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Compound external remedy for treating psoriasis

A compound prescription and medicament technology, applied in the field of compound external medicaments, can solve the problems of unsatisfactory treatment effect, easy recurrence, toxic and side effects of superficial mycosis, and achieve the effects of reducing treatment cost, improving curative effect, and reducing toxic and side effects.

Inactive Publication Date: 2005-03-30
李跃亨
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to: for the problem of unsatisfactory treatment curative effect of superficial fungal disease, easy recurrence, and existing medicines have certain toxic and side effects, the application provides a method for treating tinea manus, pedis, jock corporis, and tinea versicolor, which can improve A compound topical medicine that can reduce the curative effect, reduce toxic and side effects, shorten the course of treatment, reduce the cost of treatment, and effectively prevent recurrence

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1 butenafine hydrochloride cream

[0030] Formula: (1) butenafine hydrochloride 10g, (2) ketoconazole 10g, (3) propylene glycol 100g, (4) 2% sodium hydroxide aqueous solution 60g, (5) white petrolatum 90g, (6) liquid paraffin 200g , (7) octadecyl alcohol 50g, (8) glyceryl monostearate 50g, (9) propyl p-hydroxybenzoate 0.5g, (10) menthol 5g, (11) polyoxyl stearate (40 ) ester 30g, (12) methyl p-hydroxybenzoate 0.5g, (13) distilled water 394g.

[0031] Preparation method: Mix (2)(3)(4)(5)(6)(7)(8)(9) and (10), put in a water bath at 70°C-80°C and stir to dissolve, then add (1) Stir to dissolve and keep the temperature at 70°C-80°C, this is the oil phase; add (11) (12) to (13) to dissolve and keep the temperature at 70°C-80°C, this is the water phase; slowly add the water phase to the oil phase, stir vigorously while adding to emulsify completely, and cool down.

Embodiment 2

[0032] Embodiment 2 butenafine hydrochloride spray

[0033] Formula: 10g of butenafine hydrochloride, 50g of salicylic acid, 200g of propylene glycol, 300g of ethanol, and 440g of distilled water.

[0034] Preparation method: Weigh 10 g of butenafine hydrochloride, dissolve it in 200 g of propylene glycol; weigh 50 g of salicylic acid, dissolve it in 300 g of ethanol, add 440 g of distilled water; add the butenafine solution into the salicylic acid solution, and stir evenly Quickly subpackage and seal tightly.

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PUM

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Abstract

An externally-applied compound medicine in the form of ointment, cream, lotion, liniment or aerosol for treating skin tinea is prepared from butenafine hydrochloride, other antifungal medicines (salicylic acid, spirofulvin, amorolfine, etc), and assistant.

Description

technical field [0001] The invention relates to a compound external medicament for treating skin fungus infections such as tinea manus, pedis, jock corporis and tinea versicolor. Background technique [0002] Superficial fungal infection is very common in the world, and clinically mainly divided into tinea manuum, tinea pedis, tinea corporis, and jock itch. Fungal skin infections are mainly caused by three dermatophyte genera: Trichophyton, Microsporum, and Epidermophyton. Tinea manus and pedis are mainly caused by Trichophyton crimson rubrum and Trichophyton mentagrophytes, and tinea corporis is mainly caused by Trichophyton crimson rubrum, Trichophyton mentagrophytes and Epidermophyton flocculum. Fungal infection is highly contagious. When the body comes into contact with joint conidia produced by dermatophyte hyphae, it will be infected. Since joint conidia can survive in the scales of the skin and hair for many years, fungal infections are difficult to cure and often ea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/137A61K31/60A61K45/00A61P17/00A61P31/10
Inventor 李跃亨马丽芳姜涛李莉
Owner 李跃亨
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