18 results about "Normal bone" patented technology

The invention provides a multi-column integrated biological fixation partial femoral head replacement device, and relates to the field of medical instruments. The device comprises a bone nail, an auxiliary fixing piece and a joint prosthesis, the bone nail is provided with a first end part and a second end part nailed into a femoral neck medullary cavity, and the first end part, the auxiliary fixing piece and the joint prosthesis are integrally formed; the auxiliary fixture has a first surface and a second surface in contact with the conical osteotomy femoral head to prevent sinking and lateral rotation. The joint prosthesis only replaces the cut part of the necrotic femoral head, more normal sclerotin can be reserved, trauma is small, femoral head supporting and bearing are not affected or changed, long-term stability of the joint prosthesis is guaranteed, and meanwhile future rebuilding is facilitated. In addition, the first end part, the auxiliary fixing piece and the joint prosthesis are integrally formed, so that joint prosthesis failure caused by looseness or corrosion among the first end part, the auxiliary fixing piece and the joint prosthesis can be avoided.

The present invention discloses an osteosarcoma molecular marker and its application. The osteosarcoma molecular marker is spindle and centriole associated protein 1, the amino acid sequence of which is shown in SEQ ID No: 1. Tissue sequencing revealed that the expression level of spindle and centriole associated protein 1 having the amino acid sequence of SEQ ID No: 1 was significantly higher in osteosarcoma tissue than in normal bone tissue. After knocking down the protein, osteosarcoma proliferation, invasion, and migration were significantly inhibited, and apoptosis was increased. Therefore, the molecular marker can be used as an osteosarcoma marker, playing a role in assisting the diagnosis of osteosarcoma in its early stages, enabling patients to receive timely treatment and preventing the problem of osteosarcoma metastasis.

To provide image processing programs and the like that can generate image data and images that enable more adequate evaluation and diagnosis than conventional methods. [Solution] The present invention's image processing program is characterized by causing a computer to execute the following: an image acquisition process in step S305, which acquires a plurality of image data obtained by performing CT scanning of the hip joint of a subject; an image generation process in step S310, which generates display image data for displaying a predetermined image on a display device based on the plurality of image data acquired in the image acquisition process in step S305; and a first region identification process in step S320, which identifies a first region that is a necrotic area of ​​the femur surrounded by a plurality of image data corresponding to the femur, where the CT value is greater than that of a normal bone, based on the display image data of the femur in the hip joint generated in the image generation process in step S310.

Disclosed are systems and methods for rapid generation of simulations of a patient's spinal morphology that enable pre-operative viewing of a patient's condition and to assist surgeons in determining the best corrective procedure and with any of the selection, augmentation or manufacture of spinal devices based on the patient specific simulated condition. The simulation is generated by morphing a generic spine model with a three-dimensional curve representation of the patient's particular spinal morphology derived from existing images of the patient's condition. Other anatomical structures in the patient's skeletal system are likewise simulated by morphing a generic normal skeletal model, as applicable, particularly those skeletal entities that are connected directly or indirectly to the spinal column.

The invention provides a visual bone tissue planing system, the planing system comprises a bone tissue cutting knife system and a visual bone tissue planing system, the bone tissue cutting knife system comprises a grinding head, an image acquisition device and a fluid conveying device, the fluid conveying device comprises a liquid conveying pipeline used for conveying liquid to the image collecting device and a public conveying pipeline used for outputting gas or liquid to the grinding head. The public conveying pipeline is provided with a first input branch, a second input branch and a public pipeline communicated with the first input branch and the second input branch and located on the downstream portion. The visual bone tissue planing equipment comprises an image processor, an image processing device and a visual processing device, wherein the image processor is used for displaying bone tissue images acquired by an image acquisition device and performing image processing on the bone tissue images; the power controller comprises a power control module and a fluid control module. By the adoption of the scheme, the wound surface of the grinding head entering the channel can be reduced, precise cutting of part of bone tissue is conducted synchronously when diseased tissue is observed, and excessive cutting of normal bone tissue is avoided.

According to the application of the sodium taurocholate in preparing the medicine for coordinating the metabolic balance of the bone fat, the sodium taurocholate is used for coordinating the metabolic balance of the bone fat by inhibiting the accumulation of bone marrow adipose tissues. According to the application, the bone marrow adipose tissue can be accurately targeted to inhibit abnormal accumulation of the bone marrow adipose tissue, and normal bone marrow adipose tissue is not influenced. And moreover, by inhibiting abnormal accumulation of bone marrow adipose tissues, the bone fat metabolism balance is synergistically regulated and controlled, and particularly, adipogenesis inhibition and continuous osteogenesis promotion are combined. Sodium taurocholate is an endogenous bile acid derivative, so that the safety is higher, and sodium taurocholate is a micromolecular drug, so that sodium taurocholate can be orally taken compared with the current macromolecular drug injection administration route. In the application of the sodium taurocholate in preparing the medicine for coordinating the metabolism balance of the bone fat, the volume reduction amount of bone marrow adipose tissue is not less than 40%, and the bone mass increase amount is not less than 30%.

The invention relates to the technical field of implantation orthopedics, in particular to a proximal tibia anatomical bone defect cushion block prosthesis which comprises a cushion block prosthesis structure and a lateral steel plate, and the cushion block prosthesis structure comprises an anatomical bone defect cushion block and a cage structure fixedly arranged at the bottom end of the anatomical bone defect cushion block. The lateral steel plate is arranged on the side face of the anatomical bone defect cushion block. By arranging a cushion block prosthesis structure and a lateral steel plate, an anatomical bone defect cushion block and an anatomical prosthesis with cage structures on the two sides are customized according to the condition of internal bone defects on the basis of minimum osteotomy of proximal tibia bone defects, a normal bone articular surface can be reserved, the osteotomy amount is reduced, meanwhile, normal patellar ligaments and tibial collateral ligaments are reserved, and the osteotomy effect is improved. The joint function is maintained to the maximum extent, the cushion block prosthesis structure and the lateral steel plates can provide initial stability and provide a structural foundation for long-term stability, and the hollow cage structures on the two sides can be used for bone grafting, have a bone guiding function and can promote formation of new bones.

The present invention relates to a pad for tibial bone defects, which belongs to the field of bone implantation technology. The pad comprises a main body that is pressed into the bone defect area on the inner posterior side of the tibial plateau, one side of the main body is an arcuate surface, the main body is fixedly connected to the tibial tray, the main body is a porous structure, the porosity of the main body along the length direction of the tibia increases gradually from the tibial tray to the bone bed, and the porosity of the main body along the radial direction of the tibia increases gradually from the cortical bone to the medullary cavity; the present invention utilizes the arcuate surface on the main body to match the morphology of the bone defect on the inner posterior side of the tibial plateau, so as to avoid cutting off too much normal bone, the porosity of the main body with a porous structure increases gradually from the proximal end to the distal end of the tibia along the length direction of the tibia, and the porosity along the radial direction of the tibia increases gradually from the bone cortex to the medullary cavity, the pad fits the elastic modulus of the surrounding bone tissue, effectively reduces stress shielding, can effectively support the tibial tray, and avoids various complications such as prosthesis loosening and displacement after surgery.

The invention discloses orthopedic nursing drilling equipment, belongs to the technical field of orthopedic nursing, and provides the following scheme that the orthopedic nursing drilling equipment comprises a drilling supporting mechanism, a drilling mechanism is arranged on the drilling supporting mechanism, the drilling supporting mechanism comprises two adjusting assemblies, and guide assemblies are arranged at the opposite ends of the two adjusting assemblies; a mounting cylinder is arranged on the guide assembly; the air pressure type limiting assembly makes contact with the affected part of a patient, when muscle spasm or unconscious activity of the affected part of the patient occurs, the air pressure type limiting assembly deviates, the locking state of the drilling assembly is relieved through air control, and at the moment, the adjustable alarm assembly drives the drilling assembly to recycle a drill bit and sends out a sound-light alarm signal to remind medical staff to conduct treatment in time; the situation that the drill bit continuously drills due to displacement of an affected part, and surrounding normal bone tissue, blood vessels and nerves are damaged is avoided, the problems that secondary damage is easily caused by displacement of the affected part and safety early warning is lacked are effectively solved, and therefore the safety of drilling operation of orthopedic nursing is remarkably improved.

The invention discloses a 3D printing Ti metal bone trabecular acetabulum reconstruction pile and an operation method thereof, the 3D printing Ti metal bone trabecular acetabulum reconstruction pile comprises a plurality of reconstruction piles corresponding to the ilium, the pubis and the ischium, and adaptive acetabular cup prostheses are arranged between the reconstruction piles; the reconstruction pile comprises a pile body, one end of the pile body is a conical head end, the other end of the pile body is a tail end, a hollow hole channel allowing a guide pin to penetrate through is formed in the pile body in the axial direction, holes are distributed in the side wall of the pile body, and the stable foundation of the acetabulum is expanded to normal sclerotin of the ilium, the ischium and the pubis. The reconstruction pile is arranged in the medullary cavity of the part to form stable support, the bone cement is connected with the acetabular cup prosthesis, the shape and degree of acetabular bone defects do not need to be considered, the method is suitable for reconstruction of all types of acetabular bone defects, and the problem that a traditional method is limited in adaptation range is solved.

The utility model discloses a bone connection slip sheet structure, which relates to the field of skull repair of children, and comprises a repair component, the repair component consists of a fixed part and a sliding part, and the sliding part is embedded into the fixed part and is in sliding connection with the fixed part; according to the scheme, a slide way type bone connection mode is adopted, and compared with an existing titanium steel mesh fixing and repairing mode, the first repairing sliding piece and the second repairing sliding piece which are used for connection during skull repairing or long bone fracture connection can extend in a sliding mode, the firmness degree of connection between normal bones can be guaranteed, growth of the bones of children cannot be limited, and the safety of the children is improved. The bone repairing agent is very suitable for children bone repairing.

The application relates to the technical field of implanting bone surgery, in particular to a proximal tibia anatomical bone defect pad block prosthesis which comprises a pad block prosthesis structure and a side plate, the pad block prosthesis structure comprises an anatomical bone defect pad block and a sleeve cage structure fixed at the bottom end of the anatomical bone defect pad block, and the side plate is arranged on the side of the anatomical bone defect pad block. Through the arrangement of the pad block prosthesis structure and the side plate, on the basis of minimal osteotomy of proximal tibia bone defect, the anatomical bone defect pad block and the anatomical prosthesis with sleeve cage structures on two sides are customized according to the internal bone defect condition, the normal bone joint surface can be reserved, the amount of osteotomy is reduced, the normal patellar ligament and tibial collateral ligament are reserved, the joint function is maximally maintained, the pad block prosthesis structure and the side plate can provide initial stability and provide a structural basis for long-term stability, and the hollow sleeve cage structures on the two sides can be implanted with bone, have a bone guiding effect and can promote the formation of new bone.

The application provides a template image-based bone marrow abnormal chromosome detection method, device and medium. The method comprises: acquiring a bone marrow chromosome image to be detected; determining a target category of chromosomes in the bone marrow chromosome image through a trained and tested classification model; selecting a template image corresponding to the target category from a template library, wherein the template library stores a plurality of images representing normal bone marrow chromosomes; inputting the template image and the bone marrow chromosome image into a trained and tested difference analysis model to obtain a detection result, wherein the detection result comprises identification information representing whether the chromosomes in the bone marrow chromosome image are normal or abnormal, and an abnormal type corresponding to the abnormality when the chromosomes are abnormal. In this way, the accuracy of chromosome abnormality detection can be improved.

The utility model discloses a long bone fracture dislocation reduction fixator which comprises an arc-shaped bottom provided with an arc surface, and the arc-shaped bottom supports a normal bone and a dislocation bone through the arc surface; the upper reduction forceps comprise an upper handheld end and an upper occlusion end; the lower reduction forceps and the upper reduction forceps are connected through a rotating shaft, the lower reduction forceps comprise a lower handheld end and a lower occlusion end, the upper occlusion end abuts against the arc-shaped bottom, and the lower occlusion end abuts against the malposed bone; the bone screw is arranged on a normal bone, and at least part of the bone screw extends into a dislocated bone. During reduction, the upper occlusion end abuts against the arc-shaped bottom, the lower occlusion end abuts against the malposed bone, the malposed bone is reduced to the normal position, the medullary cavity axis of the malposed bone coincides with the medullary cavity axis of the normal bone, at the moment, the malposed bone is fixed to the normal bone through the bone screw, reduction of the bone is achieved, and it is guaranteed that the fracture position does not deviate or distort any more.

The application belongs to the technical field of biology and relates to a circRNA marker for auxiliary diagnosis, prognosis diagnosis or risk stratification of acute myeloid leukemia and application thereof. The application finds that the expression level of circular RNA hsa_circ_0002782 is significantly increased relative to normal bone marrow samples, indicating that it has great potential as an AML biomarker, which provides a new and possibly more accurate method for early detection of AML, and helps timely intervention and treatment. Through development of a gene detection product based on circular RNA hsa_circ_0002782, the application realizes early diagnosis of AML at the molecular level, and this high-precision diagnostic tool can help doctors identify potential risk patients in the early stage of the disease, thereby providing a more effective personalized medical solution.

The application provides a visual bone tissue planing system, the planing system comprises a bone tissue cutting knife system and a visual bone tissue planing system, the bone tissue cutting knife system comprises a grinding head, an image acquisition device and a fluid delivery device, the fluid delivery device comprises a liquid delivery pipeline for delivering liquid to the image acquisition device and a common delivery pipeline for outputting gas or liquid to the grinding head, the common delivery pipeline has a first input branch, a second input branch and a common pipeline in communication with the two and located downstream; the visual bone tissue planing device comprises an image processor for displaying and image processing the bone tissue image collected by the image acquisition device; a power controller comprises a power control module and a fluid control module. The above scheme can reduce the trauma surface of the grinding head access channel, and simultaneously perform accurate cutting of part of the bone tissue when observing the diseased tissue, thereby avoiding excessive cutting of the normal bone tissue.

The invention belongs to the technical field of biology, and relates to a circRNA marker for auxiliary diagnosis, prognosis diagnosis or risk stratification of acute myelogenous leukemia and application of the circRNA marker. The invention finds that the expression level of the circular RNA hsacirc0002782 is obviously increased compared with that of a normal bone marrow specimen, which indicates that the circular RNA hsacirc0002782 has huge potential as an AML biomarker, thereby providing a new and possibly more accurate method for early detection of AML, and being beneficial to timely intervention and treatment. By developing a gene detection product based on circular RNA hsacirc0002782, early diagnosis of AML at the molecular level is realized, and a high-precision diagnosis tool can help a doctor to identify a patient with potential risk at the initial stage of a disease, so that a more effective personalized medical scheme is provided.

The application discloses a layered and blocked bone cement spacer and a preparation method thereof, and belongs to the technical field of orthopedic clinical treatment. After complete lesion removal, flushing and disinfection are completed, antibiotic bone cement is filled in a layered filling manner, S1: a first layer thin layer filling step: the prepared antibiotic bone cement is uniformly filled on the inner wall of a lesion gap in a thin layer smearing manner, the bone cement is fully attached to the bone wall in a soft pressing manner, a bone cement thin layer with a thickness of 2-3 mm is formed, the bone cement thin layer completely covers the inner wall of the lesion gap and is closely attached to the normal bone cortex, gaps are avoided, the layered filling manner of the thin layer and the block is adopted, the thin layer and the block are not completely fused, and slight gaps exist between the blocks, in a second operation, the thin layer can be first separated from an induction film by prying, and then the blocks are taken out one by one, without forcibly stripping, the difficulty of taking out is greatly reduced, the operation time is shortened, and the operation operation strength is reduced.