95 results about "Stenosis" patented technology

The embodiment of the invention provides a dynamic evaluation method and device for the NVC function of a carotid artery stenosis crowd, a medium and a program product, and relates to the field of intelligent medical treatment. The method comprises the following steps: acquiring a resting middle cerebral artery average blood flow velocity Vm of a sample in a resting state and an exercise middle cerebral artery average blood flow velocity Vm of the sample in an exercise load state; according to the average blood flow velocity Vm of the middle cerebral artery during movement and the average blood flow velocity Vm of the middle cerebral artery during resting, a movement-induced blood flow response index EIFR is obtained through calculation; the motion-induced blood flow response index EIFR is an NVC parameter; and obtaining an evaluation result of whether the NVC function is abnormal or not according to whether the NVC parameter is reduced or not. On the basis of a quantifiable NVC function evaluation system in a constant motion state, objective screening standards are provided for stroke high-risk groups, a long-term follow-up visit plan is made, and an accurate quantitative basis is provided for clinical intervention decision and postoperative complication prediction.

The invention relates to the technical field of medical image analysis, in particular to a dynamic DR digestive tract radiography automatic tracking and focus marking system which comprises a dynamic DR imaging module, an image real-time processing module, a contrast agent motion tracking module and a focus intelligent marking module. A deep learning algorithm is utilized to segment a contrast agent flowing area in real time and construct a dynamic three-dimensional model of a digestive tract, a contrast agent movement track is analyzed and tracked in combination with time-space domain features, and meanwhile, based on morphological anomaly detection and comparison with a focus feature library, focus positions such as stenosis, ulcers and space-occupying lesions are automatically marked; the problems of image blurring and tracking offset caused by alimentary canal peristalsis are solved by adopting a self-adaptive registration optimization algorithm of dynamic DR images and motion characteristics of alimentary canal contrast agents; by means of the method, the problems that traditional digestive tract radiography depends on manual interpretation of dynamic DR images, the focus tracking efficiency is low, and marking is prone to omission are solved.

The present disclosure provides to generate ground truth data for training a machine learning (ML) model to infer pressure information (e.g., a pressure curve, a pressure ratio, or the like) for a cardiac artery from border segmentations generated from images of the cardiac artery. The ground truth data can comprise vessel and / or lumen segmentations for several cardiac arteries and associated pressure information for the cardiac arteries. The vessel and / or lumen segmentations can be generated from images from different image modalities (e.g., IVUS, angiographic, CT, etc.). Further, some of the associated pressure information can be based on measured pressure information (e.g., using a pressure sensing catheter) while other associated pressure information can be derived from the vessel and / or lumen border segmentations using numerical analysis techniques (e.g., CFD, or the like).

Therapeutic agents such as Prasugrel, a thienopyridine ADP receptor inhibitor, which inhibit ADP mediated signaling through the P2Y12 receptor, done or in combination with an angiotensin II receptor blocker (ARB) such as Losartan that specifically blocks the angiotensin II type 1 (AT1) receptors, have been shown to be effective in reducing thrombosis and stenosis of grafts, including vascular grafts and tissue engineered vascular grafts ("TEVGs") in multiple in vivo, and that the combination of a inhibitor of the purinergic receptors P2Y12 such as Prasugrel, with losartan, an angiotensin II type 1 receptor inhibitor, more than additively reduced the incidence of TEVG stenosis. In a preferred embodiment, a multi-dosing unit for treatment to reduce stenosis delivers a 2-week course of losartan and Prasugrel.

A stent is provided with a central portion between two end portions, and with the central portion narrower than the end portions to provide a stenosis within the stent, such as for improving function of a dialysis graft or fistula. The stent can be merely a metal wire cage or can additionally include a liner inside and / or outside of the metal cage. One stent includes tapering transitions between the end portions and the central portion. The stent can be self-expanding with a retracted form held by a surrounding sheath until the sheath is retracted and the stent returns to its biased expanded form. A balloon can provide a radial expansion force to expand the stent. The balloon or self¬ expansion can expand the stent partially, with the central portion narrower than the end portions, and optionally further expanded to have a diameter matching that of the end portions.

The application discloses an expansion stent for preventing stenosis after external auditory canal operation and belongs to the technical field of external auditory canal postoperative care. The position of the adjusting ring is adjusted by operating the locking assembly, so that the five hollow rods can be in contact with the inner wall of the external auditory canal. Since the internal structure of the external auditory canal is not a regular circle, the multiple hollow rods are in contact with the internal structure of the external auditory canal in sequence during movement, thereby preventing long-term stenosis or recurrence of the external auditory canal. When the dynamic adjustment is performed according to the individual differences and growth changes of the external auditory canal, the gas is introduced into the hollow rods, the gas entering the internal structure of the hollow rods can extrude the multiple rubber air rings, the rubber air rings can be inflated and in contact with the inner wall of the external auditory canal, the sensing module is used for monitoring the pressure and deformation data in the external auditory canal in real time, the expansion state can be dynamically adjusted according to the individual differences and growth changes of the external auditory canal, the expansion effect is improved, and the rubber air rings are used for flexibly supporting the external auditory canal, so that the external auditory canal is not damaged.

The application discloses application of miR-30a-5p in preparation of a product for treating airway stenosis. The application finds that miR-30a-5p plays an important regulatory role between airway basal stem cells and airway fibroblasts, and through the carrying of extracellular vesicles, miR-30a-5p is transmitted from the airway basal stem cells to the airway fibroblasts, targets and regulates the expression of a key gene FAP, inhibits the activation of the airway fibroblasts, reduces the collagen gel contraction ability of the airway fibroblasts, improves the extracellular matrix remodeling of the airway fibroblasts, can effectively stabilize the tracheal granulation tissue, prevents the recurrence of airway stenosis, and has application value for treating airway stenosis.

The invention discloses a flexible actuator and a preparation method thereof. And combining the hydrogel film with the inverse opal photonic crystal structure with PDMS (Polydimethylsiloxane) to prepare the hydrogel stent actuator capable of treating cervical stenosis. The contact angle of the prepared hydrogel film with the inverse opal photonic crystal structure can reach 90 degrees or below, and the hydrogel film has strong affinity to water on a super-hydrophobic surface. Due to the super-hydrophobicity, the thin film can be tightly attached to an air-water interface while keeping self stable floating. The cervical stent disclosed by the invention has controllable adhesiveness, adjustable form, stimulation responsiveness and drug release property, the stent can be retained at the cervical part, and the application potential of the cervical stent in the aspect of treating cervical stenosis is shown.

The invention discloses a lumbar surgery AI dynamic simulation system and decision making method based on multi-modal data fusion, and belongs to the field of medical artificial intelligence, the technical scheme is that the system comprises a multi-modal data input interface, a dynamic modeling engine, a surgical decision making matrix and a three-dimensional comparison unit, and specifically, CT / MRI, electromyogram and gait mechanics data are fused; constructing a spinal canal 4D model through improved U-Net < 3 + >, and predicting a nerve root dynamic path by means of GCN-LSTM; and in combination with a lumbar stenosis type, matching an adaptive operation form, and generating a pre-operation and post-operation quantitative comparison report marked by three colors. A spinal canal-nerve-biomechanics dynamic correlation model is innovatively established, 217 L4-S1 segment anatomical variation templates are arranged in the model, and the anatomical variation adaptation rate reaches 92.3%. Clinical test results show that the operation time planned by the system is averagely shortened by 26 minutes, and the postoperative reoperation rate is reduced to 2.4%.

An elastic dialysis stent comprises a central restrictor segment located between two tapered segments. The tapered segments are tapered from a larger diameter suitable for joining to tubular graft segments or attaching the stent in a graft or fistula, to the narrower diameter of the elastic central restrictor segment which provides a stenosis. The central restrictor is made of an elastic material which enables the stent to be radially expanded by a balloon catheter to a larger diameter for passage of endovascular devices through the stent for repair of blockages on the venous side of the stent. When the balloon catheter is deflated and removed, the elastic properties of the stent cause it to retract to its original stenotic configuration.

The utility model provides a kind of nipple cutting balloon dilatation catheter, comprising: the balloon part of being arranged in the front part of catheter, the tube wall of the balloon part is wrapped with balloon, the outer surface of the balloon is equipped with multiple knife filaments, and the knife filament is used to be connected with high frequency generator.The utility model can be sent into or pulled out duodenal nipple in the guide of guide wire, and dilate duodenal nipple, when nipple sphincter stenosis appears, handle joint connects high frequency generator, and the knife filament on the surface of balloon can carry out electroincision effect to the tissue of stenosis, increase stenosis dilatation efficiency and effect.

This application discloses a restraint balloon, its preparation method, and a balloon catheter, relating to the field of medical devices. The restraint balloon includes: an expandable balloon body; and a restraint component, composed of fibrous strands and fixed to the outer surface of the balloon body, used to limit the radial deformation of the balloon body during expansion. The restraint balloon of this application can limit the radial deformation of the balloon body, effectively dispersing stress during expansion. It can be used for the clinical treatment of non-vascular lumen stenosis. Because the fibrous strand restraint component can deform synchronously with the balloon body during expansion, and can contract to a near-initial state along with the balloon body after decompression due to its own elastic recovery characteristics, it significantly reduces the difficulty of balloon retraction, improving the safety and convenience of surgical procedures. It also has the advantages of low cost, high yield, simple processing, and high manufacturing efficiency.

An elastic dialysis stent comprises a central restrictor segment located between two tapered segments. The tapered segments are tapered from a larger diameter suitable for joining to tubular graft segments or attaching the stent in a graft or fistula, to the narrower diameter of the elastic central restrictor segment which provides a stenosis. The central restrictor is made of an elastic material which enables the stent to be radially expanded by a balloon catheter to a larger diameter for passage of endovascular devices through the stent for repair of blockages on the venous side of the stent. When the balloon catheter is deflated and removed, the elastic properties of the stent cause it to retract to its original stenotic configuration.

Provided is a balloon for a balloon catheter that is easy to insert in a body cavity, has good pushability, and can easily incise a stenosis. A balloon for a balloon catheter, having a balloon body (20), the balloon body (20) having a protrusion part (60) that projects outwardly in the radial direction y from its outer surface in the straight tubular part (23) and the proximal tapered part (22), wherein a ratio W1 / H1 of a height H1 of the protrusion part (60) and a width W1 of the protrusion part (60) in the straight tubular part (23) is greater than a ratio W2 / H2 of a height H2 of the protrusion part (60) and a width W2 of the protrusion part (60) in the proximal tapered part (22).

The invention belongs to the technical field of biology, and relates to application of ZEB1 in analysis and treatment of Crohn disease related diseases. Specifically, the invention discloses application of a reagent for detecting the expression level of ZEB1 in preparation of a product for analyzing the severity of Crohn's disease and the risk and severity of intestinal fibrosis stenosis, and application of ZEB1 in preparation of an animal model of Crohn's disease complicated with intestinal fibrosis or DNBS chronic colitis complicated with intestinal fibrosis, and application of ZEB1 in preparation of an animal model of Crohn's disease complicated with intestinal fibrosis or DNBS chronic colitis complicated with intestinal fibrosis. The reagent for inhibiting ZEB1 expression is applied to preparation of products for inhibiting Crohn's disease complicated with intestinal fibrosis or stenosis. The invention determines that ZEB1 can be used as a biomarker of intestinal fibrosis of Crohn's disease, the expression level of ZEB1 is associated with the risk and severity of intestinal fibrosis or intestinal fibrosis stenosis complicated by Crohn's disease, and a new method is provided for clinically evaluating the risk and severity of disease. Meanwhile, it is clear that ZEB1 can be used as a target spot for treating Crohn's disease complicated with intestinal fibrosis or intestinal fibrosis stenosis.

Described herein is a computer implemented method for assessing functionally significant stenosis. Also described, is a method of estimating distribution of tracer mass in a plurality of cardiovasculatures of interest. Also described, is a method of estimating stenosis -induced pressure loss. Systems and non-transitory computer-readable media for executing the methods are also described.

The transparent cap of the choledochoscope comprises a cap portion and a connecting portion, the tube wall of the front end, away from the connecting portion, of the cap portion is in an arc shape, and a first annular thread is arranged on the inner wall of the connecting portion. The choledochoscope tip is of a convex structure composed of a head part and a body part, the outer diameter of the head part is smaller than that of the body part, a second annular thread is arranged on the outer wall of the head part, and the second annular thread is connected with the first annular thread in a matched mode to achieve connection between the connecting part and the head part; and the outer diameter of the connecting part is the same as that of the body part. The transparent sleeve can be installed at the front end of a choledochoscope to carry out operations such as gall bladder or bile duct washing, calculus removal, stenosis expansion, gall bladder duct or Oddi sphincter exploration and the like; the transparent cap is firmly mounted and cannot fall off; the outer diameter of the connecting part of the transparent cap is consistent with the outer diameter of the choledochoscope body part, the tube wall at the front end of the cap part of the transparent cap is arc-shaped, and tissues such as fistulous tracts, gallbladders and bile duct mucosa are not damaged in the choledochoscope examination and treatment process.

The application discloses a scale perception progressive learning method for X-ray coronary angiography stenosis segmentation. The technical problem to be solved is how to solve the problem of insufficient segmentation accuracy caused by multi-scale characteristics and small target characteristics in coronary angiography stenosis segmentation. The application combines a scale perception strategy and a progressive feature reservation mechanism to provide a scale perception progressive learning method for X-ray coronary angiography stenosis segmentation. The application significantly improves the segmentation capability of multi-scale stenosis. The scale perception strategy dynamically aggregates context features of different scales, effectively adapts to the scale difference of coronary arteries in XCA images, enhances the sensitivity of the model to subtle stenosis changes, realizes more accurate stenosis boundary delineation, effectively solves the problem of easy loss of small target information, improves the robustness of the model to complex background interference, has stronger generalization capability, can adapt to different devices and imaging conditions, reduces the work burden of doctors and improves efficiency.

A balloon catheter for easy insertion into a body cavity, with good pushability and the ability to easily cut stenosis is provided. The balloon catheter balloon (1) has a balloon body (20) with a protrusion (60) that protrudes radially outward from the outer surface at the straight tube portion (23) and the proximal conical portion (22) and extends in the long axis direction x. The ratio of the height H1 of the protrusion (60) at the straight tube portion (23) to the width W1 of the protrusion (60) is W1 / H1, which is greater than the ratio of the height H2 of the protrusion (60) at the proximal conical portion (22) to the width W2 of the protrusion (60) is W2 / H2.

The application discloses a stenosis lesion three-dimensional reconstruction method and system based on a blood vessel center line, wherein the method comprises the following steps: acquiring blood vessel center line data, a radius sequence corresponding to the center line and medical image data; determining a minimum radius value and a corresponding index position according to the radius sequence, and performing filtering processing on the radius sequence to obtain a smooth radius sequence; performing regression correction processing according to the minimum radius value and the smooth radius sequence to obtain a corrected radius sequence; acquiring a target region mask according to the medical image data, determining a center line point to be removed and a clipping flag according to the spatial position relationship between the blood vessel center line data and the target region mask; constructing a blood vessel mask in a voxel space according to the corrected radius sequence and the blood vessel center line data after removing the center line point to be removed; generating a three-dimensional grid model according to the blood vessel mask, and performing end face clipping processing on the three-dimensional grid model according to the clipping flag. The application forms a blood vessel three-dimensional reconstruction result with continuous structure and clear boundary.

The utility model discloses a ureter intestinal anastomotic stoma stenosis prevention support which comprises an anti-stenosis support body, the front end of the anti-stenosis support body is fixedly connected with a leading-out ring, the rear end of the anti-stenosis support body is fixedly connected with a leading-in ring, the anti-stenosis support body is arranged in a circular truncated cone shape and is arranged in a grid shape, and the leading-in ring is arranged on the anti-stenosis support body. The cross section of the leading-out ring and the cross section of the leading-in ring are both circular, the radius of the leading-out ring is larger than the radius of the leading-in ring, the anti-stenosis support, the leading-out ring and the leading-in ring are all made of titanium alloy, the anti-stenosis support is wrapped with a covering film, the covering film is located between the leading-out ring and the leading-in ring, and the covering film is located between the leading-out ring and the leading-in ring. The circular truncated cone-shaped latticed anti-stenosis stent is matched with the leading-out ring with the large radius at the front end and the leading-in ring with the small radius at the rear end, so that the stent can be placed in and taken out of the ureteral intestinal anastomotic stoma more smoothly, damage to the interior of the anastomotic stoma is reduced, and the operation convenience is greatly improved; the trumpet-shaped design can better play a role in preventing the anastomotic stoma from being narrow, and the effect is remarkable.

The application relates to the technical field of electric field ablation, and particularly discloses an electric field ablation method and an ablation catheter for atherosclerotic plaque, which comprises the following steps: analyzing the lesion degree of a target stenosis site during coronary angiography, and judging whether the target animal needs to be focused on according to the distribution of all stenosis sites and the lesion degree of the stenosis sites; through the analysis of the lesion degree of the target stenosis site, the application is helpful for doctors to accurately diagnose the illness of patients, and is helpful for doctors to understand the severity of the lesion, so that a targeted treatment plan can be made; the analysis of the lesion degree of the stenosis site is also helpful for predicting the illness progress and prognosis of the patients; meanwhile, during the treatment process, the change of the lesion degree of the stenosis site is regularly evaluated, so that the treatment effect can be known; through the judgment of whether the target animal needs to be focused on, the animals with serious illness can be focused on, and the animals needing to be focused on are gathered, so that the resources can be most effectively utilized.

The invention relates to a cavity pipeline suture with a hydrogel coating as well as a preparation method and application of the cavity pipeline suture. The cavity pipeline suture comprises a core suture and the hydrogel coating, wherein the surface of the core suture is coated with the hydrogel coating; the hydrogel coating layer is prepared from a hydrogel matrix and vitepofen, and the hydrogel matrix is coated with the vitepofen. The cavity pipeline suture is reasonable in structural design, high in function synergy and simple and convenient in preparation process, and effectively solves the technical problems that an existing cavity pipeline suture can only achieve mechanical suture and cannot synchronously meet the requirements for needle eye hemostasis and postoperative stenosis resistance.

The present application relates to a kind of multi-dimension lock regulating airway management training model, comprising: neck range of motion adjustment unit, neck range of motion adjustment unit is used to simulate the normal activity state and activity limited state of neck;Tongue body swelling simulation unit, tongue body swelling simulation unit is used to simulate the natural state and different degrees of swelling state of tongue body;Glottic area stenosis simulation unit, glottic area stenosis simulation unit is used to simulate the natural open state and different degrees of stenosis state of glottic area;Multi-dimension lock regulating airway management training model is configured to: by independently adjusting neck range of motion adjustment unit, tongue body swelling simulation unit and glottic area stenosis simulation unit, the laryngeal view of model is presented as a plurality of preset states corresponding to different levels of difficult airway.The present application can simulate different levels of difficult airway scene, accurately restore the difficult airway caused by single factor or multi-factor superposition in clinic.

This invention discloses a pressure-distance measurement system and method for venous sinus stenosis, relating to the field of venous sinus stenosis pressure measurement technology. The system includes a localizable radiopaque guidewire, a pressure-measuring microcatheter, a projection imaging adjustment unit, a retraction speed adjustment unit, and a pressure-distance measurement unit. The localizable radiopaque guidewire is delivered and fixed to the venous sinus segment to be measured under X-ray fluoroscopy. The pressure-measuring microcatheter is delivered along the guidewire to collect pressure signals. The projection imaging adjustment unit is used to dynamically correct the projection angle to obtain accurate target images. The retraction speed adjustment unit dynamically adjusts the sampling density in areas of stenosis and optimizes the retraction speed in conjunction with physiological movement amplitude. The pressure-distance measurement unit controls the catheter to move at a uniform speed, synchronously collecting pressure signals and axial movement distance in real time, forming pressure-distance relationship data and plotting curves, providing continuous and accurate data for the functional assessment of venous sinus stenosis.

According to the present invention, a user can non-invasively identify a carotid artery stenosis state by using only a smartphone terminal without separate medical equipment or specialized ultrasonic diagnostic technology. Accordingly, the present invention can recognize the risk of stenosis or blood flow abnormality early even in an environment with low medical accessibility, and can be utilized for daily self-health management.

The application provides application of a DPP-4 inhibitor in preparation of a medicine for preventing and / or treating digestive tract stenosis, and belongs to the technical field of medicines. Based on morphological performance of stenosis segment esophageal tissue outer membrane scar fibrosis, it is found that a DPP-4+ fibroblast subpopulation in stenosis segment esophageal outer membrane fibrosis hyperplasia tissue is obviously highly expressed. The DPP-4 inhibitor can prevent and treat refractory stenosis after esophageal ESD operation through anti-inflammatory and anti-fibrosis effects on stenosis segment esophageal outer layer tissue, and is a powerful supplement to the current esophageal ESD postoperative stenosis which focuses on intraluminal prevention and treatment of esophageal submucosa and part of inherent muscle layer scar fibrosis.

The invention provides an intracranial atherosclerotic plaque progress early warning system and method based on multi-stage MRA image and multi-modal blood flow parameter fusion, and is applied to the technical field of medical data processing. The method comprises the following steps: on the basis of a patient baseline, a follow-up period MRA image and a black blood sequence magnetic resonance image, firstly obtaining blood vessel binary volume data through a blood vessel segmentation technology, and generating a blood vessel geometric model through curved surface construction and triangularization; and converting the target blood vessel into a surface model, processing and encrypting the narrow area by using gridding software to obtain a target blood vessel grid, and further obtaining whole-brain whole-brain hemodynamic parameters. Subsequently, a high-risk area is determined according to blood flow parameter characteristic values of an anatomical segment, a structured matrix is established, parameter change abnormity is compared, a plaque progress index is defined, after parameter differences are grouped and compared, a risk prediction model is established by fusing various types of information, and finally, a multi-dimensional visualization and quantification result is generated by combining three-dimensional blood vessel space information. And support is provided for early warning of the progress of the intracranial atherosclerotic

The invention provides a thrombus resection system with a curved tubular cutting device and a method of using the same. These systems, devices, and methods enable: (i) efficient cutting and removal of various thrombus tissue from a blood vessel, including soft tissue, tough tissue, and hard tissue; (ii) safely self-collecting and removing tissue particles to avoid embolic release; and (iii) effectively treating the blood vessel and reducing the risk of suffering from vascular injury that may lead to aggravation of stenosis.