Biodegradable and absorbable polymer superfine fibre film with radioactive nuclide marker and preparation and use thereof

A biopolymer and radionuclide technology, applied in the field of polymer ultrafine fiber membrane and its preparation, can solve the problems of insufficient hydrogel strength and in vivo stability

Inactive Publication Date: 2008-11-12
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are serious deficiencies in the strength and in vivo stability of hydrogels

Method used

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  • Biodegradable and absorbable polymer superfine fibre film with radioactive nuclide marker and preparation and use thereof
  • Biodegradable and absorbable polymer superfine fibre film with radioactive nuclide marker and preparation and use thereof
  • Biodegradable and absorbable polymer superfine fibre film with radioactive nuclide marker and preparation and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] See figure 1 . The high-voltage power supply 2 adopts a negative DC high-voltage output power supply, and the maximum output voltage is 40kV. The high-voltage power supply is connected to the injection end of the spinneret 5 of the syringe 1 through wires; the output mode of the syringe pump 4 adopts output pumps with various output frequencies to drive the syringe. Feeding, the maximum output range is 300 microliters per minute, the syringe pump is connected to the feed end of the spinneret of the syringe 1 through a catheter; the material of the spinneret is stainless steel, and the diameter of the spinneret is 0.8mm; the collection device is a rotating drum, The diameter is 80mm; the electrospinning environment temperature control device adopts infrared lamp heating method, the system is controlled by PID (proportional integral and proportional differential controller), and the control accuracy is within ±3°C.

[0092] (1) Preparation of solution: preparation of PLA...

Embodiment 2

[0097] The equipment is the same as in Example 1.

[0098] (1) Preparation of solution: prepare PLGA (LA / GA=75 / 25, molecular weight 150,000) concentration is 10ml of DMF solution of 25w / w%, add radionuclide compound 177 LuCl 3 0.01ml of aqueous solution, 177 LuCl 3 Quality: The quality of PLA is 1:200,000, and the polymer solution is placed in the syringe;

[0099] (2) Adjust the electrospinning device: select a single spinneret device and a metal plate as a collector; adjust the distance between the spinneret and the collector to be 10cm; the ambient temperature of spinning is 40 degrees, and the air velocity in the environment Controlled at 0.5~0.8m 3 / hr;

[0100] (3) Set the spinning process parameters: turn on the high-voltage power supply, adjust the voltage to 22KV, and the feeding speed of the solution is 40ul / min to spin, and the collected PLGA ultrafine fiber membrane is repeatedly used with deionized water and absolute ethanol After rinsing, vacuum-dry in a va...

Embodiment 3

[0103] See figure 2 . The high-voltage power supply 2 adopts a negative DC high-voltage output power supply, and the maximum output voltage is 40kV. The high-voltage power supply is connected to the injection end of the spinneret 5 of the syringe 1 through wires; the output mode of the syringe pump 4 adopts output pumps with various output frequencies to drive the syringe. Feeding, the maximum output range is 300 microliters per minute, the syringe pump is connected to the feed end of the spinneret of syringe 1 through a catheter; the spinneret material is made of stainless steel, and the diameter of the spinneret is 0.8mm; the spinneret is 60 degrees The included angle, the distance between the spinnerets is 1-5cm; the collection device is a rotating drum 3 with copper wires arranged in parallel, with a diameter of 120mm, and the electrostatic spinning environment temperature control device adopts infrared lamp heating method, and the system is PID control with high control ...

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Abstract

The invention relates to a bio-degradable and bio-absorbable macromolecule superfine fiber film with a radioactive nuclide mark and a method for making the same as well as medical use. The invention comprises the bio-degradable and bio-absorbable macromolecule superfine fiber film material or a composite superfine fiber film material with physically embedding radioactive nuclide mark, or the bio-degradable and bio-absorbable macromolecule superfine fiber film material or the composite superfine fiber film material with chelate radioactive nuclide mark having a bi-functional group coupling agent with surface chemical modification. The film material is a non-woven material consisting of fibers with diameters ranging from scores of nanometers to thousands of nanometers which is made through an electrostatic spinning process, and the radioactive nuclide is compounded inside the fibers or on the surfaces of the fibers by means of physics and chemic. The fiber film material with the radioactive nuclide mark is covered at a tumour part or a lesion tissue part after resection, thereby effectively killing the residual tumour cells, and playing roles in stanching, healing wound and preventing adhesion and so on.

Description

technical field [0001] The invention belongs to the field of radionuclide-containing polymer microfiber membranes, in particular to biodegradable and bioabsorbable polymer microfiber membranes labeled with radionuclides, a preparation method and medical application thereof. Background technique [0002] Tumor treatment methods can basically be divided into surgery, drug therapy and radiation therapy. In drug therapy, through oral or intravenous injection of anticancer drugs, only a small amount of drugs accumulate in the tumor due to the lack of targeting, and the systemic distribution of drugs will cause serious side effects. In addition, through arterial injection, a relatively large amount will be accumulated in the tumor site to improve the curative effect, but it will still inevitably accumulate in the liver, kidney, spleen and other organs, causing serious damage to the above organs. [0003] At present, most radiotherapy methods are external radiation therapy or intr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/16A61L31/04A61K51/06C08L67/00C08J5/18D01F8/14C08K5/53C08L5/00C08L1/02C08L3/02C08K5/17C08K3/08
Inventor 韩志超贺爱华许杉杉李军星聂华容
Owner INST OF CHEM CHINESE ACAD OF SCI
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