56 results about "Pulmonary vein" patented technology

This document provides devices and methods for the treatment of heart conditions, hypertension, and other medical disorders. For example, this document provides devices and methods for treating atrial fibrillation by performing thoracic vein ablation and / or electroporation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation and / or electroporation is delivered in differing areas in and / or around the pulmonary vein in coordination with each other for enhanced efficacy.

An apparatus and method for prediction of pulmonary vein reconnection is disclosed. The apparatus includes an electrocardiogram device, at least a processor, and a memory communicatively connected to the at least a processor, wherein the memory contains instructions configuring the at least a processor to generate ablation evaluation training data, train an ablation evaluation machine-learning model using the ablation evaluation training data, receive, from the electrocardiogram device, the electrocardiogram data, and generate, using the ablation evaluation machine-learning model, ablation evaluation data of the patient, wherein generating the ablation evaluation data of the patient includes inputting, into the ablation evaluation machine-learning model, the electrocardiogram data and receiving as output, from the ablation evaluation machine-learning model, the ablation evaluation data of the patient.

A system trains a set of machine-learning models to predict which atrial fibrillation patients would respond to which treatments using ablation lines. The models identify an ablation line treatment for a patient based on atrial fibrillation-related features associated with the patient. The models estimate reconnection probabilities for ablation sites associated with at least one ablation line treatment. The models identify patient atrial fibrillation predictors associated with the patient, based on demographics and heart component dimension parameters associated with the patient, and use the at least one ablation line treatment, reconnection probabilities, patient atrial fibrillation predictors, and patient demographics to predict whether the patient would not respond to pulmonary vein isolation only treatment. In response to a prediction that the patient would not respond to pulmonary vein isolation only treatment, the system enables a healthcare provider to provide the at least one ablation line treatment for the patient.

The present invention is entitled "Identifying Pulmonary Vein Occlusion by Dimensional Deformation of a Balloon Catheter." The present invention discloses a method comprising receiving a position signal indicating the position of a plurality of electrodes disposed on an inflatable balloon mounted at a distal end of a shaft for engaging a lumen of an organ to thereby occlude the lumen. Based on the received position signal, a change in one or more dimensions of the balloon between (i) a first configuration in which the balloon is inflated but not engaged in the lumen and (ii) a second configuration in which the balloon is inflated and engaged in the lumen is calculated. Using the calculated change, the degree to which the balloon occludes the lumen is estimated. The estimated degree of occlusion is presented to a user.

To provide a system and a method for achieving linear alignment between elements in a procedure.SOLUTION: The system and method include determining the axis of a first element, such as the ostium, of multiple elements utilized in the procedure, determining the axis of a second element, such as a catheter, of the multiple elements utilized in the procedure, and aligning the determined axis of the first element and the determined axis of the second element. The method may further include determining the axis of a third element, such as a sheath of the catheter, of the multiple elements utilized in the procedure, and aligning the determined axis of the third element with the aligned axis of the first element and the aligned axis of the second element.SELECTED DRAWING: Figure 1

A gap between a plurality of ablation sites in a heart that hinders electrical propagation therethrough is found by projecting the locations of the sites in a 3-dimensional coordinate system onto a simulation plane, identifying a set of shortest 3-dimensional paths that correspond to 2-dimensional connections between pairs of the projected locations of the sites, and reporting a gap as a longest one of the set.

Devices and methods can be used to treat heart conditions, hypertension, and other medical disorders. For example, devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation are described herein. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation.

The present technology relates to standardized coordinate systems for mapping three-dimensional structures. An exemplary method includes: obtaining imaging data including a representation of a left atrium of a subject; identifying anatomical features represented in the imaging data, the anatomical features including pulmonary veins that connect to the left atrium; generating a 3D surface mesh corresponding to the left atrium; determining a reference point on the 3D surface mesh based on locations of junctions of the pulmonary veins with the left atrium; establishing a reference axis based on the reference point; determining, on the 3D surface mesh and based on the reference axis, lines of longitude; determining, on the 3D surface mesh, lines of latitude along the lines of longitude; assigning coordinate values to points on the 3D surface mesh based on the lines of longitude and latitude; and generating a 2D map of the left atrium using the coordinate values.

The present invention relates to an equal-dose opposed-vessel monitoring pulmonary artery-pulmonary vein CT angiography method and system. For the method, the dose of the contrast agent bolus test, the flow rate and volume of the contrast agent, and the flow rate and volume of the normal saline are all consistent with those in the formal scan; during the bolus test, it is confirmed that a small amount of contrast agent flows into the pulmonary vein of the monitored slice while the pulmonary artery is filled, so as to obtain the optimal delay time of pulmonary artery CTA; it is confirmed that almost all of the contrast agent in the monitored slice has flowed through the pulmonary artery, and there is a trace amount of contrast agent at the end of the pulmonary artery near the periphery, so as to obtain the optimal delay time of pulmonary vein CTV. The system includes each module for realizing the above functions. The present invention can achieve accurate timing of pulmonary artery CTA and pulmonary vein left atrial CTV scans, and can also achieve accurate timing of combined one-stop right atrium ventricle pulmonary artery and pulmonary vein left atrium ventricle combined scans, realizing precise diagnosis and treatment.

A method of cardiac treatment to provide a synergetic therapeutic effect of lowering the hyperactive sympathetic response observed in microvascular disease (MVD) and heart failure (HF) pathologies and promoting cardiac remodeling of left ventricular hypertrophy in a patient. The method may include ablating renal sympathetic nerves of the patient to reduce sympathetic afferent and efferent activity to the kidney, thereby reducing blood pressure, and ablating a greater splanchnic nerve to reduce stressed blood volume with exertion. The method may include ablating renal sympathetic nerves of the patient to reduce sympathetic afferent and efferent activity to the kidney, thereby reducing blood pressure and at least one of: ablating pulmonary artery nerves of the patient to reduce cardiac sympathetic activity; and ablating pulmonary vein nerves of the patient to reduce arrhythmias.

The present invention relates to the technical field of medical image processing. More specifically, it relates to a pulmonary vascular perfusion analysis method based on watershed dynamics, including: acquiring a pulmonary artery vascular tree and a pulmonary arterial CT angiogram; extracting the pulmonary artery vascular tree based on the pulmonary artery vascular tree and the pulmonary arterial CT angiogram; calculating the pressure gradient field inside and on the wall of the pulmonary artery vascular tree based on the pulmonary artery vascular tree; extracting the pulmonary vein watershed based on the pressure gradient field; realizing perfusion analysis by combining dynamic hemodynamic simulation based on the pulmonary vein watershed; evaluating the blood supply of lung tissue based on the perfusion analysis results. By adopting the multi-level connected domain detection method, this method can more accurately extract the complex structure of the pulmonary artery vascular tree. The watershed division method based on the pressure gradient field can more truly reflect the actual distribution of blood flow. The introduction of dynamic blood flow simulation enables this method to comprehensively capture the perfusion changes during the breathing process and provide more comprehensive diagnostic information.

A method of sensing a physiological parameter involves advancing a delivery catheter to a right atrium of a heart of a patient via a transcatheter access path, advancing the delivery catheter through an atrial septal wall into a left atrium of the heart, deploying a distal anchor of a sensor implant device from the delivery catheter, anchoring the distal anchor of the sensor implant device to a first pulmonary vein, withdrawing the delivery catheter from the first pulmonary vein, thereby exposing at least a portion of a sensor module of the sensor implant device in the left atrium, deploying a proximal anchor of the sensor implant device from the delivery system, anchoring the proximal anchor of the sensor implant device to a second pulmonary vein, and withdrawing the delivery catheter from the heart.

The invention provides a cattail pollen content prediction method and system based on a hyperspectral double-flow multi-scale CNN, and belongs to the field of quality detection of traditional Chinese medicinal materials. The method comprises the following steps: acquiring hyperspectral image data of a pollen typhae sample, preprocessing the acquired hyperspectral image data, and extracting region-of-interest spectral data of the pollen typhae sample; inputting the extracted spectral data of the region of interest into a trained double-flow multi-scale residual fusion CNN model, performing multi-scale feature extraction and fusion by using a VNIR multi-scale branch and an NIR multi-scale branch, and outputting multi-scale fusion features; inputting the multi-scale fusion features into an attention fusion module, and outputting final fusion features; and based on the final fusion features, outputting a content prediction value of the active ingredients of the pollen typhae through a content prediction layer. The method solves the problems that a traditional detection method is low in efficiency, samples are damaged, and an existing spectrum model ignores wave band characteristic differences, so that precision is insufficient, and rapid, lossless and high-precision prediction of the pollen typhae content is achieved.

The utility model discloses a double-bend double-basket array electrode PFA (perfluoroalkoxy) mapping ablation catheter, which relates to the technology of medical instruments and comprises a catheter body, one end of the catheter body leads out a guide wire from a guide wire outlet, the other end of the catheter body is connected to a catheter handle, and a first basket and a second basket are respectively arranged at the head end of the catheter body; and the catheter handle is connected with the catheter body part, a second mesh basket telescopic control wheel and a first mesh basket telescopic control wheel are arranged on the catheter handle, the second mesh basket telescopic control wheel and the first mesh basket telescopic control wheel are respectively connected with the corresponding traction wires, and the catheter handle leads out corresponding electrode tail wires and the other ends of the guide wires. According to the utility model, the double net baskets at the head part of the catheter can respectively or simultaneously enter and exit from the near end of the target pulmonary vein and cling to and leave from the vestibule of the pulmonary vein through retraction and extension.

An apparatus includes a shaft, the shaft including a plurality of stepped sections along the length of the shaft. The apparatus further includes a plurality of electrodes disposed along the length of the shaft, each electrode characterized by a geometric aspect ratio of the length of the electrode to the outer diameter of the electrode. Each electrode is located at a different stepped section of the plurality of stepped sections of the shaft and includes a set of leads. Each lead of the set of leads is configured to attain an electrical voltage potential of at least about 1 kV. The geometric aspect ratio of at least one electrode of the plurality of electrodes is in the range between about 3 and about 20.

The invention discloses an artificial intelligence-assisted pulmonary blood vessel image omics acquisition method and device, a medium and a product, and relates to the technical field of medical image processing, and the method comprises the steps: firstly, based on an input original file, in response to the operation of a user, reconstructing a lung model and a pulmonary blood vessel model; based on the pulmonary blood vessel model, generating a first simplified model of each pulmonary artery model blood vessel branch and a second simplified model of each pulmonary vein model blood vessel branch in response to operation of a user; and finally, based on the lung model, the pulmonary vessel model, the first simplified model and the second simplified model, generating peripheral vessel distribution parameters of pulmonary artery and pulmonary vein and radiomics characteristic parameters of the peripheral vessel distribution parameters, generating radiomics characteristic parameters of the whole vessel, calculating a vessel center line, and grading the vessel. The technical problem of how to improve the yield of information acquired by pulmonary blood vessel imaging omics is solved.

The present invention is a high resolution, multi-function, conformal electronics device generally having a flexible and stretchable, high-density electrode array, integrated with a catheter (e.g., balloon catheter) for mapping, ablating, pacing and sensing of cardia tissue associated with heart arrhythmias. The active sensing electrode array can acquire diagnostic information including electrical (e.g., electrograms), mechanical (e.g., strain measurements), impedance (e.g., resistance), metabolic (e.g., pH or NADH measurement) from the underlying heart tissue surface with which it is in contact. The electrode array may be designed to be of various sizes and shapes to conform to the targeted cardiac tissue architecture (e.g. atrial, ventricle, right ventricular outflow tract, coronary sinus, pulmonary veins, etc.) corresponding to the specific type of cardiac arrhythmia. The present invention can precisely locate the source of arrhythmia as described above and deliver therapy from the same electrode array. This is achieved using a capacitive sensing electrode array that can not only monitor but also deliver electrical stimulation.

Devices, systems, and methods are provided for treating conditions of the heart, particularly the occurrence of arrhythmias. The devices, systems, and methods deliver therapeutic energy to portions of the heart, such as to the pulmonary vein ostia when treating atrial fibrillation, to provide tissue modification. Generally, the tissue modification systems include a specialized catheter, a high voltage waveform generator, and at least one different energy delivery algorithm. Other embodiments include conventional ablation catheter and system components to support use with the high voltage waveform generator. Example catheter designs include a variety of delivery types, including localized delivery, "single shot" delivery, and various combinations thereof. In some embodiments, energy is delivered in a monopolar fashion. However, it will be appreciated that a variety of other embodiments are also provided.

The application discloses an ex vivo heart perfusion system and a perfusion control method, wherein the perfusion system comprises: an organ bin, which is externally provided with a constant temperature heating film for controlling the temperature in the organ bin to be a first preset temperature threshold; a liquid storage container for containing a perfusion medium, an outlet end of the liquid storage container being connected to a first active branch vein through a first liquid supply pipe and connected to a pulmonary vein through a second liquid supply pipe, an inlet end of the liquid storage container being connected to a second active branch vein through a first liquid return pipe and connected to a pulmonary artery through a second liquid return pipe; a circulating pump connected to the first liquid supply pipe; an oxygenator connected to the first liquid supply pipe, the oxygenator being connected with a gas supply module for adjusting the gas mixing ratio in the perfusion medium; and an injection pump group for supplementing injection of nutrient substances or therapeutic drugs. The application can effectively prolong the heart supply storage time, reduce the heart supply discard rate, and further improve the utilization rate of the heart supply.

Apparatus for automatic suggestion of atrial fibrillation cases as a function of a presence of abnormal pulmonary vein anatomy and methods used therein are described, wherein the apparatus includes a processor and a memory communicatively connected to the processor, wherein the memory includes instructions configuring the processor to receive query pulmonary vein anatomy data, detect at least an abnormal pulmonary vein anatomy within the received query pulmonary vein anatomy data, and suggest a case of atrial fibrillation as a function of the at least a detected abnormal pulmonary vein anatomy, wherein the query pulmonary vein anatomy data are automatically processed and analyzed.

Disclosed herein are technologies for addressing elevated left-sided filling pressures to mitigate the effects of diastolic dysfunction. Embodiments provide ways to decrease the temporal increase in blood flow and pressure into the heart from the venous system. Under exertion, there is a shift of blood from the 'unstressed' reservoir of vasculature, which primarily comprises the splanchnic system, to the 'stressed' reservoir, which comprises the heart and lungs. By inhibiting this acute shifting of blood from the 'unstressed' reservoir to the 'stressed' reservoir, an undesirable influx of blood volume to the already overloaded left heart can be avoided. Certain embodiments provide ways to increase atrial elasticity, or atrial compliance. This enhancement of atrial compliance enables the atrium to 'absorb' the energy of short bursts of high left atrial pressure. Consequences are a reduction in the retrograde flow in the pulmonary veins to inhibit acute pulmonary congestion.

The utility model discloses a controllable windmill-shaped PFA catheter, and relates to the technical field of catheter ablation and medical instruments, the controllable windmill-shaped PFA catheter comprises a catheter (1), the catheter (1) is led out from a catheter body (2), the head end of the catheter is of a windmill structure, a magnetic sensor and a plurality of electrodes are arranged on a framework of the windmill structure, and the windmill structure can be contained in a sheath tube; one end of the catheter body (2) is led out of the catheter (1), and the catheter body (2) is arranged in the sheathing canal; one end of the catheter handle (3) is led out of the catheter body (2), the catheter handle (3) is matched with a gear assembly of an electrophysiological interventional instrument, and the gear assembly at least comprises three sets of gears used for achieving corresponding operation actions. According to the windmill-shaped PFA ablation catheter, the electrodes are evenly distributed on the windmill-shaped framework, even electrode distribution is formed on the target pulmonary vein, and an operator can conduct ablation without replacing the catheter while completing three-dimensional point mapping dissection.

The invention provides a left atrium volume automatic calculation method and system. The method comprises the steps of obtaining three-dimensional medical image data, and performing coarse segmentation on a left atrium through a deep learning model; morphological corrosion is adopted to remove accessory structures such as pulmonary veins and left auricles, and main morphological characteristics are extracted; the center point offset of the corroded structure and the original structure is calculated, and position correction is completed; gradually expanding the structure based on morphological expansion operation, and recording volume change, the number of overflow voxels and the number of intersection voxels; analyzing the second-order change rate, and determining an optimal expansion termination point; and extracting a final left atrium structure, performing morphological optimization, and calculating the left atrium volume in combination with the voxel number and the spatial resolution. The method does not need special equipment, has the characteristics of high automation, strong stability and good adaptability, and is suitable for auxiliary diagnosis and curative effect evaluation of heart diseases such as atrial fibrillation.

The application provides a lung recognition processing method and device and a server, relates to model processing technology, and the method comprises the following steps: obtaining a model recognition instruction, the model recognition instruction comprises a lung model identifier, determining a lung model corresponding to the lung model identifier, and the lung model comprises a lung parenchyma model, a trachea model, a pulmonary vein model and a pulmonary artery model. Based on the growth information of at least one of the trachea model, the pulmonary vein model and the pulmonary artery model, a plurality of initial segmentation cross sections of the lung parenchyma model are determined. According to at least one of the intrasegment trachea, intrasegment vein and intrasegment artery in each initial lung segment, a plurality of target segmentation cross sections of the lung parenchyma model are generated. According to the target segmentation cross sections of the reconstructed lung model, the distribution information of each lung segment can be obtained, thereby helping to improve the accuracy of the surgical plan, reduce the surgical risk index, improve the surgical success rate, and solve the technical problem that it is difficult to recognize the distribution of the intrapulmonary trachea, blood vessels and lung segments.

The utility model discloses a petal type pulsed electric field ablation catheter, which relates to the medical instrument technology, and comprises a catheter body part, a guide wire is arranged in the catheter body part, the guide wire is led out from a guide wire outlet at one end of the catheter body part, and the other end of the catheter body part is connected with a catheter tail handle; the petal skeleton comprises a plurality of skeleton branches and one end, arranged at the guide wire outlet of the catheter body part, of the skeleton branches, each skeleton branch comprises a free end, each free end can be stretched and separated based on the one end of the guide wire outlet and can be bent, and each free end can be folded into a bundle shape based on the led-out guide wire; a plurality of electrodes and positioning sensors are arranged on the skeleton branches at intervals; a bending control knob is arranged on the catheter tail handle, and the bending control knob is connected to the catheter head end through a bending traction steel wire. The petal skeleton is large in deformation range, and double-insurance ablation of the pulmonary vein open muscle sleeve and the vestibular tissue can be achieved.

A device for providing cardiac treatment at the left atrium of a patient's heart. The device includes a retention body and a prosthetic valve. The retention body has a shape that can be manipulated between a collapsed state and a normal or expanded state. First and second openings are defined at one side of the retention body, and a lower opening is defined at an opposite side. The prosthetic valve is carried by the retention body at the lower opening. The retention body is configured to engage a substantial portion of an interior surface of the left atrium, securing the prosthetic valve at a desired location relative to a native mitral valve (e.g., within the mitral valve or slightly spaced from the mitral valve). The first and second openings are sized and shaped so as to permit blood flow from the pulmonary veins into the interior region.

To provide a device, system and method for treating a heart state, in particular the occurrence of arrhythmias.SOLUTION: A device, system, and method deliver therapeutic energy to portions of a heart to provide tissue modification such as to entrances to pulmonary veins in a treatment of atrial fibrillation. In general, a tissue modification system includes a specialized catheter, a high voltage waveform generator, and at least one distinct energy delivery algorithm. Other embodiments include conventional ablation catheters and system components to enable use with a high voltage waveform generator. Example catheter designs include a variety of delivery types including focus delivery, a "one-shot" delivery, and various possible combinations. In some embodiment, the energy is delivered in a monopolar fashion. However, it may be appreciated that a variety of other embodiments are also provided.SELECTED DRAWING: Figure 34

This application discloses a method and system for three-dimensional point cloud modeling of cardiac cavities, involving three-dimensional modeling and data processing technologies, including: interpolating a spherical three-dimensional point cloud position data set based on the movement of an integrated catheter, point cloud vector position data collected by each magnetic positioning sensor, and the windmill diameter of the integrated catheter; filtering data in the three-dimensional point cloud position data set based on impedance data collected by microelectrodes; segmenting the data arcs based on the three-dimensional point cloud position data retained after screening, and segmenting the contours of each segmented arc; and constructing triangulated rendering of key points in the segmented line segments to complete three-dimensional modeling within the cardiac cavity. The method of this application can simultaneously complete three-dimensional point cloud modeling of the target cardiac cavity and ablation of pulmonary vein isolation for atrial fibrillation using a single catheter.

The invention is entitled "Sensing and mapping catheter for guiding and supporting balloon catheters". The invention discloses a catheter configured to guide and support balloon catheters for use in and around the pulmonary veins and their ostia, the catheter having an elongated shaft including a proximal portion having a first flexibility and a distal portion having a second flexibility greater than the first flexibility, and a distal assembly including an elbow portion and a generally circular portion generally transverse to the longitudinal axis, and the generally circular portion including a third flexibility greater than the second flexibility. A single axis position sensor and a sensing ring electrode are carried on the generally circular portion.