82 results about "Griseofulvin" patented technology

This invention relates to a method of treating otitis externa, and in particular otitis externa of fungal etiology, using topical medication, including antifungal agents such as, for example fluconazole, voriconazole, itraconazole, clotrimazole, amphotericin B, caspofungin (Cancidas®), micafungin (Mycamine®), terbinafine, naftifine, butenafine, amorolfine, ravuconazole, posaconazole, flucytosine, econazole, enilaconazole, miconazole, oxiconazole, saperconazole, sulconazole, terconazole, tioconazole, nikkomycin Z, anidulafungin (LY303366), nystatin, pimaricin, griseofulvin, ciclopirox, haloprogin, tolnaftate, and undecylenate.

The invention relates to a method for removing griseofulvin in biological medicine waste residues. The method for removing the griseofulvin in the biological medicine waste residues specifically comprises the following steps of (1) a pretreatment process including the sub-steps that (1-1) the to-be-treated biological medicine waste residues containing the griseofulvin is mixed with water, and waste residue slurry with the solid content being 5%-45% is prepared through slurry mixing and dispersing, and (1-2) the waste residue slurry is sterilized; and (2) a catalytic and oxidative degradation process, specifically, catalytic and oxidative degradation is conducted by adding an oxidative and catalytic agent into the sterilized waste residue slurry, and then filtering separation and drying are conducted. Compared with the prior art, a wet catalytic and oxidative treatment integrated technique is used for removing the griseofulvin left in the waste residues, the removal rate is high, secondary pollutants are avoided, and harmless treatment is achieved; the concentration of the griseofulvin left in the waste residues can be rapidly decreased to 0-50 ppm from the original 1000-5000 ppm, the mass reduction rate of the biological medicine waste residues is smaller than 10%, and the method has extremely good application prospects.

The invention discloses a culture medium for producing fermentation by fermentation, which comprises a seed culture medium and a fermentation medium. In the process of fermentation culture, when total sugar reduces to 2.0-3.0%, a feed supplement culture medium is added; and corn is used as a main carbon source to prepare the fermentation culture medium. Preferentially, the seed culture medium and the feed supplement culture medium are also prepared by using the corn as the main carbon source. Since the price of corn flour is much lower than that of rice flour, the production cost is greatly reduced; in addition, the corn flour has sufficient supply and stable quality, thereby ensuring the stability of fermentation production.

The invention belongs to the technical field of Chinese and western medicinal compounds, and in particular relates to a Chinese and western medicinal composition for treating empyrosis, which comprises the following Chinese medicaments or western medicaments in part by weight: 80 to 120 parts of golden thread, 800 to 1,200 parts of medicinal charcoal, 8 to 12 parts of borneol, 80 to 120 parts of elephant's hide, 60 to 90 parts of chloramphenicol, 3 to 7 parts of vitamin B2, 80 to 120 parts of furazolidone, 230 to 270 parts of oxytetracycline and 30 to 70 parts of griseofulvin. The Chinese and western medicinal composition can stop pain quickly, clear away heat and toxic materials, eliminate stasis to subdue swelling, remove slough and promote the growth of tissue regeneration and repair tissue epithelium quickly, has high cure rate and low cost (the cost is 1/20 of regular hospitals), and is not limited by prophetical environment during treatment; and particularly, the Chinese and western medicinal composition has the unique advantage on the aspect of treating diabetes empyrosis patients, namely the blood sugar is not needed to be controlled, the patients are bound up by thickening, the healing time is shortened greatly, and the diabetes empyrosis patients can be basically synchronous with normal empyrosis patients.

The invention discloses a preparation method of an avermectin-griseofulvin composite nano-emulsion pesticide. The avermectin-griseofulvin composite nano-emulsion pesticide is prepared from 10 parts of avermectin, 5-15 parts of griseofulvin, 100-200 parts of an oil phase, 20-40 parts of an emulsifier and 10-15 parts of a co-emulsifier. Compared with the prior art, the avermectin-griseofulvin composite nano-emulsion pesticide has the characteristics of good medicinal stability, strong medicinal effects and long action period. The avermectin-griseofulvin composite nano-emulsion pesticide has stomach poisoning and contact toxicity effects on mites and insects, is mainly used for killing internal and external parasites of livestock and poultry and injurious insects of crops, and can prevent and control a plurality of injurious insects such as parasitic red insects, dipteran, coleopteran, lepidopteran and pest mites on a plurality of crops such as orange, woods, cotton, vegetables, tobacco and paddy rice.

The invention discloses a preparation method of griseofulvin. The preparation method comprises the following steps of: A, heating griseofulvin fermentation liquor, adding calcium oxide to adjust the PH, carrying out solid-liquid separation by using a sheet frame, adding calcium oxide to a filter cake to granulate, and extracting by using acetone to obtain a griseofulvin acetone extracting solution; B, decoloring the griseofulvin acetone extracting solution by using an active carbon column to obtain a griseofulvin decoloring solution, feeding the decoloring solution into a concentration tank, and crystallizing by concentrating to obtain wet griseofulvin crystals; and C, washing the wet griseofulvin crystals once by using a dichloromethane and ethanol mixed solution while stirring, then washing the wet griseofulvin crystals once by using medicinal ethanol with the concentration of 95 percent while stirring, drying the crystals by using a vacuum drier, and carrying out superfine grinding on the dried crystals to obtain the griseofulvin product. Compared with a traditional preparation method, the preparation method disclosed by the invention has the advantages that the crystallization times in the process of preparing the griseofulvin in the prior art is reduced, the yield loss caused by recrystalization of griseofulvin is effectively avoided, the total yield of the griseofulvin is improved by 7-10 percent, and the production cost is greatly reduced.

The invention relates to a culture medium for producing griseofulvin through fermentation of penicillium expansum and a culture method. A seed culture medium for producing griseofulvin through fermentation of penicillium expansum, a carbon source and a nitrogen source in a fermentation culture medium and the best compatibility proportion are confirmed. With the adoption of the formula of the culture medium and the fermentation control process, the fermentation unit of griseofulvin can be increased, the fermentation cost can be reduced, raw materials and auxiliary materials are reduced to the largest extent, are free of environmental influence and can be sufficiently supplied, and stable and efficient production of griseofulvin is realized.

The present invention is a topical skin preparation for treatment of fungal infections of the skin and nails. The preparation comprises triacetin in combination with one or more antifungal agents. In a preferred form, the preparation comprises a combination of the antifungal agents tolnaftate and grisiofulvin are used in combination with triacetin. The concentrations of these constituents are 40 to 50% concentration triacetin, 30 to 50% acetone, 0.5-3.0% concentration tolnaftate and 0.5-4.0% concentration grisiofulvin, in one preferred embodiment. Other compounds, such as ethyl alcohol, acetone, amino acids such as n-acetylcysteine, and herbal additives may also be added to the preparation. Further, other antifungal agents such as nystatin, clortimazole, econazole, ketoconazole, miconazole, solconazole, oxiconizole, naftifine, terbinafine, and butenafine, for example, may be substituted for the antifungal agents tolnaftate and grisiofulvin. The preparation of the present invention is effective in treating immune compromised patients and those with diabetes, as well as relatively healthy persons.

The invention discloses a method for producing penicillium griseofulvum, a main ingredient of Songgang mycin, through microbial fermentation. The method comprises the following steps: fermenting and culturing penicillium griseofulvum FH1816, to obtain penicillium griseofulvum from a fermented product, wherein the preservation number of the penicillium griseofulvum FH1816 in the China Center for Type Culture Collection is CCTCC NO:M 2018187. The provided penicillium griseofulvum FH1816 is used to produce the penicillium griseofulvum, a material route using no lactose or corn syrup and the novelprocess of feeding in batches, supplementing chlorine and fermenting are adopted, the fermentation potency of the penicillium griseofulvum is greatly improved, the production cost is lowered, and themethod provides reliable material sources for developing the antifungal biopesticide, namely the Songgang mycin.

The invention discloses a griseofulvin-producing strain and application thereof. The invention provides Penicillium griseofulvum FH1816, which has a preservation number of CCTCC NO: M 2018187 in ChinaCenter for Type Culture Collection. The Penicillium griseofulvum FH1816 provided by the invention is utilized to produce griseofulvin, a raw material route without using lactose and corn syrup and anew process of fed-batch fermentation with continuous feeding of chlorine are adopted, the fermentation potency of griseofulvin can be greatly increased, and the production cost can be reduced, and areliable raw material source is provided for development of the antifungal biopesticide songgangmeisu.

The invention discloses a water glass anti-staling agent for eggs. The water glass anti-staling agent comprises water glass, vitamin C, griseofulvin and water. The water glass anti-staling agent of the invention has the advantages of reasonable formula, good usage effect and low production cost.

The invention discloses a griseofulvin production strain culture medium. The griseofulvin production strain medium is prepared from the following raw materials in parts by weight: 700-900 parts of water, 35-70 parts of corn flour, 3-4 parts of potassium dihydrogen phosphate, 1-2 parts of sodium chloride, 1-1.5 parts of potassium chloride, 1-1.5 parts of ammonium sulfate, 1-2 parts of sodium nitrate, 1-2 parts of ferrous sulfate and 3-5 parts of calcium carbonate. By using the griseofulvin production strain culture medium for producing a griseofulvin production strain, the quality is stable, the reproductivity is high, the cost is low, and economic benefits are significant.

The invention discloses a medicine for treating burns and scalds, acne rosacea and acnes. The medicine is prepared from the following raw materials: radix stemonae, Chinese blister beetle, semen arecae, bletilla striata, rhizoma arisaematis, cortex pseudolaricis, radix angelicae, rhubarb root, asarum, nux vomica, realgar, alumen, borneol, gleditsia sinensis lam, plantain herb, cortex dictamni, monkshood, radix aconiti agrestis, oldenlandia diffusa, sulphur, camphor, mint, angelica sinensis, schisandra chinensis, honeysuckle, flowers carthami, frankincense, coptis chinensis, myrrh, musk, gentamicin, erythrocin, tetracycline, chloromycetin, dexamethasone, oxytetracycline, nysfungin, griseofulvin, vitamin B1, vitamin B2, vitamin C, vitamin B6, hemostatic acid, sulfanilamide, vitamin K3, salicylic acid ester and a sulfanilamide ointment. The medicine disclosed by the invention is capable of treating burns and scalds, and has the characteristics of good curative effect and small side effect.

The invention provides a nano-emulsion insecticide including: 1-2 parts of cyhalothrin, 0.1-0.6 parts of spinosad, 0.2-0.9 parts of sophocarpidine, 11-21 parts of a nano titanium dioxide, 200-310 parts of soya bean oil, 52-71 parts of yolk lecithin, 11-17 parts of n-butyl alcohol, 0.2-0.6 parts of Tween, 10-11 parts of abamectin and 5-15 parts of griseofulvin. Compared with the prior art, the nano-emulsion insecticide is low in cost and simple in processes, has excellent insecticidal effect even under very low dosage, has long lasting time and has low damage on ecological system.

The invention discloses a griseofulvin strain solid medium. The griseofulvin strain solid medium is prepared from the following raw materials in parts by weight: 100-150 parts of potato starch, 20-30parts of sucrose, 2-4 parts of monopotassium phosphate, 3-4 parts of potassium chloride, 1-2 parts of sodium nitrate, 0.4-0.5 part of magnesium sulfate, 0.01-0.02 part of ferrous sulfate and 15-25 parts of agar. The medium is smooth in surface, moderate in hardness and uniform in inoculation; strains cultured by the medium are full in bacterial colony, white in color, round in shape, large in spore quantity, good in spore synchronization and stable in strain fermentation unit; and the medium is convenient to prepare, simple and easy to learn and high in work efficiency.

An ointment for treating beriberi is prepared through pulverizing propolis by 40-60 meshes, immersing it along with flavescent sophora root, ciccada slough and shrubalthea bark in alcohol, sealing for 7 days while stirring once each day, filtering, mixing with royal jelly, mint oil and griseofulvin, and sealing for 3 days. Its advantages are radically treating and no recurrence.

The invention discloses a method for performing induced mutation on griseofulvin strain through diethyl sulfate and ultraviolet rays. The method comprises the following steps: firstly, crushing selected bacterial colony through glass balls, preparing spore suspension, sucking 1ml of single spore suspension, diluting to obtain a contrast, and adding filtrate to double discs in which a diethyl sulfate containing culture medium is prepared in advance; uniformly irradiating for 30mn through the ultraviolet rays, covering with a black cloth, diluting with sterile water, uniformly applying onto a flat vessel to obtain a single bacterial colony, transferring the single bacterial colony into a constant-temperature box for culturing, selecting a mitogenetic single bacterial colony 8 days after thebacterial colony grows, and transferring the mitogenetic single bacterial colony into a bevel for culturing for 8 days; transferring the manure bacterial colony into a shake flask for primarily screening, selecting 10 bevels of which the potency unit is 3% more than the beginning bacterial colony, transferring the bevel, culturing until the bacterial colony is manure, and screening again through the shake flask; selecting 5 bevels with relatively high unit after screening again, burying the bevels with corresponding numbers into sandy soil, and storing. With the adoption of the method, the fermenting unit can be further increased; and the strain can remain outstanding properties.

A medicine for treating beriberi is prepared from 10 raw materials including borneol, realgar, sulfur, chlorpheniramine, benadryl, griseofulvin, VB1, etc.

The present invention relates to a preparation process of ganoderma spore skin ointment. It is characterized by that in the skin ointment made up by using ganoderma spore powder, a banana peel solvent is added, and its raw material composition includes an erythromycin ointment, a urea ointment, a sulphur ointment, 20 tablets of metronidazole and 10 tablets of griseofulvin.