8 results about "Chronic gastritis" patented technology

Helicobacter pylori (HP) is a chronic bacterium that infects the gastric mucosa. It is widespread in the general population, with an infection rate between 55% and 70%. HP is closely related to gastric ulcers and gastritis. Western medicine treatment for HP infection is relatively complex, including bismuth substituents and proton pump inhibitors plus two antibiotics. Gastric ulcers and gastritis are common digestive system diseases. Compound 1, "Exterminate the Ghost," is a traditional Chinese medicine composition mainly composed of Coptis chinensis, plus Scutellaria baicalensis and Fraxinus chinensis, which can eradicate HP. Compound 2, "Ulcer Relief," is a traditional Chinese medicine composition mainly composed of Coptis chinensis, plus Rheum palmatum and Bletilla striata, which can cure gastric ulcers. Compound 3, "Gasitis Relief," is a traditional Chinese medicine composition mainly composed of Coptis chinensis, plus Glycyrrhiza uralensis or Taraxacum mongolicum, made into a tea bag, which can cure chronic gastritis.

The invention discloses a urine protein marker for diagnosing helicobacter pylori as well as application, a kit and a risk assessment model of the urine protein marker, and belongs to the technical field of biomedicine. And the protein marker is a combination of PHB1, C20orf202, CP and P0DOX5. Compared with a healthy control, the expression level of PHB1 in a helicobacter pylori patient is lowered, and the expression levels of C20orf202, CP and P0DOX5 in the helicobacter pylori patient are all increased. By detecting expression levels of PHB1, C20orf202, CP and P0DOX5, diagnosis of helicobacter pylori patients can be realized, detection capability and efficiency can be improved, intervention measures can be taken actively, and risks of diseases such as chronic gastritis, peptic ulcer, MALT lymphoma and gastric cancer can be reduced.

The invention discloses a plant composite extract for inhibiting helicobacter pylori as well as a preparation method and application of the plant composite extract, and belongs to the field of plant extracts. The plant compound extract comprises 7%-45% of sulfide volatile oil, 1%-9% of mushroom terpenoids and 10%-33% of compound polysaccharide; the plant compound extract is extracted from garlic, Chinese chive seeds, hericium erinaceus and lucid ganoderma; wherein the sulfide volatile oil is extracted from garlic and Chinese chive seeds, and the sulfide volatile oil comprises allicin; the mushroom terpenoids are extracted from hericium erinaceus and lucid ganoderma; the compound polysaccharide is extracted from garlic, Chinese chive seeds, hericium erinaceus and lucid ganoderma. Efficient bacteriostasis and mucous membrane repair are achieved through the synergistic effect of natural components, the drug resistance and hepatorenal toxicity of antibiotics are avoided, the possibility that helicobacter pylori relapses in the stomach can be effectively reduced, the traditional Chinese medicine composition is suitable for drug-resistant patients or chronic gastritis patients needing long-term conditioning, and the curative effect is good. The health-care food is a safe and effective health-care food raw material and a dietary supplement.

This invention discloses the application of a traditional Chinese medicine composition in the preparation of drugs for the prevention and treatment of gastritis. The composition comprises the following ingredients: Astragalus membranaceus, ginseng, Atractylodes macrocephala, fermented Cordyceps militaris powder, Lycium barbarum, Hedyotis diffusa, Fagopyrum dibotrys, Bistorta officinalis, Panax notoginseng, and Caesalpinia sappan. This invention is the first to discover and confirm that this traditional Chinese medicine composition can be used to prevent or treat chronic gastritis, especially chronic atrophic gastritis. Experiments have verified that it can significantly prevent or improve the pathological state of the gastric mucosa in rats with chronic atrophic gastritis. Specifically, it can significantly increase the serum pepsinogen I / II ratio, decrease gastrin-17 levels, reverse gastric gland atrophy, and repair the morphological structure of the gastric mucosa, achieving a systematic repair of the function and structure of the CAG gastric mucosa. Furthermore, the ingredients in this traditional Chinese medicine composition are rationally combined, and no obvious toxic side effects were observed under experimental conditions, demonstrating good safety and potential for long-term use.

The invention relates to the technical field of microorganisms, and particularly discloses a kit and a probiotic product for predicting, diagnosing, preventing and treating the occurrence risk of gastric diseases of a helicobacter pylori (HP) infected person. The method comprises the following steps: (1) screening specific and enriched microorganisms of each stomach disease (chronic gastritis, superficial gastritis, atrophic gastritis, intestinal metaplasia and stomach cancer) in HP infected persons, and preparing the microorganisms into a kit for predicting and diagnosing the risk of disease occurrence; and (2) screening specific or enriched microorganisms in healthy people (HP positive infected people are not likely to develop stomach diseases) infected with HP to prepare probiotic products for preventing and treating stomach diseases. HP-denier is colonized in the stomach and becomes an absolutely dominant microflora in the stomach (the abundance exceeds 50% of the total microflora), but the current antibiotic quadruple therapy enables HP to generate drug resistance. The kit and the probiotic product provided by the invention can predict, diagnose, prevent and treat stomach diseases on the premise of avoiding generation of HP or enhancing drug resistance.

This application discloses the use of naphthalene ring-based low-molecular-weight compounds. This application is the first to discover that compounds represented by general formula I have excellent therapeutic effects against various intractable diseases, including reproductive system diseases, autoimmune diseases, skin diseases, eye diseases, muscle or bone degenerative diseases, neurological diseases, anemia, adrenal diseases, chronic gastritis, myocarditis, periodontitis, hypothyroidism, alopecia, liver damage, tinnitus, and chronic obstructive pulmonary disease. Therefore, this has extremely great application value in the prevention and treatment of the aforementioned diseases.

The invention provides a medicinal composition for reinforcing primordial qi and tonifying spleen as well as a preparation method and application of the medicinal composition. The composition is prepared from 20 medicines including radix pseudostellariae, rhizoma atractylodis macrocephalae stir-fried with bran, semen coicis stir-fried with bran, poria cocos, Chinese yam, scorched hawthorn fruit, stir-fried massa medicata fermentata fujianensis, stir-fried white hyacinth beans, stir-fried malt, stir-fried rice-grain sprouts, radix astragali preparata, radix aucklandiae, pericarpium citri reticulatae, rhizoma pinellinae praeparata, platycodon grandiflorum, wine-fried rhizoma cimicifugae, pachyrhizua angulatus, Chinese dates, longan aril and donkey-hide gelatin. And adding auxiliary materials, and uniformly mixing to prepare a decocted extract. Clinical use proves that the prepared vitality-cultivating and spleen-tonifying paste can improve and relieve the symptoms of chronic gastritis such as abdominal fullness and stuffiness, poor appetite, thin sloppy stools, fatigue, poor breath and laziness to speak, and improve the symptoms of gastric mucosa erythema, erosion and bleeding. The traditional Chinese medicine can be used for treating chronic gastritis, is convenient to take, and has no adverse reaction and toxic and side effects.

The invention discloses a culture medium for colonization of intestinal flora and intestinal gas of people with chronic gastritis, and belongs to the technical field of biology. The culture medium contains yeast extract, tryptone, mucoprotein, mycoprotein, worm protein, soybean protein, casein, whey protein, vitellin, fructo-oligosaccharide, galactooligosaccharide, wheat flour, inulin, resistant dextrin, dietary fiber, sialic acid, algal oil DHA, calcium chloride, potassium chloride, sodium chloride, monopotassium phosphate and the like. By means of the bionic colon reactor, by referring to real in-vivo parameters of people with chronic gastritis, the real intestinal environment of people with chronic gastritis in China is well simulated in vitro, intestinal flora ecology and intestinal gas distribution of people with chronic gastritis reappear, and a normal intestinal microorganism and intestinal gas database of people with chronic gastritis can be constructed. The method is beneficial to accurate diagnosis and personalized treatment of intestinal microecology of people with chronic gastritis, and can better evaluate the health state of people with chronic gastritis and formulate preventive measures.