The invention discloses a composite
solid filler and a preparation method and application thereof, the composite
solid filler comprises
polylactic acid microspheres,
calcium source particles, a suspending aid and a freeze-
drying protective additive, the particle size D50 of the
polylactic acid microspheres is 10-100 [mu] m, the particle size D50 of the
calcium source particles is 5-70 [mu] m, and the
mass ratio of the
polylactic acid microspheres to the
calcium source particles is 1: (0.4-50). The dosage of the suspending aid is 5-30% of the total
mass of the composite
solid filler, and the dosage of the freeze-
drying protective agent is 5-10% of the total
mass of the composite solid filler. The polylactic acid microspheres and the calcium source particles are compounded, so that the acidity generated by the polylactic acid microspheres can be neutralized with the
alkalinity of the calcium source particles in the in-vivo
degradation process, and the
inflammation and
irritation of the two materials to the
human body are reduced. And the solid preparation is obtained through a freeze-
drying process, so that the transportation and storage stability of the product is improved. The product is uniformly dispersed after being redissolved, has relatively low pushing force, and can be applied to the fields of filling of
skin or other tissue parts,
drug carriers and the like.