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124 results about "Cost of treatment" patented technology

Method and system for providing medical decision support

A medical information management system is disclosed comprising at least one patient record repository that includes information identifying treatments and corresponding outcomes for a plurality of different patients. The system further comprises a query generator for generating a message to acquire information concerning a medical condition of a particular patient from the record repository. The query message initiates the acquisition of information from the record repository including data identifying, (i) a group of patients and a number of patients in a group, (ii) those attributes of the patients in the group which are similar to attributes of the particular patient and, (iii) different treatments associated with a medical condition employed by the patients in the group. The system further includes a data analyzer for analyzing the information acquired by the query generator to provide analysis results including (1) mortality of the patients of the group, (2) the length of patient stay in a healthcare facility of the patients of the group and (3) the cost of treatment incurred by the patients of the group.
Owner:SIEMENS MEDICAL SOLUTIONS HEALTH SERVICES CORPORAT

Prostatic hormonal implants treatment of prostate cancer

InactiveUS20030147936A1BiocideOrganic active ingredientsIntermediate riskWhole body
An improved method and products for the primary hormonal treatment of early stage, low and intermediate risk prostate cancers by prostatic implants of androgen suppressive drugs formulated as fused with a lipoid carrier or encapsulated in microcapsules or in Silastic capsules is provided. Such prostatic implants renders a constant slow-release of their contents to the prostate for extended periods by biodegradation and diffusion. It facilitates higher prostatic and lower systemic concentrations of androgen suppressive hormones. Because of their high prostatic and lower systemic concentrations, tumor control is much improved and the their systemic toxicity is minimized. Tumor control after such primary hormonal implant treatment is followed by clinical examinations and the biochemical tumor control is followed by periodic estimations of serum levels of PSA and acid phosphatase. More complex and expensive surgery or radiation therapy for this group of good prognostic early stage prostate cancer is reserved for those patients failing to this primary hormonal treatment. It will preserve potency more than by surgery or radiation therapy. Furthermore, it would reduce the cost of treatment for early stage prostate cancer significantly. Androgen suppressive hormonal implants to the prostate before, during or after lower dose conventional radiation therapy would also facilitate equal or better cure rates of localized prostate cancer as compared to the more complex and toxic higher dose radiation therapy.
Owner:SAHADEVAN VELAYUDHAN

Method for extracting lithium and other alkali metal elements from lepidolite mineral

The invention discloses a high-temperature mineral phase reconstruction method for extracting lithium and other alkali metal elements from lepidolite mineral, comprising the following steps: mixing raw materials, pelletizing, calcining at high temperature, water quenching, ball milling, dissolving out, producing compounds and the like. The invention teaks raw mineral component composition to design target reconstruction mineral and composition to obtain the purpose of optimizing processes, lowering energy consumption and cost of treatment process and efficiently extracting lithium, potassium, rubidium, caesium and the like. Silicon and aluminum in lepidolite can enter anorthite type mineral phase (CaO.Al2O3.2SiO2, (Ca, Na)O. (Al, Si)2O3.2SiO2) and calcium ash quarry phase (CaO.SiO2) after mineral phase reconstruction, and do not dissolve in water and aqueous solution. After mineral phase reconstruction reaction, fluorine in lepidolite enters calcium fluoride mineral phase and does not dissolve in water and aqueous solution. Lithium and other alkali metal elements in lepidolite enter salt (chloride, sulfate) or alkali (hydroxide) phase of lithium and other alkali metal elements after mineral phase reconstruction reaction and can be dissolved in water and aqueous solution.
Owner:CENT SOUTH UNIV

Compounds and methods for modulating expression of gccr

The present disclosure describes short antisense compounds, including such compounds comprising chemically-modified high-affinity monomers 8-16 monomers in length. Certain such short antisense compound are useful for the reduction of target nucleic acids and / or proteins in cells, tissues, and animals with increased potency and improved therapeutic index. Thus, provided herein are short antisense compounds comprising high-affinity nucleotide modifications useful for reducing a target RNA in vivo. Such short antisense compounds are effective at lower doses than previously described antisense compounds, allowing for a reduction in toxicity and cost of treatment. In addition, the described short antisense compounds have greater potential for oral dosing.
Owner:IONIS PHARMA INC

Exhaust gas treatment system

In an exhaust gas treatment system, dust in a high temperature exhaust gas is caught by a high temperature dry electrostatic precipitator, a nitrogen oxide NO2 in the exhaust gas is removed by denitration means, then the exhaust gas is cooled by an air heater, and the exhaust gas is passed through an activated carbon fiber layer of activated carbon treatment means to remove sulfur oxides SO2 and SO3 contained in the exhaust gas. The exhaust gas treatment system reduces the costs of treatment and equipment, and downsizes the system.
Owner:MITSUBISHI HEAVY IND LTD

Treatment method for paint spraying waste gas

The invention belongs to the technical field of environmental protection and discloses a treatment method for paint spraying waste gas. The method is characterized in that paint spraying waste gas is treated through a circulating concentration manner, namely after large-flow and low-concentration gas discharged from a spraying chamber is treated by paint mist, most of the gas is circulated to the spraying chamber, and a small amount of the gas is discharged after being purified; and as paint spraying is performed, the concentration of gas in the spraying chamber increases gradually, and then large-flow gas is concentrated into small-flow gas to be purified, so that the purification efficiency, the stability and the security of waste gas can be improved advantageously, and the investment and running cost of treatment equipment can be reduced at the same time. The method has the advantages that the discharge flow rate of waste gas can be reduced, and paint spraying waste gas can be treated effectively to meet the national requirements of discharge of 'three wastes'.
Owner:ZHEJIANG HUANTAI ENVIRONMENTAL PROTECTION EQUIP

Comprehensive utilization method of wastewater containing phosphorus and fluorine

The invention relates to the field of wastewater comprehensive utilization, and particularly relates to a comprehensive utilization method of wastewater containing phosphorus and fluorine. The comprehensive utilization method comprises the following steps: carrying out twice neutralization on the wastewater containing phosphorus and fluorine, and controlling the final pH value after each time of neutralization; separating calcium fluoride from wastewater according to the solubility product of calcium fluoride and calcium orthophosphate, so as to enable the main ingredients of wastewater to be calcium orthophosphate and silica gel; separating silica gel by centrifugal separation to obtain a waste liquid containing phosphorus; carrying out secondary neutralization on the waste liquid containing phosphorus to enable the pH value to be 4-7; after generating calcium hydrophosphate, carrying out cooling crystallization treatment; separating calcium hydrophosphate to obtain a clear liquid, so as to realize treatment on wastewater containing phosphorus and fluorine. By adopting the comprehensive utilization method, maximal reutilization of the phosphorus fluorine resource is realized, the by-product silica gel is generated, the product additional value is increased, and the cost of treatment on wastewater containing phosphorus and fluorine is reduced.
Owner:GUIZHOU KAILIN GRP CO LTD

Thin plate combined type photocatalyst carrier structure

InactiveCN101096014ALarge UV-irradiated specific surface areaLow investment costCatalyst carriersUltraviolet lightsUltraviolet irradiation
The invention discloses a thin-plate combined photocatalyst carrier structure, comprising several thin plates and ultraviolet light source. Several thin plates are arranged in laminated shape on the vertical axis direction of ultraviolet light source. Ultraviolet light source passes through the middle part among thin plates. Photocatalyst is carried on the surface of each thin plate and gaps for fluid flow are provided among thin plates. The photocatalyst carrier structure can make full use of linear propagation characteristic of ultraviolet light and make photocatalyst carrier obtain ultra-large ultraviolet irradiation ratio surface area. At the same time by adding the number of thin plates or developing blade dimension of thin plate arranging position of thin plate can be adjusted correspondingly to obtain larger ultraviolet irradiation ratio surface area. After the thin-plate combined photocatalyst carrier structure is applied in contamination treatment system, higher treating efficiency can be obtained. The invention provides technical support for practical application of contamination treatment system by photocatalyst. At the same time invest and use costs of treatment system are decreased.
Owner:杨小明

Method and system for providing medical decision support

A medical information management system is disclosed comprising at least one patient record repository that includes information identifying treatments and corresponding outcomes for a plurality of different patients. The system further comprises a query generator for generating a message to acquire information concerning a medical condition of a particular patient from the record repository. The query message initiates the acquisition of information from the record repository including data identifying, (i) a group of patients and a number of patients in a group, (ii) those attributes of the patients in the group which are similar to attributes of the particular patient and, (iii) different treatments associated with a medical condition employed by the patients in the group. The system further includes a data analyzer for analyzing the information acquired by the query generator to provide analysis results including (1) mortality of the patients of the group, (2) the length of patient stay in a healthcare facility of the patients of the group and (3) the cost of treatment incurred by the patients of the group.
Owner:SIEMENS MED SOLUTIONS HEALTH

Composite catalyst used for industrial wastewater treatment via electrolytic oxidation, and preparation method thereof

The invention discloses a composite catalyst used for industrial wastewater treatment via electrolytic oxidation, and a preparation method thereof, and belongs to the field of waste water treatment via electrolysis. The composite catalyst comprises a catalyst carrier and active components, wherein sulfonated polystyrene resin is used as the catalyst carrier, and metal ions including Fe<2+>, Mn<2+>, Cr<3+>, and Cu<2+> are taken as the active components. According to the preparation method, loading of the active component metal ions on the sulfonated polystyrene resin carrier is realized via ion exchange so as to obtain a catalyst precursor A, a catalyst precursor B, a catalyst precursor C, and a catalyst precursor D; and the catalyst precursors are mixed. The composite catalyst used for industrial wastewater treatment via electrolytic oxidation possesses following advantages: catalytic activity is high; dispersity of the active components is high; sulfuration performance is excellent; carrier true density is low; the composite catalyst possesses corrosion resistance; cost of treatment of waste water, which is difficult for biodegradation, is low; COD treatment efficiency is high; and service life is relatively long. The composite catalyst can be used as a filling material of electrolytic oxidation equipment for electrolytic oxidation of waste water, which is difficult for biodegradation; and waste water COD removal ratio is 75% or more.
Owner:CHINA PETROLEUM & CHEM CORP

Automatic hydrating device for invalids and the disabled

A water bottle and dispenser system that allows a measured quantity of water to be supplied to the patient's mouth automatically. The delivery of the water can be timed for any convenient interval. There is no need for specialized needles and other paraphernalia related to an IV, and no specialized training is needed to install and operate the device. This means that a homeowner can use this device for a patient at home, which will reduce the cost of treatment.
Owner:DURON SMITH OLIVIA

Dental appliances and systems and methods for distributing dental appliances

Dental appliances and systems and methods for distributing dental appliances are provided. The dental appliances may be worn within a mouth of a patient to treat a dental condition. The dental appliances may be distributed to the patient through various venues. The venues range from those in which the patient has direct contact with a care provider to those in which the patient is able to independently determine an appropriate dental appliance to treat the dental condition. As a result, the amount of interaction between the patient and a care provider is significantly reduced, as well as an overall cost of treatment. The time necessary for appointments, if any, is also reduced and / or eliminated.
Owner:ORTHO TAIN INC

Method for preparing flash glazed wall tile

ActiveCN103102181AGlitter naturalRich lusterFurnace typesClaywaresCold airCombustion
The invention discloses a method for preparing a flash glazed wall tile. The flash glazed wall tile is prepared from the following roller kiln; the roller kiln is composed of a kiln chamber, combustion equipment, a ventilating device, and conveying equipment; the kiln chamber enters a brick outlet from a brick inlet, and orderly comprises a heating section and a cooling section; the heating section orderly comprises a preheating section, an oxidization section and a firing section; a vibrating cold air pipe is arranged above a tile conveying surface of the preheating section; a blow hole is formed on the cold air pipe; and the air outlet direction of the blow hole tipsily blows downwards at 30-60 degrees. Crystals of glisten glaze are obtained by furnace transmutation of kiln waste gas; the waste is changed into a valuable resource; the problem that the kiln waste gas pollutes the environment is solved; the cost of treatment of the kiln waste gas is reduced; the method is simple to operate and easy to control; and the prepared flash glazed wall tile is stable in performance and unique in effect.
Owner:FOSHAN DONGPENG CERAMIC +3

A method for recovering and reusing waste lithium ion battery

The invention relates to a method for recovering and reusing waste lithium ion batteries, comprising the following steps: (1) placing the waste lithium ion batteries in an airtight box for disassembling to obtain an active positive electrode sheet; 2, collectING that active positive electrode sheet, and cleaning the active positive electrode sheet with deionize water and ethanol; (3) drying and recycling the washed materials; (4) at room temperature, adding appropriate amount of dried material into o-phenylphenol solution, and then adding a certain amount of potassium persulfate complex salt to generate SO4-. to oxidize and degrade o-phenylphenol. Compared with the prior art, the invention has the advantages of short aging time and simple operation, on the one hand, the problem of environmental pollution caused by waste lithium ion battery and secondary pollution caused by metal extraction is solved; On the other hand, it is used in the treatment of refractory sewage, which saves the cost of treatment and creates environmental benefits.
Owner:SHANGHAI UNIVERSITY OF ELECTRIC POWER

Deep-treatment and reusing system and method for industrial standard-meeting externally-discharged wastewater

The invention relates to a deep-treatment and reusing system and method for industrial standard-meeting externally-discharged wastewater, and belongs to the technical field of water treatment. The system comprises an ultrafiltration device, a nanofiltration device, an electroadsorption device and a coagulation / electrocoagulation / enzyme electropolymerization-electrocoagulation device; an ultrafiltration fresh water outlet is successively communicated with the ultrafiltration device and the electroadsorption device; concentrated water of the ultrafiltration device and concentrated water of the nanofiltration device are communicated with the coagulation / electrocoagulation / enzyme electropolymerization-electrocoagulation device. The system can further include a reverse osmosis device; a water inlet of the reverse osmosis device is communicated with a water outlet of the electroadsorption desalting device, and a concentrated water outlet of the reverse osmosis device is communicated with an inlet of the coagulation / electrocoagulation / enzyme electropolymerization-electrocoagulation device. The industrial standard-meeting externally-discharged wastewater can be used for water supplementary in industrial circulating water and circulating cooling water after being treated by the system, and can also be further used for boiler water feeding after reverse osmosis treatment. The system removes various pollutants in the wastewater to a largest extent, and lower the cost of treatment.
Owner:INST OF PROCESS ENG CHINESE ACAD OF SCI

Traditional Chinese medical decoction for treatment of tuberculous pleural effusion

The invention discloses traditional Chinese medical decoction for treatment of tuberculous pleural effusion. According to the theory of traditional Chinese medicine, pleural effusion is considered as qi stagnation and blood stasis caused by clogging of main and collateral channels, phlegm and wetness. Traditional Chinese herbs with the effects of promoting blood circulation to remove blood stasis, clearing and activating the channels and collaterals and eliminating phlegm to stimulate the appetite are selected in the traditional Chinese medical decoction, including poria cocos, coninshaped blueberry branchlet and leaves, rhizoma alismatis, cortex periplocae, fructus aurantii immaturus, semen brassicae, fritillaria cirrhosa, orange peels, areca catechu, herba lycopi, tripterygium wilfordii, licorice, ginseng, gecko, lily, rhizoma polygonati and semen euryales. The materials are brewed into the decoction. Results of clinical trials show that the total efficiency is 96.8 percent which issignificantly higher than the total efficiency of a control group. Moreover, the cost of treatment is low, no side effects can be caused, and the decoction is worth promoting.
Owner:孙毅

Method of producing sensors for monitoring corrosion of heat-exchanger tubes

The present invention relates to a method of producing the sensors for monitoring corrosion of heat exchanger tubes in a thermal power plant. The sensor is made of the tubes taken out from actual heat-exchanger. As a result, the sensor not only has the same material as the actual heat-exchanger tubes, but also has the same surface state where it contacts the working medium. Therefore, a serious technical difficulties have been solved that the sensor made by the prior art can't measure different corrosion states of actual heat-exchanger tubes, that the corrosion rate measured is different from the corrosion rate of actual heat-exchanger tubes, and that the cost of anti-corrosive treatments is high . By use of the sensor made by the present invention, the different corrosion states of actual heat-exchanger tubes can be measured, not only the rate of uniform corrosion of actual heat-exchanger tubes can be measured but also the rate of localized corrosion of the heat-exchanger tubes can be measured. Moreover, the cost of treatment of anti-corrosion can be decreased.
Owner:THERMAL POWER RES INST

Method for preparing micron fine-crystal titanium-nickle-hafnium high-temp. shape memory alloy cube matherial

The invention relates to a method to produce micrometer crystal titanium-nickel- hafnium shape memory alloy. The raw material includes 99.95% purity titanium sponge, 99.90% purity hafnium filament, and 99.95% purity nickel. Smelting in vacuum, the titanium-nickel- hafnium alloy ingot would be gained, and cutting the ingot into blank to take surface process and covered with graphite lubricant, heating the blank under the condition of 300-400 degree centigrade in heating furnace, taking equal diameter bend angle extruding process after taking out to gain the titanium-nickel- hafnium alloy block material. The invention improves the mechanical property of the alloy and decreases the cost of treatment.
Owner:SHANGHAI JIAO TONG UNIV

Claim expense early warning method and system

PendingCN108898316AImprove claims management and control efficiencyReduce claims management and control costsFinanceResourcesDiseaseComputer science
The invention relates to a claim expense early warning method and system. The method comprises the following steps: step 1, extracting the medical treatment information of the customer and the expenseinformation related to each medical treatment item from the claim request of the customer; step 2, determining the international classification of diseases corresponding to the claim request of the customer according to the medical treatment information and further determining the group to which the international classification of diseases belongs; step 3, obtaining the statistical data corresponding to the group from the medical big data, wherein the statistical data include the distribution information of the treatment expense corresponding to the group; step 4, determining whether the medical treatment expense of the customer deviates from the preset range according to that distribution information and the expense information of the customer; and step 5, performing expense warning prompting if the medical treatment expense of the customer deviates from the preset range.
Owner:PING AN HEALTH INSURANCE CO LTD

Method for treating cadmium containing soil by utilizing low-accumulation cadmium crops

The invention discloses a method for treating cadmium containing soil by utilizing low-accumulation cadmium crops. The method comprises the following steps: selecting a sweet potato variety with low cadmium absorption, high tolerance and high yield; applying lime and a ZH-type soil conditioner, adjusting the pH value and the like of soil, and restoring the soil in a polluted area; performing a mode of intercropping corn and sweet potato, and guaranteeing growth and yield of the sweet potato by adopting a special sweet potato standardized cultivation technology; and after harvesting of spring cropping and autumn cropping, performing autumn planting of the sweet potato so as to guarantee adequate yield and full utilization of land. The invention has the following beneficial effects: absorption and accumulation of crops in a cadmium polluted area to cadmium metal are reduced; the cost of treatment is low; and no secondary pollution occurs.
Owner:湖南省作物研究所

Medicament for curing cold urticaria

The invention discloses a medicine for treating cold-induced urticaria. lead. The medicine of the present invention has the advantages of no toxic and side effects, no stimulating effect, no allergic reaction, quick action, difficult relapse after curing, low treatment cost, wide source of medicine and low price. The medicine of the present invention has an effective rate of 96% in treating cold-induced urticaria, and a cure rate of 86%.
Owner:李玉珍 +2

Medicament for treating various kinds of gastroenteropathy and preparation method thereof

The invention relates to a medicament for treating various kinds of gastroenteropathy and a preparation method thereof, and belongs to the technical field of Chinese medicaments. The medicament mainly solves the problems of not good effect and high cost of treatment for gastrointestinal diseases such as cholecystitis, enteritis, chronic appendicitis, acute and chronic gastritis, gastric ulcer, duodenal ulcer, duodenal ulcer, nausea, emesia and dyspepsia by adopting Sanjiu Weitai, Wenweishu, Yangweishu, coptis teeta pills, crataegus pills and the like. The medicament is characterized in that: the medicament is prepared from the following raw materials by weight: 2 to 8 of dark common monkshood daughter root, 2 to 8 of golden thread, 30 to 50 of white paeony root, 20 to 40 of largehead atractylodes rhizome, 2 to 8 of mix-fried liquoric root, 2 to 8 of villous amomum fruit, 20 to 40 of cassia twig, 2 to 8 of cassia bark, 2 to 5 of Chinese angelica, 0.8 to 1.2 of fructus evodiae and 2 to 5 of dried ginger. The medicament has the characteristics of obvious curative effect and low cost. The medicament is particularly suitable for treating various kinds of gastroenteropathy in rural areas.
Owner:陈明阳

Bioremediation of nitrate contaminated groundwater

The invention disclosed relates to a method and apparatus for the denitrification of groundwater in situ in an aquifer under substantially anaerobic conditions, the method comprising(a) providing a network, including an extraction well for removal of groundwater from the aquifer and a plurality of injection wells for returning groundwater to the aquifer, the injection wells being arranged in a line substantially perpendicular to the direction of groundwater flow, the extraction well being located downstream or upstream of the line of injection wells, and the spacing of the wells and the number of injection wells being determined by the mathematical relationshipwhere J is the cost of treatment, CP and CI are the costs of extraction and injection wells, respectively; n is the number of injection wells, and W is the distance across the protected area, and wherein the water stream is evenly distributed between injection wells, according to the relationship:where F is the water flow rate (e-extraction well, i-injection well) and n is the number of injection wells,(b) removing groundwater from the aquifer by the extraction well,(c) adding a carbon source to the groundwater in a controlled manner,(d) returning the carbon source amended groundwater to the aquifer by the injection wells in even distribution, the water flow rate being controlled, and(e) monitoring the nitrate concentration of the groundwater removed from the extraction well, a decrease in nitrate concentration being indicative of denitrification.
Owner:NAT RES COUNCIL OF CANADA

Ceramic substrate catalyst and preparation method thereof

The invention discloses a ceramic substrate catalyst and a preparation method thereof. A potassium permanganate aqueous solution, a manganese sulfate aqueous solution and a carrier are mixed and then are subjected to high temperature sintering; the carrier is prepared by mixing the following raw materials in parts by weight: 40-60 parts of kaolin, 20-40 parts of bentonite, 10-30 parts of spinel, and 10-30 parts of a puffing agent. With fly ash and kaolin as the carrier, the catalyst capable of high-efficiency catalysis of ozone oxidation is prepared and is used for improving the ozone utilization rate and the degradation rate of ozone on organic matters which are difficult to decompose; the ceramic substrate catalyst exists in a form of solid and is easy to separate, the loss of the catalyst is avoided, and thus the cost of wastewater treatment is reduced; the ceramic substrate catalyst has the characteristics of low cost, high catalytic performance and high stability, is used for catalysis of ozone oxidation for deep treatment of wastewater, allows the wastewater to meet reuse standards, reduces the cost of treatment, contains huge environmental and economic benefits, and has relatively profound social development significance and practical value.
Owner:SHANDONG FENGYUAN CHEM CO LTD

Resource recycling method of calcium-adding drying sludge

The invention relates to a resource recycling method of calcium-adding drying sludge. The calcium-adding drying sludge comprises the following components in percentage by weight: more than or equal to 80 percent of granules with grain diameter of 5mm, less than or equal to 10 percent of organic matters, 5-20 percent of water and over 30 percent of calcium hydroxide. The calcium-adding drying sludge is mixed with cement, gravel and water uniformly according to a certain proportion to form a mixture; and the mixture is used as a roadbed material of road, cushion soil of refuse landfill, covering soil, improved soil and environmental modification basic layer to be paved on the corresponding bases. The calcium-adding drying sludge replaces inorganic materials, thereby fulfilling the aims of saving energy and reducing discharge value in the waste resource recycling process, saving natural resources, and greatly reducing the cost of treatment of the waste.
Owner:BEIJING AOLIAIDE S&T DEV

Spirulina yogurt and the production method

The invention relates to the technical field of spirulina yoghurt, in particular to a spirulina yogurt and the production method thereof. The bactericidal treatment is carried out by using ultrasonic treatment to improve the quality and taste of spirulina yogurt, and the sterilization effect is improved. Through the addition of the components of spirulina, the nutrients in the spirulina are mixed with the raw milk, which makes the prepared yogurt rich in protein, polysaccharide, fatty acid, vitamins and trace elements, thereby the health effect of spirulina yoghurt is enhanced, the growth and reproduction of bacteria is promoted in the process of yogurt fermentation, the cycle of fermentation treatment becomes short, the cost of treatment is reduced, and the addition of pigment is avoided, making better taste, better taste, fully retained nutrient content become possible. The cost of preparation of spirulina yogurt is reduced.
Owner:北海生巴达生物科技有限公司

Tumor-targeted tnf-related apoptosis-inducing ligand's variant and the application thereof

The invention belongs to the field of genetic engineering and biotechnology, and specifically discloses a design, preparation and pharmic application of a tumor-targeted TNF-related apoptosis-inducing ligand's variant. The tumor-targeted TNF-related apoptosis-inducing ligand's variant is generated by a fused protein which is consisted of the ligand of CD13, the connecting peptide and TNF-related apoptosis-inducing ligand's variant, and which is by the construction of coding gene of the variant according to the technology of genetic engineering and clone, soluble recombinant expression and ordinary separation and purification. The variant, produced by the method of preparation of the tumor-targeted TNF-related apoptosis-inducing ligand's variant, has favorable tumor-targeting characteristics and the significant enhancement of the anti-tumor effect. It is possible to reducing the required dosage of protein to the treatment effect, increasing the bioavailability, reducing the cost of treatment and overcome the potential toxic effects of the TNF-realated apoptosis-inducing ligand. Moreover, the preparation method of the tumor targeted TNF-related apoptosis-inducing ligand's variant of the present invention provides a method for producing the variant of soluble expression and high concern of polymer forms and a process of separation and purification thereof.
Owner:JIANGSU TARGET BIOMEDICINE RES INST +1
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