A
carpal tunnel splint for being custom-fitted to a hand and
wrist to be supported, and comprising an elongate, narrow flexible inner
cushion layer for being placed on and conformed to the shape of the hand and
wrist, an initially flexible intermediate layer overlying the inner
cushion layer and an intermediate layer comprised of a fabric impregnated with a
moisture-curable resin which hardens upon curing to form a
rigid structure of the fabric which retains a shape into which it is molded during curing, thereby also holding the flexible inner
cushion layer in a conforming shape against the hand and
wrist. A flexible protective outer layer overlies the intermediate layer and is attached to the inner cushion layer for enclosing the intermediate layer and forming the inner layer, intermediate layer and outer layer into a single, integrated elongated, narrow splint structure.