21 results about "Depressive symptoms" patented technology

The invention relates to the technical field of intelligent wearing monitoring, in particular to a multifunctional head-mounted device for improving anxiety and depression symptoms in the perioperative period, which comprises a main body base, an electric treatment assembly and a power supply assembly are arranged on the main body base, extending ear hooks are arranged at two ends of the main body base, binding straps are arranged on the extending ear hooks, and a nose pad block is arranged at the bottom of the main body base. The electric treatment assembly is in signal connection with an evaluation and control system, heart rate monitoring assemblies are arranged on the extension ear hooks, and an eye movement monitoring assembly is arranged at the bottom of the main body base; a displacement monitoring assembly is arranged on the main body base, and a respiration monitoring assembly is arranged on the nose pad block. According to the invention, physiological parameter monitoring, anxiety and depression assessment and percutaneous nerve stimulation treatment functions are integrated, and multi-node fixed design and real-time dynamic data processing are combined, so that redundant steps depending on preposed medical assessment in the traditional technology are omitted, doctors can remotely and accurately adjust personalized schemes based on dynamic data, and the accuracy of diagnosis and treatment is improved. The anxiety depression intervention efficiency and reliability in the perioperative period are improved.

The present invention relates to techniques for detection of depression cues in EEG signals using power spectral density-based features for deep learning. In an embodiment, a system for detecting depression in a person may comprise an Electroencephalogram (EEG) electrode array attached to the person, the EEG electrode array comprising at least ten electrodes adapted to read EEG signals, an amplifier, a filter, and an Analog to Digital Convert to digitize the read EEG signals, and computing circuitry comprising a processor, memory accessible by the processor, and computer program instructions stored in the memory and executable by the processor to perform: processing on the digitized read EEG signals to detect signal patterns indicative of depression in the person, and outputting a prediction indicating a likelihood of depression in the person based on the deep learning processing.

The invention belongs to the technical field of traditional Chinese medicine, and particularly discloses a traditional Chinese medicine composition for treating fibromyalgia syndrome and a preparation method and application thereof.The traditional Chinese medicine composition is prepared from radix polygoni multiflori preparata, fructus citri sarcodactylis, radix pseudostellariae, caulis spatholobi, flos rosae rugosae, rhizoma dioscoreae, semen lablab album, rhizoma curcumae longae, lucid ganoderma, arillus longan, flos albiziae and fructus ziziphi jujubae. The traditional Chinese medicine has the effects of soothing liver and strengthening spleen, nourishing and activating blood, calming heart and tranquilizing mind, and activating meridians Pharmacodynamic experiment research and clinical observation results show that the traditional Chinese medicine composition can significantly relieve pain of patients and improve depressive symptoms, and can be used for treating fibromyalgia syndrome.

The invention relates to the fields of biotechnology, traditional Chinese medicines and nutritional health-care products, in particular to a bifidobacterium breve-containing medicinal and edible composite composition and application thereof in preparation of products for preventing or treating anxiety and depression, improving sleep disorders and assisting in weight management. The composite composition is prepared from bifidobacterium breve and a medicinal and edible composition, and the ratio of the bifidobacterium breve to the medicinal and edible composition is 1 * 10 < 10 > CFU of the bifidobacterium breve and 60 g of the medicinal and edible composition. The composition disclosed by the invention has a remarkable synergistic effect, can effectively prevent or relieve anxiety and depression symptoms, can improve sleep quality, and can assist in reducing body weight and body fat. The action mechanism relates to double targets of'intestine-brain-metabolic axis', and the double targets supplement each other to synergistically promote nerve-immunity-endocrine and metabolic balance. The composition disclosed by the invention can be used for preparing medicines, functional foods or health-care products, and provides a safe and effective brand-new choice for intervention of multiple health problems (emotion, sleep and metabolic disorders).

The invention provides a traditional Chinese medicine composition for treating Parkinson's depression and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1-10 parts of radix acanthopanacis semticosi and 1-10 parts of bulbus lilii. The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps: taking the acanthopanax and the lily, adding water to soak, heating, refluxing and extracting, and combining filtrate to obtain the traditional Chinese medicine composition. Animal experiments find that the acanthopanax-lily traditional Chinese medicine composition has a good treatment effect on Parkinson depression for the first time, and can remarkably improve dyskinesia and depression symptoms, regulate neurotransmitter disorder, relieve damage to nigra and hippocampal neurons and reduce the level of inflammatory factors in serum. After being taken for a long time, the traditional Chinese medicine composition disclosed by the invention can improve depression and life quality, slow down the progress of Parkinson disease and reduce the use of Parkinson drugs.

The invention relates to corn capable of bidirectionally regulating anxiety and depression symptoms. The mass ratio of campesterol to stigmasterol to beta-sitosterol in the corn is 1: (0.5-5): (1-5). The planted corn can bidirectionally regulate anxiety and depression symptoms, and has the advantages of high yield of planted corn and corn straw, good taste, convenience in use, high bioavailability, safety, effectiveness, high comprehensive utilization rate of resources, environmental friendliness and the like.

A system for remotely determining the potential presence of depression in a user. The system includes a virtual agent that administers one or more tasks to the user. The user performs the tasks and the performance is captured by a camera. The captured audiovisual data is sent to a server that derives objective metrics which are then applied to a classifying algorithm. If certain metrics meet certain thresholds, the system determines that the user is exhibiting depression symptoms. In embodiments, the system can further determine whether a user has been taking depression medication.

The invention discloses application of allyl isothiocyanate in preparation of drugs or health-care foods for improving mental disorder, and belongs to the technical field of medicines. Allyl isothiocyanate shows rapid, convenient and efficient intervention potential for depression, emotional disorder, social difficulty, biphasic emotional fluctuation, anxiety and autism spectrum symptoms when used as a functional component of a medicine or health food. Specific experiments verify that in a depression model constructed by adopting social contusion stress, the component can obviously reverse typical depression-like behaviors such as social avoidance tendency and behavioral despair states shown by mice. In a chronic unpredictable stress induced model, allyl isothiocyanate effectively relieves anxiety and depression symptoms of mice and recovers pleasant sensation experience ability of the mice. In a drug-induced bipolar affective disorder model, the component obviously stabilizes the manic attack and depression alternating behavior of mice. In an autism model mouse, the allyl isothiocyanate effectively relieves the repetitive engraving behavior of the autism model mouse.

The application discloses application of hippuric acid in preparation of a medicine for preventing and / or treating depression, and belongs to the technical field of biological medicine. The hippuric acid or pharmaceutically acceptable salt thereof has significant and multi-target antidepressant pharmacological activity through chronic mild stress depression animal model experiment. Specifically, in terms of improving core depressive symptoms, the sugar water preference experiment result shows that the hippuric acid can effectively reverse CUMS-induced hedonic deficiency of mice, and significantly improves the sucrose preference rate, and the forced swimming experiment proves that the hippuric acid can significantly shorten the immobility time of mice and relieve behavioral despair; in terms of improving anxiety-like behavior, the mine field experiment data show that after the hippuric acid intervention, the number of times of entering the central area, the residence time and the total activity distance of the depressive model mice are all significantly increased, which indicates that the hippuric acid can effectively improve the spontaneous activity reduction caused by chronic stress.

The invention belongs to the field of chemical medicines, and particularly relates to a combined medicine for treating anxiety and / or depression. The combined medicine disclosed by the invention is a combined medicine of glucosylceramide and a PPAR gamma agonist; the combined medicine improves anxiety and depression symptoms by enhancing the transcriptional activity of PPAR gamma and the target gene level of PPAR gamma, shows a synergistic effect, opens up a new direction for treating anxiety and depression, and has a wide application prospect.

The invention provides a traditional Chinese medicine composition for treating coronary heart disease complicated with depressive state and application of the traditional Chinese medicine composition. Specifically, the invention provides a composition which comprises trichosanthes kirilowii maxim, allium macrostemon, salvia miltiorrhiza and blighted wheat. The composition can effectively cope with the problem that coronary heart disease patients are combined with the depressive state. The traditional Chinese medicine not only has the curative effect of treating qi stagnation and blood stasis, but also can remarkably improve the depressive symptom of a patient, so that the comprehensive treatment effect is realized.

The invention relates to the technical field of traditional Chinese medicine preparation, in particular to a traditional Chinese medicine composition for improving depression and a preparation method and application thereof, and the traditional Chinese medicine composition comprises the following raw materials: a spina date seed modified extract, cortex albiziae, vinegar-processed modified radix bupleuri, angelica sinensis, radix paeoniae alba, polygala tenuifolia, poria cocos and a functional additive. According to the invention, the spina date seed modified extract can tranquilize mind by nourishing the heart, calm the heart and calm palpitation, and effectively improve symptoms such as insomnia and anxiety accompanied by depression; the vinegar-processed modified radix bupleuri can soothe liver-qi stagnation and smooth qi activity, and plays a key role in liver-qi stagnation of the depression core pathogenesis; the pretreated cortex albiziae can relieve depression, calm the nerves, activate blood, diminish swelling and assist in improving accompanying symptoms such as blood stasis and qi stagnation; the traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition, the traditional Chinese medicine extract, the radix angelicae sinensis, the radix paeoniae alba and other traditional Chinese medicinal materials have a synergistic effect, the hypothalamus-pituitary-adrenal axis function is improved through multi-target regulation of central neurotransmitters, the improvement effect on depressive symptoms is obviously improved, the compatibility of the medicinal materials is good, the synergistic effect is higher, and the traditional Chinese medicine composition can be widely applied to preparation of medicines or health care products for improving the depressive symptoms.

The application discloses application of allyl isothiocyanate in preparation of a medicine for improving mental disorders and belongs to the technical field of medicines. The application of allyl isothiocyanate in preparation of a medicine for improving mental disorders has a rapid, convenient and efficient intervention potential for depression, emotional disorder, social difficulty, bipolar emotional fluctuation, anxiety and autism spectrum symptoms. Specific experimental verification: in a depression model constructed by using social frustration stress, the component can obviously reverse typical depression-like behaviors of the mouse, such as social avoidance tendency and behavior despair state. In a model induced by chronic unpredictable stress, allyl isothiocyanate effectively relieves anxiety and depression symptoms of the mouse and restores the hedonic experience ability of the mouse. In a medicine-induced bipolar affective disorder model, the component significantly suppresses the mania onset and depression alternating behavior of the mouse. In a mouse model of autism, allyl isothiocyanate effectively relieves the repetitive stereotyped behavior of the mouse.

The invention belongs to the technical field of biological medicines, and particularly relates to application of an O-GlcNAc glycosyl hydrolase inhibitor in preparation of a medicine for treating depression caused by opioid withdrawal. Experimental research shows that after being used for a long time, the opioids are abstinged, so that the glycosylation modification of dopaminergic neurons O-GlcNAc in a covered region on the abdominal side of a mouse is reduced, and the phenotypes of pleasant sensation loss and despair-like depression are caused. Intracranial sustained release and intraperitoneal injection of the O-GlcNAc glycosyl hydrolase inhibitor MK-8719 can recover the glycosylation modification level of dopaminergic neurons O-GlcNAc, can significantly improve pleasant sensation loss and despair symptoms caused by withdrawal of opioid analgesic drugs, and has an anti-depression curative effect. Therefore, the O-GlcNAc glycosyl hydrolase inhibitor MK-8719 can effectively reduce pleasant sensation loss and despair-like behaviors, the inhibition effect is clear in target and remarkable in effect, and the O-GlcNAc glycosyl hydrolase inhibitor MK-8719 can be applied to preparation of drugs for treating depression caused by withdrawal of opioid analgesic drugs.

The invention relates to application of lycorine and derivatives thereof in preparation of antidepressant drugs, and belongs to the technical field of biological medicines. According to the application disclosed by the invention, a drug compound library is screened by utilizing a per2- / -mutant zebrafish depression model, and the situation that 10 mu M of lycorine chloride can effectively rescue the depression-like phenotype of the per2- / -mutant zebrafish is found; the monomer shows remarkable treatment effects in a per2 gene knockout zebrafish depression model: (1) behavioral improvement: depression-like phenotypes such as per2- / -zebrafish exploration behavior reduction, social interaction defects and sleep-awakening rhythm disorder can be effectively reversed; (2) molecular mechanism regulation: restoring neurotransmitter steady state by down-regulating cortisol level and inflammation-related gene expression; lycorine chloride comes from plants, is easy to obtain and low in cost, and can be combined with existing western medicines in the market to treat depression, so that depression symptoms can be relieved.

The application discloses a traditional Chinese medicine composition and application thereof in preparation of a medicine for treating anxiety symptoms and / or depression symptoms of a vascular dementia patient, and relates to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine composition in the application has the function of nourishing blood and tranquilizing the mind, and the medicine developed by combining the traditional Chinese medicine composition with a brain metabolism medicine component has obvious improvement effect on the treatment of anxiety symptoms and depression symptoms of the vascular dementia patient, can preferably improve the healthy qi to stabilize the mood, promote blood circulation to relieve the anxiety symptoms and depression symptoms of the vascular dementia patient, is beneficial to the improvement of the mental state of the patient, and will not cause harmful side effects.

The present invention relates to a digital phenotyping-based depression analysis device and method, the device comprising: a data collection unit for monitoring a digital learning process on a user terminal so as to collect multimodal data related to finger or stylus pen use-related behavior of a user; a data analysis unit for analyzing the multimodal data so as to detect at least one digital marker associated with a symptom of depression of the user; and a depression identification unit for determining the severity of the symptom of depression of the user and whether the user has depression in the digital learning process on the basis of the at least one digital marker.

This invention discloses a model, system, and device for predicting the risk of chronic postoperative pain after surgery in adolescents with idiopathic scoliosis, belonging to the field of medical decision support technology. This application provides the first CPSP prediction model integrating psychological and physical factors, and a risk assessment system built based on this model. By acquiring relevant patient parameters, it can calculate an individualized probability of chronic postoperative pain risk and further output risk levels and personalized perioperative management recommendations. This invention is the first to integrate psychological factors (depressive symptoms) with physiological factors (gender, surgical extent, etc.) to construct a prediction model, which has been verified to have excellent discriminative power (AUC up to 0.852), enabling rapid and accurate preoperative identification of high-risk patients and providing a usable decision support tool for clinical implementation of integrated "psychological-pain" interventions.

The application provides a composition for relieving depression, comprising 10-17 parts of star anise, 10-15 parts of fennel, 9-12 parts of balm mint, 18-25 parts of day day flower, 8-15 parts of clove, 12-20 parts of black sesame, 12-16 parts of bergamot, 5-17 parts of hawthorn, 15-20 parts of turmeric, 5-10 parts of pumpkin, 5-10 parts of red bean, 15-20 parts of citrus fruit drop, 5-17 parts of walnut, 4-7 parts of medlar. The preparation method comprises the following steps: crushing, water distillation, physical field treatment, decocting, reduced pressure concentration, drying, embedding by using liposome, spray drying into powder and the like. The application constructs a multi-directional anti-depression formula. Compared with the health care product / medicine with single or few components in the prior art, the application can more effectively restore liver function, relieve depression symptoms, and avoid the problem of insignificant effect caused by short-acting single component, drug resistance and large side effect in the prior art.

The application discloses a kind of training method and system of depression intervention model based on deep knowledge graph, it is related to intelligent medical treatment and artificial intelligence technical field, the method is by obtaining the medical record text of patient, emotional language interaction data, sleep behavior data and physiological monitoring data.Data are carried out semantic analysis and entity relationship extraction, construct depression intervention knowledge graph, and embedding representation learning is carried out based on graph neural network, generates patient state vector.Patients state vector is input into intervention strategy generation model, and generates personalized intervention scheme prediction result.Based on prediction result, rehabilitation training is carried out, and intervention strategy is iteratively optimized through patient feedback.The method realizes the dynamic association of symptom, intervention and situation, and can continuously optimize personalized intervention scheme according to curative effect feedback, improve the rehabilitation effect of depression symptom and sleep disorder.

A neural repair composition, and a preparation method and use thereof are provided. The neural repair composition includes the following components in parts by weight: 0.1 part to 10 parts of curcumin or a turmeric powder and 4 parts to 460 parts of an Acer truncatum bunge seed oil. Through the synergistic interaction between Acer truncatum bunge seed oil and curcumin, the composition demonstrates excellent anti-aging and neural repair efficacy, while exhibiting mild action and non-irritating properties to the human body. The composition shows significant effects in preventing and treating neurodegenerative diseases, particularly in alleviating depression and enhancing memory.