858 results about "ExAblate" patented technology

The invention discloses an ablation impedance dynamic prediction method based on multi-modal time sequence fusion and a related device. The method comprises the following steps: acquiring multi-modal time sequence data of an ablation electrode in real time, and constructing a multi-dimensional input vector containing a temperature change rate, an ultrasonic echo gradient and a standardized timestamp; performing parameter fine tuning by using a pre-trained two-channel long-short-term memory neural network, respectively extracting feature vectors of the physical parameters and the image parameters, fusing the feature vectors, and outputting an impedance predicted value in a future preset time window; and dynamically adjusting the ablation output power by adopting a proportional control strategy based on the deviation between the predicted impedance and the target impedance. Through time sequence fusion of the multi-modal data and the prediction capability of the deep learning model, the real-time monitoring and power adjustment precision of the ablation process is improved, and the safety and effect stability of ablation treatment are effectively improved.

The embodiment of the present application provides an ultrasonic ablation device and equipment. The ultrasonic ablation device is used for being selectively placed in a cavity of a human body and performing ultrasonic ablation on a tissue to be ablated in the human body, and comprises a catheter and a deformation transducer. Two ends of the catheter are respectively a liquid inlet end and a liquid outlet end, and a positioning capsule is arranged on the outer wall close to the liquid inlet end, the positioning capsule is used for being placed in the cavity and being deformed to selectively position the catheter. The deformation transducer is arranged on the outer periphery of the positioning capsule, and under the action of the deformation force of the positioning capsule, the deformation transducer is deformed to selectively emit ultrasonic energy along a first direction, and the first direction can form an included angle of 10 degrees to 90 degrees with the axial direction of the catheter. The embodiment of the present application can effectively expand the size of the deformation transducer, and then can make the treatment range of the ultrasonic ablation device wider, and effectively improve the treatment effect.

A method for mid-intensity non-ablative acoustic treatment of injured tissue is disclosed. The method involves continuously moving an ultrasound probe across an extracorporeal skin surface while emitting non-ablative therapeutic ultrasound into the injured tissue in a non-ablative therapeutic ultrasound beam profile. The method terminates energy delivery if movement speed is below a speed threshold. The non-ablative therapeutic ultrasound beam profile provides substantially uniform heating throughout a treatment volume. The heating is non-ablative and triggers a healing response in the injured tissue.

The invention belongs to the technical field of ablation puncture navigation, and particularly relates to an ablation puncture surgery navigation system under AI visual guidance. Through cooperative work of the phase monitoring module, the channel construction module, the needle moving control module, the displacement prediction module and the feedback control module, an intelligent surgical navigation system is constructed, breathing phase information and multi-modal medical image data of a patient can be obtained in real time, and therefore a safe and optimized needle moving path is accurately planned, and the operation accuracy is improved. Meanwhile, through real-time monitoring and quantitative evaluation of parameters such as tissue deformation and pressure distribution in the needle moving process, potential operation risks can be found and corrected in time, smooth operation is ensured, in addition, the system can dynamically adjust the needle moving path and the puncture angle according to the real-time breathing state of a patient, and the operation safety is improved. The accuracy and the safety of the operation are further improved, so that intelligent management and personalized treatment in the ablation puncture operation process are realized.

Treatment of damaged, diseased, abnormal, obstructive, cancerous or undesired tissue (e.g. a tumor, a benign tumor, a malignant tumor, a cyst, or an area of diseased tissue, etc) is provided by delivering specialized pulsed electric field energy to target tissue areas in a specific dose so as to obtain a superior outcome. The specialized PEF energy and delivery has been optimized to provide advanced treatment of target tissue areas, including destruction of undesired tissue and generation of improved inflammatory and immune responses. The specialized PEF energy provides superior outcomes to radiofrequency ablation and irreversible electroporation.

The invention discloses a tumor ablation puncture operation planning method and system, and relates to the technical field of medical image processing, and the method comprises the steps: obtaining multi-modal image data of a tumor region, carrying out the preprocessing, carrying out the fusion processing of the preprocessed multi-modal image data through an image fusion algorithm, generating a fusion image, and carrying out the planning of a tumor ablation puncture operation based on the fusion image. A tumor area is automatically marked by using an image segmentation technology, a doctor manually corrects a segmentation result, an optimal puncture path is selected through design and simulation according to a fusion image with a tumor mark, a model and a tumor entity position are accurately aligned by using a space positioning technology based on the fusion image and augmented reality equipment, and an AR view is generated. And under the guidance of the AR view, the puncture needle carries out ablation operation according to the optimal puncture path. Through high-quality images and three-dimensional guidance, high precision and visualization of the whole process from image acquisition to operation implementation are achieved, and the safety and success rate of the operation are remarkably improved.

The invention discloses a thoracoscope minimally invasive cardiac surgery navigation system based on multi-modal image fusion, and the system comprises the steps: constructing a 5D heart digital twin containing an anatomical structure, a soft tissue boundary, metabolic activity and electrophysiological information through fusing preoperative CT, MRI, PET and intraoperative ultrasonic images; real-time dynamic registration is realized by using an electrocardio gating driven biomechanical model; superposing the multi-color coding navigation information to the visual field of the thoracoscope through a wavelength selection type spectroscope; a dynamic risk scoring model is constructed based on the distance, the speed and the tissue vulnerability, and three-level grading intervention is triggered; a miniature force feedback actuator is integrated to realize closed-loop control; and pre-operation virtual drilling and post-operation federal learning optimization are supported. The system remarkably improves the surgical precision and safety, and is suitable for high-difficulty heart minimally invasive surgeries such as mitral valve repair and atrial fibrillation ablation.

The invention provides a microwave ablation control system and method used based on nuclear magnetic resonance, and belongs to the technical field of ablation control, and the system comprises an MRI rapid temperature measurement module, a temperature prediction module, a microwave ablation power control module, a tissue impedance monitoring module and a data fusion processing module. The microwave ablation instrument, the MRI rapid temperature measurement module and the tissue impedance monitoring module are all connected with the data fusion processing module, the microwave ablation instrument is further connected with a microwave ablation needle inserted in ablation area tissue, and the temperature prediction module and the microwave ablation power control module operate on the data fusion processing module; in combination with the method, the defects that in an existing microwave ablation control method used based on nuclear magnetic resonance, due to the fact that the MRI temperature measurement sequence collection and reconstruction speed is limited, the closed loop control period is too long, the nonlinear change of the heating rate caused by tissue impedance mutation cannot be coped with, and then the overtemperature or undertemperature problem occurs are overcome.

The invention relates to the technical field of minimally invasive ablation, in particular to a liver tumor microwave ablation postoperative contraction deformation prediction method, which comprises the following steps: performing unified standardization processing on different periods of liver MRI images; accurately marking a preoperative liver tumor area, a postoperative ablation area and a postoperative liver tumor ghost area of the liver MRI image to obtain masks of the corresponding areas; designing a distance perception function as an attention parameter of different areas of the liver MRI image; constructing a multi-sequence distance guide complementary network model; selecting a loss function; selecting an elastic registration method to perform pre-operation and post-operation registration; and calculating an ablation safety boundary through the ablation area mask and the adjusted tumor mask. The liver tumor microwave ablation postoperative curative effect evaluation accuracy can be effectively improved, and a foundation is laid for formulating a subsequent treatment plan of a patient.

The invention relates to the technical field of medical equipment, and provides a focused ultrasound system with multiple treatment modes. The drive circuit comprises a signal generation module which outputs a first ultrasonic generation signal suitable for a thermal ablation mode or a second ultrasonic generation signal suitable for a histotripsy mode; the energy amplification module comprises a signal end, a power supply end and an output end coupled with the ultrasonic transducer; the energy amplification module comprises an isolation driving circuit which outputs a first switch driving signal and a second switch driving signal which are opposite based on an input ultrasonic generation signal; and the power amplification circuit comprises a second switch unit and a first switch unit which are set to be in opposite switch states by opposite driving signals so as to output ultrasonic driving signals to excite the ultrasonic transducer to form focused ultrasound in a histotripsy mode or a thermal ablation mode. The driving circuit is simple in structure and easy to realize, and can meet power supply requirements of various modes such as thermal ablation, histotripsy and the like.

The invention belongs to the technical field of physical thermal ablation, and relates to a physical thermal ablation energy regulation and control method based on intelligent feedback, and the method comprises the steps: collecting point-shaped temperature data, impedance data and ultrasonic data, eliminating the asynchronization and heterogeneity problems through space-time alignment, and combining with focus region segmentation, thereby achieving the energy regulation and control of the physical thermal ablation. Discrete data and continuous images are integrated into a voxelization data cube containing space coordinates, physical attributes and semantic tags, then the temperature change rate and the impedance change rate are calculated based on the voxelization data cube, and then a morphological prediction network is fused with multi-modal features to output a voxel-level ablation probability graph. The method comprises the following steps: realizing prospective prediction of an ablation range, ensuring ablation accuracy by morphological deviation through a three-layer parallel regulation and control strategy, preventing and controlling local overheating by temperature gradient, avoiding tissue carbonization by an impedance change rate, and cooperatively deciding through multi-dimensional indexes to solve the contradiction that single regulation and control cannot give consideration to accurate coverage of a focus and protection of normal tissues; and misjudgment caused by abnormity of single data is avoided.

The present invention discloses a method and device for determining ablation parameters for high-frequency pulse electric field ablation. The method comprises: acquiring collected medical image data containing depth information, determining a corresponding lesion box containing three-dimensional information of the lesion based on the medical image data; analyzing and segmenting the lesion box to obtain the contour and depth of the lesion and the contour of the electrode used to ablate the lesion; starting from a plurality of equally spaced points on the boundary of the electrode contour, emitting a preset number of rays to the surrounding area, obtaining the number of intersections between the rays and the lesion box to determine whether the electrode and the lesion are in contact; when the electrode and the lesion are in contact, determining the corresponding ablation parameters based on the contour and depth of the lesion, the ablation parameters including pulse voltage, pulse width, number of pulse trains, and number of discharges. The present invention solves the problem of inaccurate ablation parameter determination in the prior art.

The invention relates to the technical field of medical instruments, and provides a steep pulse-based ablation system and method for liver cancer cells, and the system comprises a tumor feature recognition module which is used for obtaining imaging images of the liver cancer cells and recognizing tumor features, blood supply conditions and tumor centers of the liver cancer cells; the electrode inlet setting module is used for setting a safety boundary of liver cancer cells and setting an ablation area and a focus skin surface of the liver cancer cells based on the safety boundary and tumor characteristics; the ablation effect analysis module is used for calculating the electrode depth and the electrode angle of the liver cancer cells and analyzing the coverage effect of an ablation area; the electric field intensity identification module is used for analyzing cell membrane characteristics of the hepatoma cells, identifying the electroporation effect of the hepatoma cells and identifying the electric field intensity of the hepatoma cells; and the steep pulse ablation module is used for performing ablation treatment on the liver cancer cells in combination with the electric field intensity and a pulse generator to obtain an ablation result. The invention aims to avoid heat injury of surrounding tissues and improve the ablation effect of liver cancer cells.

The invention relates to the technical field of medical instruments, in particular to a steep pulse ablation coordinated control system and method based on three-dimensional dynamic electrode array.The steep pulse ablation coordinated control system comprises a multi-degree-of-freedom electrode array module, a dynamic pulse control module, a multi-modal fusion module and an intelligent optimization module; self-adaptive layout is carried out according to the shape and size of a tumor, the electrode needles can be accurately distributed no matter the tumor is spherical or irregular, for the tumor with the diameter being 3.5 cm close to the porta hepatis, six-electrode annular arrangement and vertical insertion of a central electrode can be planned, and the distance between the electrodes can be dynamically adjusted; the problems that a traditional electrode is rigid in layout and difficult to adapt to complex tumor forms are effectively solved, it is ensured that an electric field completely covers a tumor area, the matching degree of an ablation area is improved, and complete ablation of irregular tumors is facilitated.

The invention relates to a diagnosis and treatment integrated endoscopic catheter, and belongs to the technical field of medical instruments. The endoscopic catheter comprises a catheter probe, an imaging assembly and an ablation assembly. A first accommodating space and a second accommodating space are formed in the catheter probe, the first accommodating space is formed in the middle of the catheter probe in the axial direction, and the second accommodating space is formed in the catheter wall of the catheter probe in the axial direction; the imaging assembly is placed in the first accommodating space, laser beams emitted by the imaging assembly are emitted to one side of the second accommodating space, and an imaging area is formed after the laser beams are absorbed by the imaging tissue; the ablation assembly is placed in the second containing space, the laser emitting end face of the ablation assembly is an inclined face, the emitted ablation laser beams are emitted out along the inclination angle of the inclined face, laser ablation is directly conducted on the focus area of the imaging area, and the diagnosis and treatment integrated endoscopic catheter achieves integrated miniaturization integration of the imaging function and the ablation function.

The invention belongs to the technical field of medical instruments, and provides a multi-modal focused ultrasound treatment system which comprises an image acquisition device and a multi-angle focused ultrasound treatment system, and the multi-angle focused ultrasound treatment system comprises a transmitting-receiving integrated focused ultrasound probe, a multi-degree-of-freedom moving device and a multi-modal treatment workstation. The system acquires an image of a region of interest through the image acquisition device, adjusts the position of the focused ultrasound probe by using the multi-degree-of-freedom moving device, receives and processes the image by the multi-modal treatment workstation, controls the focused ultrasound probe to emit various wave band pulses, generates a cavitation bubble cloud in a cavitation region, positions the cavitation region, and transmits the cavitation bubble cloud to the multi-modal treatment workstation. And performing cavitation / ablation / treatment on the tissue of the region of interest. The system adopts a high-intensity focused ultrasound multi-channel phased array probe, has a multi-mode phase control function, can overcome the reflection and refraction problems of ultrasound in tissues, accurately focuses a focus on a treatment area, realizes accurate treatment of target tissues, and improves the treatment effect and safety.

A high and low temperature composite ablation surgery system, relating to the technical field of cryotherapy, used to improve the safety and effectiveness of therapy, and comprising a main unit (100) and a cryogenic-thermal ablation probe (200) connected to the main unit (100). The main unit (100) comprises a cold working medium supply system (300), a hot working medium supply system (400), and a working medium distribution system (500). The working medium distribution system (500) can respectively control the cold working medium supply system (300) to deliver a cold working medium to the cryogenic-thermal ablation probe (200) and control the hot working medium supply system (400) to deliver a hot working medium to the cryogenic-thermal ablation probe (200). Therefore, after low-temperature therapy is completed, a therapy area can be quickly rewarmed, thereby providing a basis for improving the safety, economy and convenience of the surgery.

Disclosed herein is a composition for enhanced ultrasound ablation and methods relating to same. The composition may include a microbubble-microdroplet cluster composition, wherein the microbubble-microdroplet cluster composition may include groups of negatively charged microbubbles and positively charged microdroplets permanently held together by their opposing electrostatic attractive forces to form a single, agglomerated entity.

The invention discloses an ablation system and method, the system integrates a handheld ablation unit and a guiding device, the guiding device fixed on the surface of an ablated tissue is used for fixing and guiding the direction of the handheld ablation unit, and the focus of focused ultrasound is located at a target ablation position in combination with an intelligent image guiding and energy self-adaptive regulation and control technology; and accurate positioning of the target ablation position is realized. According to the system, the digital twin navigation technology is utilized, the millimeter-level miniature parallel robot is combined, high-precision automatic measurement and ablation site positioning are achieved, the workload of manual adjustment of doctors is reduced, the treatment process is optimized, the treatment efficiency is greatly improved, and the system is suitable for patient groups in a larger range.

The invention relates to the technical field of temperature control, in particular to a multi-dimensional compensation ablation system temperature control system, method and device and a medium. The system calculates a medium texture index representing the structural change of the load medium by synchronously acquiring electrical parameters and ultrasonic image data; constructing an anti-interference control model comprising an extended state observer, and defining energy transmission loss caused by contact thermal resistance as an extended state variable; calculating an adaptive correction factor based on the texture index, dynamically correcting the state updating process of the observer to obtain an energy loss correction estimated value, and constructing a compensation control model to adjust the output power according to the energy loss correction estimated value; according to the invention, the technical problem of incomplete heating caused by false high temperature of the sensor and system misjudgment due to state deterioration of the contact interface is effectively solved; accurate reconstruction and closed-loop compensation of effective heat flow in a non-ideal contact environment are realized, sufficient energy penetration can still be maintained even if contact thermal resistance is sharply increased, and the integrity of an ablation area is guaranteed.

Apparatus and methods for deactivating bronchial nerves and ablating smooth muscle extending along a bronchial branch of a mammalian subject to treat asthma and related conditions. An ultrasonic transducer (11) is inserted into the bronchus as, for example, by advancing the distal end of a catheter (10) bearing the transducer into the bronchial section to be treated. The ultrasonic transducer emits ultrasound so as to heat tissues throughout a relatively large impact volume (13) to a temperature sufficient to inactivate nerve conduction and ablate smooth muscle but insufficient to cause rapid ablation or necrosis of the surrounding tissues. The treatment can be performed without locating or focusing on individual bronchial nerves or smooth muscle.

The invention discloses a prostate ablation operation needle insertion position construction method and a navigation system, and the method employs a three-dimensional model constructed by an MRI image, and determines the position of a needle insertion point and the number of inserted needles according to the ratio of the longitudinal axis distance between cystamen and verufugu to the diameter of a cylinder of single ablation needle ablation. If the upper and lower diameters of the prostate lateral lobes of the horizontal section corresponding to a single needle insertion point are smaller than 4cm, one needle is inserted into the horizontal plane; if the upper diameter and the lower diameter are greater than or equal to 4cm, entering two stitches; if the maximum diameter of the prostate lateral lobe at a certain longitudinal axis position in the horizontal direction is larger than 1 cm, a needle inserting point is additionally added, and if the length of the part protruding to the middle lobe of the bladder is larger than 1 cm, the needle inserting point is additionally added. The needle inserting point is utilized to enter a surgical navigation system, and the operation is accurately carried out in a unified mode under the guidance of the navigation system. A good treatment effect can be achieved when the hot steam ablation needle is punctured into a hyperplastic prostate near the urethra through the needle insertion point for ablation, the needle insertion point is constructed on the coronal section to ensure the ablation range, and the surgical risk is reduced.

The invention provides a radiofrequency ablation system based on multi-source data, and relates to the technical field of medical instruments, and the system comprises an ablation area judgment device which is used for judging whether an operation target meets the ablation requirement or not according to a real-time ultrasonic image of the operation target; the data processing device is used for determining an ablation strategy of an ablation area of the operation target according to the real-time electrocardiogram data and the real-time vital sign data of the operation target in combination with a preset radiofrequency ablation working mode when the operation target meets the ablation requirement; the radio frequency energy generating device is used for generating corresponding radio frequency energy according to the ablation strategy; and the ablation device is used for performing ablation operation according to the radio frequency energy action. By integrating multi-source data such as real-time ultrasonic images, electrocardiogram monitoring and vital sign monitoring, accurate judgment of ablation requirements, dynamic adjustment of ablation strategies and accurate output of ablation energy are achieved, and the safety, accuracy and curative effect of cardiac radiofrequency ablation treatment are improved.

A device for therapeutic ablative treatment of residual plaque on, in, and / or surrounding a stent within a blood vessel of a subject includes a jacket configured for insertion within a stent within a blood vessel of a subject. The device further includes an ultrasound transducer located within the jacket and having at least one active element oriented to deliver ultrasound energy in a radial and / or axial direction of the jacket from within the stent to ablate the residual plaque.

The invention provides an electric tungsten fire needle tumor ablation system, and the system comprises an image navigation module which is used for integrating CT / MRI / ultrasonic images, constructing a three-dimensional tumor model in real time, tracking a target region through electromagnetic positioning, and dynamically calibrating a needle insertion path; the insulating tungsten fire needle execution module is used for adopting a high-density tungsten alloy needle body and a multi-axis mechanical arm to control multi-angle puncture; the energy output module is used for intelligently adjusting radio frequency / microwave power and releasing energy in a pulse mode; and the temperature control feedback module is used for monitoring the temperature in real time and automatically terminating overheating energy. According to the technical scheme, accurate, safe and effective ablation of tumors is achieved.

The invention belongs to the technical field of medical instruments, and particularly relates to a prostate microwave ablation device which comprises a handle, an outer catheter is fixed to one end of the handle, an ablation cavity and a flushing cavity are formed in the outer catheter, and a needle outlet is formed in the end, away from the handle, of the outer catheter. The ablation cavity and the needle outlet are communicated with each other, the flushing cavity and the needle outlet are communicated with each other, a coil driving unit is assembled at the end, close to the outer catheter, of the interior of the handle, a needle advancing and retreating button is assembled at the upper end of the handle, and the coil driving unit and the needle advancing and retreating button are electrically connected through a wire. The prostate focus tissue is rapidly heated to about 150 DEG C through microwave energy, thermal coagulation and necrosis of the focus tissue are achieved, the method has the advantages of being rapid in effect taking and low in recurrence rate, meanwhile, water molecules are gasified through high temperature, the ablation process is conveniently monitored in real time through ultrasonic images, and compared with the prior art, the diameter is obviously reduced, and implementation of a soft needle is facilitated.

The invention relates to a crack segmentation deep learning method based on logging imaging. The method comprises the steps of data acquisition and preprocessing; optimizing a target detection algorithm, specifically including adding an MSF attention mechanism module, replacing a network loss function, replacing with a more lightweight network, and optimizing a pyramid pooling layer; and carrying out an ablation experiment, and screening out an electrical imaging fracture segmentation network model with optimal performance by combining comprehensive index analysis of experimental data. According to the invention, an attention mechanism module-MSF is designed, so that crack characteristics can be accurately represented and background interference can be effectively suppressed. By optimizing an original network structure, including improving a pyramid pooling network layer to integrate higher-scale features, replacing a more appropriate loss function and replacing the pyramid pooling network layer with a more lightweight skeleton network, the overall generalization ability and robustness of the model are remarkably improved through the optimization, and a model foundation is laid for a subsequent imaging crack segmentation task.

The invention discloses steam ablation equipment which comprises an industrial personal computer, a steam generator, a gear pump system based on PID self-regulation, a heat tracing pipe, a sensor, an upper computer and an electromagnetic valve. The temperature index of steam output is controlled, the steam outlet pressure is controlled, and it can be known through simulation that in steam ablation, the temperature and the outlet pressure have important influences on the ablation effect; in order to realize accurate control of air pressure, a gear pump system based on PID self-regulation is adopted to realize closed-loop control of air outlet pressure; in order to realize accurate temperature control, the steam generator is divided into a vaporizing chamber and a heating chamber; the air outlet pressure and the air outlet temperature can be set at will, and by matching with different steam outlet needles, the device can be applied to the field of steam ablation in various occasions, such as chronic obstructive pulmonary disease, prostate and tumor fields possibly involved in the future.

Presented herein are methods, systems, devices, and computer-readable media for image management in image-guided medical procedures. Some embodiments herein allow a physician to use multiple instruments for a surgery and simultaneously provide image-guidance data for those instruments. Various embodiments disclosed herein provide information to physicians about procedures they are performing, the devices (such as ablation needles, ultrasound transducers or probes, scalpels, cauterizers, etc.) they are using during the procedure, the relative emplacements or poses of these devices, prediction information for those devices, and other information. Some embodiments provide useful information about 3D data sets and allow the operator to control the presentation of regions of interest. Additionally, some embodiments provide for quick calibration of surgical instruments or attachments for surgical instruments.

The invention provides a numerical simulation method for large tumor treatment of single-needle multi-point microwave ablation, and belongs to the technical field of large liver tumor data simulation. The method comprises the following steps: establishing a finite element simulation model, and solving the finite element simulation model according to the interaction among an electromagnetic field, heat conduction and biological tissues to obtain a simulation result; constructing a single-needle multi-point microwave ablation numerical model; carrying out ablation simulation by utilizing the single-needle multi-point microwave ablation numerical model, outputting multi-point ablation result data, quantifying the size and form of a solidification area, and carrying out space overlapping analysis on a contour surface to obtain the characteristics of the solidification area; ablation simulation is carried out by setting parameter combinations of pull-back distances and ablation time of a plurality of antennas, and an optimal parameter combination is obtained by combining feature analysis of a solidification area, so that numerical simulation of large tumor treatment is completed; according to the invention, the problems of low ablation temperature, long simulation time and difficulty in accurate positioning of the antenna in the existing single-needle multi-point microwave ablation simulation method are solved.