368 results about "Hydroxyapatite composite" patented technology

The present invention is related to methods for preparing composite materials, which include nanoscale hydroxyapatite, and the composite materials and articles prepared therewith.

Tissue engineering is a growing field where new materials are being developed for implantation into the body. One important area involves bone graft materials to replace areas of bone lost to trauma or disease. Traditionally, graft material may be harvested from the bone of the individual receiving the graft material. However, this requires an additional surgery and additional recovery. Bone also may be taken from others, or even cadavers, but this introduces biocompatibility problems as well as the risk of disease transfer. Ideally, a biocompatible material is sought that will act as a filler with appropriate mechanical strength, encourage bone healing, and degrade to allow new bone ingrowth without the risk of disease transfer. The present invention is a new composite bone graft material made from biocompatible poly(D,L-lactic-co-glycolic acid) (PLGA) and nano-sized hydroxyapatite particles exposed on its surface using a gas foaming particle leaching (GF / PL) method. A further embodiment of this invention involves coating this PLGA / hydroxyapatite biomaterial with an adherent, fast, uniform coating of a mineral such as apatite. The PLGA polymer portion of the composite provides sufficient mechanical strength to replace bone and is degradable over time to allow new bone tissue ingrowth. The incorporated hydroxyapatite particles increase the composite material's osteogenic properties by providing sites for tissue attachment and propagation. Finally, a uniform coating of mineral apatite on the surface of this novel biomaterial composite further enhances its osteogenic qualities.

A method for preparing a hydroxyapatite composite is disclosed. This method comprises alternately soaking a matrix which has been made hydrophilic at least on its surface, in a calcium ion aqueous solution containing calcium ions and substantially free of phosphate ions and in a phosphate ion aqueous solution containing phosphate ions and substantially free of calcium ions to securely form hydroxyapatite at least on the surface of the matrix. Also disclosed is a biocompatible material composed of the hydroxyapatite composite obtained by the method.

The invention relates to a polyvinyl alcohol / sodium alginate / hydroxyapatite composite fiber membrane as well as a preparation method and application of the polyvinyl alcohol / sodium alginate / hydroxyapatite composite fiber membrane. The preparation method of the composite fiber membrane comprises the following steps: firstly, taking diammonium phosphate and calcium nitrate to react to prepare hydroxyapatite; carrying out ultrasonic dispersion on the hydroxyapatite and sodium alginate to form a stable hydroxyapatite suspension solution; secondly, preparing a sodium alginate solution with the mass percent of 2 percent of a polyvinyl alcohol solution with the mass percent of 18 percent by adopting the suspension solution; finally, uniformly mixing the two types of solutions according to a ratio and carrying out electrostatic spinning. According to the preparation method of the composite fiber membrane, the hydroxyapatite is stably and uniformly dispersed into water by combining the sodium alginate with an ultrasonic method under the condition that other substances are not introduced, and the problem that the hydroxyapatite is easy to agglomerate is solved; the biocompatibility of a natural high polymer and a synthesized high polymer and the bioactivity of hydroxyapatite nanoparticles are combined by adopting the electrostatic spinning to successfully prepare the composite fiber membrane capable of being used as repairing dressing of soft tissue injuries.

The present invention is related to methods for preparing composite materials, which include nanoscale hydroxyapatite, and the composite materials and articles prepared therewith.