35 results about "Primary bone" patented technology

A clip to interconnect primary and secondary bone zones having edges and surfaces, comprising in combination a first tab to extend proximate a surface of the secondary bone zone; a second tab associated with the first tab, and located to extend proximate a surface of the primary bone zone, the second tab having at least one barb oriented to engage the primary bone to resist displacement of the second tab in a longitudinal direction toward the secondary bone zone.

Surfaces useful for cell culture comprise a support to which is bound a CAR material, and, bound to the CAR material, collagen VI or a biologically active fragment or variant thereof and, optionally, one or more other ECM proteins (or fragments or variants thereof) such as elastin, fibronectin, vitronectin, tenascin, laminin, entactin, aggrecan, decorin, collagen I, collagen III, and collagen IV. Also, optionally present on the surface is one or more polycationic polymers, such as poly-D-lysine or poly-D-ornithine. This surface is used in cell culture to promote cell attachment, survival, and/or proliferation of a number of different cell types such as (a) liver cells (e.g., HepG2 tumor cells, and a newly discovered line of rat liver epithelial stem cells) (b) osteoblasts, such as the murine cell line MC3T3 cell line and (c) primary bone marrow cells. Kits comprising the surfaces and additional reagents are also disclosed.

The invention discloses a method for preparing a bone white soup basal material for hot pot. The preparation method comprises the following: a step of preparing: an animal bone is extracted to obtain primary bone soup, and the primary bone soup is added with ingredients and auxiliary agents, so that the protein content in weight percentage is between 10 and 50 percent, the fat content in weight percentage is between 5 and 35 percent, the salt content in weight percentage is between 12 and 18 percent, and the pH value is between 3.5 and 6.2; a step of sterilization: the primary bone soup is kept at a temperature of between 60 and 85 DEG C for 23 to 42 minutes: a step of homogenizing: the primary bone soup is homogenized under the working conditions the temperature is between 40 and 60 DEG C and the pressure is between 10 and 30MPa; and a step of drying: the air inlet temperature is between 190 and 220 DEG C, the air outlet temperature is between 80 and 110 DEG C, and the rotary speed of a centrifugal disc is between 13,000 and 15,600 rev/min. The bone white soup basal material prepared by the method is of a powder shape or a paste shape according to use requirement, and has the advantages of having flavor and taste of the corresponding animal and convenient use, and is used to prepare hot pot white soup bedding material, and ensures that the bone white soup basal material stably keeps milk white.

The invention relates to the technical field of orthopedics and discloses an orthopedic implant. The orthopedic implant is spherical in shape and concave in a region of a bottom surface portion of theorthopedic implant to form an inner concave surface for contacting an acetabular liner or a femoral ball head to form a joint movable friction pair; at least a portion of that bottom region of the external spherical surface of the orthopedic implant extend outwardly to form an extension structure for contacting the human primary bone outside the acetabular fossa aft the orthopedic implant is implanted into the acetabular fossa of the human primary pelvis. In the manner described above, the present invention can improve the biological fixation performance of orthopedic implants.

The invention belongs to the technical field of regenerative medicine, and particularly relates to a sodium alginate/collagen composite bone scaffold as well as a preparation method and application thereof, and the preparation method comprises the following steps: providing hydroxyapatite hollow microspheres loaded with antibacterial drugs; carrying out a pre-crosslinking reaction on water, hydroxyapatite nanoparticles, a collagen crosslinking agent, collagen, D-glucolactone, sodium alginate and the hydroxyapatite hollow microspheres loaded with the antibacterial drugs, so as to obtain a pre-crosslinked mixture; printing the pre-crosslinked mixture to obtain a primary bone scaffold; subjecting the primary bone scaffold and bivalent copper ions to a re-crosslinking reaction so as to prepare the sodium alginate/collagen composite bone scaffold. The sodium alginate/collagen composite bone scaffold obtained by using the preparation method disclosed by the invention has good mechanical properties and a relatively stable structure, and has an antibacterial effect.

The invention discloses a design method and device for a bone cement spacer female mould. The design method for the bone cement spacer female mould includes: establishing a primary three-dimensional CAD model of a joint prosthesis according to acquired point cloud data of the joint prosthesis of a patient; obtaining a three-dimensional CAD model of the joint prosthesis according to the measured actual size of a joint of the patient; defining a joint surface of a relevant die of the three-dimensional CAD model of the joint prosthesis according to analysis on a connection manner and a working process of the three-dimensional CAD model of the joint prosthesis, and establishing a primary bone cement spacer female mould; and editing the primary bone cement spacer female mould to obtain the bone cement spacer female mould according to the characteristics of bone cement. The design method and device can quickly produce a high-precision high-matching-degree bone cement spacer female mould.

The invention belongs to the technical field of artificial bones, in particular to a hip joint prosthesis. The hip joint prosthesis comprises a thighbone handle, a ball head, an inner lining, an acetabular cup and connection screws, wherein the thighbone handle is inserted into bone marrow of a thighbone at a location wherein transplanting needs to be performed; the acetabular cup is connected with a fossa acetabuli where transplanting needs to be performed through the connection screws; the thighbone handle is connected with the acetabular cup through the ball head and the inner lining; and the curvature of the inner side of the thighbone handle is 127-135 degrees. Through the adoption of the technical scheme of the hip joint prosthesis provided by the invention, through cooperation of each component of the hip joint prosthesis, the transplanted hip joint prosthesis is stably connected with the primary bone; besides, the curvature of the inner side of the thighbone handle is set to be127-135 degrees, so that the thighbone handle can be attached to the bone marrow of the thighbone of the location where transplanting needs to be performed, fixing is convenient, and after fixing, loosing is not liable to generate; and the technical defect that in the prior art, the transplanted hip joint prosthesis and primary bone locations are easy to loosen, and periodic replacement is required is solved.

New compounds and pharmaceutical compositions comprising active ingredients having inhibition effects on osteoclast differentiation are provided. The pharmaceutical compositions comprising the new compounds can be used as medicines for treating metabolic bone diseases such as bone metastatic cancer, solid cancer bone metastasis, musculoskeletal complication by solid cancer bone metastasis, hypercalcemia by malignant tumor, multiple myeloma, primary bone tumor, osteoporosis, rheumatoid arthritis, osteoarthritis, periodontal disease, inflammatory resorption of alveolar bone, inflammatory resorption of bone, and Paget's disease.

The invention belongs to the field of biotechnology, and relates to a fluorescent protein labeling method for studying osteoclast fusion, which is characterized in that: primary mouse bone marrow mononuclear cells (bone marrow monocytes, BMMs) containing CTSK-Cre transgene Mix culture with RosamTmG-containing transgenic mouse primary bone marrow mononuclear cells at a ratio of 3:1-1:3, perform osteoclast differentiation induction and fluorescence microscope observation steps, the osteoclast fusion process can be visually and visually observed, thereby Observe the morphology of osteoclasts, the number of nuclei and the number of fused cells that can be quantitatively studied.

The present invention relates to the synthesis of porous polymer scaffold from polyethyleneglycol-polyurethane having castor oil linkages under controlled conditions and their use as stem cell delivery vehicles thereby accelerating the tissue regeneration process. The present invention further studies the biodegradability, stability and biocompatibility of porous polymer scaffolds in varios cell lines and primary bone marrow stem cells. Particularly the present invention further relates to the physio-chemical characterization of the porous polymer scaffolds.

A retro guidewire reamer includes a cutting member, and a mechanism for moving the cutting member from a closed position to a deployed position in a single manual motion. Once a desired size of a bone tunnel is established, a surgeon uses the reamer to create a primary bone tunnel over a guidewire from the outside in. The surgeon retracts the guidewire, and activates the mechanism to deploy the cutting member within the bone joint to conform to the size of a tendon graft. The surgeon uses the deployed cutting member to create a counter bore through the bone in a retrograde manner. Once the counter bore is drilled, the surgeon activates the mechanism to close the cutting member, allowing the reamer to be withdrawn through the primary tunnel. The retro guidewire reamer can be used to provide more accurate bone tunnel placement during ligament reconstruction surgery.