97 results about "Hydroxyapatite composite" patented technology

The invention relates to the field of anticorrosive paint, in particular to anticorrosive paint containing lanthanum cerium oxide and a preparation method of the anticorrosive paint. The invention relates to an anticorrosive coating containing lanthanum cerium oxide. The anticorrosive coating is prepared from the following raw materials: 28 to 45 parts of ultraviolet stable composite film forming matter, 5 to 10 parts of composite rare earth filler, 6 to 12 parts of supported synergistic antirust agent, 18 to 30 parts of mixed solvent, 0.8 to 2.5 parts of dispersing agent, 2.7 to 5.3 parts of functional additive and 0.5 to 1.2 parts of nano montmorillonite, the composite rare earth filler is lanthanum cerium oxide-hydroxyapatite composite powder with a core-shell structure, wherein lanthanum cerium oxide is used as a core, hydroxyapatite is used as a shell, and the thickness of the shell layer is 10-20 nm; the ultraviolet stable composite film forming substance comprises epoxy resin and ultraviolet grafting modified polyurethane in a weight ratio of 1: (0.6-2.2); the supported synergistic antirust agent is a mixture of mesoporous silica supported benzotriazole and zinc molybdate. And the obtained coating is high in adhesive force and long in service life.

The invention discloses a titanium-based hydroxyapatite composite coating and a preparation method thereof. The problems that a traditional coating is weak in interface bonding, single in porosity and mismatched in drug sustained release are solved. The composite coating comprises a gradient component layer and a bionic porous outer layer which are sequentially stacked on the surface of a titanium substrate, wherein the gradient component layer comprises a bottom layer (a titanium-based hydroxyapatite transition layer, 70-80% of HA and bonded through Ti-O bonds) and a middle layer (an HA / bioglass composite layer, 50-70% of HA and 10-20% of bioglass); the bionic porous outer layer is a porous HA layer, the porosity is 40-60%, the porosity is gradually increased in a gradient mode in the direction away from the titanium substrate, surface layer pores are loaded with anti-infection drugs, and inner layer pores are loaded with bone growth factors. The method realizes improvement of the interface bonding strength of the coating, consideration of mechanical and biological activity and staged slow release of the medicine, and is suitable for the field of bone joint implantation.

The invention relates to the technical field of biological tissue adhesives, in particular to a biological tissue adhesive composition. The biological tissue adhesive composition comprises a powder A, a powder B and a powder C, wherein the powder A is obtained by curing calcium silicate and acidic calcium phosphate in a curing liquid, curing, drying and crushing; powder B: bivalent metal salt; powder C: phosphorylated amino acid; and an aqueous solvent; the biological tissue adhesive is used for bone adhesion and bone repair. According to the biological tissue adhesive composition provided by the invention, a silicate / hydroxyapatite composite material with a bone induction function is synthesized through optimized bone cement reaction, a curing liquid is added to react with phosphorylated amino acid, and a bone adhesive material is obtained through organic and inorganic material coordination reaction; the bone repairing and regenerating capability and the bone bonding capability are good.

The invention provides a composite sun-screening agent based on an encapsulation technology as well as a preparation method and application of the composite sun-screening agent. The preparation method of the composite sun-screening agent comprises the following steps: fully dispersing hydroxyapatite nanoparticles in an alkaline solvent, adding a dopamine monomer, and carrying out oxidative polymerization reaction, centrifugal washing and drying to obtain HAP-PDA composite nanoparticles; and fully dispersing the HAP-PDA composite nanoparticles in a solvent, adding a mixed solution of a chemical sun-screening agent and an antioxidant and a surfactant, and performing encapsulation reaction and centrifugation to obtain the product. According to the invention, a polydopamine and hydroxyapatite composite encapsulation technology is innovatively adopted, so that the stability and biocompatibility of the sun-screening agent and the antioxidant are remarkably improved, the sun-screening effect is enhanced, and the product is endowed with a lasting sun-screening effect and excellent oxidation resistance. According to the invention, the limitation of a traditional sunscreen product is broken through, and safer, more efficient and more comfortable sunscreen experience can be provided for consumers.

Provided herein are chromatography media comprising a porous solid substrate (such as a membrane, a metal, or a metal alloy) coated with hydroxyapatite (HA). Also provided are chromatography media comprising the HA coated substrate, and uses thereof. Thus, the present disclosure provides chromatographic media comprising a porous solid substrate coated with HA, such as a membrane, metal, or metal alloy. Also provided are chromatography media comprising the HA coated substrate, and uses thereof. A method of preparing the HA coated substrate is also provided.

The invention relates to the technical field of orthopedic repair materials, in particular to a polycaprolactone and nano-hydroxyapatite composite bone repair implant and a preparation method thereof.The preparation method comprises the steps that PCL-PLA serves as a shell material, citric acid serves as a core material, and n-HA degradation accelerator microcapsules are prepared; the preparation method comprises the following steps: weighing the following raw materials in parts by mass: n-HA, PCL, CNW, PEG and n-HA degradation accelerator microcapsules; the implant prepared through the preparation method is excellent in mechanical property, has the performance of replacing an existing steel plate and an existing steel nail and is applied to bone repair, compared with natural degradation, the degradation rate is increased by 2.1 times, the degradation period of n-HA can be greatly shortened through the n-HA degradation accelerator micro-capsules, the situation that the difference between the degradation periods of PCL and n-HA is large is avoided, and the degradation efficiency of the implant is greatly improved. After the later-stage PCL degradation and implant material mechanical failure, the n-HA has a large number of residual particles, and bone remodeling is affected.

The present application relates to a kind of bone repair compositions and its preparation method, belong to biological medicine technical field, pharmaceutical composition includes acid anhydride bovine beta-lactoglobulin peptide, casein phosphopeptide, yak bone peptide, loquat leaf extract, pterostilbene, honeysuckle chlorogenic acid and cyperus rotundus extract;Acid anhydride bovine beta-lactoglobulin peptide is prepared using special enzymolysis method.Acid anhydride bovine beta-lactoglobulin peptide, casein phosphopeptide and yak bone peptide are loaded using carboxymethyl chitosan-hydroxyapatite composite microspheres, then using sodium alginate-sodium carboxymethyl cellulose containing loquat leaf extract, pterostilbene, honeysuckle chlorogenic acid and cyperus rotundus extract one coating, then using sodium alginate-sodium carboxymethyl cellulose secondary coating.The present application develops high-efficiency pharmaceutical combination component, using polymer material to coat drug to form sustained-release system, improve bioavailability, using granular carrier to increase the stability and solubility of drug, promote intestinal absorption, improve bone repair process.

The invention discloses a shapeable bone repair material capable of being implanted in a positioning manner and a preparation method thereof. The interior of the bone repair material is a core layer made of a gelatin, gallic acid and hydroxyapatite particle composite material, and the exterior of the bone repair material is a porous spongy collagen wrapping layer; the density of the wrapping layer is 20-100mg / cm < 3 >; the density of the core layer is 100-800 mg / cm < 3 >; and the particle size of the hydroxyapatite particles is 0.1-2 mm. The collagen sponge on the outer layer of the material wraps the gelatin / hydroxyapatite composite material, so that the problems of loose structure, weak binding force and displacement and powder falling after implantation of bone meal or collagen bone meal composite materials are solved, stimulation and trauma of bone meal particles to surrounding tissues can be avoided, and the conditions of bone meal discharge, bone grafting part collapse and the like are avoided. And in the self tissue regeneration process, the collagen component is degraded and absorbed, and the hydroxyapatite is fused with the new bone, so that bone regeneration is realized, and the success rate of tooth implantation can be improved.

The invention discloses a micron-sized gelatin-hydroxyapatite composite fiber material and a preparation method thereof. The preparation method comprises the following steps: (a) dissolving or dispersing gelatin in a volatile acid solution to obtain a gelatin solution; adding a cross-linking agent into the gelatin solution for in-situ cross-linking, and then adding hydroxyapatite nanoparticles for dispersion to obtain a mixed solution; the mass ratio of the hydroxyapatite nano particles to the gelatin is 0.30 to 1.50; (b) performing centrifugal spinning on the mixed solution, and drying to obtain a gelatin-hydroxyapatite composite fiber precursor; and (c) carrying out secondary crosslinking treatment on the gelatin-hydroxyapatite composite fiber precursor to obtain the gelatin-hydroxyapatite composite fiber material. The interference of HA particles on an electric field can be avoided, the uniformity of fibers is ensured, the production efficiency is higher, and the method is suitable for large-scale industrial production; by optimizing the formula of the mixed solution, the bone conduction performance of the composite fiber is effectively enhanced.

The invention discloses a porous oil-containing hydroxyapatite knuckle bearing surface preparation method based on electrochemical deposition, which is combined with surface texture design to improve the binding force of porous hydroxyapatite and is applied to a composite surface of a titanium alloy knuckle bearing. The method is specifically implemented according to the following steps that 1, the titanium alloy knuckle bearing micro-arc coating is prepared; step 2, surface texture design and laser etching; 3, hydroxyapatite is electrochemically deposited to form a porous liquid storage coating structure, and a hydroxyapatite composite lubricating interface is prepared on the outer surface of the inner ring of the knuckle bearing. The composite surface can improve the lubricating performance, the wear resistance and the storage and conveying capacity of lubricating liquid, and is particularly suitable for a knuckle bearing working under the conditions of high load, high speed and extreme temperature.

The invention provides a method for predicting the friction performance of a titanium alloy surface coating based on image features. The method comprises the following steps: preparing an electroplating solution; the Ti6Al7Nb titanium substrate is subjected to pretreatment; a titanium substrate is used as a cathode, a copper rod is used as an anode, and the copper and nano-hydroxyapatite composite coating is obtained through a jet electrodeposition process; collecting a coating surface image, and obtaining a coating surface friction coefficient through a friction test; extracting image features and carrying out normalization processing on test data; obtaining the most significant factors influencing the friction coefficient of the coating according to a grey correlation analysis method; and establishing a prediction model of the average friction coefficient with respect to image features based on a multiple regression algorithm, and performing reliability analysis. According to the method, the surface friction coefficient can be effectively predicted through the surface image features on the premise that the integrity of the titanium alloy coating is not damaged.

A biodegradable magnesium metal fixation pin for oral tissue fixation and its preparation method are disclosed. The fixation pin includes a pin head and a pin body. The entire fixation pin is made of 99.9-99.99% high-purity magnesium substrate, with no alloying elements added and an impurity content ≤0.01%. The surface of the fixation pin is sequentially coated with an oxide film layer and a polydopamine / hydroxyapatite composite coating. The oxide film layer has a thickness of 5-15 μm and a porous structure with pore sizes of 1-5 μm. The oxide film layer is prepared by a micro-arc oxidation process. The polydopamine / hydroxyapatite composite coating has a thickness of 10-20 μm, wherein the mass fraction of hydroxyapatite is 30-50%. This biodegradable magnesium metal fixation pin for oral tissue fixation features a reasonable structural design, excellent mechanical properties, and controllable degradation behavior.

The invention provides a magnesium alloy-hydroxyapatite composite bone prosthesis and a preparation method thereof.The preparation method of the magnesium alloy-hydroxyapatite composite bone prosthesis comprises the following steps that a target bone is scanned through CT, and a three-dimensional model containing an appearance structure and an internal structure is obtained; simplifying the appearance structure of the bone prosthesis, simulating an internal porous structure of the bone prosthesis, and designing a three-dimensional structure of the bone prosthesis; preparing hydroxyapatite printing slurry; printing a hydroxyapatite bracket by using a three-dimensional photocuring technology; carrying out cleaning, degreasing and high-temperature sintering on the hydroxyapatite scaffold; injecting molten magnesium alloy into the hydroxyapatite stent by using a pressureless permeation technology; and removing redundant materials by adopting a cutting tool, and grinding and polishing to obtain the magnesium alloy-hydroxyapatite composite bone prosthesis. The prepared magnesium alloy-hydroxyapatite composite auditory ossicle prosthesis has the advantages of being stable in positioning, not prone to shifting and disengaging, high in sound conduction efficiency, controllable in cost and capable of achieving personalized customization.

The present invention relates to a recombinant humanized type III collagen-hydroxyapatite composite bone repair material and its preparation method and application. At present, the industry has always expected to achieve efficient production of macromolecular humanized collagen or whole human collagen, which is a technical difficulty that is difficult to completely break through. The molecular weight of the recombinant humanized type III collagen of the present invention is close to that of natural collagen; at the same time, its encoding gene is optimized to achieve efficient and secretory expression of recombinant collagen with high yield. The composite bone repair material prepared with the collagen of the present invention has a more uniform microstructure than the products prepared with commercially available natural collagen or type III human collagen, and achieves the combination of hydroxyapatite grains and collagen fibers at the nanoscale. At the same time, there is a multi-scale pore structure inside the material, which achieves the purpose of better biomimetic natural bone composite material preparation. Therefore, this product can be widely used in dental (jaw) bone defects, as well as dental or bone surgery such as filling and repair of bone defects, nonunion, delayed bone healing or nonunion caused by various reasons, so that more patients can benefit from it.

The invention discloses a collagen and hydroxyapatite composite bone scaffold as well as a preparation method and application thereof, and relates to the technical field of bone scaffolds. The preparation method of the collagen and hydroxyapatite composite bone scaffold comprises the following steps: dissolving collagen in an acid solution to obtain a collagen solution with the concentration of 10-80 mg / L, mixing the collagen solution with hydroxyapatite, and stirring to obtain a compound; freeze-drying the compound, and cross-linking to obtain a primary product; washing the primary product with water to remove acid residues, and then freeze-drying to obtain the collagen and hydroxyapatite composite bone scaffold. The composite bone scaffold is spongy, has relatively high porosity, is beneficial to bone conduction and bone induction, is not easy to disintegrate and slag when being wetted, and is relatively good in supporting property.

The application relates to the field of anticorrosive coatings, in particular to an anticorrosive coating containing lanthanum cerium oxide and a preparation method thereof. The anticorrosive coating containing lanthanum cerium oxide comprises the following raw materials: 28-45 parts of ultraviolet stable type composite film forming substances, 5-10 parts of composite rare earth fillers, 6-12 parts of supported type synergistic antirust agents, 18-30 parts of mixed solvents, 0.8-2.5 parts of dispersants, 2.7-5.3 parts of functional additives and 0.5-1.2 parts of nano montmorillonite. The composite rare earth fillers are core-shell structure lanthanum cerium oxide-hydroxyapatite composite powders with lanthanum cerium oxide as the core and hydroxyapatite as the shell, and the shell thickness is 10-20 nm. The ultraviolet stable type composite film forming substances comprise epoxy resin and ultraviolet graft modified polyurethane with a weight ratio of 1: (0.6-2.2). The supported type synergistic antirust agent is a mixture of mesoporous silica loaded benzotriazole and zinc molybdate. The obtained coating has strong adhesion and long service life.

The invention belongs to the field of biomedical materials, and discloses a preparation method of a zinc phosphate / hydroxyapatite composite coating, which comprises the following steps: pretreating the surface of a titanium alloy; putting the pretreated sample into a conversion solution for galvanic induced chemical conversion; hydroxyapatite is sprayed on the surface of the conversion coating (transition layer zinc phosphate); according to the invention, zinc phosphate is used as a transition layer to spray hydroxyapatite, so that the bonding strength of the coating can be improved, and the hydroxyapatite layer is prevented from peeling off. The preparation process is simple, quick, simple and convenient to operate and easy to popularize and apply.

The application provides a multilayer polymer biomimetic membrane for dura mater repair and a preparation method thereof. The biomimetic membrane comprises a three-layer biomimetic nanofiber composite structure: a cell adhesion inner layer on the side facing the brain tissue, an anti-adhesion outer layer on the side facing the skull, and an intermediate reinforcing layer between the cell adhesion inner layer and the anti-adhesion outer layer. The cell adhesion inner layer is a PCL / chitosan / collagen composite fiber layer, the intermediate reinforcing layer is a PCL / hydroxyapatite composite fiber layer, and the anti-adhesion outer layer is a PCL / polylactic acid-hydroxyacetic acid copolymer (PLGA) layer. The method comprises cell adhesion inner layer preparation, intermediate reinforcing layer preparation, anti-adhesion outer layer preparation, and continuous production processing. The application obtains a multilayer artificial dura mater with strong interlayer bonding, high adhesion, and biomimetic mechanical properties.

The invention relates to a hydroxyapatite injection and a preparation method thereof, belongs to the field of bionic bioremediation materials, and particularly relates to a self-assembled polypeptide, a nano-scale hydroxyapatite composite injection and a preparation method thereof, the hydroxyapatite which can be used for injection is obtained by modifying and compounding hydroxyapatite. The composite material has the advantages of injectable permeability, strong biomimetic mineralization capability, cell adhesion promotion and the like, overcomes the defects of microsphere fillers in the prior art, and has a remarkable bone repair promotion effect and a good clinical application prospect.

The invention belongs to the technical field of catalysts, and particularly relates to a metal palladium immobilized hydroxyapatite composite catalyst as well as a preparation method and application thereof. A solution impregnation method is adopted, hydroxyapatite serves as a solid carrier, metal palladium serves as an active component, a hydroxyapatite solution and a palladium salt solution are heated in a water bath at the temperature of 40-80 DEG C, so that the metal palladium is fixed to the hydroxyapatite, and the metal palladium immobilized hydroxyapatite composite catalyst is obtained. The prepared metal palladium immobilized hydroxyapatite composite catalyst is high in catalytic activity and easy to recycle and reuse, and has efficient adsorbability and selective activity when being applied to dehydrogenation self-coupling reaction of styrene. The preparation method is simple, convenient and easy to operate, the process complexity and the production cost are reduced, and industrial large-scale production is facilitated.

The present invention relates to a silk fibroin / hydroxyapatite composite material, and a preparation method therefor and an application thereof. A uniform mixture of hydroxyapatite nanoparticles, silk fibroin, and hexafluoroisopropanol is maintained at a temperature range from 50° C. to 60° C. for at least 1 hour to obtain a silk fibroin / hydroxyapatite solution; the silk fibroin / hydroxyapatite solution is poured into a long cylindrical mold, two ends of the long cylindrical mold being respectively an end A and an end B; at room temperature, the end A is opened and the end B is closed, and the mold is vertically immersed in methanol with the opening facing up and let stand for at least 2 days; the mold is turned upside down, the end A is closed and the end B is opened, and the mold is vertically immersed in the methanol with the opening facing up and let stand for at least 2 days; the mold is removed, and ventilation and drying are performed to obtain a silk fibroin / hydroxyapatite composite material. The silk fibroin / hydroxyapatite composite material prepared in the present invention has uniform strength, good mechanical properties, and significant osteoinductivity.

The invention relates to a chiral hydroxyapatite composite biological material with a multilayer structure as well as preparation and application of the chiral hydroxyapatite composite biological material. The biological material is prepared from a CS / CA-CMHAP composite scaffold and silver ions (Ag < + >) loaded on the CS / CA-CMHAP composite scaffold, wherein the CS / CA-CMHAP composite scaffold is obtained by compounding CS, CA and a hydroxyapatite nanosheet CMHAP. Compared with the prior art, the biological material provided by the invention has a remarkable healing promoting effect on old-age infected skin wounds in an in-vivo experiment, and can effectively reduce inflammatory response, promote tissue regeneration and the like by regulating and controlling an immune microenvironment.

The invention relates to the technical field of medical materials, in particular to a method for hydrothermally generating a nano-zinc oxide / hydroxyapatite composite coating on a cold spraying zinc coating. Zinc powder is cold-sprayed on the surface of a metal matrix to form a zinc coating, and a first intermediate is obtained; placing the first intermediate above the liquid level of a sodium hydroxide solution, and carrying out a first hydrothermal reaction to form a nano-zinc oxide coating so as to obtain a second intermediate; and placing the second intermediate in a mixed solution of disodium calcium ethylene diamine tetraacetate and monopotassium phosphate, and carrying out a second hydrothermal reaction to generate nano-hydroxyapatite so as to obtain the nano-zinc oxide / hydroxyapatite composite coating. The nano-zinc oxide / hydroxyapatite composite coating prepared by the method has good biological properties, is firmly combined with a matrix, and is not easy to crack or peel off.

The invention relates to medical-grade polyether-ether-ketone / hydroxyapatite compound powder for selective laser sintering (SLS) and a preparation method of the medical-grade polyether-ether-ketone / hydroxyapatite compound powder, and belongs to the field of biological medicine. Specifically, the invention provides medical grade polyether-ether-ketone / hydroxyapatite compound powder, and the medical grade polyether-ether-ketone / hydroxyapatite compound powder comprises polyether-ether-ketone particles and hydroxyapatite distributed on the surfaces of the polyether-ether-ketone particles, wherein the volume distribution particle size Dv50 of the polyetheretherketone / hydroxyapatite compound powder is in a range of 30 microns to 60 microns, and the particle size distribution span Span of the polyetheretherketone / hydroxyapatite compound powder is less than 2.0, where Span = (Dv90-Dv10) / Dv50. The medical-grade polyether-ether-ketone / hydroxyapatite compound powder can be used for preparing bone implants or bone repair scaffolds with excellent mechanical properties and biocompatibility.

The invention provides a preparation method of polymethyl methacrylate / hydroxyapatite with a lasting antibacterial function, which means that silver bisphosphonate containing unsaturated quaternary ammonium cations or copper bisphosphonate containing unsaturated quaternary ammonium cations is deposited on the surface of hydroxyapatite to prepare antibacterial hydroxyapatite with polymerization reaction characteristics. And the polymethyl methacrylate participates in a polymerization reaction of methyl methacrylate to prepare composite material micro powder with the hydroxyapatite surface grafted with polymethyl methacrylate. The polymethyl methacrylate / hydroxyapatite composite material micro powder has antibacterial and bacteriostatic performance, medical efficacy of diphosphonate, water absorption performance in a medium and biocompatibility performance, and can improve the binding force and dispersity of hydroxyapatite and polymethyl methacrylate; further, the tensile strength, the bending strength and the compressive strength of the polymethyl methacrylate-based bone cement are improved; the addition amount of hydroxyapatite in the polymethyl methacrylate-based bone cement is increased, so that the curing thermal effect and the curing shrinkage of the polymethyl methacrylate-based bone cement are reduced.

The application discloses a preparation method and application of a composite aerogel for treating radioactive contamination, and comprises the following steps: soaking Physocarpus amurensis seeds in ultrapure water, then oscillating and stirring, rotating evaporation of a polysaccharide solution obtained to 1 / 4 of the original volume, and storing in an ethanol solution overnight; collecting precipitates and redissolving in ultrapure water, freeze-drying to obtain Physocarpus amurensis seed glue; mixing ultrapure water with the Physocarpus amurensis seed glue and calcium nitrate, and simultaneously performing mechanical stirring; adding (NH4)2HPO4 while stirring, and maintaining the pH level at about 10; aging the mixture, and then freeze-drying; and obtaining a natural polymer Physocarpus amurensis seed glue / hydroxyapatite aerogel. The composite gel freeze-drying technology is used to combine the large contact area of three-dimensional materials with the effective adsorption characteristics of nanometer adsorption materials, and the prepared Physocarpus amurensis seed glue / hydroxyapatite composite aerogel has a remarkable adsorption effect on uranium in radioactive wastewater.

The invention discloses a preparation method of a moldable composite porous sponge with antibacterial performance, which comprises the following steps: by taking chitosan as an organic phase, magnesium-doped hydroxyapatite as an inorganic phase and gelatin and glutaraldehyde as cross-linking agents, freeze-drying to obtain the chitosan-magnesium-doped hydroxyapatite composite porous sponge with plasticity and antibacterial effect. The synthesis process is simple, reaction conditions are controllable, batch production is easy, and the prepared chitosan-magnesium-doped hydroxyapatite composite porous sponge has a unique porous structure and has good filling and repairing effects on dentistry and orthopedics.

This invention relates to a modified boron fluoride-nitrogen-hydroxyapatite composite corrosion-resistant friction material and its preparation method. By weight, its composition includes: 18-25 parts bisphenol A type epoxy resin, 4-6 parts curing agent, 4-10 parts modified boron fluoride-nitrogen nanosheets, 5-12 parts hydroxyapatite, 15-22 parts basalt fiber, 6-10 parts graphite, 4-8 parts silicon carbide, and 1-3 parts dispersant. The boron fluoride-nitrogen nanosheets and hydroxyapatite form a synergistic corrosion-resistant system, combined with the dense cross-linked structure of the bisphenol A type epoxy resin, giving the material excellent bulk corrosion resistance. After immersion in 5% NaCl solution (simulating a marine environment) and 10% H2SO4 solution (simulating an acidic environment) for 720 hours, the material's mass loss rate is less than 0.5%, and its corrosion resistance is far superior to existing surface coating materials and single fluoride filler materials.

The invention provides a polylactic acid / silicon-doped hydroxyapatite composite material for a bone fixation instrument as well as a preparation method and application of the polylactic acid / silicon-doped hydroxyapatite composite material. According to the invention, polylactic acid is taken as a matrix, silicon-doped hydroxyapatite is taken as a reinforcement, and polylactic acid-silicon-doped hydroxyapatite composite materials with different formula ratios are prepared by adopting a melt blending method. When the content of the silicon-doped hydroxyapatite is 10%, the composite material has optimal thermal stability and mechanical properties (the bending strength is 66.1 MPa); an in-vitro degradation experiment proves that the degradation rate of the composite material can be changed by changing the content of the silicon-doped hydroxyapatite, so that the requirement of an implanted part is met; in a cytotoxicity experiment, after 10wt% of silicon-doped hydroxyapatite is added into polylactic acid, the reduction amplitude of the cell survival rate is reduced, which indicates that the addition of silicon-doped hydroxyapatite improves the cell activity of the polylactic acid composite material.

The application discloses an antibacterial hydrogel dressing and a preparation method thereof, relates to the technical field of biomedical materials, and belongs to the patent classification A61L27 / 52. The preparation method of the antibacterial hydrogel dressing comprises the following steps: firstly, preparing nano-silver-hydroxyapatite composite particles; secondly, mixing the nano-silver-hydroxyapatite composite particles with a hydrogel solution to obtain a mixed hydrogel solution; and finally, allowing the mixed hydrogel solution to undergo a cross-linking reaction under the action of a cross-linking agent to obtain the antibacterial hydrogel dressing. The antibacterial hydrogel dressing prepared by the application has good antibacterial ion release performance and mechanical strength.