36 results about "Cardiac Ablation" patented technology

A force sensor assembly for use in the field of cardiac ablation, for the ablation-based treatment of atrial fibrillation and other cardiac arrhythmias. Various embodiments of the disclosure are directed to a catheter distal force sensor for measuring catheter tip-to-endocardial wall force by measuring displacement of irradiation patterns sensed with a two-dimensional imaging sensor. The disclosed devices sense an array of irradiation pattern characteristics, including changes in size and location of irradiation shapes of the irradiation pattern. In some embodiments, multiple irradiation spots are tracked with the two-dimensional imaging sensor to infer the components of a reaction force vector acting the force sensor assembly. The disclosed force is designed to accommodate typical catheter tip dimensions, the outer diameter of these usually being less than or equal to 3 mm.

Various aspects of the present disclosure are directed towards apparatuses, systems, and methods for electroporation ablation. The electroporation ablation catheter may include an electrode assembly comprising one or more electrodes configured to generate electric fields in target tissue in response to a plurality of electrical pulse sequences delivered in a plurality of therapy sections, and an ultrasound transducer configured to generate a first set of ultrasound signals during a first electrical pulse sequence of the plurality of electrical pulse sequences and generate a second set of ultrasound signals after an end of the first electrical pulse sequence and before a beginning of a second electrical pulse sequence, the second electrical pulse sequence being an electrical pulse sequence subsequent to the first electrical pulse sequence.

A gap between a plurality of ablation sites in a heart that hinders electrical propagation therethrough is found by projecting the locations of the sites in a 3-dimensional coordinate system onto a simulation plane, identifying a set of shortest 3-dimensional paths that correspond to 2-dimensional connections between pairs of the projected locations of the sites, and reporting a gap as a longest one of the set.

A catheter deploys a flexible electrode that is at least partially made of preformed hydrogel to a target location in order to provide radiofrequency catheter ablation. The catheter stores the flexible electrode, which can be deployed and retracted. The preformed hydrogel is conductive and thus can provide an interface between a conductive metal wire and a target cardiac tissue. Electric energy is applied to the portions of the cardiac tissue target tissue that are the genesis of the errant and abnormal heartbeats via the flexible electrode. The electric energy may create lesions with lower risks of steam pops and tissue perforation.

In one exemplary mode, an apparatus includes a catheter including an electrode to provide an intracardiac electrogram (IEGM) signal and a signal used to sense impedance, an ablation energy generator configured to conduct ablative energy to the electrode of the catheter based on user input, a controller configured to sample the IEGM signal from the electrode before and after a given ablation, and sense impedance between the electrode and tissue, and a processor configured to compare the sensed impedance with a TPI threshold to determine a contact status of the electrode with respect to the tissue, render to a display an indication of the determined contact status, compute a change in the IEGM signal due to the given ablation, and adjust the TPI threshold for subsequent ablations based on the computed change in the IEGM signal due to the given ablation of the tissue with the electrode.

The animated GUI displays the detection results of multiple electrodes on a ring-shaped catheter contacting adjacent tissue during cardiac ablation procedures using transparent spheres of various sizes and shapes surrounding each electrode. The design is characterized by a combination of the shape, position, and contrast of graphical elements. The design is displayed in grayscale. Protection is not sought for the specific color of the design. The red-colored area within the dashed lines in the design drawings indicates portions of the graphical user interface that do not form part of the design sought to be registered. Figure 4.1 shows the first image in a sequence of a graphical user interface for a display screen or portion thereof. Figure 4.2 shows the second image. Figure 4.3 shows the third image. Figure 4.4 shows the fourth image. Figure 4.5 shows the fifth image. Figure 4.6 shows the sixth image. Figure 4.7 shows the seventh image. 4.1) Front view; 4.2) Front view; 4.3) Front view; 4.4) Front view; 4.5) Front view; 4.6) Front view; 4.7) Front view

The invention discloses application of an Fn1-PPARbeta / delta signal channel related to a cardiac liver disease. The cardiac liver disease model is constructed according to the conditions that the liver development of young individuals is delayed due to heart injury and both adult and young individuals have serious fatty livers. In the model, the Fn1 protein level in the heart and blood is obviously increased compared with the normal level. Based on a zebra fish heart ablation means, after heart ablation injury, the heart specific knock-down Fn1 can lead to reduction of the Fn1 protein level in blood and alleviation of liver development retardation and fat deposition. Through the screening of transcriptomics, the PPARbeta / delta protein in the liver is found to be a potential downstream effect factor of Fn1. The liver specific overexpression PPARbeta / delta protein can significantly relieve abnormal phenotypes such as liver fat deposition caused by heart injury, and after the liver specific knock-down PPARbeta / delta protein, the protection effect of knock-down Fn1 on the liver disappears under the condition of heart injury. Therefore, the Fn1 protein and the PPARbeta / delta protein can be used as targets for preventing and treating the cardiac liver injury, and are used for preparing medicines for improving the cardiac liver injury, so that a new way is provided for treating the cardiac liver disease.

Systems, devices, and methods for electroporation ablation therapy are disclosed with protection devices for isolating isolation electronic circuitry, devices, and / or other components from a set of electrodes during a cardiac ablation procedure. A system can include a first set of electrodes disposable proximate to cardiac tissue of a heart and a second set of electrodes disposable in contact with patient anatomy. The system can also include a signal generator configured to generate a pulsed waveform, where the signal generator is coupled to the first set of electrodes and configured to repeatedly deliver the pulsed waveform to the first set of electrodes. The system can also include a protection device configured to selectively couple and decouple electronic devices from the second set of electrodes.

Described embodiments include a system and method for pulsed RF ablation that includes generating a plurality of pulses of radiofrequency (RF) current for application to tissue of a subject for cardiac ablation, driving the RF each one of the pulses such that the power of the pulse initially rises from zero to a maximum value, each one of the pulses having a duration from a start point in time to an end point in time, and an intermission between the end point and the start point of successive pulses, receiving at least one signal from a temperature sensor configured to measure a temperature of the tissue being ablated and controlling the power of the plurality of pulses to fractionally change the power of each of the pulses between the start point and end point in response to the measured temperature of the tissue being ablated.

Systems and methods for improving cardiac ablation procedures are disclosed. The systems and methods include a cloud server including a database containing information about previously performed cardiac ablations, a local server communicably coupled to the cloud server via a first network, and a surgical system communicably coupled to the local server via a second network. The cloud server is configured to receive electrical data and anatomical data of a patient's heart from the surgical system via the local server, perform a comparison of the electrical data and the anatomical data of the heart to the database information, generate a surgical treatment plan for the heart based on the comparison, and transmit the surgical treatment plan to the surgical system via the local server, wherein the surgical treatment plan includes a mesh of the heart.

A system that enables safe cardiac pulsed field ablation by using multiple types of sensors on a patch to detect and cross-check that the heartbeat is in a safe phase to receive an ablation pulse. The patch may contain for example any or all of ECG electrodes, PPG sensors, accelerometers, and microphones. The patch may also contain one or more pulse return electrodes for unipolar ablation. A signal analyzer coupled to a pulse generator may receive sensor data from the patch and may analyze this data to determine the heartbeat phase. If data from different sensors are inconsistent, then pulse generation may be disabled as a safety feature. Otherwise, pulses may be enabled when the heartbeat is in a safe phase; for example, pulses may be excluded during the T wave.

Systems and methods of automatically controlling, on a graphical user interface used by a physician, display views of an anatomic structure of a patient. Such systems and methods of automatically controlling display views of an anatomic structure of a patient can facilitate visualizing a position of a medical device relative to the anatomic structure during a medical procedure directed to the anatomic structure. In certain implementations, the systems and methods of the present disclosure provide automatic display views of a cardiac catheter relative to a three-dimensional model of a patient's heart cavity during a medical procedure such as cardiac ablation.

A described example relates to a method that includes receiving one or more electrograms measured by one or more sensors carried by a catheter. The method also includes controlling a generator to deliver reversible energy to one or more electrodes carried by the catheter to temporarily alter electrical activity of first target tissue of an anatomical structure of a patient. The method also includes detecting a change in the one or more electrograms in response to the reversible energy. The method also includes identifying second target tissue of the anatomical structure based on the detected change in the one or more electrograms. The method also includes controlling the generator to deliver irreversible energy to permanently alter the second target tissue.

Devices, systems, and methods for treating cardiac arrhythmia are disclosed herein. In some embodiments, devices, systems, and methods disclosed herein deliver interrogating energy to tissue at a position on a wall of an anatomical structure of a patient. If the devices, systems, and methods disclosed herein detect a change in electrical activity of the anatomical structure in response to the interrogating energy, the devices, systems, and methods disclosed herein can apply irreversible therapy to the tissue. In some embodiments, the change in electrical activity corresponds to slowing or termination of a detected arrhythmia.

The animated GUI displays the detection results of multiple electrodes on a ring-shaped catheter contacting adjacent tissue during cardiac ablation procedures using transparent spheres of various sizes and shapes surrounding each electrode. The design is characterized by a combination of the shape, position, and contrast of graphical elements. The design is displayed in grayscale. Protection is not sought for the specific color of the design. The red-colored area within the dashed line in the design drawing indicates the portion of the graphical user interface that does not form part of the design sought to be registered. Figure 3.1 shows the first image in a sequence of a graphical user interface for a display screen or portion thereof. Figure 3.2 shows the second image. Figure 3.3 shows the third image. Figure 3.4 shows the fourth image. Figure 3.5 shows the fifth image. Figure 3.6 shows the sixth image. Figure 3.7 shows the seventh image. 3.1) Front view; 3.2) Front view; 3.3) Front view; 3.4) Front view; 3.5) Front view; 3.6) Front view; 3.7) Front view

Systems, apparatus, and methods for protecting electronic components from high power noise caused by high voltage pulses are disclosed. In particular, systems, devices, and methods are disclosed for electroporation ablation therapy having a protection device for isolating an isolation electronic circuit, device, and / or other component from a set of electrodes during a cardiac ablation procedure. A system may include a first set of electrodes that may be disposed proximate to heart tissue of a heart and a second set of electrodes that may be disposed in contact with patient anatomy. The system may also include a signal generator configured to generate a pulse waveform, where the signal generator is coupled to the first set of electrodes and configured to repeatedly deliver the pulse waveform to the first set of electrodes. The system may also include a protection device configured to selectively couple and decouple the electronic device with the second set of electrodes.

The present disclosure applies to methods of cardiac ablation that use an algorithm to determine where in the heart a driver of atrial fibrillation is located. Catheters with multi-electrode arrays are used to measure electrograms from cardiac signals wherein abnormal signals are identified as electrogram deflections with characteristic shapes. The electrogram deflections are compared to each other in pairs to determine which came first in time in order to determine the net direction of propagation of a fibrillatory wave. The signal that came first is assigned a positive point value so that once the plurality of electrograms have been compared, the signal with the highest point value can be identified as a driver of fibrillation. The data can be displayed graphically as a map of atrial fibrillation drivers on a 3D representation of a heart, allowing surgeons to quickly and easily identify where on the heart the driver is.

The animated GUI displays the detection results of multiple electrodes on a ring-shaped catheter contacting adjacent tissue during cardiac ablation procedures using transparent spheres of various sizes and shapes surrounding each electrode. The design is characterized by a combination of the shape, position, and contrast of graphical elements. The design is displayed in grayscale. Protection is not sought for the specific color of the design. The red-colored area within the dashed line in the design drawing indicates the portion of the graphical user interface that does not form part of the design sought to be registered. Figure 2.1 shows the first image in a sequence of a graphical user interface for a display screen or portion thereof. Figure 2.2 shows the second image. Figure 2.3 shows the third image. Figure 2.4 shows the fourth image. Figure 2.5 shows the fifth image. Figure 2.6 shows the sixth image. Figure 2.7 shows the seventh image. 2.1) Front view; 2.2) Front view; 2.3) Front view; 2.4) Front view; 2.5) Front view; 2.6) Front view; 2.7) Front view

A system that enables safe cardiac pulsed field ablation by using multiple types of sensors on a patch to detect and cross-check that the heartbeat is in a safe phase to receive an ablation pulse. The patch may contain for example any or all of ECG electrodes, PPG sensors, accelerometers, and microphones. The patch may also contain one or more pulse return electrodes for unipolar ablation. A signal analyzer coupled to a pulse generator may receive sensor data from the patch and may analyze this data to determine the heartbeat phase. If data from different sensors are inconsistent, then pulse generation may be disabled as a safety feature. Otherwise, pulses may be enabled when the heartbeat is in a safe phase; for example, pulses may be excluded during the T wave.

A gap between a plurality of ablation sites in a heart that hinders electrical propagation therethrough is found by projecting the locations of the sites in a 3-dimensional coordinate system onto a simulation plane, identifying a set of shortest 3-dimensional paths that correspond to 2-dimensional connections between pairs of the projected locations of the sites, and reporting a gap as a longest one of the set.

The invention relates to the technical field of cardiac ablation, in particular to an irreversible electroporation ablation system with OCT (optical coherence tomography), which comprises an electrophysiology catheter, the electrophysiology catheter comprises a catheter head end, the catheter head end is provided with an electrode, a magnetic positioning sensor, a pressure sensor and an OCT sensor, and the OCT sensor is used for emitting a light beam to irradiate an ablation position and collecting scattered light from tissues; the ablation equipment is electrically connected with the electrophysiology catheter; the three-dimensional mapping system is electrically connected with the electrophysiology catheter and the ablation device, the three-dimensional mapping system comprises a magnetic positioning module, a pressure monitoring module and an OCT processing module, the OCT processing module is used for optical coherence tomography, and the three-dimensional mapping system is used for displaying electrophysiology catheter position information, catheter head end pressure and OCT imaging information. According to the invention, a one-dimensional depth image, a two-dimensional section image and a three-dimensional image can be generated in real time, an ablation position is scanned through an OCT technology, real-time image display can be obtained, and a doctor performing a pulse ablation operation is helped to timely and accurately judge an ablation result.

Various systems and methods for improving cardiac ablation procedures are disclosed. The system and method includes: a cloud server including a database containing information about previously performed cardiac ablation; a local server, wherein the local server is connected to the cloud server through a first network in a communication manner; and a surgical system communicably coupled to the local server via a second network. The cloud server is configured to receive electrical data and anatomical data of a heart of a patient from the surgical system via the local server, perform a comparison of the electrical data and the anatomical data of the heart to the database information, generate a surgical treatment regimen for the heart based on the comparison, and transmitting the surgical treatment regimen to the surgical system via the local server, wherein the surgical treatment regimen includes a grid of the heart.

Ablation electrode assemblies include an inner core member and an outer shell surrounding the inner core member. The inner core member and the outer shell define a space or separation region therebetween. The inner core member is constructed from a thermally insulative material having a reduced thermal conductivity. In an embodiment, the space is a sealed or evacuated region. In other embodiments, irrigation fluid flows within the space. The ablation electrode assembly further includes at least one thermal sensor in some embodiments. Methods for providing irrigation fluid during cardiac ablation of targeted tissue are disclosed that include calculating the energy delivered to irrigation fluid as it flows within the ablation electrode assembly through temperature measurement of the irrigation fluid. Pulsatile flow of irrigation fluid can be utilized in some embodiments of the disclosure.

A medical device includes an elongate hollow shaft having a shaft proximal end, a shaft distal end, and a lumen extending along the elongate hollow shaft. A handle is disposed at a proximal end of the shaft. And a connector assembly having a connector assembly proximal end and a connector assembly distal end, the connector assembly proximal end and the connector assembly distal end being opposite ends of the connector assembly. An expandable frame is removably disposed at a distal end of the connector assembly, the expandable frame comprising a plurality of interconnection members formed of an electrically conductive material, where the interconnection members located in a first portion of the expandable frame are coated with a dielectric layer, and where the first portion of the expandable frame is in contact with the second portion of the expandable frame. An interconnect member in the second portion of the expandable frame is uncoated and configured as an electrode region of the expandable frame.

The heart mapping for cardiac ablation treatment process using five artificial intelligence sets with different functions and objectives. Starting from receiving atrial intracardiac electrogram data from the patient to identify the severity level of the complex fractionated atrial electrograms abnormalities (CFAEs Score) and patterns of complex fractionated atrial electrograms (CFAEs Pattern) and sending both results along with the data of the intracardiac electrogram signal measurement location to identify the location of the heart for the first ablation. Next, intracardiac electrogram signals are measured at the ablation location to collect Ablation distal (ABLd) and Ablation proximal (ABLp) signals. Then, bringing the two results of data, the data of the ablation location, and the Coronary Sinus Cycle Length (CS-CCL) value into the analysis and prediction process until the output is the parameter values for ablation. The process will loop until the output is that no abnormal locations are found in the heart.

Devices and methods for cardiac ablation are described herein. In some embodiments, a device can include a catheter having a plurality of splines that generate helicoidal or spiral-shaped ablation lesions. By translating the catheter proximally or distally to an ablation site, multiple helicoidal or spiral-shaped lesions can intersect, forming a cross-hatch pattern of lesions that surround and isolated clusters of non-ablated tissue. The apparatus can further include a basket that is expanded or collapsed using a handle. The handle can pull or push a central shaft coupled to the plurality of splines, which causes a portion of the ablation device to abut an inner wall of the blood vessel. The position of the central shaft can be locked via a knob and grooves mechanism, with each groove being associated with an intensity of an ablation treatment needed to adjust for variations in the diameter of the blood vessel.

In one exemplary mode, an apparatus includes: a catheter including an electrode providing an intracardiac electrogram (IEGM) signal and a signal for sensing impedance; an ablation energy generator configured to conduct ablation energy to the electrodes of the catheter based on a user input; a controller configured to: sample the IEGM signal from the electrode before and after a given ablation, and sense an impedance between the electrode and tissue; and a processor configured to: compare the sensed impedance to a TPI threshold to determine a contact state of the electrode relative to the tissue, present an indication of the determined contact state to a display, calculate a change in the IEGM signal due to a given ablation, and determine a change in the IEGM signal due to the given ablation. And adjusting a TPI threshold for subsequent ablation based on the calculated change in the IEGM signal due to a given ablation of the tissue with the electrode.

The present disclosure applies to methods of cardiac ablation that use catheters able to conform and adapt to the heart of a patient in the middle of surgery. The catheters comprise paddles at the distal ends that have an array of electrodes on at least one side. The durometer of the paddles can be changed through physical manipulation of wires attached to the paddles or through other means such as the material the paddles are made of. Electrodes on the paddle record cardiac signals and a computer analyzes these signals to determine where in the heart fibrillation is originating. The computer then outputs a site for ablation.

The present application relates to the field of cardiac ablation, and provides a pulse ablation forceps, the pulse ablation forceps include forceps body and be installed on the forceps body, the jaw part that is composed of fixed jaw arm and the movable jaw arm parallel to fixed jaw arm, the forceps body includes sliding slot, fixed jaw arm is fixedly connected at the distal end of sliding slot, the movable jaw arm is along sliding slot and is away from fixed jaw arm, along the direction of jaw part extension, from the distal end to the proximal end, n first electrodes are arranged on the movable jaw arm, n+1 second electrodes are arranged on the fixed jaw arm, n≥2;In the direction perpendicular to the extension of fixed jaw arm, the projection of each first electrode on fixed jaw arm is located between two second electrodes;All first electrodes are arranged outside the sliding slot, and at least a part of the n+1 second electrode is arranged in the sliding slot.The pulse ablation forceps of the present application avoids the situation of leakage ablation, and does not produce arc at the same time, improves the ablation effect.