167 results about "Stenosis" patented technology

Methods of treating a central airway obstruction (CAO), benign airway stenosis, asthma, chronic obstructive pulmonary disease (COPD), or an airway tumor in a human subject, methods of treating chronic rhinosinusitis (CRS) or chronic rhinosinusitis with nasal polyps (CRSwNP) in a human subject, methods of treating a eustachian tube disorder in a human subject, and devices and systems for performing the methods. A method of treating a central airway obstruction (CAO), benign airway stenosis, asthma, chronic obstructive pulmonary disease (COPD), or an airway tumor in a human subject includes inserting a drug-coated balloon catheter into a target site in a trachea, mainstem bronchus, bronchus intermedius, lobar bronchus, segmental bronchus, or sub-segmental bronchus, wherein the balloon is coated with a coating layer including the therapeutic agent and one or more additives. The therapeutic agent includes paclitaxel, sirolimus, or a derivative thereof. The method includes inflating the balloon to dilate the airway and deliver a therapeutic agent to the airway wall. The method includes deflating the balloon. The method also includes withdrawing the balloon catheter from the target site.

Laser IVL systems and methods are disclosed. A laser IVL system can include at least one light energy source and a catheter. The catheter can include an elongate sheath, an enclosure sealed to a distal end of the elongate sheath, and at least one optical fiber contained within the elongate sheath. The enclosure may have a fill volume less than 10 mL and may be fillable with a fluid. The at least one optical fiber can be optically coupled to receive light from the at least one light energy source and configured to transmit the received light at a light emitting region of the at least one optical fiber into a distal region of the catheter that is enclosed by the enclosure to generate shock waves in the fluid.

The invention provides application of a monascus composition in preparation of a medicine for preventing and / or treating coronary microcirculation disturbance. The monascus composition comprises one or more of cortex mori, ramulus mori and folium mori, monascus and radix puerariae. When the composition containing the red yeast rice is applied to preparation of the medicine for preventing and / or controlling coronary microcirculation disturbance, the abnormal microvascular structure can be improved (myocardial microvascular density MVD is increased, edema around microvessels is relieved, the lumen stenosis phenomenon is improved, and the endothelial cell condition is good); 2) microvascular occlusion is improved (pathologic results show that microvascular contents are reduced); (3) the abnormal vasodilatation and contraction function of the microvessels is improved (NO is increased); 4) improving blood lipid metabolism disorder; and (5) the heart function is improved (the left ventricular ejection fraction LVEF and the left ventricular short axis shortening rate LVFS are improved, and the left ventricular pressure maximum rising rate LV + dp / dtmax and the left ventricular pressure maximum falling rate LV-dp / dtmax are increased).

The invention relates to the technical field of medical image auxiliary diagnosis, and provides an intervertebral joint osteoarthritis image feature evaluation method based on deep learning, which can synchronously identify five types of FJOA image features such as joint space stenosis, osteophyte, hypertrophy, subchondral bone erosion and subchondral cyst, and improves the comprehensiveness and efficiency of evaluation. The nnU-Net model is adopted to perform high-precision segmentation on an intervertebral joint region, so that the positioning precision is effectively improved; by introducing a shared feature extraction network based on ResNet-18 and five parallel classification sub-networks, joint modeling of multi-scale semantic information is realized, and the recognition accuracy and generalization ability of the model are improved; according to the method, a Grad-CAM technology is combined to generate an activation thermodynamic diagram, a model interpretation basis is superposed to an original image, visual display of an evaluation result is realized, interpretability and clinical applicability of the model are enhanced, and FJOA image features in axial lumbar vertebra CT images from two central data sets can be quantitatively evaluated so as to comprehensively quantify individual FJOA image features.

The invention discloses a robot guide path optimization method and system for gastrointestinal tumor assisted surgery, particularly relates to the technical field of robot assisted navigation, and is used for solving the problem of unstable and inaccurate path planning. According to the method, fusion of multi-modal information under the unified time and space is achieved through space-time alignment of a preoperative model and intraoperative perception data, registration uncertainty and visibility indexes are dynamically calculated, and the fusion of the multi-modal information under the unified time and space is achieved through construction of an anatomical risk layer, a forbidden zone, geometric stenosis, perfusion evidence, a collision distance margin and a puncture point remote rotation center constraint satisfaction degree. A multi-channel path cost graph is generated, the safety of the path is evaluated, a constraint propagation and regulation causal graph mechanism is combined, a conflict solution contribution degree and a path optimization priority sequence can be rapidly output, it is ensured that the robot executes the optimal path in a complex anatomical environment, a conservative mode is switched when a key risk index triggers a threshold value, and the optimal path is obtained. Real-time regulation and control and safety guarantee are achieved, and the stability of the operation process is improved.

Medical balloons and methods used to retain and expand a stent within a stenosis or stricture of a bodily passage are disclosed. The balloons include a base material layer and a friction enhancing feature coupled to an exterior surface of the base material layer. The friction enhancing feature includes a second material layer disposed over the exterior surface to form a laminar formed balloon. The second material layer is more compressible than the base material layer to provide an increased static stent holding force.

The embodiment of the invention provides a dynamic evaluation method and device for the NVC function of a carotid artery stenosis crowd, a medium and a program product, and relates to the field of intelligent medical treatment. The method comprises the following steps: acquiring a resting middle cerebral artery average blood flow velocity Vm of a sample in a resting state and an exercise middle cerebral artery average blood flow velocity Vm of the sample in an exercise load state; according to the average blood flow velocity Vm of the middle cerebral artery during movement and the average blood flow velocity Vm of the middle cerebral artery during resting, a movement-induced blood flow response index EIFR is obtained through calculation; the motion-induced blood flow response index EIFR is an NVC parameter; and obtaining an evaluation result of whether the NVC function is abnormal or not according to whether the NVC parameter is reduced or not. On the basis of a quantifiable NVC function evaluation system in a constant motion state, objective screening standards are provided for stroke high-risk groups, a long-term follow-up visit plan is made, and an accurate quantitative basis is provided for clinical intervention decision and postoperative complication prediction.

The invention provides an internal arteriovenous fistula monitoring method and system, and the method comprises the steps: extracting feature parameters based on the blood vessel pulsation sound of an internal arteriovenous fistula region, preprocessing the feature parameters, and inputting the preprocessed feature parameters into a first prediction model, thereby obtaining a stenosis probability; extracting risk factors from a biochemical examination result, preprocessing the risk factors, and inputting the preprocessed risk factors into a second prediction model to obtain a sequence of contribution degrees of the risk factors to the internal fistula stenosis from high to low; the stenosis probability and the contribution degree of the first L risk factors are input into a risk assessment model, the internal arteriovenous fistula risk level is obtained, and the risk assessment model is integrated based on a TOPSIS multi-index weighting method weighted by equal weights. The invention provides an internal arteriovenous fistula monitoring method and system which are used for solving the problems that a palpation method is greatly influenced by experience and subjective judgment of medical staff, and an ultrasonic monitoring method is expensive in equipment, large in size, complex in operation, not suitable for daily monitoring and incapable of providing a remote monitoring function.

The invention relates to the technical field of medical image analysis, in particular to a dynamic DR digestive tract radiography automatic tracking and focus marking system which comprises a dynamic DR imaging module, an image real-time processing module, a contrast agent motion tracking module and a focus intelligent marking module. A deep learning algorithm is utilized to segment a contrast agent flowing area in real time and construct a dynamic three-dimensional model of a digestive tract, a contrast agent movement track is analyzed and tracked in combination with time-space domain features, and meanwhile, based on morphological anomaly detection and comparison with a focus feature library, focus positions such as stenosis, ulcers and space-occupying lesions are automatically marked; the problems of image blurring and tracking offset caused by alimentary canal peristalsis are solved by adopting a self-adaptive registration optimization algorithm of dynamic DR images and motion characteristics of alimentary canal contrast agents; by means of the method, the problems that traditional digestive tract radiography depends on manual interpretation of dynamic DR images, the focus tracking efficiency is low, and marking is prone to omission are solved.

The present disclosure provides to generate ground truth data for training a machine learning (ML) model to infer pressure information (e.g., a pressure curve, a pressure ratio, or the like) for a cardiac artery from border segmentations generated from images of the cardiac artery. The ground truth data can comprise vessel and / or lumen segmentations for several cardiac arteries and associated pressure information for the cardiac arteries. The vessel and / or lumen segmentations can be generated from images from different image modalities (e.g., IVUS, angiographic, CT, etc.). Further, some of the associated pressure information can be based on measured pressure information (e.g., using a pressure sensing catheter) while other associated pressure information can be derived from the vessel and / or lumen border segmentations using numerical analysis techniques (e.g., CFD, or the like).

Therapeutic agents such as Prasugrel, a thienopyridine ADP receptor inhibitor, which inhibit ADP mediated signaling through the P2Y12 receptor, done or in combination with an angiotensin II receptor blocker (ARB) such as Losartan that specifically blocks the angiotensin II type 1 (AT1) receptors, have been shown to be effective in reducing thrombosis and stenosis of grafts, including vascular grafts and tissue engineered vascular grafts ("TEVGs") in multiple in vivo, and that the combination of a inhibitor of the purinergic receptors P2Y12 such as Prasugrel, with losartan, an angiotensin II type 1 receptor inhibitor, more than additively reduced the incidence of TEVG stenosis. In a preferred embodiment, a multi-dosing unit for treatment to reduce stenosis delivers a 2-week course of losartan and Prasugrel.

A stent is provided with a central portion between two end portions, and with the central portion narrower than the end portions to provide a stenosis within the stent, such as for improving function of a dialysis graft or fistula. The stent can be merely a metal wire cage or can additionally include a liner inside and / or outside of the metal cage. One stent includes tapering transitions between the end portions and the central portion. The stent can be self-expanding with a retracted form held by a surrounding sheath until the sheath is retracted and the stent returns to its biased expanded form. A balloon can provide a radial expansion force to expand the stent. The balloon or self¬ expansion can expand the stent partially, with the central portion narrower than the end portions, and optionally further expanded to have a diameter matching that of the end portions.

Devices and methods can be used to treat heart conditions, hypertension, and other medical disorders. For example, devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation are described herein. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation.

The application discloses an expansion stent for preventing stenosis after external auditory canal operation and belongs to the technical field of external auditory canal postoperative care. The position of the adjusting ring is adjusted by operating the locking assembly, so that the five hollow rods can be in contact with the inner wall of the external auditory canal. Since the internal structure of the external auditory canal is not a regular circle, the multiple hollow rods are in contact with the internal structure of the external auditory canal in sequence during movement, thereby preventing long-term stenosis or recurrence of the external auditory canal. When the dynamic adjustment is performed according to the individual differences and growth changes of the external auditory canal, the gas is introduced into the hollow rods, the gas entering the internal structure of the hollow rods can extrude the multiple rubber air rings, the rubber air rings can be inflated and in contact with the inner wall of the external auditory canal, the sensing module is used for monitoring the pressure and deformation data in the external auditory canal in real time, the expansion state can be dynamically adjusted according to the individual differences and growth changes of the external auditory canal, the expansion effect is improved, and the rubber air rings are used for flexibly supporting the external auditory canal, so that the external auditory canal is not damaged.

The application discloses application of miR-30a-5p in preparation of a product for treating airway stenosis. The application finds that miR-30a-5p plays an important regulatory role between airway basal stem cells and airway fibroblasts, and through the carrying of extracellular vesicles, miR-30a-5p is transmitted from the airway basal stem cells to the airway fibroblasts, targets and regulates the expression of a key gene FAP, inhibits the activation of the airway fibroblasts, reduces the collagen gel contraction ability of the airway fibroblasts, improves the extracellular matrix remodeling of the airway fibroblasts, can effectively stabilize the tracheal granulation tissue, prevents the recurrence of airway stenosis, and has application value for treating airway stenosis.

The invention discloses a flexible actuator and a preparation method thereof. And combining the hydrogel film with the inverse opal photonic crystal structure with PDMS (Polydimethylsiloxane) to prepare the hydrogel stent actuator capable of treating cervical stenosis. The contact angle of the prepared hydrogel film with the inverse opal photonic crystal structure can reach 90 degrees or below, and the hydrogel film has strong affinity to water on a super-hydrophobic surface. Due to the super-hydrophobicity, the thin film can be tightly attached to an air-water interface while keeping self stable floating. The cervical stent disclosed by the invention has controllable adhesiveness, adjustable form, stimulation responsiveness and drug release property, the stent can be retained at the cervical part, and the application potential of the cervical stent in the aspect of treating cervical stenosis is shown.

The invention discloses a lumbar surgery AI dynamic simulation system and decision making method based on multi-modal data fusion, and belongs to the field of medical artificial intelligence, the technical scheme is that the system comprises a multi-modal data input interface, a dynamic modeling engine, a surgical decision making matrix and a three-dimensional comparison unit, and specifically, CT / MRI, electromyogram and gait mechanics data are fused; constructing a spinal canal 4D model through improved U-Net < 3 + >, and predicting a nerve root dynamic path by means of GCN-LSTM; and in combination with a lumbar stenosis type, matching an adaptive operation form, and generating a pre-operation and post-operation quantitative comparison report marked by three colors. A spinal canal-nerve-biomechanics dynamic correlation model is innovatively established, 217 L4-S1 segment anatomical variation templates are arranged in the model, and the anatomical variation adaptation rate reaches 92.3%. Clinical test results show that the operation time planned by the system is averagely shortened by 26 minutes, and the postoperative reoperation rate is reduced to 2.4%.

An elastic dialysis stent comprises a central restrictor segment located between two tapered segments. The tapered segments are tapered from a larger diameter suitable for joining to tubular graft segments or attaching the stent in a graft or fistula, to the narrower diameter of the elastic central restrictor segment which provides a stenosis. The central restrictor is made of an elastic material which enables the stent to be radially expanded by a balloon catheter to a larger diameter for passage of endovascular devices through the stent for repair of blockages on the venous side of the stent. When the balloon catheter is deflated and removed, the elastic properties of the stent cause it to retract to its original stenotic configuration.

The utility model provides a kind of nipple cutting balloon dilatation catheter, comprising: the balloon part of being arranged in the front part of catheter, the tube wall of the balloon part is wrapped with balloon, the outer surface of the balloon is equipped with multiple knife filaments, and the knife filament is used to be connected with high frequency generator.The utility model can be sent into or pulled out duodenal nipple in the guide of guide wire, and dilate duodenal nipple, when nipple sphincter stenosis appears, handle joint connects high frequency generator, and the knife filament on the surface of balloon can carry out electroincision effect to the tissue of stenosis, increase stenosis dilatation efficiency and effect.

This application discloses a restraint balloon, its preparation method, and a balloon catheter, relating to the field of medical devices. The restraint balloon includes: an expandable balloon body; and a restraint component, composed of fibrous strands and fixed to the outer surface of the balloon body, used to limit the radial deformation of the balloon body during expansion. The restraint balloon of this application can limit the radial deformation of the balloon body, effectively dispersing stress during expansion. It can be used for the clinical treatment of non-vascular lumen stenosis. Because the fibrous strand restraint component can deform synchronously with the balloon body during expansion, and can contract to a near-initial state along with the balloon body after decompression due to its own elastic recovery characteristics, it significantly reduces the difficulty of balloon retraction, improving the safety and convenience of surgical procedures. It also has the advantages of low cost, high yield, simple processing, and high manufacturing efficiency.

An elastic dialysis stent comprises a central restrictor segment located between two tapered segments. The tapered segments are tapered from a larger diameter suitable for joining to tubular graft segments or attaching the stent in a graft or fistula, to the narrower diameter of the elastic central restrictor segment which provides a stenosis. The central restrictor is made of an elastic material which enables the stent to be radially expanded by a balloon catheter to a larger diameter for passage of endovascular devices through the stent for repair of blockages on the venous side of the stent. When the balloon catheter is deflated and removed, the elastic properties of the stent cause it to retract to its original stenotic configuration.

Provided is a balloon for a balloon catheter that is easy to insert in a body cavity, has good pushability, and can easily incise a stenosis. A balloon for a balloon catheter, having a balloon body (20), the balloon body (20) having a protrusion part (60) that projects outwardly in the radial direction y from its outer surface in the straight tubular part (23) and the proximal tapered part (22), wherein a ratio W1 / H1 of a height H1 of the protrusion part (60) and a width W1 of the protrusion part (60) in the straight tubular part (23) is greater than a ratio W2 / H2 of a height H2 of the protrusion part (60) and a width W2 of the protrusion part (60) in the proximal tapered part (22).

The invention relates to the technical field of medical instruments, in particular to an airway stent for airway stenosis treatment, which comprises an end stent, the end stent is composed of an outer tube body, a conical body and an inner tube body which are coaxially distributed, the outer side ring surface of the outer tube body is fixedly connected with the inner wall of a narrowed port of the conical body, and the inner tube body is arranged on the inner side ring surface of the outer tube body. By means of the optimized design of the connecting mechanism, the end support and the valve support are effectively connected, self-adaptive contraction of the valve support can be achieved, the valve support can be matched with the inner membrane mechanism, the dynamic change of an air channel is coped, the self shape and the supporting force are effectively adjusted, the valve support is tightly attached to the wall of the air channel all the time, stable supporting is provided, and the service life of the valve support is prolonged. Support displacement or insufficient support caused by diameter change of the airway is prevented; and through mutual combination of the limiting assembly and the rotary flow distribution assembly, the limiting function during dynamic adjustment is achieved, a flushing agent can be conveniently injected into the support, and granulation is prevented from growing through meshes of the support.

The application discloses an artificial intelligence-based image analysis method and system for degenerative cervical spinal cord disease, relates to the technical field of artificial intelligence, and solves the technical problems of the existing technology, such as non-uniform image report standards, rough image analysis, increased patient anxiety, wasted medical resources, significant observer bias in DCM evaluation, and low efficiency of degenerative cervical spinal cord disease image analysis. A cervical vertebra dissection segmentation model is used to obtain a segmentation label; an intervertebral canal stenosis quantification grading model is used to obtain an intervertebral canal stenosis prediction grade of the segmentation label for the intervertebral canal; a spinal cord compression classification model is used to obtain a spinal cord compression result of the segmentation label for the cervical spinal cord; and a cervical vertebra image analysis model is used to obtain an analysis report of the cervical vertebra nuclear magnetic image. The image report is standardized, improved segmentation models are used, classification models are used in cooperation, and cervical vertebra image analysis models are used for processing, so that the accuracy of analysis is improved, and the efficiency of degenerative cervical spinal cord disease image analysis is improved.

The disclosure relates to compositions and methods for reducing SMAD3 expression in a blood vessel in a patient in need thereof. Also provided herein are compositions and methods for reducing blood vessel graft stenosis in a subject, preventing occlusion of a blood vessel or a blood vessel graft, reducing neointimal hyperplasia in a blood vessel or a blood vessel graft, increasing endothelization in a blood vessel or a blood vessel graft, increasing patency in a blood vessel or a blood vessel graft, reducing endothelial to mesenchymal transition (EndMT) in a blood vessel or a blood vessel graft, reducing thrombosis in in a blood vessel or a blood vessel graft and / or reducing TGF-beta signaling in a blood vessel or a blood vessel graft. In embodiments, the patient is undergoing arterio-venous fistula (AVF) surgery.

The invention belongs to the technical field of biology, and relates to application of ZEB1 in analysis and treatment of Crohn disease related diseases. Specifically, the invention discloses application of a reagent for detecting the expression level of ZEB1 in preparation of a product for analyzing the severity of Crohn's disease and the risk and severity of intestinal fibrosis stenosis, and application of ZEB1 in preparation of an animal model of Crohn's disease complicated with intestinal fibrosis or DNBS chronic colitis complicated with intestinal fibrosis, and application of ZEB1 in preparation of an animal model of Crohn's disease complicated with intestinal fibrosis or DNBS chronic colitis complicated with intestinal fibrosis. The reagent for inhibiting ZEB1 expression is applied to preparation of products for inhibiting Crohn's disease complicated with intestinal fibrosis or stenosis. The invention determines that ZEB1 can be used as a biomarker of intestinal fibrosis of Crohn's disease, the expression level of ZEB1 is associated with the risk and severity of intestinal fibrosis or intestinal fibrosis stenosis complicated by Crohn's disease, and a new method is provided for clinically evaluating the risk and severity of disease. Meanwhile, it is clear that ZEB1 can be used as a target spot for treating Crohn's disease complicated with intestinal fibrosis or intestinal fibrosis stenosis.

The present invention relates to a vascular dilation device, which includes an outer tube, a balloon connected to the distal end of the outer tube, a grasping forceps disposed within the balloon, and a handle connected to the proximal end of the outer tube. The balloon has a shaping region and a deformation region. The deformation region includes a plurality of flaps arranged circumferentially along the shaping region. The plurality of flaps are hinged to the shaping region and can be operatively rotated in a direction away from or close to the axis of the balloon to enable the balloon to switch between an expanded state and a closed state. The grasping forceps are slidably disposed within the balloon along the axial direction of the balloon and have a clamped state and a released state. The balloon of the present invention is a mechanical balloon that can be controlled to open and close. It has greater support force in the expanded state and has a better treatment effect on calcified stenosis. In addition, the balloon is provided with a grasping forceps that can be moved as needed to grasp diseased tissue or foreign matter inside and outside the balloon.

Described herein is a computer implemented method for assessing functionally significant stenosis. Also described, is a method of estimating distribution of tracer mass in a plurality of cardiovasculatures of interest. Also described, is a method of estimating stenosis -induced pressure loss. Systems and non-transitory computer-readable media for executing the methods are also described.

The transparent cap of the choledochoscope comprises a cap portion and a connecting portion, the tube wall of the front end, away from the connecting portion, of the cap portion is in an arc shape, and a first annular thread is arranged on the inner wall of the connecting portion. The choledochoscope tip is of a convex structure composed of a head part and a body part, the outer diameter of the head part is smaller than that of the body part, a second annular thread is arranged on the outer wall of the head part, and the second annular thread is connected with the first annular thread in a matched mode to achieve connection between the connecting part and the head part; and the outer diameter of the connecting part is the same as that of the body part. The transparent sleeve can be installed at the front end of a choledochoscope to carry out operations such as gall bladder or bile duct washing, calculus removal, stenosis expansion, gall bladder duct or Oddi sphincter exploration and the like; the transparent cap is firmly mounted and cannot fall off; the outer diameter of the connecting part of the transparent cap is consistent with the outer diameter of the choledochoscope body part, the tube wall at the front end of the cap part of the transparent cap is arc-shaped, and tissues such as fistulous tracts, gallbladders and bile duct mucosa are not damaged in the choledochoscope examination and treatment process.

The application discloses a scale perception progressive learning method for X-ray coronary angiography stenosis segmentation. The technical problem to be solved is how to solve the problem of insufficient segmentation accuracy caused by multi-scale characteristics and small target characteristics in coronary angiography stenosis segmentation. The application combines a scale perception strategy and a progressive feature reservation mechanism to provide a scale perception progressive learning method for X-ray coronary angiography stenosis segmentation. The application significantly improves the segmentation capability of multi-scale stenosis. The scale perception strategy dynamically aggregates context features of different scales, effectively adapts to the scale difference of coronary arteries in XCA images, enhances the sensitivity of the model to subtle stenosis changes, realizes more accurate stenosis boundary delineation, effectively solves the problem of easy loss of small target information, improves the robustness of the model to complex background interference, has stronger generalization capability, can adapt to different devices and imaging conditions, reduces the work burden of doctors and improves efficiency.