31 results about "Hydroxyapatite composite" patented technology

The invention provides a composite sun-screening agent based on an encapsulation technology as well as a preparation method and application of the composite sun-screening agent. The preparation method of the composite sun-screening agent comprises the following steps: fully dispersing hydroxyapatite nanoparticles in an alkaline solvent, adding a dopamine monomer, and carrying out oxidative polymerization reaction, centrifugal washing and drying to obtain HAP-PDA composite nanoparticles; and fully dispersing the HAP-PDA composite nanoparticles in a solvent, adding a mixed solution of a chemical sun-screening agent and an antioxidant and a surfactant, and performing encapsulation reaction and centrifugation to obtain the product. According to the invention, a polydopamine and hydroxyapatite composite encapsulation technology is innovatively adopted, so that the stability and biocompatibility of the sun-screening agent and the antioxidant are remarkably improved, the sun-screening effect is enhanced, and the product is endowed with a lasting sun-screening effect and excellent oxidation resistance. According to the invention, the limitation of a traditional sunscreen product is broken through, and safer, more efficient and more comfortable sunscreen experience can be provided for consumers.

The present application relates to a kind of bone repair compositions and its preparation method, belong to biological medicine technical field, pharmaceutical composition includes acid anhydride bovine beta-lactoglobulin peptide, casein phosphopeptide, yak bone peptide, loquat leaf extract, pterostilbene, honeysuckle chlorogenic acid and cyperus rotundus extract;Acid anhydride bovine beta-lactoglobulin peptide is prepared using special enzymolysis method.Acid anhydride bovine beta-lactoglobulin peptide, casein phosphopeptide and yak bone peptide are loaded using carboxymethyl chitosan-hydroxyapatite composite microspheres, then using sodium alginate-sodium carboxymethyl cellulose containing loquat leaf extract, pterostilbene, honeysuckle chlorogenic acid and cyperus rotundus extract one coating, then using sodium alginate-sodium carboxymethyl cellulose secondary coating.The present application develops high-efficiency pharmaceutical combination component, using polymer material to coat drug to form sustained-release system, improve bioavailability, using granular carrier to increase the stability and solubility of drug, promote intestinal absorption, improve bone repair process.

The invention discloses a shapeable bone repair material capable of being implanted in a positioning manner and a preparation method thereof. The interior of the bone repair material is a core layer made of a gelatin, gallic acid and hydroxyapatite particle composite material, and the exterior of the bone repair material is a porous spongy collagen wrapping layer; the density of the wrapping layer is 20-100mg / cm < 3 >; the density of the core layer is 100-800 mg / cm < 3 >; and the particle size of the hydroxyapatite particles is 0.1-2 mm. The collagen sponge on the outer layer of the material wraps the gelatin / hydroxyapatite composite material, so that the problems of loose structure, weak binding force and displacement and powder falling after implantation of bone meal or collagen bone meal composite materials are solved, stimulation and trauma of bone meal particles to surrounding tissues can be avoided, and the conditions of bone meal discharge, bone grafting part collapse and the like are avoided. And in the self tissue regeneration process, the collagen component is degraded and absorbed, and the hydroxyapatite is fused with the new bone, so that bone regeneration is realized, and the success rate of tooth implantation can be improved.

A biodegradable magnesium metal fixation pin for oral tissue fixation and its preparation method are disclosed. The fixation pin includes a pin head and a pin body. The entire fixation pin is made of 99.9-99.99% high-purity magnesium substrate, with no alloying elements added and an impurity content ≤0.01%. The surface of the fixation pin is sequentially coated with an oxide film layer and a polydopamine / hydroxyapatite composite coating. The oxide film layer has a thickness of 5-15 μm and a porous structure with pore sizes of 1-5 μm. The oxide film layer is prepared by a micro-arc oxidation process. The polydopamine / hydroxyapatite composite coating has a thickness of 10-20 μm, wherein the mass fraction of hydroxyapatite is 30-50%. This biodegradable magnesium metal fixation pin for oral tissue fixation features a reasonable structural design, excellent mechanical properties, and controllable degradation behavior.

The invention discloses a collagen and hydroxyapatite composite bone scaffold as well as a preparation method and application thereof, and relates to the technical field of bone scaffolds. The preparation method of the collagen and hydroxyapatite composite bone scaffold comprises the following steps: dissolving collagen in an acid solution to obtain a collagen solution with the concentration of 10-80 mg / L, mixing the collagen solution with hydroxyapatite, and stirring to obtain a compound; freeze-drying the compound, and cross-linking to obtain a primary product; washing the primary product with water to remove acid residues, and then freeze-drying to obtain the collagen and hydroxyapatite composite bone scaffold. The composite bone scaffold is spongy, has relatively high porosity, is beneficial to bone conduction and bone induction, is not easy to disintegrate and slag when being wetted, and is relatively good in supporting property.

The application relates to the field of anticorrosive coatings, in particular to an anticorrosive coating containing lanthanum cerium oxide and a preparation method thereof. The anticorrosive coating containing lanthanum cerium oxide comprises the following raw materials: 28-45 parts of ultraviolet stable type composite film forming substances, 5-10 parts of composite rare earth fillers, 6-12 parts of supported type synergistic antirust agents, 18-30 parts of mixed solvents, 0.8-2.5 parts of dispersants, 2.7-5.3 parts of functional additives and 0.5-1.2 parts of nano montmorillonite. The composite rare earth fillers are core-shell structure lanthanum cerium oxide-hydroxyapatite composite powders with lanthanum cerium oxide as the core and hydroxyapatite as the shell, and the shell thickness is 10-20 nm. The ultraviolet stable type composite film forming substances comprise epoxy resin and ultraviolet graft modified polyurethane with a weight ratio of 1: (0.6-2.2). The supported type synergistic antirust agent is a mixture of mesoporous silica loaded benzotriazole and zinc molybdate. The obtained coating has strong adhesion and long service life.

The application provides a multilayer polymer biomimetic membrane for dura mater repair and a preparation method thereof. The biomimetic membrane comprises a three-layer biomimetic nanofiber composite structure: a cell adhesion inner layer on the side facing the brain tissue, an anti-adhesion outer layer on the side facing the skull, and an intermediate reinforcing layer between the cell adhesion inner layer and the anti-adhesion outer layer. The cell adhesion inner layer is a PCL / chitosan / collagen composite fiber layer, the intermediate reinforcing layer is a PCL / hydroxyapatite composite fiber layer, and the anti-adhesion outer layer is a PCL / polylactic acid-hydroxyacetic acid copolymer (PLGA) layer. The method comprises cell adhesion inner layer preparation, intermediate reinforcing layer preparation, anti-adhesion outer layer preparation, and continuous production processing. The application obtains a multilayer artificial dura mater with strong interlayer bonding, high adhesion, and biomimetic mechanical properties.

The invention relates to medical-grade polyether-ether-ketone / hydroxyapatite compound powder for selective laser sintering (SLS) and a preparation method of the medical-grade polyether-ether-ketone / hydroxyapatite compound powder, and belongs to the field of biological medicine. Specifically, the invention provides medical grade polyether-ether-ketone / hydroxyapatite compound powder, and the medical grade polyether-ether-ketone / hydroxyapatite compound powder comprises polyether-ether-ketone particles and hydroxyapatite distributed on the surfaces of the polyether-ether-ketone particles, wherein the volume distribution particle size Dv50 of the polyetheretherketone / hydroxyapatite compound powder is in a range of 30 microns to 60 microns, and the particle size distribution span Span of the polyetheretherketone / hydroxyapatite compound powder is less than 2.0, where Span = (Dv90-Dv10) / Dv50. The medical-grade polyether-ether-ketone / hydroxyapatite compound powder can be used for preparing bone implants or bone repair scaffolds with excellent mechanical properties and biocompatibility.

This invention relates to a modified boron fluoride-nitrogen-hydroxyapatite composite corrosion-resistant friction material and its preparation method. By weight, its composition includes: 18-25 parts bisphenol A type epoxy resin, 4-6 parts curing agent, 4-10 parts modified boron fluoride-nitrogen nanosheets, 5-12 parts hydroxyapatite, 15-22 parts basalt fiber, 6-10 parts graphite, 4-8 parts silicon carbide, and 1-3 parts dispersant. The boron fluoride-nitrogen nanosheets and hydroxyapatite form a synergistic corrosion-resistant system, combined with the dense cross-linked structure of the bisphenol A type epoxy resin, giving the material excellent bulk corrosion resistance. After immersion in 5% NaCl solution (simulating a marine environment) and 10% H2SO4 solution (simulating an acidic environment) for 720 hours, the material's mass loss rate is less than 0.5%, and its corrosion resistance is far superior to existing surface coating materials and single fluoride filler materials.

The application discloses an antibacterial hydrogel dressing and a preparation method thereof, relates to the technical field of biomedical materials, and belongs to the patent classification A61L27 / 52. The preparation method of the antibacterial hydrogel dressing comprises the following steps: firstly, preparing nano-silver-hydroxyapatite composite particles; secondly, mixing the nano-silver-hydroxyapatite composite particles with a hydrogel solution to obtain a mixed hydrogel solution; and finally, allowing the mixed hydrogel solution to undergo a cross-linking reaction under the action of a cross-linking agent to obtain the antibacterial hydrogel dressing. The antibacterial hydrogel dressing prepared by the application has good antibacterial ion release performance and mechanical strength.

The present application relates to the technical field of composite materials, and particularly relates to a degradable zinc-based composite material for biomedical stents and a preparation method thereof, which comprises the following steps: taking zinc sheets after surface cleaning, coating hydroxyapatite on the surface of the zinc sheets after surface cleaning, stacking the zinc sheets coated with hydroxyapatite and the zinc sheets without hydroxyapatite coating, and rolling the zinc sheets with hydroxyapatite inside the stack; folding the zinc sheets after each rolling pass, and then continuing to roll; repeating the folding-rolling until the desired rolling pass; and after the obtained sample is pressed into a block, performing multi-pass hot rolling, thereby obtaining the degradable zinc-based composite material for biomedical stents. The present application adopts a cumulative roll bonding preparation process, which can effectively improve the combination of hydroxyapatite and zinc, and improve the dispersity of hydroxyapatite in zinc, and can effectively refine the grains and strengthen the matrix, so as to finally obtain a zinc / hydroxyapatite composite material with uniform structure and excellent performance.

This invention provides a polylactic acid / zinc-doped hydroxyapatite composite material for bone fixation devices, its preparation method, and its applications. The invention utilizes a melt blending method to prepare composite materials with different formulation ratios under optimal process conditions. When the zinc-doped hydroxyapatite content is 10%, the composite material exhibits the best thermal stability and mechanical properties (tensile strength of 63.2 MPa). The composite material shows the lowest rate of flexural performance degradation after 20 days of degradation. In vitro degradation experiments demonstrate that the mechanical properties of the composite material can be altered by changing the zinc-doped hydroxyapatite content, and the degradation rate can be modified by changing the zinc-doped hydroxyapatite content to meet the requirements of the implantation site. Cytotoxicity experiments show that an appropriate zinc ion concentration can promote the cell activity of mouse osteoblasts.

The invention discloses a modified chitosan-hydroxyapatite composite material as well as a preparation method and application thereof, and relates to the technical field of dental materials. The problems that an existing oral care product and a chitosan-hydroxyapatite composite material are narrow in antibacterial spectrum, not lasting in dentin desensitization effect, low in remineralization efficiency, poor in stability and difficult to give consideration to biological safety are solved. The preparation method of the modified chitosan-hydroxyapatite composite material comprises the following steps: dropwise adding an acetic acid aqueous solution of chitosan into an aqueous solution containing alkaline amino acid and a carboxyl activator, and carrying out mixed reaction, dialysis, filtration and freeze drying to obtain alkaline amino acid modified chitosan; dropwise adding a hydroxyapatite aqueous solution into the alkaline amino acid modified chitosan aqueous solution to carry out self-assembly reaction, centrifuging, taking supernate, filtering, and freeze-drying to obtain the modified chitosan-hydroxyapatite composite material. The prepared modified chitosan-hydroxyapatite composite material can be applied to the fields of oral care materials and nano sustained-release drug carriers.

The present application relates to the field of bone tissue engineering materials, and relates to a synthetic bone repair material with a biomimetic structure.The present application prepares a nano wool protein / hydroxyapatite composite biomimetic bone material through an in-situ mineralization process, and the wool material is dissolved, purified, dialyzed and separated and purified to obtain a wool protein solution.The wool protein solution is mixed with a calcium ion solution, and a proper surfactant, a pH value regulator and a performance control substance are added to obtain a precursor solution.On this basis, the in-situ mineralization reaction is carried out by dropping the phosphate to obtain the nano wool protein / hydroxyapatite composite biomimetic bone material.The composite biomimetic bone material obtained by the in-situ mineralization deposition has high rigidity and toughness, can simulate the organic / inorganic components in human bones, and has good bone replacement performance.

The invention relates to the technical field of cosmetics, in particular to a rapid acne-removing composition containing colloidal sulfur as well as a preparation method and application of the rapid acne-removing composition. The invention relates to a rapid acne-removing composition containing colloidal sulfur. The rapid acne-removing composition is prepared from the colloidal sulfur, cyclodextrin inclusion licochalcone A and hydroxyapatite, the invention relates to a preparation method of a rapid acne-removing composition containing colloidal sulfur. The preparation method comprises the following steps: S1, preparing cyclodextrin inclusion licochalcone A; s2, constructing a colloidal sulfur-hydroxyapatite composite system; mixing and preparation: mixing the cyclodextrin inclusion licochalcone A prepared in the step S1 with the composite dispersion system prepared in the step S2, then adding dermatologically acceptable auxiliary materials, and homogenizing to obtain a target composition; the acne-removing mask has the beneficial effects that the acne-removing mask has a synergistic effect and can quickly remove acnes; slow-release synergism is realized, and irritation is reduced; repairing the skin barrier; the preparation method is simple.

The invention provides a preparation method of a hydroxyl phosphate composite hydrogel electrolyte, which comprises the following steps: sequentially soaking hydrogel in a metal salt precursor solution, a phosphate radical solution and a zinc salt solution, and forming hydroxyl phosphate in a hydrogel network by metal ions in a metal salt precursor and a mineralizing agent through in-situ mineralization reaction, the hydroxyl phosphate composite hydrogel electrolyte is obtained. The invention also provides the hydroxyl phosphate composite hydrogel electrolyte obtained by the preparation method and application of the hydroxyl phosphate composite hydrogel electrolyte in a zinc ion battery. The hydroxyl phosphate is introduced into the hydrogel electrolyte, and the cycling stability of the zinc ion battery can be remarkably improved when the obtained electrolyte is applied to the negative electrode of the zinc ion battery.

The application relates to a method for preparing chitosan-hydroxyapatite composite microparticles through high-speed shearing and synergic double-reverse-phase fine emulsion, which continuously acts on the emulsification and homogenization process of the emulsification mixing of a chitosan-containing calcium salt and phosphate precursor aqueous solution and an oil phase system and a triethanolamine precursor aqueous solution and an oil phase system (constituting double-reverse-phase fine emulsion droplets) and the subsequent collision-mixing-neutralization-reaction process of chitosan, calcium salt and phosphate in the dispersed phase emulsion droplets (water droplets) and triethanolamine in another dispersed phase emulsion droplet (water droplet), realizes the continuous operation of the high-speed shearing effect reinforced physical emulsification mixing process and in-situ precipitation chemical reaction process, and achieves the purpose of preparing CS-HAP composite microparticles which are good in dispersity, not prone to agglomeration, closely combined with each other, high in porosity, uniformly dispersed and nano-level dispersed. The method is simple in preparation process, low in equipment requirement and cost, mild in reaction condition, easy to control in preparation process and easy to enlarge.

The invention discloses a preparation method of phosphate solubilizing bacteria mixed ball-milled charcoal and hydroxyapatite composite microspheres and application of the phosphate solubilizing bacteria mixed ball-milled charcoal and hydroxyapatite composite microspheres in coupling sweet potato, and relates to the technical field of material coupling green manure. The invention aims to solve the problems that the Cd pollution treatment efficiency in the dry farmland is low, and the improvement of soil fertility and the increase of crop yield are difficult to realize at the same time. The method comprises the following steps: fully mixing phosphate solubilizing bacteria mixed ball-milled biochar and hydroxyapatite composite microspheres with soil, adding the mixture into a polyethylene plastic flowerpot, then uniformly sowing seeds of the sweet potato into the flowerpot, and irrigating once every 3-4 days during the growth period of the sweet potato; when the sweet potatoes grow to the full-bloom stage, the whole plants are cut into pieces and turned and pressed into the soil, and synergistic passivation of cadmium in the soil is completed after 15-17 days. The invention can obtain the preparation method of the phosphate solubilizing bacteria mixed ball-milled charcoal and hydroxyapatite composite microspheres and the application of the phosphate solubilizing bacteria mixed ball-milled charcoal and hydroxyapatite composite microspheres in coupling of sweet potatoes.

This invention discloses an injectable bone powder with anti-inflammatory biological activity, its preparation method, and its application. The bone powder is a hydrogel internally loaded with a hydroxyapatite composite material, wherein the hydroxyapatite composite material is hydroxyapatite with membrane vesicles coated on its surface; the membrane vesicles are derived from pulp-derived suppressor cells; the mass-to-volume ratio of the hydroxyapatite composite material to the hydrogel is 20-30%. This injectable bone powder with anti-inflammatory biological activity, containing membrane vesicles derived from pulp-derived suppressor cells coated on the surface of the hydroxyapatite, has biological effects that inhibit T cell proliferation and macrophage differentiation into osteoclasts, thus blocking the inflammatory environment, suppressing the inflammatory response, and promoting alveolar bone repair and regeneration.

The invention belongs to the technical field of activated carbon composite materials, and particularly relates to a preparation method of an activated carbon-loaded hydroxyapatite composite material. The preparation method comprises the following steps: under a temperature control condition, adding biomass powder into hydrochloric acid for impregnation, and adding aniline and an oxidant solution for reaction to obtain a hydrochloric acid doped polyaniline / biomass composite material; carbonizing and grinding the polyaniline / biomass composite material to obtain a carbonized material; dispersing the carbonized material into a soluble calcium salt solution, and adding a soluble phosphate solution for reaction to obtain a precursor; and mixing the precursor with an alkali activator, and activating to obtain the activated carbon-loaded hydroxyapatite composite material. The activated carbon-loaded hydroxyapatite composite material prepared by the method is a complex in which hydroxyapatite nanocrystals are uniformly dispersed in a nitrogen-doped porous carbon skeleton, and the structure has excellent mechanical stability, high specific surface area, abundant pore channels and a large number of active adsorption sites.

The invention relates to a high-weather-resistance electrical conduit and a preparation process thereof, and belongs to the technical field of electrical conduits. The electrical conduit comprises a base tube and a weather-proof protective coating compounded on the surface of the steel base tube, the weather-proof protective coating is obtained by coating the outer surface of the base tube with a weather-proof protective coating and curing the weather-proof protective coating, and the formula of the weather-proof protective coating is as follows: by weight, the content of the weather-proof protective coating is 1-5% of that of the base tube. The coating is prepared from 55-75 parts of epoxy resin, 5-10 parts of composite filler, 1-2 parts of a flatting agent, 1-2 parts of a defoaming agent, 10-20 parts of a curing agent and 40-60 parts of a solvent. The composite filler is of a graphite phase carbon nitride-hydroxyapatite composite structure of which the surface is modified by dodecyl phosphate. The electrical conduit prepared by the invention has good mechanical property, high weather resistance and high corrosion resistance.

The invention discloses nano-hydroxyapatite composite acoustic ink as well as a preparation method and application thereof, and relates to the technical field of biology and new medicine. The ink comprises the following components in percentage by mass: 20%-30% of a hydrogel substrate, 3%-6% of a temperature-sensitive phase change material, 0%-2% of a rheology modifier, 0.8%-1.2% of a thermal initiator, 5%-15% of nano-hydroxyapatite and the balance of an aqueous solvent. The ink system depends on ultrasonic waves with high penetrating power as an energy source, the bottleneck that a traditional photocuring technology is limited by the optical property of a material is broken through, and direct printing of a high-concentration and non-transparent nano-hydroxyapatite composite material becomes possible. According to the preparation method, the high-quality acoustic ink which is uniform in nano-particle dispersion, full in component mixing and free of bubbles is prepared through key operations such as batch ultrasonic dispersion, and the preparation method is very important for realizing the precision of deep-penetration sound wave volume printing and the mechanical property and biological activity of a bone repair scaffold.

The application discloses a sericin / bacterial cellulose / nano-hydroxyapatite composite gel as well as a preparation method and application thereof, and belongs to the technical field of high polymer materials. The application aims to construct a gel meeting the performance characteristics of bone repair / bone filling materials. The composite gel is prepared by blending sericin, bacterial cellulose and amino-functionalized nano-hydroxyapatite, activating by calcium carbonate, and cross-linking by 1-ethyl-3(3-dimethylaminopropyl) carbodiimide hydrochloride to form the sericin / bacterial cellulose / nano-hydroxyapatite composite gel. The composite gel has a porous structure in the inside, good mechanical properties, and can efficiently promote the adhesion, proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells, and is an excellent bone repair / bone filling material.

The invention relates to an ultrasonic response bionic piezoelectric periosteum and a preparation method thereof, and belongs to the technical field of biological materials. According to the present invention, the electrospinning technology is adopted, and a polydopamine (PDA) assisted biomimetic mineralization process is combined to construct the polycaprolactone / zinc oxide (at) polydopamine / hydroxyapatite composite periosteum, such that the polycaprolactone / zinc oxide (at) polydopamine (at) PDA / hydroxyapatite (HA) composite periosteum, which is called PCL / ZnO (at) PDA / HA (PZPH) for short, is constructed; the composite periosteum has a piezoelectric effect, antibacterial activity and a bone-like mineralization structure, and can generate a bioelectrical signal for promoting osteogenesis under the stimulation of low-intensity pulse ultrasound (LIPUS), so that osteogenesis-related cell behaviors are regulated and controlled, and bone repair is promoted. The bionic piezoelectric periosteum prepared by the invention has the characteristics of high porosity, good osseointegration, excellent osteogenic activity and the like, can effectively solve the problems of insufficient biological activity, easy postoperative infection and the like of the existing bone repair material, provides a new solution for the field of bone tissue engineering, and has a good application prospect.

The invention discloses a cerium-doped hydroxyapatite composite salinized soil salt expansion resistant curing agent and a preparation method thereof, and the cerium-doped hydroxyapatite composite salinized soil salt expansion resistant curing agent comprises the following components in parts by mass: 30-40 parts of phosphoaluminate cement, 5-8 parts of nano silica fume, 0.1-0.5 part of cerium-doped hydroxyapatite, 3-5 parts of modified bamboo fiber chitosan, 1-2 parts of a polyethylene glycol-polypropylene glycol block copolymer, 0.3-0.8 part of zinc citrate and 10-15 parts of deionized water. The cerium-doped hydroxyapatite ion stabilizer is combined with the modified environment-friendly component and the composite curing agent of the efficient gelling system, so that the long-acting fixation of harmful ions in the salinized soil is realized, and the strength and toughness of the cured body are synergistically improved.

The present application relates to the preparation and testing method of wood sponge-hydroxyapatite-collagen composite scaffold. The preparation method comprises four steps of wood sponge preparation, silanized wood sponge preparation, silanized wood sponge-hydroxyapatite composite scaffold preparation and silanized wood sponge-hydroxyapatite-collagen composite scaffold preparation; the testing method comprises scaffold material characterization and performance test, scaffold material in-vitro biocompatibility test and scaffold material osteogenesis and angiogenesis test. The present application uses natural wood as raw material, adopts the top-down modification path, combines vacuum impregnation, freeze drying and other mild processes, and the prepared composite scaffold has good scalability and biocompatibility.

The invention discloses a plastic chitosan-hydroxyapatite composite bone repair material and a preparation method thereof, the plastic chitosan-hydroxyapatite composite bone repair material is prepared by using chitosan and hydroxyapatite prepared from oyster shells as raw materials, and the chitosan-hydroxyapatite composite material is prepared by firstly freeze-drying and then neutralizing pH; the porous structure and good liquid absorption capability are realized; in a dry state, the material is relatively hard and is convenient to transport; the material has flexibility and moldability under a wet condition, and compared with a common rigid bone repair material in the market, the material is more suitable for a bone defect part and has a good application prospect.

The invention belongs to the technical field of biomedical materials, and discloses a hydroxyapatite composite microsphere, an injection filling preparation and a preparation method and application of the hydroxyapatite composite microsphere and the injection filling preparation. The hydroxyapatite composite microsphere comprises the following components in final concentration: a water phase: 1wt%-3wt% of hydroxyapatite, 5wt%-10wt% of recombinant collagen, 1wt%-5wt% of reduced glutathione, 3wt%-3.5 wt% of a cross-linking agent EDC, and 1.5 wt%-1.75 wt% of NHS; the oil phase is prepared by dissolving span 80 and Tween 80 in liquid paraffin, so that the final concentrations of span 80 and Tween 80 are respectively 3wt%-5wt% and 1wt%. The invention also discloses a preparation method of the hydroxyapatite composite microsphere, and an injection filler containing the hydroxyapatite composite microsphere. According to the multi-heavy-component modified hydroxyapatite, the problems of poor hydrophilicity, irregular shape and the like of the existing hydroxyapatite microsphere material are solved, so that the product is uniform in sphere shape and controllable in particle size specification, and has good biocompatibility.

The invention provides a silicon-doped hydroxyapatite composite biological ceramic material and application thereof, and belongs to the technical field of biomedical materials. The silicon-doped hydroxyapatite composite biological ceramic material is prepared by compounding silicon-doped hydroxyapatite (SiHAp) and pure hydroxyapatite (HAp) according to the mass ratio of (1: 5) to (3: 3), wherein the silicon content in the SiHAp is 0.15-0.6 wt%. Through the synergistic effect of silicon doping modification and composite proportion optimization of hydroxyapatite and silicon-doped hydroxyapatite, on the premise of keeping high porosity and excellent biocompatibility, the compression strength is greatly improved, the mechanical property of the hydroxyapatite material is remarkably enhanced, and the application prospect is wide. And the method is particularly suitable for manufacturing bone tissue engineering scaffolds and bone repair implants.

The invention relates to the technical field of biomedical materials, in particular to a volume-weight-controllable coral hydroxyapatite bone repair material and a preparation method thereof.The preparation method of the volume-weight-controllable coral hydroxyapatite bone repair material comprises the steps that coral particles are subjected to an incomplete hydrothermal reaction, hydroxyapatite is controlled to be incompletely converted, and the volume-weight-controllable coral hydroxyapatite bone repair material is obtained; the preparation method comprises the following steps: preparing a coral hydroxyapatite composite material, circularly cleaning, drying, carrying out gradient acid treatment, preparing an acid treatment solution, immersing the cleaned coral hydroxyapatite composite material, reacting, taking out, cleaning, and drying to obtain the coral hydroxyapatite bone repair material. Acid in the acid treatment liquid is weak acid; the coral hydroxyapatite bone repair material has the advantages that the volume weight of the coral hydroxyapatite bone repair material can be reduced, and meanwhile, the natural porous structure of the coral hydroxyapatite bone repair material is kept.