1121 results about "ExAblate" patented technology

The invention relates to the technical field of region segmentation, in particular to a tumor medical image processing method and system of a tumor ablation treatment system. According to the method, a CT image of a disease site is primarily segmented to obtain a tissue region, an initial abnormal region is screened out, and a final abnormal region is screened out according to the difference between the shape change degrees of the initial abnormal region and an analysis region thereof and the difference between the image numbers of the CT image of the disease site where the initial abnormal region and the analysis region thereof are located. Then, mistakenly segmented areas are screened; and according to the position distribution difference of the edge pixel points of the mistakenly segmented region and the analysis region thereof, adjusting the gradient value of the edge pixel points of the mistakenly segmented region, and then performing region segmentation on the CT image of the diseased part again by using the adjusted gradient value. According to the method, the accuracy of region segmentation of the CT image of the diseased part is effectively improved.

Ablation systems and methods of the present disclosure include a catheter including one or more image sensors. The one or more image sensors can facilitate, for example, positioning an ablation electrode at a treatment site of an anatomic structure and, additionally or alternatively, can facilitate controlling delivery of therapeutic energy to a treatment site of an anatomic structure.

The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.

The invention discloses an ablation impedance dynamic prediction method based on multi-modal time sequence fusion and a related device. The method comprises the following steps: acquiring multi-modal time sequence data of an ablation electrode in real time, and constructing a multi-dimensional input vector containing a temperature change rate, an ultrasonic echo gradient and a standardized timestamp; performing parameter fine tuning by using a pre-trained two-channel long-short-term memory neural network, respectively extracting feature vectors of the physical parameters and the image parameters, fusing the feature vectors, and outputting an impedance predicted value in a future preset time window; and dynamically adjusting the ablation output power by adopting a proportional control strategy based on the deviation between the predicted impedance and the target impedance. Through time sequence fusion of the multi-modal data and the prediction capability of the deep learning model, the real-time monitoring and power adjustment precision of the ablation process is improved, and the safety and effect stability of ablation treatment are effectively improved.

The embodiment of the present application provides an ultrasonic ablation device and equipment. The ultrasonic ablation device is used for being selectively placed in a cavity of a human body and performing ultrasonic ablation on a tissue to be ablated in the human body, and comprises a catheter and a deformation transducer. Two ends of the catheter are respectively a liquid inlet end and a liquid outlet end, and a positioning capsule is arranged on the outer wall close to the liquid inlet end, the positioning capsule is used for being placed in the cavity and being deformed to selectively position the catheter. The deformation transducer is arranged on the outer periphery of the positioning capsule, and under the action of the deformation force of the positioning capsule, the deformation transducer is deformed to selectively emit ultrasonic energy along a first direction, and the first direction can form an included angle of 10 degrees to 90 degrees with the axial direction of the catheter. The embodiment of the present application can effectively expand the size of the deformation transducer, and then can make the treatment range of the ultrasonic ablation device wider, and effectively improve the treatment effect.

A method for mid-intensity non-ablative acoustic treatment of injured tissue is disclosed. The method involves continuously moving an ultrasound probe across an extracorporeal skin surface while emitting non-ablative therapeutic ultrasound into the injured tissue in a non-ablative therapeutic ultrasound beam profile. The method terminates energy delivery if movement speed is below a speed threshold. The non-ablative therapeutic ultrasound beam profile provides substantially uniform heating throughout a treatment volume. The heating is non-ablative and triggers a healing response in the injured tissue.

The invention discloses a puncture robot tumor ablation method and system based on magnetic resonance. The method comprises the following steps: scanning a focus through medical imaging examination to obtain a preoperative magnetic resonance image; reconstructing to obtain a three-dimensional model of the focus and surrounding tissues, and planning to obtain an optimal puncture path; updating the position relation between the needle point of the puncture needle and the focus center in real time, feeding back deviation information of the needle point position, and guiding the puncture needle to a tumor ablation area in real time; two-way ablation is adopted, real-time temperature monitoring and whole blood circulation dynamic monitoring are conducted, and ablation power and time are correspondingly adjusted; the ablation effect is consolidated by adopting a postoperative wound management and closing technology; the ablation effect is evaluated through magnetic resonance imaging examination and postoperative biopsy. According to the puncture robot tumor ablation method based on magnetic resonance, tumor ablation can be achieved, temperature and blood flow monitoring is effectively carried out, and the ablation effect and the residual focus condition are reflected in real time through a comprehensive postoperative evaluation method.

The invention discloses a real-time monitoring puncture robot tumor ablation method and system, and the method comprises the steps: obtaining a tumor molecular level image, combining the tumor molecular level image with medical image data, carrying out the multi-level reconstruction, and obtaining a three-dimensional model of an organ and a tumor; extracting feature points of a tumor and a surrounding anatomical structure, and performing precision registration on a tumor position in the three-dimensional model and an ablation needle; adopting a self-adaptive path planning algorithm to formulate an optimal insertion path of the puncture needle; a sensor network is integrated on the ultrasonic probe and the puncture needle, information of a needle tip and surrounding tissue is monitored, thermal field distribution and the real-time position of the needle are updated in combination with the three-dimensional model, and the power and time of the ablation needle are adjusted; after ablation is finished, ultrasonic and CT image combined examination is carried out, and the tumor coverage condition of an ablation area is detected. According to the system, more accurate real-time guidance can be provided in the puncture process, the system cost is remarkably reduced, and the operation convenience is improved.

The multi-electrode assembly of the present disclosure includes a plurality of electrodes and an electrode support member, a portion of which is adapted to selectively ablate tissue in contact therewith, and at least a portion of the electrodes are disposed on the electrode support member and configured to detect electrophysiological properties of the tissue. The electrode support member may be constructed of a flexible material and may be shaped to easily contact a particular anatomical structure (e.g., a straight shape, a loop shape, a spiral shape, a planar array shape, or a basket shape). The described embodiments allow for selective actuation of the electrode support member for ablation and selective actuation of the electrodes for electrophysiological mapping and / or ablation.

The invention belongs to the technical field of ablation puncture navigation, and particularly relates to an ablation puncture surgery navigation system under AI visual guidance. Through cooperative work of the phase monitoring module, the channel construction module, the needle moving control module, the displacement prediction module and the feedback control module, an intelligent surgical navigation system is constructed, breathing phase information and multi-modal medical image data of a patient can be obtained in real time, and therefore a safe and optimized needle moving path is accurately planned, and the operation accuracy is improved. Meanwhile, through real-time monitoring and quantitative evaluation of parameters such as tissue deformation and pressure distribution in the needle moving process, potential operation risks can be found and corrected in time, smooth operation is ensured, in addition, the system can dynamically adjust the needle moving path and the puncture angle according to the real-time breathing state of a patient, and the operation safety is improved. The accuracy and the safety of the operation are further improved, so that intelligent management and personalized treatment in the ablation puncture operation process are realized.

Treatment of damaged, diseased, abnormal, obstructive, cancerous or undesired tissue (e.g. a tumor, a benign tumor, a malignant tumor, a cyst, or an area of diseased tissue, etc) is provided by delivering specialized pulsed electric field energy to target tissue areas in a specific dose so as to obtain a superior outcome. The specialized PEF energy and delivery has been optimized to provide advanced treatment of target tissue areas, including destruction of undesired tissue and generation of improved inflammatory and immune responses. The specialized PEF energy provides superior outcomes to radiofrequency ablation and irreversible electroporation.

According to the precise diagnosis and treatment integrated platform and method based on the coupling model, the cavitation effect is predicted through numerical simulation, negative feedback adjustment is conducted on microbubble mediated ultrasonic treatment, and precise control over the microbubble mediated ultrasonic treatment is achieved. Acoustic parameters are adjusted in real time, it can be ensured that treatment focuses on a lesion area, damage to surrounding healthy tissue is reduced, and therefore the accuracy and safety of treatment are improved. The platform integrates cavitation detection and an acoustic feedback mechanism, the microbubble cavitation effect can be monitored in real time, and treatment parameters can be automatically adjusted. Negative feedback closed-loop control can ensure a stable cavitation state, tissue damage caused by excessive cavitation is effectively avoided, and the stability and reliability of treatment are improved. The platform simplifies the operation process of controlling acoustic parameters. A doctor can complete the whole process from treatment to monitoring on the same operation interface through the integrated platform, and convenience and efficiency of clinical operation are improved. The platform is not only suitable for tumor treatment, ablation and drug delivery, but also can be applied to multiple treatment fields such as vascular diseases and neuromodulation, and has wide clinical application prospects and market potential.

The invention discloses a tumor ablation puncture operation planning method and system, and relates to the technical field of medical image processing, and the method comprises the steps: obtaining multi-modal image data of a tumor region, carrying out the preprocessing, carrying out the fusion processing of the preprocessed multi-modal image data through an image fusion algorithm, generating a fusion image, and carrying out the planning of a tumor ablation puncture operation based on the fusion image. A tumor area is automatically marked by using an image segmentation technology, a doctor manually corrects a segmentation result, an optimal puncture path is selected through design and simulation according to a fusion image with a tumor mark, a model and a tumor entity position are accurately aligned by using a space positioning technology based on the fusion image and augmented reality equipment, and an AR view is generated. And under the guidance of the AR view, the puncture needle carries out ablation operation according to the optimal puncture path. Through high-quality images and three-dimensional guidance, high precision and visualization of the whole process from image acquisition to operation implementation are achieved, and the safety and success rate of the operation are remarkably improved.

The invention relates to an ablation monitoring system based on real-time temperature and image feedback data, and the system comprises a temperature collection device which collects first temperature change information in a tumor internal ablation process in real time; the ablation device is configured to provide energy required by tumor ablation and is provided with a model of a color and temperature corresponding relation of a tumor surface image, and the model is called a first relation model for short; the image acquisition device acquires tumor surface ablation process image information in real time, which is called a first image for short; the temperature identification device is used for matching the color of each pixel of the first image with the first relation model to obtain the second temperature change information; the three-dimensional model simulation device is used for establishing a tumor three-dimensional model; and displaying the first temperature change information and the second temperature change information on the three-dimensional model in real time. By monitoring the temperature change in the tumor and the temperature change of the surface in the ablation process, the tumor ablation boundary is accurately controlled, and transition ablation is prevented.

The invention provides a thyroid ablation intraoperative monitoring method and system, a storage medium and electronic equipment. The system comprises a data acquisition unit; the image segmentation unit is used for obtaining a thyroid organ segmentation region and a focus region, and generating an ablation safety region based on the spatial information of the focus region; the three-dimensional reconstruction unit is used for acquiring reconstructed organ volume data; and the dynamic monitoring unit is used for carrying out real-time registration on the preoperative image volume data and the ultrasonic image sequence obtained in the operation so as to observe the position of the focus, obtaining thyroid deformation and the ablation state of the focus, and dynamically monitoring the ablation process and the ablation completion condition of the focus area. According to the method, through one-time registration and multiple times of rapid secondary precise registration, the 3d reconstruction process of data collected in the operation is omitted, deformation of the thyroid gland in the ablation state is conveniently monitored, the problem that positioning is not clear enough in the ultrasonic focus operation is solved through registration in the operation and before the operation, and a better ablation result is obtained.

The invention discloses a multi-attention mechanism network model and a thyroid ultrasound contrast focus segmentation method and system based on a multi-attention mechanism network. The multi-attention mechanism network model adopts an RFM-ResNeXt module to extract spatial and temporal feature information of an input video; aggregating the three-dimensional feature maps into a two-dimensional feature map through a bidirectional convolution LSTM module; inputting the two-dimensional feature map into a double attention module (DAM) to obtain an attention feature map; and carrying out convolution and up-sampling on the attention feature map to obtain a binary segmentation result image. The time-space information of the ultrasound contrast video can be effectively extracted by utilizing three attention mechanisms of channel attention, time attention and space attention, and the ablation area in the thyroid ultrasound contrast image can be automatically and accurately segmented.

The invention discloses a thoracoscope minimally invasive cardiac surgery navigation system based on multi-modal image fusion, and the system comprises the steps: constructing a 5D heart digital twin containing an anatomical structure, a soft tissue boundary, metabolic activity and electrophysiological information through fusing preoperative CT, MRI, PET and intraoperative ultrasonic images; real-time dynamic registration is realized by using an electrocardio gating driven biomechanical model; superposing the multi-color coding navigation information to the visual field of the thoracoscope through a wavelength selection type spectroscope; a dynamic risk scoring model is constructed based on the distance, the speed and the tissue vulnerability, and three-level grading intervention is triggered; a miniature force feedback actuator is integrated to realize closed-loop control; and pre-operation virtual drilling and post-operation federal learning optimization are supported. The system remarkably improves the surgical precision and safety, and is suitable for high-difficulty heart minimally invasive surgeries such as mitral valve repair and atrial fibrillation ablation.

The present disclosure provides a method and system for estimating the distance between an optical fiber end and a target. Treatments using laser and optical fiber technology require high precision to ensure that the laser is aimed at the correct target (stone, tissue, tumor, etc.) to achieve clinical objectives such as tissue ablation, coagulation, stone fragmentation, dust removal, etc. Therefore, it is important to know the distance between the target and the optical fiber end (distal end) from which the laser light is emitted, because laser treatment parameters such as energy, pulse width, laser power modulation, and / or repetition rate are often determined based on the distance from the tip of the optical fiber to the target.

The invention provides a microwave ablation control system and method used based on nuclear magnetic resonance, and belongs to the technical field of ablation control, and the system comprises an MRI rapid temperature measurement module, a temperature prediction module, a microwave ablation power control module, a tissue impedance monitoring module and a data fusion processing module. The microwave ablation instrument, the MRI rapid temperature measurement module and the tissue impedance monitoring module are all connected with the data fusion processing module, the microwave ablation instrument is further connected with a microwave ablation needle inserted in ablation area tissue, and the temperature prediction module and the microwave ablation power control module operate on the data fusion processing module; in combination with the method, the defects that in an existing microwave ablation control method used based on nuclear magnetic resonance, due to the fact that the MRI temperature measurement sequence collection and reconstruction speed is limited, the closed loop control period is too long, the nonlinear change of the heating rate caused by tissue impedance mutation cannot be coped with, and then the overtemperature or undertemperature problem occurs are overcome.

Disclosed in the present invention is an ablation system. The ablation system comprises: a radio frequency generation module, which is used for generating a radio frequency output; a pulse generation module, which is used for generating a pulse output; an output control module, which is used for choosing, according to a characteristic of an ablation region, between ablation output modes, namely, radio frequency output and pulse output; and an ablation consumable, which is used for performing output for the ablation region according to the ablation output mode, which is selected by the output control module. According to the ablation system of the present invention, radio frequency ablation technology can be combined with pulsed electric field ablation technology, such that different application requirements in a clinical surgical operation are better met.

The invention discloses a new medicine application of a local injection acoustic response stent in enhancing ultrasound histotripsy. The acoustic response scaffold (ARS) comprises a scaffold material, fluorocarbon gas or liquid fluorocarbon particles with liquid-vapor phase change capacity, and microbubble cloud in the scaffold generates a strong cavitation ablation treatment effect in a target area under the action of low-frequency and low-sound-pressure ultrasound. Fluorocarbon gas or liquid fluorocarbon particles contained in the ARS form microbubble cloud and ideal cavitation nuclei under low-frequency low-sound-pressure ultrasonic excitation, inertia cavitation resonance is achieved under the ultrasonic action, and then cavitation mechanical damage with local tissue controllable strength is generated. The low-intensity ultrasonic histotripsy has the characteristics of low sound pressure, low sound intensity, high targeting property, small tissue damage outside a target region, simplicity in instrument manufacturing and the like, and the targeting property and the safety of treatment are improved. The method does not need very accurate ultrasonic focusing, reduces the operation difficulty, and has application prospects in multiple medical fields such as prostatic hyperplasia, tumor ablation and tumor immunotherapy.

The invention provides a magnetic resonance temperature measurement imaging method. According to the method, based on proton resonance frequency temperature dependence, phase self-calibration echoes are added in a temperature measurement imaging sequence; the phase unwrapping of the spatial dimension is carried out on the phase image by using the prior art, and the phase unwrapping of the time dimension is carried out on the temperature measurement phase image by using the self-calibration phase image. According to the method provided by the invention, the problem of reference basis failure of magnetic resonance temperature measurement imaging can be solved, the temperature measurement precision is not lost, and additional temperature measurement tools and intraoperative waiting time are not increased. According to the method provided by the invention, the temperature measurement precision can be improved by prolonging the echo time TE. The method provided by the invention can be used for thermal ablation treatment guided by magnetic resonance.

The invention relates to the technical field of minimally invasive ablation, in particular to a liver tumor microwave ablation postoperative contraction deformation prediction method, which comprises the following steps: performing unified standardization processing on different periods of liver MRI images; accurately marking a preoperative liver tumor area, a postoperative ablation area and a postoperative liver tumor ghost area of the liver MRI image to obtain masks of the corresponding areas; designing a distance perception function as an attention parameter of different areas of the liver MRI image; constructing a multi-sequence distance guide complementary network model; selecting a loss function; selecting an elastic registration method to perform pre-operation and post-operation registration; and calculating an ablation safety boundary through the ablation area mask and the adjusted tumor mask. The liver tumor microwave ablation postoperative curative effect evaluation accuracy can be effectively improved, and a foundation is laid for formulating a subsequent treatment plan of a patient.

The invention relates to the technical field of medical equipment, and provides a focused ultrasound system with multiple treatment modes. The drive circuit comprises a signal generation module which outputs a first ultrasonic generation signal suitable for a thermal ablation mode or a second ultrasonic generation signal suitable for a histotripsy mode; the energy amplification module comprises a signal end, a power supply end and an output end coupled with the ultrasonic transducer; the energy amplification module comprises an isolation driving circuit which outputs a first switch driving signal and a second switch driving signal which are opposite based on an input ultrasonic generation signal; and the power amplification circuit comprises a second switch unit and a first switch unit which are set to be in opposite switch states by opposite driving signals so as to output ultrasonic driving signals to excite the ultrasonic transducer to form focused ultrasound in a histotripsy mode or a thermal ablation mode. The driving circuit is simple in structure and easy to realize, and can meet power supply requirements of various modes such as thermal ablation, histotripsy and the like.

The invention belongs to the technical field of physical thermal ablation, and relates to a physical thermal ablation energy regulation and control method based on intelligent feedback, and the method comprises the steps: collecting point-shaped temperature data, impedance data and ultrasonic data, eliminating the asynchronization and heterogeneity problems through space-time alignment, and combining with focus region segmentation, thereby achieving the energy regulation and control of the physical thermal ablation. Discrete data and continuous images are integrated into a voxelization data cube containing space coordinates, physical attributes and semantic tags, then the temperature change rate and the impedance change rate are calculated based on the voxelization data cube, and then a morphological prediction network is fused with multi-modal features to output a voxel-level ablation probability graph. The method comprises the following steps: realizing prospective prediction of an ablation range, ensuring ablation accuracy by morphological deviation through a three-layer parallel regulation and control strategy, preventing and controlling local overheating by temperature gradient, avoiding tissue carbonization by an impedance change rate, and cooperatively deciding through multi-dimensional indexes to solve the contradiction that single regulation and control cannot give consideration to accurate coverage of a focus and protection of normal tissues; and misjudgment caused by abnormity of single data is avoided.

The present invention belongs to the technical field of medical devices, and provides an ablation device with a cutting function, including an insulating sleeve with a through first channel; an ablation electrode with a hollow structure, which is arranged at one end of the insulating sleeve, and the ablation electrode has a plurality of ablation claws, and the ablation claws can expand toward the outside direction of the ablation electrode under stress, wherein one or more ablation claws on the ablation electrode are provided with a cutting edge for cutting; and a puncture needle with a needle tip, which is arranged at the second end of the ablation electrode; by applying an external force to the ablation electrode to expand the ablation electrode, the ablation claws of the ablation electrode are transformed and maintained from an initial state without stress to an expanded state after stress. The present application arranges a plurality of ablation claws that can expand under stress, combined with the cutting edges arranged on the ablation claws, thereby achieving the separation and expansion of tumor tissue, avoiding the occurrence of an ablation vacuum zone, and allowing the tumor tissue to be completely ablated.

A system and method for assessing effective delivery of ablation therapy to a tissue in a body is provided. A three-dimensional anatomical map of the tissue is generated and displayed with the map defining a corresponding volume. An index is generated corresponding to a location within the volume with the index indicative of a state of ablation therapy at the location. The index may be derived from one or more factors such as the duration an ablation electrode is present at the location, the amount of energy provided, the degree of electrical coupling between an ablation electrode and the tissue at the location and temperature. A visual characteristic (e.g., color intensity) of a portion of the anatomical map corresponding to the location is then altered responsive to the index.

The present invention discloses a method and device for determining ablation parameters for high-frequency pulse electric field ablation. The method comprises: acquiring collected medical image data containing depth information, determining a corresponding lesion box containing three-dimensional information of the lesion based on the medical image data; analyzing and segmenting the lesion box to obtain the contour and depth of the lesion and the contour of the electrode used to ablate the lesion; starting from a plurality of equally spaced points on the boundary of the electrode contour, emitting a preset number of rays to the surrounding area, obtaining the number of intersections between the rays and the lesion box to determine whether the electrode and the lesion are in contact; when the electrode and the lesion are in contact, determining the corresponding ablation parameters based on the contour and depth of the lesion, the ablation parameters including pulse voltage, pulse width, number of pulse trains, and number of discharges. The present invention solves the problem of inaccurate ablation parameter determination in the prior art.

The invention relates to the technical field of medical instruments, and provides a steep pulse-based ablation system and method for liver cancer cells, and the system comprises a tumor feature recognition module which is used for obtaining imaging images of the liver cancer cells and recognizing tumor features, blood supply conditions and tumor centers of the liver cancer cells; the electrode inlet setting module is used for setting a safety boundary of liver cancer cells and setting an ablation area and a focus skin surface of the liver cancer cells based on the safety boundary and tumor characteristics; the ablation effect analysis module is used for calculating the electrode depth and the electrode angle of the liver cancer cells and analyzing the coverage effect of an ablation area; the electric field intensity identification module is used for analyzing cell membrane characteristics of the hepatoma cells, identifying the electroporation effect of the hepatoma cells and identifying the electric field intensity of the hepatoma cells; and the steep pulse ablation module is used for performing ablation treatment on the liver cancer cells in combination with the electric field intensity and a pulse generator to obtain an ablation result. The invention aims to avoid heat injury of surrounding tissues and improve the ablation effect of liver cancer cells.

The ablation system comprises ablation forceps, an ablation instrument and an operation part, the ablation forceps comprise a forceps holder assembly, an ablation assembly and an electrical connection assembly, and the forceps holder assembly comprises a far-end forceps holder and a near-end forceps holder which can be close to or away from each other; the ablation assembly comprises a far-end electrode set installed on the far-end forceps holder, a near-end electrode set installed on the near-end forceps holder and electrode marks arranged on the surface of the near-end forceps holder, the far-end electrode set and the near-end electrode set respectively comprise at least one electrode, and each electrode on the near-end forceps holder corresponds to one electrode mark. The ablation method comprises the steps that after target tissue is clamped by the forceps holder assembly, the positions of the electrodes corresponding to the electrodes are judged according to the electrode identifiers, the attaching states of the electrodes are judged according to local impedance data of the electrodes, and then the positions of the ablation forceps are adjusted or an ablation area is arranged. According to the invention, the safety and effectiveness of the operation are improved, the ablation effect is better, and the operation duration is shorter.