The invention discloses a full-load-bearing passenger car frame weight lightening method based on high-strength steel. By the use of 700MPa high-strength steel products, combining a reasonable wall thickness replacement formula with a finite element simulation method, the yielding strength of the structure is effectively improved, frame mass reduction is achieved by thinning the wall thickness ofsquare pipes, the energy consumption of a whole vehicle is reduced, and the driving range of the whole vehicle is increased. Only the wall thickness of the square steel is changed, the size of the outer cross section of the square steel is not changed, the original structural design change is small, the method almost has no effect, the universality of steel structure is better, and the method is beneficial to mass production. Compared with aluminum alloy, the high-strength steel has better price and better processability, and the method is beneficial to reduce the cost of an adjusting production process. By means of simulation calculation of the stiffness sensitivity based on the wall thickness of the square steel, the weight is lightened in a targeted manner on the premise that the rigidity performance of the frame is ensured.