Degradable drug loading stent

A technology for carrying drugs and drugs, applied in the field of medical devices, to achieve the effects of low cost, excellent mechanical properties, and easy availability of raw materials

Inactive Publication Date: 2012-11-14
TAO & SEA HI TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to overcome the existing problems of non-degradable metal stents, degradable polymer stents and degradable magnesium (or iron) alloy stents, and propose a degradable metal / polymer composite medical stent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Prepare a 99.99% pure magnesium material, and prepare a metal wire with a diameter of 0.2 mm through a drawing process;

[0033](2) Surface treatment and chemical modification of the above metal wire according to the method described in detail in the associated patent CN201010555756.4;

[0034] (3) braiding the above-mentioned metal wires into a cylindrical mesh skeleton structure on the mould;

[0035] (4) Prepare a chloroform solution containing 2% polylactic acid, 3% polycaprolactone, and 0.1% paclitaxel;

[0036] (5) Soak the network skeleton structure in the above solution for 10 minutes, then take it out to dry, and rinse with ethanol and deionized water successively;

[0037] (6) Place in an oven for heat treatment at a temperature of 80 degrees for 90 minutes.

[0038] The prepared degradable drug-loaded stent has high mechanical strength and good toughness, the radial length can be stretched to 1.5 times of the original size, and the diameter can be compr...

Embodiment 2

[0040] (1) Mg-3wt%Zn-0.8wt%Zr material is prepared, and a metal wire is prepared by a drawing process, with a diameter of 0.15 mm;

[0041] (2) Surface treatment and chemical modification of the above metal wire according to the method described in detail in the associated patent CN201010555756.4;

[0042] (3) braiding the above-mentioned metal wires into a trumpet-shaped mesh skeleton structure on the mould;

[0043] (4) Prepare a chloroform solution containing 5% polylactide / glycolic acid copolymer and 0.1% paclitaxel;

[0044] (5) Soak the network skeleton structure in the above solution for 10 minutes, then take it out to dry, and rinse with ethanol and deionized water successively;

[0045] (6) Place in an oven for heat treatment at a temperature of 85 degrees for 120 minutes.

[0046] The prepared degradable drug-loaded stent has high mechanical strength and good toughness, the radial length can be stretched to twice the original size, and the diameter can be compresse...

Embodiment 3

[0048] (1) Mg-3wt%Zn-0.8wt%Zr material is prepared, and a metal wire is prepared by a drawing process, with a diameter of 0.2 mm;

[0049] (2) Surface treatment and chemical modification of the above metal wire according to the method described in detail in the associated patent CN201010555756.4;

[0050] (3) braiding the above-mentioned metal wires into a mushroom mouth-shaped mesh skeleton structure on the mould;

[0051] (4) Prepare a chloroform solution containing 5% polylactide / glycolic acid copolymer and 0.05% actinomycin D;

[0052] (5) Soak the network skeleton structure in the above solution for 10 minutes, then take it out to dry, and rinse with ethanol and deionized water successively;

[0053] (6) Place in an oven for heat treatment at a temperature of 85 degrees for 120 minutes.

[0054] The prepared degradable drug-loaded stent has high mechanical strength and good toughness, the radial length can be stretched to 1.5 times of the original size, and the diameter...

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Abstract

The invention relates to a degradable drug loading stent and a preparation method of the degradable drug loading stent. The degradable drug loading stent is characterized by comprising a skeleton structure made of a medical degradable metal or an alloy of the metal, a degradable macromolecular transition layer adhered to the surface of the skeleton structure and a drug loading layer. The degradable metal/macromolecular/drug multilayer composite stent provided by the invention has excellent mechanical property, degradable property and biocompatibility, and such drugs as taxol, taxol derivative, actinomycin D, 5-fluorouracil and sirolimus are loaded to the stent to perform active directional treatment on the focus position, so the stent is a functional degradable stent. The degradable multifunctional drug loading stent provided by the invention is suitable for interventional therapy in the blood vessel field and non-blood vessel fields and is especially suitable for interventional therapy of stenosis, obstruction or tumor of such non-blood vessel cavities as esophagus, bile duct, ductus pancreaticus, intestinal tract, urethral canal, trachea and bronchus, etc.

Description

technical field [0001] The invention belongs to the field of medical devices, and relates to a degradable drug-loaded stent and a preparation method thereof. Background technique [0002] In recent years, stent interventional therapy has been widely used in vascular surgery, thoracic surgery, urology, and digestive surgery. Using X-ray fluoroscopy, CT positioning, B-ultrasound and other medical imaging equipment, through the introduction of special catheters or instruments, interventional doctors have been able to deliver stents to almost all blood vessel branches, digestive tract lumens and other specific lesions in the human body. For the stenosis and obstruction of cardiovascular and cerebrovascular as well as the stenosis and obstruction of esophagus, bile duct, pancreatic duct, intestinal tract, urethra, trachea, bronchi, etc., stent implantation has become an effective minimally invasive treatment technology, which is a fast, effective and Relatively safe medical mean...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/08A61L31/14A61L31/16A61L31/02A61L27/34A61L27/28A61L27/50A61L27/54A61L27/04A61L17/00A61L24/02
Inventor 邢长民王文慧
Owner TAO & SEA HI TECH BEIJING
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