468 results about "Stenosis" patented technology

Embodiments of the present disclosure are configured to assess the severity of a blockage in a vessel and, in particular, a stenosis in a blood vessel. In some particular embodiments, the devices, systems, and methods of the present disclosure are configured to assess the severity of a stenosis in the coronary arteries by monitoring fluid flow. In some embodiments, the devices, systems, and methods of the present disclosure receive analog sensor data that includes fluid flow data and digitizes the analog sensor data according to a quadrature sampling rate. A weighted accumulator performs a baseband conversion on the digitized sensor data and may perform other signal processing steps. The processed data is then provided for use in any one of a number of diagnostic assessments.

A catheter for treating a stenosis in a body lumen includes an elongate tube; a member sealed to a distal end of the elongate tube that is fillable with a conductive fluid; a metallization layer comprising at least one trace forming at least one inner electrode, the metallization layer being connected to at least one wire; and at least one outer electrode extending radially outwardly of the metallization layer and separated from the at least one inner electrode by at least one gap such that, when a voltage pulse is applied to the inner and outer electrodes, current flows across the at least one gap to generate at least one shock wave.

A catheter system for treating stenosis in a body lumen includes a first energy source, a second energy source, and a catheter. The catheter includes an elongate member that is navigable through the body lumen, a first acoustic energy emitter connected to the first energy source and configured to emit acoustic energy when energy is received from the first energy source, and a second acoustic energy emitter connected to the second energy source and configured to emit acoustic energy when energy is received from the second energy source.

A method and apparatus for vascular assessment are disclosed. The apparatus, in some embodiments, receives, from a medical imaging device, a medical image of a coronary vessel tree of a subject and calculates a plurality of geometric measurements associated with individual portions of a vascular segment of the coronary vessel tree. The apparatus also determines a plurality of resistances associated with the plurality of geometric measurements associated with the individual portions of the vascular segment and determines a plurality of pressure drops across the individual portions of the vascular segment based on the determined resistances and a calculated or estimated blood flow. The apparatus further calculates based on the plurality of pressure drops, a functional index indicative of a presence or an absence of a stenosis within the vascular segment.

A method and apparatus for vascular assessment are disclosed. The apparatus, in some embodiments, receives, from a medical imaging device, a medical image of a coronary vessel tree of a subject and calculates a plurality of geometric measurements associated with individual portions of a vascular segment of the coronary vessel tree. The apparatus also determines a plurality of resistances associated with the plurality of geometric measurements associated with the individual portions of the vascular segment and determines a plurality of pressure drops across the individual portions of the vascular segment based on the determined resistances and a calculated or estimated blood flow. The apparatus further calculates based on the plurality of pressure drops, a functional index indicative of a presence or an absence of a stenosis within the vascular segment.

Methods of treating a central airway obstruction (CAO), benign airway stenosis, asthma, chronic obstructive pulmonary disease (COPD), or an airway tumor in a human subject, methods of treating chronic rhinosinusitis (CRS) or chronic rhinosinusitis with nasal polyps (CRSwNP) in a human subject, methods of treating a eustachian tube disorder in a human subject, and devices and systems for performing the methods. A method of treating a central airway obstruction (CAO), benign airway stenosis, asthma, chronic obstructive pulmonary disease (COPD), or an airway tumor in a human subject includes inserting a drug-coated balloon catheter into a target site in a trachea, mainstem bronchus, bronchus intermedius, lobar bronchus, segmental bronchus, or sub-segmental bronchus, wherein the balloon is coated with a coating layer including the therapeutic agent and one or more additives. The therapeutic agent includes paclitaxel, sirolimus, or a derivative thereof. The method includes inflating the balloon to dilate the airway and deliver a therapeutic agent to the airway wall. The method includes deflating the balloon. The method also includes withdrawing the balloon catheter from the target site.

Embodiments include example systems, methods, and computer-accessible mediums for analysis of anatomical images for assessment of stenosis and disc degeneration. In some embodiments, systems, devices, and methods described herein include selecting a region of interest (ROI) in a three-dimensional (3D) volume of image data of a plurality of vertebra of a spine, identifying one or more anatomical parts in the ROI, determining one or more parameters of the one or more anatomical parts, and assessing a severity of a spinal deformity based on the one or more parameters.

A computer-implemented method and a system for calculating a pressure drop along one or more vessels comprising one or more stenosis, the method comprising: obtaining at least one two-dimensional image of the vessels; obtaining a centerline and a boundary of each vessel by image processing algorithms; calculating a length and a diameter of each vessel; calculating a baseline volumetric flow (Qb); deriving a hyperaemic volumetric flow rate (Qh); determining a set of stenosed parts; defining a proximal part, between an inlet and a first stenosed part, a distal part, between last stenosed part and outlet, and a set of normal parts, between two stenosed parts; calculating a pressure drop at a proximal part, at a distal part, at normal parts and at stenosed parts, and calculating a total pressure drop ΔP from inlet to outlet of the vessel. Also, calculating resistance indices of the stenosis and of the microcirculation.

An automated measurement device and method for coronary artery disease scoring is disclosed. An example device includes a processor configured to obtain a computerized model of a plurality of vascular segments of a patient and create an unstenosed computerized model from the computerized model by virtually enlarging at least some locations of the vascular segments of the computerized model. The processor also determines vascular state scoring tool (“VSST”) scores based on characteristics of vascular locations along the vascular segments. The processor further determines a severity of stenosis for the vascular locations based on comparisons of first blood flow parameter values at the vascular locations in the computerized model to corresponding second blood flow parameter values at the same vascular locations in the unstenosed computerized model. A user interface of the device displays the severity of stenosis in conjunction with the VSST scores for the vascular locations.

A coronary artery disease (CAD) analysis system is disclosed that comprises a CAD analysis device and a user interface. The CAD analysis device is arranged to analyse received patient CT scan data and produce CAD analysis data indicative of presence and characterisation of coronary artery disease in the patient CT scan data. The CAD analysis data is indicative of at least one individual stenosis lesion on a coronary artery and a characterisation of the stenosis lesion, and the CAD analysis system is arranged to identify a start location and an end location of the individual stenosis lesion on the coronary artery. The user interface displays a model of coronary arteries of a patient based on the patient CT scan data, and the model is configured to visually indicate an individual stenosis lesion and the individual stenosis lesion characterisation to a user so that the user is able to identify presence and characterisation of each individual stenosis lesion based on the visual indication.

A method of treating a recurring airway stricture or stenosis in a body lumen includes inserting a scope and a drug-coated balloon catheter into a target site comprising the recurring airway stricture or stenosis in the body lumen. The method includes inflating the balloon to an inflation diameter such that the coating contacts an interior of the body lumen at the target site. The method includes deflating the balloon and withdrawing the scope and the balloon catheter from the target site.

Various embodiments disclosed relate to polymer encapsulated drug particles and drug release coatings comprising the polymer encapsulated drug particles, as well as drug coated balloon catheters for treating, preventing, or reducing recurrence of body lumen stenosis and methods of use thereof. A drug coated balloon catheter for delivering a therapeutic agent to a body lumen stenosis target site includes an elongated balloon. The balloon catheter includes a coating layer covering the outer surface of the balloon. The coating layer comprises: polymer encapsulated drug particles; or a drug release coating comprising polymer encapsulated drug particles; or a therapeutic agent and a first and / or second additive; or a combination thereof.

The invention relates to the technical field of medical instruments, in particular to a flexible ureteroscope used in cooperation with a diameter-variable ureteroscope sheath, which comprises a ureteroscope sheath body and a flexible ureteroscope body, the ureteroscope sheath body comprises a deformation section and a support section, the deformation section has a first form and a second form, and the flexible ureteroscope body comprises a handle section and a ureteroscope tube section. The endoscope tube section comprises a first tube body part and a second tube body part, a fixing groove is formed in the first tube body part, and the outer diameter of the deformation section in the first form is smaller than or equal to the outer diameter of the first tube body part; the inner diameter of the deformation section in the second form is greater than the outer diameter of the first pipe body part; a first liquid injection channel is further arranged in the endoscope tube section, and a first liquid outlet hole is formed in the fixing groove. Compared with the prior art, in the operation of expanding the human body ureterostenosis section by the deformation section, a stenosis ring in the human body ureterostenosis section does not need to be broken by supporting, so that the injury to the human body ureter in the ureteroscope lithotripsy is effectively reduced, and the postoperative pain of a patient is reduced.

The utility model discloses an interventional operation operating system with an OCT probe, and relates to the technical field of medical instruments. The interventional surgery operating system with the OCT probe comprises a micro catheter, a probe head and an OCT probe, the OCT probe is arranged at the front end of the micro catheter; the recovery pipe is arranged at the front end of the OCT probe; the recovery pipe is provided with a first through hole and a second through hole; a first control microfilament and a protective umbrella; the front end of the first control microfilament is connected with the protective umbrella; the front end of the first control microwire can penetrate into the recycling pipe through the first through hole; a micro guide wire; the front end of the micro guide wire can penetrate into the recycling pipe through the second through hole. According to the application, the micro catheter does not need to be drawn out of the carotid artery, then the OCT probe is inserted into the carotid artery, and scanning detection of a narrow part can be realized only by moving the micro catheter in the carotid artery by a small distance (dozens of millimeters or dozens of millimeters).

According to one embodiment, a medical image processing apparatus includes first specifier, second specifier, determiner and display controller. First specifier collates an ischemic region calculated from a blood vessel visualized into a three-dimensional image in a plurality of phases with a dominating region of the blood vessel, and specifies a culprit vessel in the ischemic region. Second specifier specifies a culprit stenosis in the culprit vessel based on a pressure index calculated from the blood vessel. Determiner determines a connection position to connect a bypass vessel that makes a detour around the culprit stenosis. Display controller displays the determined connection position on a display.

Laser IVL systems and methods are disclosed. A laser IVL system can include at least one light energy source and a catheter. The catheter can include an elongate sheath, an enclosure sealed to a distal end of the elongate sheath, and at least one optical fiber contained within the elongate sheath. The enclosure may have a fill volume less than 10 mL and may be fillable with a fluid. The at least one optical fiber can be optically coupled to receive light from the at least one light energy source and configured to transmit the received light at a light emitting region of the at least one optical fiber into a distal region of the catheter that is enclosed by the enclosure to generate shock waves in the fluid.

The invention discloses a spatial registration and image fusion method for deep learning based on SS-OCT and TOF data, relates to the technical field of multi-modal medical image processing, and aims to improve alignment and fusion effects based on SS-OCT and TOF blood vessel data. According to the method, firstly, blood vessel features are enhanced through preprocessing, precise registration and fusion of cross-modal data are achieved by combining high-resolution two-dimensional tomography of SS-OCT and three-dimensional blood vessel form data of TOF and utilizing an improved SIFT algorithm and a cross attention Transformer model, and finally a high-precision three-dimensional blood vessel model is generated and can be used for treating cerebrovascular diseases (such as cerebrovascular diseases). Image support with details and a global structure is provided for preoperative planning and intraoperative navigation of a patient (such as aneurysm and stenosis), and the accuracy of diagnosis and treatment is remarkably improved.

The present invention relates to a pharmaceutical composition with joint repair efficacy, which is composed of collagen, chitosan and a pharmaceutically acceptable carrier, wherein the weight ratio of collagen to chitosan in the composition is 11:1-1:11, the average molecular weight of collagen is 3kDa-500kDa, and the weight average molecular weight of chitosan is 10000-200000. The pharmaceutical composition of the present invention is used to treat and relieve pain caused by joint cavity stenosis and bone wear, effectively prevent and treat traumatic or degenerative osteoarthritis, and has the advantages of good water solubility, good biocompatibility, fast onset, good repair effect, good stability, good re-dissolution stability, long effective period, easy storage, etc.

The invention relates to the technical field of medical apparatus and instruments, in particular to a pressure sensing ureter guiding sheath which comprises a flexible sheath tube body provided with a near-end operation section and a far-end intervention section. The annular pressure sensing array is formed by equidistantly arranging a plurality of piezoresistive sensors along the circumferential direction of the far-end intervention section, and is used for monitoring the ureter wall contact pressure in real time; the signal processing module is integrated on the near-end operation section and is used for carrying out dynamic noise filtering and baseline calibration on the pressure signals from the annular pressure sensing array; and the display screen is connected to the signal processing module and is used for displaying the pressure distribution of the annular pressure sensing array in real time. The scheme is used for solving the problem of mechanical trauma caused by inappropriate size selection, pathological or physiological stenosis and the like in the sheathing canal implantation process in the prior art, and real-time monitoring and dynamic adjustment of the ureter wall contact pressure are realized, so that the surgical risk is reduced, and the surgical success rate is improved.

The invention discloses a perfusion mastoid balloon and a balloon dilatation catheter, and relates to the technical field of medical instruments. The perfusion mastoid balloon comprises a balloon main body, mastoids and a fluid channel, the mastoid process and the balloon main body are integrally formed or separately formed; the fluid channel is formed in the peripheral wall of the balloon body and extends in the length direction of the balloon body to allow liquid to pass through, and the size of the fluid channel in the radial direction of the balloon body is smaller than or equal to the size of the mastoid in the radial direction of the balloon body. The structure of the perfusion mastoid balloon is improved, the expansion time of the perfusion mastoid balloon is effectively prolonged, a narrow area can be better expanded, and meanwhile blood vessel blockage is avoided.

The invention provides application of a monascus composition in preparation of a medicine for preventing and / or treating coronary microcirculation disturbance. The monascus composition comprises one or more of cortex mori, ramulus mori and folium mori, monascus and radix puerariae. When the composition containing the red yeast rice is applied to preparation of the medicine for preventing and / or controlling coronary microcirculation disturbance, the abnormal microvascular structure can be improved (myocardial microvascular density MVD is increased, edema around microvessels is relieved, the lumen stenosis phenomenon is improved, and the endothelial cell condition is good); 2) microvascular occlusion is improved (pathologic results show that microvascular contents are reduced); (3) the abnormal vasodilatation and contraction function of the microvessels is improved (NO is increased); 4) improving blood lipid metabolism disorder; and (5) the heart function is improved (the left ventricular ejection fraction LVEF and the left ventricular short axis shortening rate LVFS are improved, and the left ventricular pressure maximum rising rate LV + dp / dtmax and the left ventricular pressure maximum falling rate LV-dp / dtmax are increased).

Thrombectomy systems having curved tubular cutting devices, and methods of using them, are provided. These systems, devices, and methods can (i) effectively cut and remove a variety of thrombus tissue from blood vessels, including soft, tough, and hard tissue; (ii) safely self-collect and remove tissue particles to avoid release of emboli; and, (iii) effectively treat a blood vessel with a reduced risk of suffering vessel injuries that can lead to increased stenosis.

The invention discloses a safe ureter dilatation guide wire system and a progressive pressure control method, and relates to the technical field of medical instruments.The safe ureter dilatation guide wire system comprises a guide wire body and a pressure sensor, the guide wire body comprises a water bag structure and a double-cavity structure which are communicated, the water bag structure is made of an elastic structure, and the double-cavity structure is made of an elastic material; the interior of the water bag structure is used for being filled with expansion liquid and expanding according to the target volume so as to expand the narrow position of the ureter. A guide wire cavity and a liquid injection cavity which are independently arranged are formed in the double-cavity structure, the guide wire cavity and the liquid injection cavity are both communicated with the water bag structure, the guide wire cavity is used for allowing the identification light source to penetrate through, and the liquid injection cavity is used for providing expansion liquid for the water bag structure; the pressure sensor is installed outside the water bag structure so as to detect the pressure of the inner wall tissue of the ureter in real time. According to the technical scheme, the problem that an existing ureter guide wire cannot monitor the deformation state of narrow tissue in real time is solved.

Thrombectomy systems having curved tubular cutting devices, and methods of using them, are provided. These systems, devices, and methods can (i) effectively cut and remove a variety of thrombus tissue from blood vessels, including soft, tough, and hard tissue; (ii) safely self-collect and remove tissue particles to avoid release of emboli; and, (iii) effectively treat a blood vessel with a reduced risk of suffering vessel injuries that can lead to increased stenosis.

A balloon catheter for treating stenosis and / or cancer, preventing stenosis and / or cancer, or reducing recurrence of stenosis and / or cancer, or for treating benign prostatic hyperplasia (BPH) in a non-vascular body lumen; the balloon catheter includes: an elongated balloon; a coating covering an outer surface of the balloon, wherein the coating comprises one or more water soluble additives and a therapeutic agent of an initial drug loading amount; and a length control mechanism (600) that stretches and elongates the balloon during contraction, providing a smaller cross-sectional contraction profile of the balloon for tracking through a body cavity and post-treatment retrieval.

The invention relates to a computer vision technology, in particular to a medical image processing technology based on deep learning and a medical diagnosis auxiliary method. The invention provides an airway stenosis automatic segmentation method, system and device based on a CT image, and the method specifically comprises the following technical means: 1) building an airway stenosis automatic segmentation model based on a marked training set and a verification set, so as to achieve the automatic recognition, positioning and segmentation of a narrow airway; (2) reasoning by using the established airway stenosis automatic segmentation model, and automatically identifying, positioning and segmenting a stenosis airway from an input CT (Computed Tomography) image; and 3) performing quantitative parameter measurement based on the narrow airway obtained by automatic segmentation. According to the automatic segmentation system and device for the airway stenosis, whether the airway stenosis exists in the CT image or not can be rapidly and accurately recognized, if yes, automatic positioning and segmentation of the stenosis can be achieved, and the system and device assist imaging departments or clinicians in rapidly and accurately diagnosing the narrow airway; meanwhile, based on the airway stenosis obtained through automatic segmentation, the stenosis range and the maximum, minimum and average lumen diameters of the stenosis part can be rapidly and accurately calculated, on one hand, the method can be used for evaluating the severity of the stenosis, and on the other hand, the method can be used for assisting clinical treatment.

The invention discloses a potential stroke risk assessment method and system after coronary artery recanalization, and the method comprises the steps: obtaining the heart and cerebral vessel image data of a patient, and constructing a complete heart and cerebral artery blood vessel geometric model; based on the cardio-cerebral artery blood vessel geometric model, numerical simulation is conducted on the flowing conditions of blood flow in coronary arteries and cerebral vessels by means of a computational fluid mechanics method, and the pressure ratio before and after coronary artery stenosis and the partial pressure ratio of the cerebral vessels are calculated; according to the pressure ratio and the partial pressure ratio, the potential risk of the cerebral arterial thrombosis is quantitatively evaluated, and a cerebral blood flow partial pressure ratio numerical value and a cerebral arterial thrombosis risk evaluation report are generated. According to the cerebral apoplexy risk quantitative evaluation method, by integrating coronary artery CTA and cranial CTA or MRA data, reconstructing a complete heart and cerebral vessel geometric model and simulating heart and cerebral blood flow changes before and after a coronary artery recanalization operation, and particularly by calculating coronary artery FFR and cerebral blood flow partial pressure ratio FPR, an evaluation report is generated, and a basis for quantitative evaluation of the cerebral apoplexy risk in the operation is provided for clinical doctors.

A catheter system for treating stenosis in a body lumen includes a first energy source, a second energy source, and a catheter. The catheter includes an elongate member that is navigable through the body lumen, a first acoustic energy emitter connected to the first energy source and configured to emit acoustic energy when energy is received from the first energy source, and a second acoustic energy emitter connected to the second energy source and configured to emit acoustic energy when energy is received from the second energy source.

The invention relates to the technical field of medical image auxiliary diagnosis, and provides an intervertebral joint osteoarthritis image feature evaluation method based on deep learning, which can synchronously identify five types of FJOA image features such as joint space stenosis, osteophyte, hypertrophy, subchondral bone erosion and subchondral cyst, and improves the comprehensiveness and efficiency of evaluation. The nnU-Net model is adopted to perform high-precision segmentation on an intervertebral joint region, so that the positioning precision is effectively improved; by introducing a shared feature extraction network based on ResNet-18 and five parallel classification sub-networks, joint modeling of multi-scale semantic information is realized, and the recognition accuracy and generalization ability of the model are improved; according to the method, a Grad-CAM technology is combined to generate an activation thermodynamic diagram, a model interpretation basis is superposed to an original image, visual display of an evaluation result is realized, interpretability and clinical applicability of the model are enhanced, and FJOA image features in axial lumbar vertebra CT images from two central data sets can be quantitatively evaluated so as to comprehensively quantify individual FJOA image features.

The invention relates to a branch blood vessel endoluminal repair system which comprises at least two guide wires and a support conveying device, the support conveying device comprises an outer sheath tube and a film covering tube which are connected in a sleeved mode, and the film covering tube comprises a main body part connected to the at least two guide wires in a sleeved mode. The main body part and the at least two branch parts are connected to the guide wires in a sleeving mode in a one-to-one correspondence mode, the film covering pipe is provided with a containing position and a working position, the film covering pipe is folded to the inner side of the outer sheath pipe at the containing position, and the main body part and the branch parts move to the outer portion of the outer sheath pipe at the working position, so that the main body part and the branch parts form a cavity channel used for implanting a support. By means of the technical scheme, the branch blood vessel intracavitary repair system can solve the problems including but not limited to iliac artery lesions (such as dilatation and stenosis lesions), the application requirement suitable for a complex blood vessel structure is met, and the applicability is high.