The invention relates to a comprehensive treatment method of arsenic-containing materials. According to the method, production of comprehensive recovery of valuable metals such as arsenic, antimony, lead, bismuth and the like from smelting dust containing the arsenic, the antimony and the lead is performed, accumulation of the arsenic in the system is reduced, and harmless treatment is performed on the arsenic. With the method, through normal pressure alkaline leaching, soluble arsenic in the dust is removed, trivalent arsenic in a leaching solution becomes pentavalent arsenic through catalytic oxidation, stable arsenic-fixing minerals are synthesized with the fractional crystallization method and then are solidified through stockpiling, leaching residues are subjected to procedures of washing, reduction smelting, oxidizing blowing and the like, and various valuable elements are recycled to the maximum extent. With the method, the arsenic is removed from the dust, the antimony, the lead, the bismuth and the like are left in the arsenic-removed residues as much as possible, and separation and harmless treatment of the arsenic and the valuable metals can be realized. According to the method, the comprehensive utilization rate of resources is high, the raw material application range is wide, the problem of pollution in the extraction process of the traditional technology is solved, and the method has the more obvious advantages for the dust produced in the lead and zinc smelting process particularly.