222 results about "Bifidobacterium lactis" patented technology

The present application relates to animal bifidobacterium lactis Ca360 and its application. The present application also provides the application of animal bifidobacterium lactis in promoting the absorption and transport of minerals, improving osteoporosis, iron deficiency anemia and zinc deficiency. The animal bifidobacterium lactis of the present application can promote the absorption and transport of minerals, improve osteoporosis, iron deficiency anemia and zinc deficiency.

The invention provides an application of bifidobacterium animalis subsp. Lactis CP-9 in preparation of a product for promoting bone growth and development or improving bone health. Long-term research and a large number of experiments show that the bifidobacterium animalis subsp. Lactis CP-9 can improve the bone volume fraction, the bone trabecula thickness, the bone density and the bone volume of an organism, and can also effectively improve the growth hormone level and the insulin-like growth factor 1 level, so that bone growth and development are promoted. Meanwhile, the bifidobacterium animalis subsp. Lactis CP-9 can effectively improve the N-terminal propeptide level, osteocalcin level, bone morphogenetic protein level and osteoprotectin level of I-type procollagen in a body, and remarkably reduce the amino-terminal peptide level of the I-type collagen and the ligand level of nuclear factor kappa B receptor activating factor, so that osteoblast differentiation is promoted, osteoclast differentiation is inhibited, and osteoclast differentiation is inhibited. Furthermore, bone formation is promoted, bone resorption is inhibited, bone metabolism is improved, and finally the effect of improving bone health is achieved.

Provided is a Bifidobacterium lactis. The Bifidobacterium lactis is Bifidobacterium animalis subsp. lactis BL-11, and the preservation number of the Bifidobacterium animalis subsp. lactis BL-11 is CGMCC No. 20847. The provided Bifidobacterium animalis subsp. Lactis can improve intestine metabolism disorder and normalize the composition of intestine microbiome so as to improve height, suppresses obesity, promote infant and youth physical development and mental development, and prevent and treat mental disorders, said mental disorders including anxiety, depression, attention-deficit / hyperactivity disorder, autism, schizophrenia, hepatic encephalopathy, anorexia, Tourette syndrome, and Asperger syndrome.

The invention discloses bifidobacterium animalis subsp. Lactis, a preparation and application of the bifidobacterium animalis subsp. Lactis in regulation of depression and intestinal flora. Belongs to the technical field of probiotic preparation. According to the application, seven strains of bacteria are separated from excrement of infants, the seven strains of bacteria comprise bifidobacterium breve, bifidobacterium animalis and bifidobacterium longum through identification, the anti-depression capacity of the seven strains of bacteria is evaluated through in-vitro experiments, a potential antidepressant bifidobacterium animalis subsp. Lactis BD1 is screened out, and further experiments prove that the antidepressant bifidobacterium animalis subsp. Lactis BD1 has the advantages that the antidepressant bifidobacterium animalis subsp. Lactis BD1 can be used for preparing the antidepressant bifidobacterium animalis subsp. Lactis BD1; the strain has the effects of improving depressive mood, intestinal bacteria unbalance and insufficient serotonin secretion in the brain caused by chronic bound stress (CRS), and compared with bifidobacterium animalis subsp. Lactis in the prior art, the strain achieves the anti-depression effect from multiple aspects, also has the effect of adjusting intestinal flora imbalance, and has the advantages of being safe and reliable. And a new treatment strategy is provided for depression and intestinal flora imbalance.

The invention relates to a bifidobacterium animalis subsp. Lactis B7 as well as a composition and application thereof, and belongs to the technical field of microorganisms, the bifidobacterium animalis subsp. Lactis B7 is preserved in the China Center for Type Culture Collection on April 19, 2024, and the preservation number is CCTCC NO: M2024734. The bifidobacterium animalis subsp. Lactis B7 is named as Bifidobacterium animalis subsp. Lactis B7, the composition is named as Bifidobacterium animalis subsp. Lactis B7, and the composition is named as Bifidobacterium animalis subsp. Lactis B7. The invention also discloses application of the B7 fermentation composition in preparation of medicines for preventing and treating ulcerative colitis, constipation and constipation-type ulcerative colitis. According to the bifidobacterium animalis subsp. Lactis B7, high-yield short-chain fatty acid and indolepropionic acid are achieved, sulforaphane is generated through glucoraphanin, intestinal tract movement is improved, ulcerative colitis or inflammatory bowel disease activity index DAI and weight loss caused by the disease activity index DAI are effectively relieved, mouse colon injury is remarkably relieved, and mucosa layers are protected; the effects of resisting inflammation, inhibiting pathogenic bacteria and improving the intestinal barrier function are achieved.

The invention discloses bifidobacterium animalis and application thereof in allergic rhinitis products, and belongs to the technical field of microorganisms. The technical problem to be solved is that the existing common allergic rhinitis treatment means cannot meet the requirements of patients on safety, long-acting effect and treatment cycle. The invention provides an animal bifidobacterium subsp. Lactis Def +, and after an effective dose of animal bifidobacterium subsp. Lactis Def + is applied to a subject, the animal bifidobacterium subsp. Lactis Def + is found to be capable of remarkably relieving the allergic rhinitis symptom. Specifically, the symptoms of sneezing, dry nose and rhinocnesmus are reduced; the number of nasal septum mucosa intrinsic layer inflammation infiltration cells and nasal septum mucosa epithelium pathological changes are reduced; the IgA and IgE levels of serum are reduced; the levels of proinflammatory factors IL-4, IL-5 and IL-13 are reduced; the normal spleen index is maintained; the imbalance state of Th1 / Th2 and Th17 / Treg is effectively improved, and the body immunity is improved; a safe and long-acting scheme is provided for allergic rhinitis diseases.

The invention discloses a primer composition and application of the primer composition in detection of animal bifidobacterium subsp. Lactis HN019. According to the present invention, bifidobacterium animalis subsp. Lactis HN019 is adopted as an object, bacterial strain specific genetic markers are screened through whole genome sequencing and single nucleotide polymorphism analysis, and a fluorescent quantitative PCR technology is combined so as to obtain the efficient, specific and stable HN019 quantitative detection primer composition and the method thereof; through system verification, the method is suitable for an HN019 strain level detection technical framework in scientific research and industrial application scenes, and also provides key technical support for market supervision and industrial healthy development of probiotic foods.

The invention discloses a panax quinquefolius probiotic beverage and a preparation method thereof, and relates to the technical field of functional foods. According to the beverage, the combination of the American ginseng extract and specific probiotics is taken as a core, the survival rate of thalli is increased by adopting a microcapsule embedding technology, and the product performance is optimized by adding a stabilizer and a flavor regulator. The formula comprises 5-15% of a panax quinquefolius extract, 3-8% of compound probiotic freeze-dried powder (lactobacillus plantarum, lactobacillus salivarius and bifidobacterium lactis), 10-25% of inulin, 5-15% of whey protein, 10-30% of a microcapsule wall material (sodium alginate / chitosan or a WPI-KGM compound), and auxiliary materials. According to the preparation method, the active ingredients are efficiently reserved through the processes of gradient extraction, microcapsule embedding, low-temperature drying and the like. The product has the functions of resisting fatigue, regulating intestinal flora and enhancing immunity, the survival rate of probiotics in simulated gastric juice reaches 85% or above, and the shelf life stability is improved by 40%.

The invention discloses a synbiotics composition with bacteriostatic and anti-inflammatory effects, which comprises probiotics and prebiotics in parts by weight, the probiotics comprise the following components in parts by weight: 0.05 to 0.15 part of freeze-dried powder of lactobacillus rhamnosus PB-LR76, 0.05 to 0.15 part of freeze-dried powder of lactobacillus acidophilus HH-LA26, 0.05 to 0.15 part of freeze-dried powder of lactobacillus bulgaricus HH-LB57, 0.05 to 0.15 part of freeze-dried powder of bifidobacterium lactis HH-BA68, 0.05 to 0.15 part of freeze-dried powder of lactobacillus reuteri PB-LR09, and 0.05 to 0.15 part of freeze-dried powder of lactobacillus plantarum HH-LP56; the prebiotics are fructo-oligosaccharide or a rhizoma polygonati extract. Compared with the single use of probiotics or prebiotics, the synbiotics composition disclosed by the invention has stronger antibacterial and anti-inflammatory effects. The invention further discloses application of the synbiotics composition in preparation of a medicine for treating enteritis.

The invention discloses a composition for promoting animal bifidobacterium subsp. Lactis to proliferate in intestinal tracts and application thereof, and belongs to the technical field of probiotics, the composition comprises a prebiotic composition and animal bifidobacterium subsp. Lactis, wherein the prebiotic composition is prepared from at least three of mannose oligomer, cotton seed oligosaccharide, isomaltooligosaccharide and galactooligosaccharide; the number of viable bacteria of the bifidobacterium animalis subsp. Lactis added in each gram of the prebiotic composition is 106-1012. According to the invention, at least three of the mannan-oligosaccharide, the cotton seed oligosaccharide, the isomaltooligosacharide and the galactooligosaccharide are compounded, so that the probiotic effect of the probiotics is coordinated and enhanced.

The invention discloses a compound probiotic for improving cognitive function of old people and a preparation method and application thereof. Firstly, maltodextrin is dried and then sieved, metal impurities are removed after sieving, and maltodextrin freeze-dried powder, lactobacillus paracasei Lpc37 freeze-dried powder, phytobacterium plantarum Lp-115 freeze-dried powder and bifidobacterium animalis subsp. Lactis Bl-04 freeze-dried powder are weighed and sieved respectively; the preparation method comprises the following steps: preparing freeze-dried powder of three strains, then premixing the freeze-dried powder of the three strains with a part of maltodextrin, adding the residual maltodextrin after the strains are premixed, continuously mixing until the materials are uniformly distributed to obtain the compound probiotics, exerting a synergistic effect through a specific strain combination (Lp115 + Lpc37 + Bl-04), providing a new way for non-drug intervention, being beneficial to regulating intestinal flora metabolism (such as generating short-chain fatty acid SCFA), and improving the immunity of the human body. The synthesis and release of neurotrophic factors are promoted, the nerve cell function is improved, and the cognitive function improvement is indirectly assisted.

The invention discloses bifidobacterium lactis BA-C44 and application of the bifidobacterium lactis BA-C44 in relieving ulcerative colitis symptoms, the bifidobacterium lactis BA-C44 is preserved in the China Center for Type Culture Collection on December 04, 2023, and the preservation number is CCTCC NO: M 2023447. A product prepared from the bifidobacterium lactis BA-C44 disclosed by the invention has the beneficial effect of relieving symptoms of ulcerative colitis. Besides, the bifidobacterium lactis BA-C44 has good temperature tolerance and gastrointestinal fluid tolerance, is convenient for storage of commercial products after preparation, is easier to survive in intestines and stomach, and achieves the purpose of relieving symptoms of ulcerative colitis, so that the bifidobacterium lactis BA-C44 has a good application prospect.

The invention provides an efficient microbial fermentation method and application thereof in production of cosmetic raw materials, and the method comprises the following steps: (1) weighing radix astragali, crushing and sieving to obtain radix astragali powder, mixing 100 parts by mass of radix astragali powder with 600-800 parts by mass of purified water, and sterilizing to obtain a dispersion liquid; (2) adding 1 part by mass of lactobacillus plantarum and the dispersion liquid into a fermentation tank, uniformly mixing, and carrying out anaerobic fermentation to obtain fermentation liquor A; (3) adding 1 part by mass of lactobacillus bulgaricus into the fermentation liquor A, uniformly mixing, performing anaerobic fermentation, and performing sterilization treatment after fermentation to obtain fermentation liquor B; (4) adding 1 part by mass of bifidobacterium lactis into the fermentation liquor B, uniformly mixing, performing anaerobic fermentation, and performing sterilization treatment after the fermentation is completed to obtain fermentation liquor C; and (5) centrifuging the fermentation liquor C, discarding precipitate, collecting supernate, and performing spray drying on the supernate to obtain the astragalus extract. The fermentation method disclosed by the invention is high in yield of the astragalus extract.

The invention discloses bifidobacterium animalis subsp. Lactis and application thereof in a product for enhancing athletic ability, and relates to the technical field of microorganisms. The invention provides an animal bifidobacterium subsp. Lactis MUS < + >, and the preservation number of the animal bifidobacterium subsp. Lactis MUS < + > is CGMCC (China General Microbiological Culture Collection Center) No.35626. The invention also provides a preparation method of the animal bifidobacterium subsp. Lactis MUS < + >. The animal bifidobacterium subsp. Lactis MUS + provided by the invention can increase the length of surrounding motor nerves and promote the development of the motor nerves; the total exercise distance is increased, and the exercise ability and endurance are promoted; body length or height development is promoted; muscle fibers are thickened, the muscle fiber density is increased, muscle fiber gaps are reduced, and muscle development is promoted; and the method has a very good application prospect in preparation of products for improving athletic ability or increasing muscle.

The invention discloses application of animal bifidobacterium subsp. Lactis GOLDGUT-BB21 in preparation of products for relieving depression, and belongs to the technical field of biological medicine. The probiotics disclosed by the invention can be used for relieving depressive symptoms, improving related symptoms, assisting in treating depression and preventing depression, and also can be used as a nutritional supplement to help maintain the balance of intestinal microflora and promote intestinal health.

The invention discloses bifidobacterium lactis BL-YR55 screened from yoghourt, the bifidobacterium lactis BL-YR55 is preserved in China Center for Type Culture Collection, the preservation number is CCTCC No.M 20221997, the bifidobacterium lactis BL-YR55 is classified and named as bifidobacterium lactis BL-YR55, the preservation date is December 23, 2022, and the preservation address is Wuhan University, China. The composition has efficient weight-losing and fat-reducing effects, is effective in viable bacteria sterilization, also has a function of relieving lactose intolerance, and has a wide application prospect of medicinal or health-care products.

The invention relates to the technical field of fishery breeding baits, and particularly discloses a fermentation inoculant for fermenting artemia, the fermented artemia and a preparation method of the fermented artemia. The fermentation inoculant for fermenting artemia at least comprises a compound of phaffia rhodozyma, lactobacillus johnsonii, lactobacillus rhamnosus and bifidobacterium lactis. The method has the advantage that artemia does not decay for a long time at normal temperature.

The invention relates to the technical field of dairy product fermentation, and discloses a high-activity probiotic microcapsule suitable for dairy product fermentation and a preparation method thereof.The microcapsule is prepared from, by weight, 6.7-13.3 parts of bifidobacterium lactis, 3.3-6.7 parts of lactobacillus plantarum, 9.1-15.2 parts of Arabic gum, 13.6-22.7 parts of maltodextrin, 7.3-12.1 parts of chitosan, 15.1-30.2 parts of trehalose, 3.8-7.5 parts of glycerinum and 1.1-2.3 parts of ascorbic acid. The molecular weight of the chitosan is 80kDa, and the weight part ratio of the bifidobacterium lactis to the lactobacillus plantarum is 2: 1. In the invention, an inner core is formed through a eutectic structure of bifidobacterium lactis, lactobacillus plantarum and trehalose to protect the probiotics, so that the problems that the existing probiotics are easily influenced by the external environment in the storage and fermentation processes, the activity is reduced, and the fermentation effect of dairy products is poor are solved.

The invention provides application of a probiotic composition in preparation of a medicine for preventing and / or treating Alzheimer's disease, and belongs to the technical field of probiotic medical application. The probiotic composition disclosed by the invention is prepared from lactobacillus rhamnosus, bifidobacterium lactis and bifidobacterium bifidum. According to the probiotic composition disclosed by the invention, on the phylum level, the relative abundance of Verrucomicrobiota (verruca microflora phylum) is improved by the probiotic composition, and the relative abundance of the verrucomicrobiota (verruca microflora phylum) is improved by the probiotic composition; in the level of genus, the probiotic composition increases the relative abundance of the beneficial bacteria genus Akkermansia (Ackermania genus) and Bifidobacterium (Bifidobacterium genus), and in the level of genus Akkermania (Ackermania genus) and Bifidobacterium (Bifidobacterium genus); the behavioral cognition level can be remarkably improved, neuron injury is improved, and intestinal barrier injury is improved.

The invention relates to the technical field of functional food production through microbial fermentation, in particular to a herba epimedii enzymolysis probiotic fermentation refined extract and a preparation method thereof.The preparation method comprises the following steps that herba epimedii and beta-cyclodextrin are mixed, an obtained mixed solution is subjected to enzymolysis treatment through pectinase, cellulase and glycosidase and then serves as a solid-state fermentation substrate, and the herba epimedii enzymolysis probiotic fermentation refined extract is obtained; adding mixed bacteria of lactobacillus casei, bifidobacterium lactis and lactobacillus gasseri, performing solid-state fermentation, and performing vacuum freeze drying to obtain a herba epimedii probiotic fermentation refined extract; the herba epimedii probiotic fermentation refined extract is prepared by adopting an enzymolysis fermentation method in cooperation with a beta-cyclodextrin inclusion technology, the extraction efficiency, the solubility, the biological activity, the stability and other performance of effective components in herba epimedii are improved, the preparation method is simple, and operation is easy and convenient; the used materials are edible, green and safe; the process saves energy consumption, has good environmental benefits, greatly saves manpower and material resources, and can be applied to industrial large-scale production.

The invention relates to a polygonatum sibiricum probiotic compound preparation with an aging delaying effect and application thereof. The compound preparation comprises a polygonatum sibiricum extract and a probiotic composition, the bacterial strains in the probiotic composition comprise a combination of a bifidobacterium animalis subsp. Lactis BLa36 bacterial strain, a bifidobacterium longum BL21 bacterial strain, a bifidobacterium adolescentis BAC30 bacterial strain, a lactobacillus plantarum Lp90 bacterial strain, a lactobacillus casei LC89 bacterial strain, a bifidobacterium breve BBr60 bacterial strain and a pediococcus acidilactici CCFM7902 bacterial strain. After the rhizoma polygonati component and the probiotic component are combined for use, the rhizoma polygonati component and the probiotic component have potential synergistic effects in the aspects of improving the intestinal flora structure, regulating the intestinal environment, delaying senescence, reducing inflammation-related symptoms and the like. Moreover, further, various probiotic strains are compounded and combined for use, so that the capability of a related compound preparation in the aspect of delaying various symptoms of senescence can also be improved in a combined manner.

The invention belongs to the technical field of biology, and particularly relates to animal bifidobacterium subsp. Lactis FMBL B24304AHDM and application thereof.The animal bifidobacterium subsp. Lactis FMBL B24304AHDM is preserved in the China Center for Type Culture Collection on November 18, 2024, the preservation number is CCTCC NO: M 20242505, and the animal bifidobacterium subsp. Lactis FMBL B24304AHDM has the good inhibition capacity on pathogenic bacteria and has the high scavenging capacity on DPPH and ABTS free radicals; the compound has the effect of inhibiting the activity of alpha-glucosidase, alpha-amylase and dipeptidyl peptidase IV, and the oral glucose tolerance and insulin tolerance of T2DM mice can be remarkably reduced; the composition of intestinal microbiome is obviously improved, the abundance and variety of effective microbial communities in the intestinal tract are improved, and the relative abundance of pathogenic bacteria is reduced, so that the disorder of short-chain fatty acids of T2DM mice is improved, and the application prospect is wide.

The invention relates to bifidobacterium animalis subsp. Lactis CBTL010 and application thereof in products for improving intestinal flora and relieving depression and anxiety, and belongs to the technical field of microorganisms. The bifidobacterium animalis subsp. Lactis CBTL010 is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation time is March 20, 2025, the preservation number is CGMCC NO.33906, and the bifidobacterium animalis subsp. Lactis CBTL010 has the effects of improving intestinal flora and relieving depression and anxiety.

The present invention belongs to the field of microbial technology, and relates to the application of Bifidobacterium lactis BLa80 in improving and alleviating allergic reactions. The present invention first provides the application of Bifidobacterium lactis BLa80 in the preparation of a medicine for improving and alleviating allergic reactions. Experiments of the present invention have shown that BLa80 can significantly reduce the scratching behavior and back skin lesion inflammation scores of mice, and significantly reduce the behavioral observation scores and the degree of ear swelling. Bifidobacterium lactis BLa80 significantly reduces the IgE level in the serum of the model group, significantly increases the IFN‑γ level, significantly reduces the IL‑4 level, and Bifidobacterium lactis BLa80 can significantly increase the IFN‑γ / IL‑4 ratio, indicating that Bifidobacterium lactis BLa80 can regulate the balance of Th1 / Th2. The present invention also provides the application of Bifidobacterium lactis BLa80 in the preparation of health foods and cosmetics for improving and allergic relief.

The invention relates to the technical field of biological fermentation, in particular to a postbiotic composition capable of regulating emotion and relieving mental stress as well as a preparation method and application of the postbiotic composition. The composition provided by the invention is prepared from the following components: lactobacillus plantarum nbk-MA2, lactobacillus kefiranofaciens subsp. Kefiranofaciens ZW3, bifidobacterium lactis nbk-W13, lactobacillus paracasei nbk-LC16 and maltodextrin. The postbiotic composition provided by the invention can regulate mood and relieve mental stress by regulating intestinal flora, stimulating an immune system, reducing inflammation, regulating the content of CRH and CORT in hypothalamus, recovering HPA axis disorder and correcting tryptophan metabolism.

The invention relates to application of bifidobacterium animalis subsp. Lactis BLa80 in preparation of a preparation for relieving depression or anxiety. The bifidobacterium animalis subsp. Lactis BLa80 is a strain of the bifidobacterium animalis subsp. Lactis BLa80 with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.22547, and the strain of the bifidobacterium animalis subsp. Lactis BLa80 is a strain of the bifidobacterium animalis subsp. Lactis BLa80 with the preservation number of CGMCC No.22547. The invention develops a brand new application of the bifidobacterium animalis subsp. Lactis BLa80 strain, namely, the bifidobacterium animalis subsp. Lactis BLa80 strain is used for relieving depression or anxiety symptoms, specifically, the bifidobacterium animalis subsp. Lactis BLa80 strain can stimulate RIN14B cells to secrete 5-HT, can relieve depression and anxiety-like behaviors of mice suffering from depression and anxiety, can relieve hyperfunction of hypothalamic-pituitary-adrenal axis (HPA axis), and can relieve depression and anxiety-like behaviors of mice suffering from depression and anxiety. The inflammatory response of mice with depression and anxiety is relieved, the expression level of brain-derived neurotrophic factors in hippocampus of the mice with depression and anxiety is improved, the abundance of intestinal beneficial flora of the mice with depression and anxiety is improved, and the diversity of intestinal flora is increased.

The present invention belongs to the technical field of extracting effective pharmaceutical ingredients, and particularly relates to a composition containing citrus polyphenols and citrus powder for burning fat and losing weight, and a preparation method and application thereof. The composition comprises a spray-dried powder prepared from citrus fruit filtrate, Flammulina velutipes fiber, soy protein isolate, aronia berry extract, and black tea extract, and a compound probiotic, wherein the compound probiotic comprises Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium lactis, and Lactobacillus casei. The present invention adopts compound spraying of Flammulina velutipes fiber, soy protein isolate, aronia berry extract, black tea extract, and citrus fruit filtrate to improve the stability of total polyphenols and Vc in citrus fruits. The obtained citrus powder is further mixed with a compound probiotic to prepare a composition with pharmacologically active ingredients, which can effectively burn fat and lose weight and can be applied to weight loss drugs.

The invention discloses a preparation process of metabiotics and functional application of the metabiotics for relieving constipation, and relates to the technical field of microorganisms. The invention provides a preparation method of a bifidobacterium animalis subsp. Lactis LIHUO 01-containing metagen, which comprises the following steps: separately inoculating bifidobacterium animalis subsp. Lactis LIHUO 01 or compounding with probiotics to inoculate in a fermentation culture medium for culturing to obtain a fermentation bacteria solution, and carrying out thermal inactivation to obtain the bifidobacterium animalis subsp. Lactis LIHUO 01-containing metagen. The fermentation medium comprises skimmed milk, soybean meal and water, the mass ratio of the skimmed milk to the soybean meal to the water is (5-30): (1-25): (78-90), and the prepared bifidobacterium animalis subsp. Lactis LISUO 01 metabolite can significantly improve the content of tryptophan metabolites, can effectively relieve constipation and has a wide application prospect.

The application discloses an animal bifidobacterium producing bile salt hydrolase and application thereof in neonatal jaundice, and belongs to the technical field of microorganisms. The animal bifidobacterium lactis WXM screened by the application has the effect of relieving neonatal jaundice, can significantly improve weight loss of a jaundice individual in an early life stage, improve abnormal increase of a bilirubin level in serum, improve liver damage, improve the level of an enzyme related to liver function, the expression level of a related inflammatory factor in the liver and the expression level of an enzyme UGT1A1 related to bilirubin metabolism, and has the effect of relieving neonatal jaundice. The strain of the application has high safety and has wide application value in the fields of food, functional food, health products, medicine and the like.

The invention provides application of manuka honey in skin antibiosis and anti-inflammation, and belongs to the technical field of cosmetics, the application comprises the following steps: (1) mixing rose petals, perilla roots, grape seeds and manuka honey, and adding the mixture into water to obtain an enzymolysis substrate; (2) sequentially adding pectinase, neutral protease and beta-glucanase into the enzymolysis substrate, and performing enzymolysis to obtain an enzymolysis product; (3) adding lactobacillus brevis, lactobacillus helveticus and bifidobacterium lactis into the enzymolysis product, and fermenting to obtain a fermentation product; (4) adding an ethanol aqueous solution into the fermentation product, stirring, filtering by using a filter membrane to obtain a supernatant, and concentrating the supernatant to obtain a mixed extract; and (5) preparing skin antibacterial and anti-inflammatory products from the mixed extract. The mixed extract disclosed by the invention is good in batch stability, relatively good in antibacterial and anti-inflammatory effects and low in irritation.