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Method for preparing calcium phosphate composite powder

A composite powder, calcium phosphate technology, applied in phosphorus compounds, chemical instruments and methods, medical science and other directions, to achieve the effects of easy realization, process environmental protection, and low cost

Inactive Publication Date: 2008-09-03
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the preparation of α-calcium phosphate / hydroxyapatite composites without impurities by traditional methods

Method used

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  • Method for preparing calcium phosphate composite powder
  • Method for preparing calcium phosphate composite powder
  • Method for preparing calcium phosphate composite powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 7.0845g Ca(NO 3 ) 2 Dissolve in 50mL of deionized water, and add 50mL of (NH 4 ) 2 HPO 4 solution, make the calcium-phosphorus molar ratio in the system be 1.500, react at room temperature, maintain the pH value of the system at 11.0 with ammonia water, stir for 24 hours, and age for 24 hours to obtain a reaction product mixed solution, and then add Ca(NO 3 ) 2 solution, so that the Ca / P molar ratio of the system reaches 1.600. After stirring evenly, age for another 24 hours, filter, wash and dry. Then calcined at 900°C for 2 hours, lowered to room temperature with the furnace, and after grinding, a multiphase α-calcium phosphate / hydroxyapatite powder with a Ca / P molar ratio of 1.600 can be obtained. The XRD spectrum and SEM photos of the product are as follows figure 1 and Figure 5 .

Embodiment 2

[0029] 7.0845g Ca(NO 3 ) 2 Dissolve in 50mL of deionized water, and add 50mL of (NH 4 ) 2 HPO 4 solution, make the calcium-phosphorus molar ratio in the system be 1.500, react at room temperature, maintain the pH value of the system at 11.0 with ammonia water, stir for 24 hours, and age for 24 hours to obtain a reaction product mixed solution, and then add Ca(NO 3 ) 2 solution, so that the Ca / P molar ratio of the system reaches 1.636. After stirring evenly, age for another 24 hours, filter, wash and dry. Then calcined at 900°C for 2 hours, lowered to room temperature with the furnace, and after grinding, a multiphase α-calcium phosphate / hydroxyapatite powder with a Ca / P molar ratio of 1.636 can be obtained. The XRD spectrum and SEM photos of the product are as follows figure 2 and Figure 6 .

Embodiment 3

[0031] 7.0845g of Ca(NO 3 ) 2 Dissolve in 50mL deionized water, and add 50mL (NH 4 ) 2 HPO 4 solution, make the calcium-phosphorus molar ratio in the system be 1.500, react at room temperature, maintain the pH value of the system at 11.0 with ammonia water, stir for 24 hours, and age for 24 hours to obtain a reaction product mixed solution, and then add Ca(NO 3 ) 2 solution, so that the Ca / P molar ratio of the system reaches 1.667. After stirring evenly, age for another 24 hours, filter, wash and dry. Then calcined at 900°C for 2 hours, then lowered to room temperature with the furnace, and after grinding, a hydroxyapatite powder with a Ca / P molar ratio of 1.667 can be obtained. The XRD spectrum and SEM photos of the product are as follows image 3 and Figure 7 .

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Abstract

A method for preparing composite calcium phosphate powder belongs to the field of medicinal material preparation. The powder is hydroxyapatite composite powder, Alpha-calcium phosphate / hydroxyapatite, or Alpha-calcium phosphate / Beta-calcium phosphate / hydroxyapatite composite powder, has a mole ratio of Ca / P higher than 1.500, lower than or equal to 1.667. The preparation process includes the following steps: mixing calcium source solution and phosphorus source solution at a Ca / P mole ratio of 1.500, stirring at the room temperature and aging for 1-48 hours; adjusting the pH value to 7.0-12.0 to obtain calcium phosphate precursor suspension; adding calcium source solution until the Ca / P ratio is higher than 1.500-1.667; continuously aging for 1-48 hours to obtain the complex phase calcium phosphate or the hydroxyapatite precursor; heat-treating at a temperature of 1,000 DEG C for 1-24 hours; cooling in the furnace; and grinding to obtain the powder. The method has the advantages of high processing controllability, environment friendliness and low cost.

Description

Technical field: [0001] The invention belongs to the field of biological material preparation, in particular to a method for preparing biomedical calcium phosphate composite powder. Background technique: [0002] The calcium-phosphorus ratio and crystal structure of hydroxyapatite are the same as the inorganic substances in human bones. It is non-toxic, harmless, and non-carcinogenic. It has good biological activity and biocompatibility, and can induce new bone growth and formation. Applied to the repair and reconstruction of biological hard tissues. The calcium-phosphorus ratio of α-tricalcium phosphate (α-TCP) and β-calcium phosphate (β-TCP) is 1.5, which is close to that of normal bone tissue. They are two biodegradable and bioabsorbable active ceramics with good biophase capacity and osteoinductivity. [0003] There are many methods for preparing calcium phosphate compounds, and traditional methods include hydrothermal method, sol-gel method, and chemical precipitation...

Claims

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Application Information

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IPC IPC(8): C01B25/32A61L27/12
Inventor 黄雅钦孙陆军
Owner BEIJING UNIV OF CHEM TECH
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