78 results about "Pulmonary vein" patented technology

This document provides devices and methods for the treatment of heart conditions, hypertension, and other medical disorders. For example, this document provides devices and methods for treating atrial fibrillation by performing thoracic vein ablation and / or electroporation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation and / or electroporation is delivered in differing areas in and / or around the pulmonary vein in coordination with each other for enhanced efficacy.

The invention relates to the technical field of medical image processing, in particular to a pulmonary blood vessel perfusion analysis method based on drainage basin dynamics, which comprises the following steps: acquiring a pulmonary artery blood vessel tree and a pulmonary artery CT film; extracting the pulmonary artery blood vessel tree based on the pulmonary artery blood vessel tree and the pulmonary artery CT film; based on the pulmonary artery blood vessel tree, pressure gradient fields in the pulmonary artery blood vessel tree and on the wall of the pulmonary artery blood vessel tree are calculated; extracting a pulmonary vein basin based on the pressure gradient field; based on the pulmonary vein drainage basin, perfusion analysis is achieved in combination with dynamic hemodynamic simulation; on the basis of perfusion analysis results, lung tissue blood supply conditions are evaluated, a multi-stage connected domain detection method is adopted, the method can more accurately extract a complex pulmonary artery blood vessel tree structure, the actual distribution condition of blood flow can be more truly reflected on the basis of a pressure gradient field drainage basin division method, and dynamic blood flow simulation is introduced, so that the dynamic blood flow simulation effect is improved. By means of the method, perfusion changes in the breathing process can be comprehensively captured, and more comprehensive diagnosis information is provided.

An apparatus and method for prediction of pulmonary vein reconnection is disclosed. The apparatus includes an electrocardiogram device, at least a processor, and a memory communicatively connected to the at least a processor, wherein the memory contains instructions configuring the at least a processor to generate ablation evaluation training data, train an ablation evaluation machine-learning model using the ablation evaluation training data, receive, from the electrocardiogram device, the electrocardiogram data, and generate, using the ablation evaluation machine-learning model, ablation evaluation data of the patient, wherein generating the ablation evaluation data of the patient includes inputting, into the ablation evaluation machine-learning model, the electrocardiogram data and receiving as output, from the ablation evaluation machine-learning model, the ablation evaluation data of the patient.

Valvular implants and blood vessel closure devices herein are configured to be positioned in the heart and to block regurgitant blood flow from the heart into blood vessels supplying blood to the heart. The valvular implants can have a cover, a membrane, a valve, a resilient frame, and / or other features. Some valvular implants can have anchors to be positioned in the blood vessels, such as in pulmonary veins, and can anchor the implant to the heart wall. Various embodiments of covers and / or membranes act as valves contracting and expanding, to alternately permit and block blood flow. The valvular implants can cover one or more blood vessels, such as one, two, three, or four pulmonary veins, and can also be configured and implanted to block an appendage to the heart, such as the left atrial appendage.

A system trains a set of machine-learning models to predict which atrial fibrillation patients would respond to which treatments using ablation lines. The models identify an ablation line treatment for a patient based on atrial fibrillation-related features associated with the patient. The models estimate reconnection probabilities for ablation sites associated with at least one ablation line treatment. The models identify patient atrial fibrillation predictors associated with the patient, based on demographics and heart component dimension parameters associated with the patient, and use the at least one ablation line treatment, reconnection probabilities, patient atrial fibrillation predictors, and patient demographics to predict whether the patient would not respond to pulmonary vein isolation only treatment. In response to a prediction that the patient would not respond to pulmonary vein isolation only treatment, the system enables a healthcare provider to provide the at least one ablation line treatment for the patient.

The present invention is entitled "Identifying Pulmonary Vein Occlusion by Dimensional Deformation of a Balloon Catheter." The present invention discloses a method comprising receiving a position signal indicating the position of a plurality of electrodes disposed on an inflatable balloon mounted at a distal end of a shaft for engaging a lumen of an organ to thereby occlude the lumen. Based on the received position signal, a change in one or more dimensions of the balloon between (i) a first configuration in which the balloon is inflated but not engaged in the lumen and (ii) a second configuration in which the balloon is inflated and engaged in the lumen is calculated. Using the calculated change, the degree to which the balloon occludes the lumen is estimated. The estimated degree of occlusion is presented to a user.

To provide a system and a method for achieving linear alignment between elements in a procedure.SOLUTION: The system and method include determining the axis of a first element, such as the ostium, of multiple elements utilized in the procedure, determining the axis of a second element, such as a catheter, of the multiple elements utilized in the procedure, and aligning the determined axis of the first element and the determined axis of the second element. The method may further include determining the axis of a third element, such as a sheath of the catheter, of the multiple elements utilized in the procedure, and aligning the determined axis of the third element with the aligned axis of the first element and the aligned axis of the second element.SELECTED DRAWING: Figure 1

A gap between a plurality of ablation sites in a heart that hinders electrical propagation therethrough is found by projecting the locations of the sites in a 3-dimensional coordinate system onto a simulation plane, identifying a set of shortest 3-dimensional paths that correspond to 2-dimensional connections between pairs of the projected locations of the sites, and reporting a gap as a longest one of the set.

The utility model provides a teaching model for simulating patent foramen ovale, which comprises an atrium module, a partition module, a base, a magnet sheet and a metal sheet, and is characterized in that the atrium module is arranged on the base and comprises a left atrium and a right atrium, and the upper part of the left atrium is connected with pulmonary veins; the upper part of the right atrium is connected with superior vena cava, and the lower part of the right atrium is connected with inferior vena cava; the partition module is used for separating the left atrium and the right atrium; the septum module comprises a secondary septum connected with the right atrium and a primary septum connected with the left atrium, the rear side of the primary septum is connected with the rear side of the secondary septum, a first groove is formed in the outer surface of the front side of the secondary septum, the magnet sheet is arranged in the first groove, a second groove is formed in the outer surface of the front side of the primary septum, and the metal sheet is arranged in the second groove. The magnet sheet and the metal sheet attract each other; and an oval hole for communicating the left atrium with the right atrium is formed between the primary septum and the secondary septum. The patent foramen ovale teaching aid enables teaching of patent foramen ovale diseases to be more convenient.

Devices and methods can be used to treat heart conditions, hypertension, and other medical disorders. For example, devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation are described herein. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation.

The present technology relates to standardized coordinate systems for mapping three-dimensional structures. An exemplary method includes: obtaining imaging data including a representation of a left atrium of a subject; identifying anatomical features represented in the imaging data, the anatomical features including pulmonary veins that connect to the left atrium; generating a 3D surface mesh corresponding to the left atrium; determining a reference point on the 3D surface mesh based on locations of junctions of the pulmonary veins with the left atrium; establishing a reference axis based on the reference point; determining, on the 3D surface mesh and based on the reference axis, lines of longitude; determining, on the 3D surface mesh, lines of latitude along the lines of longitude; assigning coordinate values to points on the 3D surface mesh based on the lines of longitude and latitude; and generating a 2D map of the left atrium using the coordinate values.

The present invention relates to an equal-dose opposed-vessel monitoring pulmonary artery-pulmonary vein CT angiography method and system. For the method, the dose of the contrast agent bolus test, the flow rate and volume of the contrast agent, and the flow rate and volume of the normal saline are all consistent with those in the formal scan; during the bolus test, it is confirmed that a small amount of contrast agent flows into the pulmonary vein of the monitored slice while the pulmonary artery is filled, so as to obtain the optimal delay time of pulmonary artery CTA; it is confirmed that almost all of the contrast agent in the monitored slice has flowed through the pulmonary artery, and there is a trace amount of contrast agent at the end of the pulmonary artery near the periphery, so as to obtain the optimal delay time of pulmonary vein CTV. The system includes each module for realizing the above functions. The present invention can achieve accurate timing of pulmonary artery CTA and pulmonary vein left atrial CTV scans, and can also achieve accurate timing of combined one-stop right atrium ventricle pulmonary artery and pulmonary vein left atrium ventricle combined scans, realizing precise diagnosis and treatment.

A method of cardiac treatment to provide a synergetic therapeutic effect of lowering the hyperactive sympathetic response observed in microvascular disease (MVD) and heart failure (HF) pathologies and promoting cardiac remodeling of left ventricular hypertrophy in a patient. The method may include ablating renal sympathetic nerves of the patient to reduce sympathetic afferent and efferent activity to the kidney, thereby reducing blood pressure, and ablating a greater splanchnic nerve to reduce stressed blood volume with exertion. The method may include ablating renal sympathetic nerves of the patient to reduce sympathetic afferent and efferent activity to the kidney, thereby reducing blood pressure and at least one of: ablating pulmonary artery nerves of the patient to reduce cardiac sympathetic activity; and ablating pulmonary vein nerves of the patient to reduce arrhythmias.

The invention discloses a conical balloon pulse ablation catheter which comprises a double-layer balloon structure, an ablation catheter body and a holding handle which are sequentially connected. The double-layer balloon structure comprises an outer-layer balloon and an inner-layer balloon arranged in the outer-layer balloon in a sleeved mode. A plurality of ablation electrodes are arranged on the outer surface of the outer-layer balloon; a control cavity and an infusion tube cavity are formed in the ablation catheter main body; a control wire is arranged in the control cavity; a cavity is formed in the middle of the inner-layer balloon; the control lead penetrates through the cavity and is connected with the ablation electrode; an infusion tube body is arranged in the infusion tube cavity; and one end of the infusion tube body is communicated with the inner-layer balloon. By arranging the conical balloon structure at the front end of the ablation catheter, the head end of the catheter can enter structures such as pulmonary veins, heart perforation caused by high tension is avoided, meanwhile, by arranging the inner and outer double-layer balloon structures, contact between a medium filled into the double-layer balloon structures and an electric appliance element on the inner surface of the outer-layer balloon structure can be avoided, and the ablation effect is improved. The service life of the ablation catheter is prolonged.

The present invention relates to the technical field of medical image processing. More specifically, it relates to a pulmonary vascular perfusion analysis method based on watershed dynamics, including: acquiring a pulmonary artery vascular tree and a pulmonary arterial CT angiogram; extracting the pulmonary artery vascular tree based on the pulmonary artery vascular tree and the pulmonary arterial CT angiogram; calculating the pressure gradient field inside and on the wall of the pulmonary artery vascular tree based on the pulmonary artery vascular tree; extracting the pulmonary vein watershed based on the pressure gradient field; realizing perfusion analysis by combining dynamic hemodynamic simulation based on the pulmonary vein watershed; evaluating the blood supply of lung tissue based on the perfusion analysis results. By adopting the multi-level connected domain detection method, this method can more accurately extract the complex structure of the pulmonary artery vascular tree. The watershed division method based on the pressure gradient field can more truly reflect the actual distribution of blood flow. The introduction of dynamic blood flow simulation enables this method to comprehensively capture the perfusion changes during the breathing process and provide more comprehensive diagnostic information.

A method of sensing a physiological parameter involves advancing a delivery catheter to a right atrium of a heart of a patient via a transcatheter access path, advancing the delivery catheter through an atrial septal wall into a left atrium of the heart, deploying a distal anchor of a sensor implant device from the delivery catheter, anchoring the distal anchor of the sensor implant device to a first pulmonary vein, withdrawing the delivery catheter from the first pulmonary vein, thereby exposing at least a portion of a sensor module of the sensor implant device in the left atrium, deploying a proximal anchor of the sensor implant device from the delivery system, anchoring the proximal anchor of the sensor implant device to a second pulmonary vein, and withdrawing the delivery catheter from the heart.

Disclosed is a multipolar catheter for pulse field ablation. The multipolar catheter for pulse field ablation according to various embodiments solves the problems of existing balloon catheters by using a shape memory alloy material, can be easily adjusted in size in accordance with the various sizes of pulmonary vein entrances, and can maximize the effect of a treatment by effectively coming into contact with target tissue.

The present invention relates to electrophysiology catheters for intramyocardial tissue ablation. In particular, the present invention relates to electrophysiology ablation balloon catheters having conductive and non-conductive surfaces for focusing ablation energy on desired portions of pulmonary vein tissue.

The invention provides a cattail pollen content prediction method and system based on a hyperspectral double-flow multi-scale CNN, and belongs to the field of quality detection of traditional Chinese medicinal materials. The method comprises the following steps: acquiring hyperspectral image data of a pollen typhae sample, preprocessing the acquired hyperspectral image data, and extracting region-of-interest spectral data of the pollen typhae sample; inputting the extracted spectral data of the region of interest into a trained double-flow multi-scale residual fusion CNN model, performing multi-scale feature extraction and fusion by using a VNIR multi-scale branch and an NIR multi-scale branch, and outputting multi-scale fusion features; inputting the multi-scale fusion features into an attention fusion module, and outputting final fusion features; and based on the final fusion features, outputting a content prediction value of the active ingredients of the pollen typhae through a content prediction layer. The method solves the problems that a traditional detection method is low in efficiency, samples are damaged, and an existing spectrum model ignores wave band characteristic differences, so that precision is insufficient, and rapid, lossless and high-precision prediction of the pollen typhae content is achieved.

The utility model discloses a double-bend double-basket array electrode PFA (perfluoroalkoxy) mapping ablation catheter, which relates to the technology of medical instruments and comprises a catheter body, one end of the catheter body leads out a guide wire from a guide wire outlet, the other end of the catheter body is connected to a catheter handle, and a first basket and a second basket are respectively arranged at the head end of the catheter body; and the catheter handle is connected with the catheter body part, a second mesh basket telescopic control wheel and a first mesh basket telescopic control wheel are arranged on the catheter handle, the second mesh basket telescopic control wheel and the first mesh basket telescopic control wheel are respectively connected with the corresponding traction wires, and the catheter handle leads out corresponding electrode tail wires and the other ends of the guide wires. According to the utility model, the double net baskets at the head part of the catheter can respectively or simultaneously enter and exit from the near end of the target pulmonary vein and cling to and leave from the vestibule of the pulmonary vein through retraction and extension.

An apparatus includes a shaft, the shaft including a plurality of stepped sections along the length of the shaft. The apparatus further includes a plurality of electrodes disposed along the length of the shaft, each electrode characterized by a geometric aspect ratio of the length of the electrode to the outer diameter of the electrode. Each electrode is located at a different stepped section of the plurality of stepped sections of the shaft and includes a set of leads. Each lead of the set of leads is configured to attain an electrical voltage potential of at least about 1 kV. The geometric aspect ratio of at least one electrode of the plurality of electrodes is in the range between about 3 and about 20.

The present invention relates to an isolated lung storage and perfusion device, which comprises a storage and perfusion box; a perfusion circulation mechanism and a breathing circulation mechanism are arranged in the storage and perfusion box, and the perfusion circulation mechanism and the breathing circulation mechanism are both electrically connected to a perfusion breathing controller in the storage and perfusion box; after the perfusion circulation mechanism is connected to the pulmonary artery and pulmonary vein of the isolated lung through an adapter, the perfusion breathing controller controls the perfusion circulation mechanism to continuously perfuse the connected isolated lung with perfusion liquid, and can remove the metabolic products generated by the isolated lung during the perfusion liquid perfusion process; the perfusion breathing controller controls the breathing circulation mechanism to assist the isolated lung in breathing, so that the isolated lung can maintain a normal breathing state. The present invention can effectively realize the cleaning and perfusion of the isolated lung during the transportation process, effectively remove the metabolic products generated during the transportation process of the isolated lung, provide the respiratory circulation of the isolated lung during the transportation process, and ensure the function of the isolated lung after transportation, which is safe and reliable.

The invention discloses a complete pulmonary vein ectopic drainage operation prognosis prediction scoring method. Comprising the following steps: S1, statistical analysis; s2, standard incorporation and exclusion; and S3, an ultrasonic parameter acquisition method. By generating an overall scoring standard, the probability of occurrence of poor prognosis of the complete pulmonary vein ectopic drainage operation can be comprehensively and scientifically predicted, the conditions that whether the operation is performed or not, which operation is specifically adopted and the like are predicted for patients and medical staff, and the success rate of the operation is increased; by analyzing the form and the inner diameter of the pulmonary vein common cavity, the overall development condition of the pulmonary vein of complete pulmonary vein ectopic drainage is evaluated, the prediction value for prognosis is very high, data support is provided for clinical decision making, the prediction accuracy is improved, the preoperative evaluation process is optimized, and scientific selection of a treatment scheme is assisted.

The invention discloses an artificial intelligence-assisted pulmonary blood vessel image omics acquisition method and device, a medium and a product, and relates to the technical field of medical image processing, and the method comprises the steps: firstly, based on an input original file, in response to the operation of a user, reconstructing a lung model and a pulmonary blood vessel model; based on the pulmonary blood vessel model, generating a first simplified model of each pulmonary artery model blood vessel branch and a second simplified model of each pulmonary vein model blood vessel branch in response to operation of a user; and finally, based on the lung model, the pulmonary vessel model, the first simplified model and the second simplified model, generating peripheral vessel distribution parameters of pulmonary artery and pulmonary vein and radiomics characteristic parameters of the peripheral vessel distribution parameters, generating radiomics characteristic parameters of the whole vessel, calculating a vessel center line, and grading the vessel. The technical problem of how to improve the yield of information acquired by pulmonary blood vessel imaging omics is solved.

The present invention is a high resolution, multi-function, conformal electronics device generally having a flexible and stretchable, high-density electrode array, integrated with a catheter (e.g., balloon catheter) for mapping, ablating, pacing and sensing of cardia tissue associated with heart arrhythmias. The active sensing electrode array can acquire diagnostic information including electrical (e.g., electrograms), mechanical (e.g., strain measurements), impedance (e.g., resistance), metabolic (e.g., pH or NADH measurement) from the underlying heart tissue surface with which it is in contact. The electrode array may be designed to be of various sizes and shapes to conform to the targeted cardiac tissue architecture (e.g. atrial, ventricle, right ventricular outflow tract, coronary sinus, pulmonary veins, etc.) corresponding to the specific type of cardiac arrhythmia. The present invention can precisely locate the source of arrhythmia as described above and deliver therapy from the same electrode array. This is achieved using a capacitive sensing electrode array that can not only monitor but also deliver electrical stimulation.

Devices, systems, and methods are provided for treating conditions of the heart, particularly the occurrence of arrhythmias. The devices, systems, and methods deliver therapeutic energy to portions of the heart, such as to the pulmonary vein ostia when treating atrial fibrillation, to provide tissue modification. Generally, the tissue modification systems include a specialized catheter, a high voltage waveform generator, and at least one different energy delivery algorithm. Other embodiments include conventional ablation catheter and system components to support use with the high voltage waveform generator. Example catheter designs include a variety of delivery types, including localized delivery, "single shot" delivery, and various combinations thereof. In some embodiments, energy is delivered in a monopolar fashion. However, it will be appreciated that a variety of other embodiments are also provided.

The application discloses an ex vivo heart perfusion system and a perfusion control method, wherein the perfusion system comprises: an organ bin, which is externally provided with a constant temperature heating film for controlling the temperature in the organ bin to be a first preset temperature threshold; a liquid storage container for containing a perfusion medium, an outlet end of the liquid storage container being connected to a first active branch vein through a first liquid supply pipe and connected to a pulmonary vein through a second liquid supply pipe, an inlet end of the liquid storage container being connected to a second active branch vein through a first liquid return pipe and connected to a pulmonary artery through a second liquid return pipe; a circulating pump connected to the first liquid supply pipe; an oxygenator connected to the first liquid supply pipe, the oxygenator being connected with a gas supply module for adjusting the gas mixing ratio in the perfusion medium; and an injection pump group for supplementing injection of nutrient substances or therapeutic drugs. The application can effectively prolong the heart supply storage time, reduce the heart supply discard rate, and further improve the utilization rate of the heart supply.

Apparatus for automatic suggestion of atrial fibrillation cases as a function of a presence of abnormal pulmonary vein anatomy and methods used therein are described, wherein the apparatus includes a processor and a memory communicatively connected to the processor, wherein the memory includes instructions configuring the processor to receive query pulmonary vein anatomy data, detect at least an abnormal pulmonary vein anatomy within the received query pulmonary vein anatomy data, and suggest a case of atrial fibrillation as a function of the at least a detected abnormal pulmonary vein anatomy, wherein the query pulmonary vein anatomy data are automatically processed and analyzed.

Disclosed herein are technologies for addressing elevated left-sided filling pressures to mitigate the effects of diastolic dysfunction. Embodiments provide ways to decrease the temporal increase in blood flow and pressure into the heart from the venous system. Under exertion, there is a shift of blood from the 'unstressed' reservoir of vasculature, which primarily comprises the splanchnic system, to the 'stressed' reservoir, which comprises the heart and lungs. By inhibiting this acute shifting of blood from the 'unstressed' reservoir to the 'stressed' reservoir, an undesirable influx of blood volume to the already overloaded left heart can be avoided. Certain embodiments provide ways to increase atrial elasticity, or atrial compliance. This enhancement of atrial compliance enables the atrium to 'absorb' the energy of short bursts of high left atrial pressure. Consequences are a reduction in the retrograde flow in the pulmonary veins to inhibit acute pulmonary congestion.