111 results about "Bifidobacterium lactis" patented technology

The present application relates to animal bifidobacterium lactis Ca360 and its application. The present application also provides the application of animal bifidobacterium lactis in promoting the absorption and transport of minerals, improving osteoporosis, iron deficiency anemia and zinc deficiency. The animal bifidobacterium lactis of the present application can promote the absorption and transport of minerals, improve osteoporosis, iron deficiency anemia and zinc deficiency.

The invention discloses bifidobacterium animalis and application thereof in allergic rhinitis products, and belongs to the technical field of microorganisms. The technical problem to be solved is that the existing common allergic rhinitis treatment means cannot meet the requirements of patients on safety, long-acting effect and treatment cycle. The invention provides an animal bifidobacterium subsp. Lactis Def +, and after an effective dose of animal bifidobacterium subsp. Lactis Def + is applied to a subject, the animal bifidobacterium subsp. Lactis Def + is found to be capable of remarkably relieving the allergic rhinitis symptom. Specifically, the symptoms of sneezing, dry nose and rhinocnesmus are reduced; the number of nasal septum mucosa intrinsic layer inflammation infiltration cells and nasal septum mucosa epithelium pathological changes are reduced; the IgA and IgE levels of serum are reduced; the levels of proinflammatory factors IL-4, IL-5 and IL-13 are reduced; the normal spleen index is maintained; the imbalance state of Th1 / Th2 and Th17 / Treg is effectively improved, and the body immunity is improved; a safe and long-acting scheme is provided for allergic rhinitis diseases.

The invention discloses a compound probiotic for improving cognitive function of old people and a preparation method and application thereof. Firstly, maltodextrin is dried and then sieved, metal impurities are removed after sieving, and maltodextrin freeze-dried powder, lactobacillus paracasei Lpc37 freeze-dried powder, phytobacterium plantarum Lp-115 freeze-dried powder and bifidobacterium animalis subsp. Lactis Bl-04 freeze-dried powder are weighed and sieved respectively; the preparation method comprises the following steps: preparing freeze-dried powder of three strains, then premixing the freeze-dried powder of the three strains with a part of maltodextrin, adding the residual maltodextrin after the strains are premixed, continuously mixing until the materials are uniformly distributed to obtain the compound probiotics, exerting a synergistic effect through a specific strain combination (Lp115 + Lpc37 + Bl-04), providing a new way for non-drug intervention, being beneficial to regulating intestinal flora metabolism (such as generating short-chain fatty acid SCFA), and improving the immunity of the human body. The synthesis and release of neurotrophic factors are promoted, the nerve cell function is improved, and the cognitive function improvement is indirectly assisted.

The invention discloses bifidobacterium animalis subsp. Lactis and application thereof in a product for enhancing athletic ability, and relates to the technical field of microorganisms. The invention provides an animal bifidobacterium subsp. Lactis MUS < + >, and the preservation number of the animal bifidobacterium subsp. Lactis MUS < + > is CGMCC (China General Microbiological Culture Collection Center) No.35626. The invention also provides a preparation method of the animal bifidobacterium subsp. Lactis MUS < + >. The animal bifidobacterium subsp. Lactis MUS + provided by the invention can increase the length of surrounding motor nerves and promote the development of the motor nerves; the total exercise distance is increased, and the exercise ability and endurance are promoted; body length or height development is promoted; muscle fibers are thickened, the muscle fiber density is increased, muscle fiber gaps are reduced, and muscle development is promoted; and the method has a very good application prospect in preparation of products for improving athletic ability or increasing muscle.

The invention discloses application of animal bifidobacterium subsp. Lactis GOLDGUT-BB21 in preparation of products for relieving depression, and belongs to the technical field of biological medicine. The probiotics disclosed by the invention can be used for relieving depressive symptoms, improving related symptoms, assisting in treating depression and preventing depression, and also can be used as a nutritional supplement to help maintain the balance of intestinal microflora and promote intestinal health.

The invention relates to a polygonatum sibiricum probiotic compound preparation with an aging delaying effect and application thereof. The compound preparation comprises a polygonatum sibiricum extract and a probiotic composition, the bacterial strains in the probiotic composition comprise a combination of a bifidobacterium animalis subsp. Lactis BLa36 bacterial strain, a bifidobacterium longum BL21 bacterial strain, a bifidobacterium adolescentis BAC30 bacterial strain, a lactobacillus plantarum Lp90 bacterial strain, a lactobacillus casei LC89 bacterial strain, a bifidobacterium breve BBr60 bacterial strain and a pediococcus acidilactici CCFM7902 bacterial strain. After the rhizoma polygonati component and the probiotic component are combined for use, the rhizoma polygonati component and the probiotic component have potential synergistic effects in the aspects of improving the intestinal flora structure, regulating the intestinal environment, delaying senescence, reducing inflammation-related symptoms and the like. Moreover, further, various probiotic strains are compounded and combined for use, so that the capability of a related compound preparation in the aspect of delaying various symptoms of senescence can also be improved in a combined manner.

The invention relates to application of bifidobacterium animalis subsp. Lactis BLa80 in preparation of a preparation for relieving depression or anxiety. The bifidobacterium animalis subsp. Lactis BLa80 is a strain of the bifidobacterium animalis subsp. Lactis BLa80 with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.22547, and the strain of the bifidobacterium animalis subsp. Lactis BLa80 is a strain of the bifidobacterium animalis subsp. Lactis BLa80 with the preservation number of CGMCC No.22547. The invention develops a brand new application of the bifidobacterium animalis subsp. Lactis BLa80 strain, namely, the bifidobacterium animalis subsp. Lactis BLa80 strain is used for relieving depression or anxiety symptoms, specifically, the bifidobacterium animalis subsp. Lactis BLa80 strain can stimulate RIN14B cells to secrete 5-HT, can relieve depression and anxiety-like behaviors of mice suffering from depression and anxiety, can relieve hyperfunction of hypothalamic-pituitary-adrenal axis (HPA axis), and can relieve depression and anxiety-like behaviors of mice suffering from depression and anxiety. The inflammatory response of mice with depression and anxiety is relieved, the expression level of brain-derived neurotrophic factors in hippocampus of the mice with depression and anxiety is improved, the abundance of intestinal beneficial flora of the mice with depression and anxiety is improved, and the diversity of intestinal flora is increased.

The invention discloses a preparation process of metabiotics and functional application of the metabiotics for relieving constipation, and relates to the technical field of microorganisms. The invention provides a preparation method of a bifidobacterium animalis subsp. Lactis LIHUO 01-containing metagen, which comprises the following steps: separately inoculating bifidobacterium animalis subsp. Lactis LIHUO 01 or compounding with probiotics to inoculate in a fermentation culture medium for culturing to obtain a fermentation bacteria solution, and carrying out thermal inactivation to obtain the bifidobacterium animalis subsp. Lactis LIHUO 01-containing metagen. The fermentation medium comprises skimmed milk, soybean meal and water, the mass ratio of the skimmed milk to the soybean meal to the water is (5-30): (1-25): (78-90), and the prepared bifidobacterium animalis subsp. Lactis LISUO 01 metabolite can significantly improve the content of tryptophan metabolites, can effectively relieve constipation and has a wide application prospect.

The application discloses an animal bifidobacterium producing bile salt hydrolase and application thereof in neonatal jaundice, and belongs to the technical field of microorganisms. The animal bifidobacterium lactis WXM screened by the application has the effect of relieving neonatal jaundice, can significantly improve weight loss of a jaundice individual in an early life stage, improve abnormal increase of a bilirubin level in serum, improve liver damage, improve the level of an enzyme related to liver function, the expression level of a related inflammatory factor in the liver and the expression level of an enzyme UGT1A1 related to bilirubin metabolism, and has the effect of relieving neonatal jaundice. The strain of the application has high safety and has wide application value in the fields of food, functional food, health products, medicine and the like.

The invention belongs to the technical field of microorganisms, and discloses a bifidobacterium animalis subsp. Lactis XB02 strain capable of inhibiting pathogenic bacteria and improving inflammation, the preservation number of the bifidobacterium animalis subsp. Lactis XB02 strain is CGMCC (China General Microbiological Culture Collection Center) No.34942, and the preservation date is June 18, 2025. Meanwhile, the probiotic composition adopting the bacterial strain XB02 also comprises a lactobacillus rhamnosus XB01 bacterial strain. The XB02 strain disclosed by the invention has excellent bacteriostatic activity, especially for vibrio parahaemolyticus and gardneria; the atopic dermatitis symptom can be obviously improved; the intestinal mucosa permeability is reduced, and the intestinal barrier function is enhanced; and when the strain is combined with the XB01 strain for use, a synergistic sleep promoting effect is shown. The invention further provides a probiotic composition containing the strain, a preparation and application of the probiotic composition and the preparation in food, medicine or health care products.

The invention relates to an application of plant lactobacillus Hi188 in promotion of bone health. The invention provides the application of the plant lactobacillus Hi188 or the afterbiogen thereof or the composition thereof in increasing the bone mineral density, increasing the bone mineral density, promoting the skeletal development, increasing the bone mineral content and / or promoting the tibia growth. Or preparing food for increasing bone mineral density, increasing bone mineral density, promoting skeletal development, increasing bone mineral content and / or promoting tibia growth; wherein the composition comprises: (A) Phytobacterium plantarum Hi188 or a postbiotic thereof, and (B) Bifidobacterium lactis Ca360 or a postbiotic thereof.

This paper discusses a strain of Bifidobacterium animalis subsp. lactis B7 and its composition and applications, belonging to the field of microbial technology. The specific strain is Bifidobacterium animalis subsp. lactis B7. Bifidobacterium animalis subsp. lactis Bifidobacterium lactis subspecies B7 was deposited at the China Center for Type Culture Collection on April 19, 2024, with accession number CCTCC NO: M2024734. This invention also discloses the application of the B7 fermentation composition in the preparation of drugs for the prevention and treatment of ulcerative colitis, constipation, and constipation-predominant ulcerative colitis. This animal bifidobacterium lactis subspecies B7 produces high levels of short-chain fatty acids and indolepropionic acid, utilizes sulforaphane to generate sulforaphane, increases intestinal peristalsis, effectively alleviates the disease activity index (DAI) and weight loss caused by ulcerative colitis or inflammatory bowel disease, significantly reduces colonic damage in mice, protects the mucosal layer, has anti-inflammatory effects, inhibits pathogens, and improves intestinal barrier function.

The invention discloses a probiotic strain Bifidobacterium animalis subsp. Lactiss S8 of a high-yield biological membrane, the preservation number is GDMCC NO.66518, the characteristics of the stable high-yield biological membrane are obtained through directional screening and adaptive evolution, and the yield of the biological membrane is three times higher than that of a positive control. The extracellular polymeric substance (EPS) of the strain can significantly enhance the tolerance of the strain to severe environments such as gastric acid, cholate and the like, and improve the intestinal colonization ability. Experiments prove that the strain remarkably reduces two liver function indexes, namely ALT and AST, in an animal model, and shows that the strain has a certain effect of improving liver injury.

The invention relates to the technical field of microbial fermentation, and discloses a moisturizing and soothing bifidobacterium lactis SF-B-20 fermentation product as well as a preparation method and application thereof, and the preservation number of bifidobacterium lactis SF-B-20 is CGMCC (China General Microbiological Culture Collection Center) No.20924. The moisturizing and soothing bifidobacterium lactis SF-B-20 fermentation product is prepared by fermenting a fermented substrate with bifidobacterium lactis SF-B-20, and the fermented substrate comprises a Chinese herbal medicine extract and a fed-batch culture medium; chinese herbal medicine raw materials for preparing the Chinese herbal medicine extract comprise the following components: silver birch juice, radix ampelopsis, astragalus membranaceus, aloe, purslane, liquorice, chamomile and radix sophorae flavescentis, the fed-batch culture medium comprises the following components: glucose, peptone, yeast extract powder and tremella polysaccharide, and the moisturizing and soothing bifidobacterium lactis SF-B-20 yeast has moisturizing and soothing effects and is safe and non-irritating.

The invention discloses bifidobacterium animalis subsp. Lactis CCMXJ2003 as well as a composition and application thereof, and belongs to the technical field of microbial preparations. In order to screen a specific probiotic strain which can form efficient synergy with 2 '-fucosyllactose and has good viability and an immunoregulation function, and construct a precise micro-ecological intervention scheme aiming at atopic dermatitis immunopathology key links, the invention provides a microecological intervention method for the atopic dermatitis immunopathology key links. The invention provides the bifidobacterium animalis subsp. Lactis CCMXJ2003 capable of efficiently utilizing the 2 '-fucosyllactose, and an in-vivo experiment proves that the composition of the 2'-fucosyllactose and the bifidobacterium animalis subsp. Lactis CCMXJ2003 shows an obvious enhancement effect in the aspect of relieving the specific dermatitis; the compound has a wide application prospect in prevention and / or treatment of atopic dermatitis.

The application provides an animal Bifidobacterium lactis HNU329 with the ability of reducing uric acid and an application thereof, the animal Bifidobacterium lactis HNU329 has been preserved in the Guangdong Microbial Culture Collection Center (GDMCC), the preservation address is the 5th floor of the 59th building of the courtyard, No. 100, Jiefang Road, Guangzhou, the preservation date is April 22, 2024, the preservation number is GDMCC No: 64546, and the classification and naming are Bifidobacterium animalis subsp. Lactis. The strain has good degradation abilities of nucleosides and purines in vitro, also shows good uric acid reducing ability and anti-inflammatory ability in animal model evaluation, and can regulate the intestinal flora of hyperuricemia mice and improve the symptoms of hyperuricemia. The strain is non-toxic and has no side effects, is safe, and has a wide application prospect.

The application discloses a preparation method and application of a composite strain of a sugar-controlling probiotic, and belongs to the technical field of microorganisms. The method comprises the steps of strain stock solution preparation, anaerobic culture, pH value determination and regulation, and composite strain proportioning. Through a dynamic shunting mechanism with pH value 4.3 as a threshold, the culture solution lower than the value is subjected to re-acidification treatment, and the culture solution higher than the value is subjected to differential dilution and coating operation. Finally, Lactobacillus gasseri, Streptococcus thermophilus, Lactobacillus bulgaricus, Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus paracasei, Bifidobacterium breve, Bifidobacterium lactis and Bifidobacterium longum are mixed at a preset ratio, and a sustained-release agent is added for storage. The method can significantly improve the screening efficiency of target probiotics, the stability of the composite preparation and the blood glucose regulation effect, and can be widely applied to the development of sugar-controlling probiotic products.

The invention discloses a composition for improving osteoporosis as well as a related product and application thereof, and relates to the technical field of biology. According to the invention, a composition system with stable coexistence and mutual synergism of the components is constructed by regulating and controlling the variety and proportion of the active components, and the main materials comprise 1-10 parts of folium cortex eucommiae and 1-20 parts of bifidobacterium lactis. According to the system, the problem that the efficacy is reduced due to improper component proportioning in a traditional compound is solved, and the overall stability and bioavailability are also remarkably improved. In terms of functions, the composition comprehensively regulates bone metabolism balance by means of a multi-target and multi-channel synergistic mechanism, and a safer, more efficient and more stable new way is provided for prevention and adjuvant therapy of osteoporosis.

The invention discloses a composition for improving osteoporosis as well as a related product and application thereof, and relates to the field of biology. By accurately optimizing the ratio of the rhizoma polygonati to the colostrum basic protein to the folium cortex eucommiae to the bifidobacterium lactis, a composition system with stable coexistence and synergistic interaction among the components is constructed. The system not only effectively overcomes the problem that the efficacy is reduced due to mutual restriction and proportion imbalance of common components in a traditional compound, but also obviously improves the stability and bioavailability of the composition. In the aspect of efficacy, the composition comprehensively regulates and controls bone metabolism balance through a multi-target and multi-channel synergistic effect, the technical bottleneck that a single component or a simple mixture is limited in effect and incomplete in curative effect is fundamentally overcome, and a safer, more efficient and more stable solution is provided for prevention and adjuvant therapy of osteoporosis.

A method of treating, preventing or ameliorating at least one symptom of obsessive compulsive disorder (OCD) in a subject is disclosed. The method comprises a step in which a multistrain probiotic formulation is administered to the subject. The multistrain probiotic formulation includes the bacterial strains Bacillus coagulans, Lactobacillus rhamnosus, Bifidobacterium lactis, Lactobacillus plantarum, Bifidobacterium breve and Bifidobacterium infantis and Glutamine in a concentration range of 100-500 mg.

The invention provides a composite plant polypeptide composition for reducing blood glucose, repairing cells, resisting oxidation and enhancing immunity as well as a preparation method and application thereof, and belongs to the technical field of biology. The invention provides a composition. Comprising a protein peptide composed of millet protein peptide, soybean protein isolate peptide, whey protein peptide and sea buckthorn protein peptide, dietary fiber composed of chia seed powder and konjaku flour, a probiotic compound composed of bifidobacterium lactis BB-12 and lactobacillus rhamnosus LGG, fructo-oligosaccharide, balsam pear peptide, a cyclocarya paliurus extract, a corn stigma extract, a mulberry leaf extract, a vitamin E extract, a vitamin E extract, a vitamin E extract, a vitamin E extract, a vitamin E extract and a vitamin E extract. The extract mixture is composed of a radix puerariae extract, a rhizoma polygonati polysaccharide extract, a moringa oleifera leaf extract and leech powder, and the vitamin mineral substance mixture is composed of other functional components. The composition provided by the invention is matched with various proteins, dietary fibers, probiotics, prebiotics, plant extracts, vitamins, minerals, other functional components and the like, so that the purpose of effectively and synergistically improving the conditions of diabetes and nephropathy from multiple targets and multiple ways is finally achieved.

The invention relates to a fermentation medium and application thereof in industrial fermentation of animal bifidobacterium subsp. Lactis, the fermentation medium is composed of the following materials by weight: 2-5% of glucose; 1-5% of a yeast extract; 0.1 to 0.5 percent of sodium acetate; 0.05 to 0.2 percent of magnesium sulfate; and the balance of water. Under the condition that the yield and the activity of the bacterial powder are not influenced, the supply chain operation cost and the material purchasing cost are reduced by 20-30%, and meanwhile, the operation error of staff can be reduced; and a technical support is provided for cost reduction and benefit improvement of other probiotics in the industrial field.

The preparation method comprises the following steps: mixing and crushing the following components in parts by weight: 10-15 parts of astragalus membranaceus, 2-3 parts of paris polyphylla, 2-6 parts of liquorice, 3-5 parts of pseudo-ginseng, 1-2 parts of pericarpium citri reticulatae, 20-30 parts of American ginseng, 5-10 parts of angelica sinensis and 4-5 parts of fructus gardeniae, and then performing purification treatment to obtain a composition I; 0.02 to 0.05 part of bifidobacterium lactis, 0.02 to 0.05 part of bifidobacterium breve, 0.02 to 0.08 part of lactobacillus rhamnosus and 0.01 to 0.02 part of lactobacillus acidophilus are used for preparing microcapsule powder, and the microcapsule powder is used as a composition II; and mixing the composition I and the composition II according to a mass ratio of (8: 1)-(10: 1) to obtain the probiotic composition for enhancing immunity. The defects in the prior art can be overcome, and the immunity is effectively improved.

The application discloses a Bifidobacterium lactis specific protein antibody, an antibody conjugated magnetic bead and application. The antibody is a monoclonal antibody BL1, comprising a heavy chain variable region and a light chain variable region, and the amino acid sequences of the heavy chain variable region and the light chain variable region are shown in SEQ ID NO: 3 and 4 respectively. The antibody conjugated magnetic bead is coupled by the monoclonal antibody BL1 and activated carboxyl magnetic beads. The antibody conjugated magnetic bead can specifically enrich Bifidobacterium lactis, has high enrichment efficiency, simple enrichment operation, and can be applied to identification of metabolic products of Bifidobacterium lactis, and can be used for qualitative and quantitative analysis.

The invention discloses a bifidobacterium animalis subsp. Lactis BT-G9 with a growth promoting function and application of the bifidobacterium animalis subsp. Lactis BT-G9, the bifidobacterium animalis subsp. Lactis BT-G9 is preserved in China Center for Type Culture Collection, the preservation date is November 20, 2025, and the preservation number is CCTCC NO: M 20252626. The brand new bifidobacterium animalis subsp. Lactis BT-G9 provided by the invention has good tolerance to gastric juice and intestinal juice, is suitable for survival in gastrointestinal tracts, can effectively inhibit bacteria, and particularly can effectively inhibit campylobacter kirscheri, streptococcus agalactiae and / or propionibacterium acnes. Experimental results show that the strain can promote animal growth and development and improve the autism, especially when the animal bifidobacterium subsp. Lactis BT-G9 and the lactobacillus acidophilus BT-C15 are combined for use, the animal bifidobacterium subsp. Lactis BT-G9 and the lactobacillus acidophilus BT-C15 have a synergistic effect, and the improvement effect on the autism can be remarkably improved. In addition, the extracellular vesicles prepared from the strain can effectively repair the skin barrier function.

The invention provides a composition for improving the intestinal bacterial phase and prolonging the colonization rate of beneficial bacteria in the intestinal tract, the composition comprises Bifidobacterium lactis GKK2, and the composition can be used for improving the intestinal bacterial phase, promoting the colonization rate of the beneficial bacteria in the intestinal tract and prolonging the activity of the beneficial bacteria in the intestinal tract.

Disclosed is the use of Bifidobacterium lactis BL-99 in the protection of cartilage. Provided in the present invention is the use of Bifidobacterium lactis in the preparation of a composition for protecting cartilage, wherein the Bifidobacterium lactis is Bifidobacterium lactis with the deposit number of CGMCC No. 15650. The Bifidobacterium lactis can promote the development of cartilage, increase cartilage density, protect cartilage from damage, promote cartilage repair and / or ameliorate cartilage damage, and is beneficial to cartilage health.

This invention provides the application of *Bifidobacterium animalis* subsp. lactis CP-9 in the preparation of compositions that promote neurodevelopment and alleviate cognitive impairment and nerve damage. This invention discovers that *Bifidobacterium animalis* subsp. lactis CP-9 can improve abnormal neurodevelopment, cognitive impairment, and nerve damage, and has a protective effect on the nervous system and overall health. This novel application expands the application scope of *Bifidobacterium animalis* subsp. lactis as a probiotic, and is of great significance for further exploring the functions of probiotics and developing probiotics with higher nutritional and health benefits. It also opens up new avenues and solutions for protecting nervous system health and preventing nervous system diseases through dietary strategies.