, and a winding drum is mounted on one side of the support column. This utility model uses a rotating rod and a stirring rod to agitate the water, causing the higher water temperature around the path to alternate with the lower water temperature in other areas, resulting in a more uniform temperature distribution and improved cooling effect.

The application discloses a preparation method of a dual-function antibacterial and anti-inflammatory absorbable coating material, which comprises the following steps: (1) blending rifampicin, artemisinin and an absorbable polymer A with a mixed solvent to obtain coating solution A; blending minocycline hydrochloride, aspirin and an absorbable polymer B with the mixed solvent to obtain coating solution B; the mixed solvent is selected from hexafluoroisopropanol and ethyl acetate; (2) uniformly spraying the coating solution A and the coating solution B on the surface of a degradable substrate by ultrasonic spraying, and performing drying treatment to obtain the dual-function antibacterial and anti-inflammatory absorbable coating material. According to the preparation method, the proportion of antibiotic active ingredients, anti-inflammatory drug active ingredients and absorbable polymers is regulated, the antibacterial and anti-inflammatory drug coating is uniformly and stably fixed on the surface of the degradable substrate by ultrasonic spraying, and the dual-function absorbable antibacterial and anti-inflammatory coating material with controllable release is prepared by optimizing process parameters.

This application relates to a colorectal surgical device, specifically an absorbable anastomotic protection and fecal diversion device for post-colorectal surgery. It includes a fecal diversion device and an absorbable elastic band. The fecal diversion device comprises an inflatable flushing section, two balloon air tubes, a cleaning tube, and an intestinal protective film. The protective film has a hollow conduit housing the tubes. Two supporting balloons are spaced apart and sleeved on the distal end of the protective film, with the absorbable elastic band positioned between them. Made of absorbable polymer material, the device provides temporary anastomosis protection and fecal diversion after colorectal surgery. The external part naturally absorbs post-healing, while the internal device is easily removable.