Degradable drug loading stent
A technology for carrying drugs and drugs, applied in the field of medical devices, to achieve the effects of low cost, excellent mechanical properties, and easy availability of raw materials
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Embodiment 1
[0032] (1) Prepare a 99.99% pure magnesium material, and prepare a metal wire with a diameter of 0.2 mm through a drawing process;
[0033](2) Surface treatment and chemical modification of the above metal wire according to the method described in detail in the associated patent CN201010555756.4;
[0034] (3) braiding the above-mentioned metal wires into a cylindrical mesh skeleton structure on the mould;
[0035] (4) Prepare a chloroform solution containing 2% polylactic acid, 3% polycaprolactone, and 0.1% paclitaxel;
[0036] (5) Soak the network skeleton structure in the above solution for 10 minutes, then take it out to dry, and rinse with ethanol and deionized water successively;
[0037] (6) Place in an oven for heat treatment at a temperature of 80 degrees for 90 minutes.
[0038] The prepared degradable drug-loaded stent has high mechanical strength and good toughness, the radial length can be stretched to 1.5 times of the original size, and the diameter can be compr...
Embodiment 2
[0040] (1) Mg-3wt%Zn-0.8wt%Zr material is prepared, and a metal wire is prepared by a drawing process, with a diameter of 0.15 mm;
[0041] (2) Surface treatment and chemical modification of the above metal wire according to the method described in detail in the associated patent CN201010555756.4;
[0042] (3) braiding the above-mentioned metal wires into a trumpet-shaped mesh skeleton structure on the mould;
[0043] (4) Prepare a chloroform solution containing 5% polylactide / glycolic acid copolymer and 0.1% paclitaxel;
[0044] (5) Soak the network skeleton structure in the above solution for 10 minutes, then take it out to dry, and rinse with ethanol and deionized water successively;
[0045] (6) Place in an oven for heat treatment at a temperature of 85 degrees for 120 minutes.
[0046] The prepared degradable drug-loaded stent has high mechanical strength and good toughness, the radial length can be stretched to twice the original size, and the diameter can be compresse...
Embodiment 3
[0048] (1) Mg-3wt%Zn-0.8wt%Zr material is prepared, and a metal wire is prepared by a drawing process, with a diameter of 0.2 mm;
[0049] (2) Surface treatment and chemical modification of the above metal wire according to the method described in detail in the associated patent CN201010555756.4;
[0050] (3) braiding the above-mentioned metal wires into a mushroom mouth-shaped mesh skeleton structure on the mould;
[0051] (4) Prepare a chloroform solution containing 5% polylactide / glycolic acid copolymer and 0.05% actinomycin D;
[0052] (5) Soak the network skeleton structure in the above solution for 10 minutes, then take it out to dry, and rinse with ethanol and deionized water successively;
[0053] (6) Place in an oven for heat treatment at a temperature of 85 degrees for 120 minutes.
[0054] The prepared degradable drug-loaded stent has high mechanical strength and good toughness, the radial length can be stretched to 1.5 times of the original size, and the diameter...
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