42 results about "Depressive symptoms" patented technology

The invention relates to a preparation method of an effective part extract of n-butyl alcohol of Eupatorium chinense and application of the effective part extract in treatment of diabetes complicated with depression. The technical scheme of the invention is to provide an extract of the n-butyl alcohol effective part of the eupatorium chinense, which can be used for treating diabetes complicated by depression diseases. In-vitro experiments show that the eupatorium chinense extract has an inhibition effect on acetylcholin esterase (AChE). In-vivo animal experiments find that classical anti-diabetes and depression treatment drugs, namely metformin hydrochloride and fluoxetine hydrochloride, are taken as positive controls, experimental research on the treatment effect of the effective part extract of the n-butyl alcohol of the eupatorium chinense on mice suffering from diabetes complicated with depression is developed, and research results show that the extract can regulate insulin resistance and can be used for treating diabetes complicated with depression. The glycometabolism of mice with diabetes mellitus complicated with depression is improved, and the depression symptom is improved. The extract has a remarkable effect of treating diabetes mellitus complicated with depression, has a good effect of treating diabetes mellitus complicated with depression, and is expected to be developed into a new natural medicine for treating diabetes mellitus complicated with depression.

The invention provides a relaxation and decompression system for relieving juvenile depression based on traditional Chinese medicine five-tone music, and relates to the technical field of five-tone relieving, the relaxation and decompression system comprises an equipment layer and a cloud service layer, the equipment layer comprises an intelligent bracelet module and a multi-mode equipment output module, a user interaction sub-module, an optical heart rate sensing sub-module, a skin electric response sensing sub-module, a body temperature sensing sub-module and a questionnaire survey sub-module are arranged in the intelligent bracelet module, the multi-modal equipment output module comprises an audio conduction unit and a wearable acupuncture point stimulation unit, and a phototherapy control sub-unit is arranged in the wearable acupuncture point stimulation unit. The cloud service layer comprises a traditional Chinese medicine five-tone generation module, a cloud intelligent analysis module and a user feedback module; by introducing the mechanism of five voices of traditional Chinese medicine and combining the theory of traditional Chinese medicine, a three-dimensional synergistic mode of music, acupoint stimulation and phototherapy is provided, and a relieving control scheme is continuously adjusted through real-time biological signal feedback, so that the depressive symptom of teenagers is effectively relieved, and the pressure is relieved.

The invention relates to the technical field of intelligent wearing monitoring, in particular to a multifunctional head-mounted device for improving anxiety and depression symptoms in the perioperative period, which comprises a main body base, an electric treatment assembly and a power supply assembly are arranged on the main body base, extending ear hooks are arranged at two ends of the main body base, binding straps are arranged on the extending ear hooks, and a nose pad block is arranged at the bottom of the main body base. The electric treatment assembly is in signal connection with an evaluation and control system, heart rate monitoring assemblies are arranged on the extension ear hooks, and an eye movement monitoring assembly is arranged at the bottom of the main body base; a displacement monitoring assembly is arranged on the main body base, and a respiration monitoring assembly is arranged on the nose pad block. According to the invention, physiological parameter monitoring, anxiety and depression assessment and percutaneous nerve stimulation treatment functions are integrated, and multi-node fixed design and real-time dynamic data processing are combined, so that redundant steps depending on preposed medical assessment in the traditional technology are omitted, doctors can remotely and accurately adjust personalized schemes based on dynamic data, and the accuracy of diagnosis and treatment is improved. The anxiety depression intervention efficiency and reliability in the perioperative period are improved.

The invention provides a depression analysis scoring method based on knowledge distillation and retrieval enhancement generation, belongs to the field of depression medical assessment, and utilizes a large language model to convert emotion self-description data of volunteers into dialogue data between doctors and the volunteers. And using a large-scale reasoning large language model to perform emotion reasoning and scoring on the part representing the volunteer in the dialogue data according to a medical scale rule. Performing supervised fine tuning on the reasoning large language model with relatively small parameter scale by using the dialogue data and the corresponding reasoning process and scoring result, and constructing a large language model specially used for depressive emotion analysis; the method comprises the following steps: constructing a CCMD-3 diagnosis system into a vector database, and performing similarity retrieval on dialogue data in a real scene and the vector database; and combining the most relevant diagnosis standard obtained by retrieval with dialogue data in a real scene, jointly inputting into the depressive emotion big language model, and finally outputting an analysis result and a score of a depressive symptom.

The present invention relates to techniques for detection of depression cues in EEG signals using power spectral density-based features for deep learning. In an embodiment, a system for detecting depression in a person may comprise an Electroencephalogram (EEG) electrode array attached to the person, the EEG electrode array comprising at least ten electrodes adapted to read EEG signals, an amplifier, a filter, and an Analog to Digital Convert to digitize the read EEG signals, and computing circuitry comprising a processor, memory accessible by the processor, and computer program instructions stored in the memory and executable by the processor to perform: processing on the digitized read EEG signals to detect signal patterns indicative of depression in the person, and outputting a prediction indicating a likelihood of depression in the person based on the deep learning processing.

The invention discloses application of lactobacillus reuteri in preparation of products for preventing and / or treating depression and anxiety, the lactobacillus reuteri comprises a lactobacillus reuteri SINE003 strain, the lactobacillus reuteri is preserved in the general microbiological center of the China Committee for Culture Collection of Microorganisms on September 7, 2022, and the preservation number is CGMCC NO.25664. The lactobacillus reuteri can be used for preventing and / or treating depression and anxiety. The lactobacillus reuteri SINE003 strain is deeply analyzed and studied, and it is found that the lactobacillus reuteri SINE003 strain shows the improvement effect on anxiety and depression symptoms in different behavioral tests, meanwhile, the lactobacillus reuteri SINE003 strain has the effects of regulating serum inflammatory factors and / or brain-derived neurotrophic factors, regulating intestinal short-chain fatty acid, regulating intestinal flora and the like, and the lactobacillus reuteri SINE003 strain has wide application prospects.

The invention discloses a magnesium boride nanosheet / inulin composite hydrogel and application thereof in treating inflammatory bowel diseases and complicated mental diseases, and the composite hydrogel is synthesized by doping magnesium boride nanosheets into inulin and carrying out hot melting and cooling to form gel. The composite hydrogel has good oxidation resistance and biocompatibility, reducing hydrogen can be generated through a hydrolysis reaction to be used for reducing active oxygen and inflammatory factors of the enteritis part, intestinal flora can be adjusted, meanwhile, the composite hydrogel can be prevented from being affected by gastric acid and reach the intestinal part through the addition of inulin, and the enteritis treatment effect is improved. Therefore, the inflammatory bowel disease and related anxiety and depression symptoms thereof are effectively treated.

The invention discloses a traditional Chinese medicine composition for treating depression and insomnia and application thereof, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following raw material components in parts by weight: 10-15 parts of fermented soybean, 10-30 parts of lily, 10-15 parts of red wolfberry, 10-15 parts of radix puerariae, 10-30 parts of cistanche, 10-15 parts of longan aril, 10-30 parts of jujube, 9-30 parts of oyster, 10-15 parts of pawpaw, 3-10 parts of fingered citron, 5-15 parts of dogwood, 6-10 parts of fried gardenia, 15-30 parts of light wheat and 3-10 parts of honey-fried licorice root. Animal experiments and clinical tests prove that the traditional Chinese medicine composition can improve insomnia and depression symptoms at the same time. The traditional Chinese medicine composition has the overall regulation advantage of traditional Chinese medicine and the controllability of a modern preparation, and a safe and efficient treatment scheme is provided for depression and insomnia.

The present invention provides a method for constructing an emotion perception model and detecting the risk of early depression, which solves the problem that the emotion content and early description of depression symptoms expressed by users in social media are ignored in the existing methods, making it difficult to accurately judge whether the user is already in the early stage of depression. The present invention constructs a data set, obtains a social media dynamic data set of a user to be detected and obtains a set of early description posts of depression of the user to be detected containing at least one content; constructs the post representation layer, and uses a pre-trained language model to capture a context representation sequence that integrates negative emotion knowledge; constructs the user representation layer, and obtains a user representation matrix that integrates heterogeneous knowledge based on the output of the post representation layer; predicts the early depression risk level of the user to be detected through the detection layer; and obtains the emotion perception model after training, which can effectively detect and evaluate users with early depression.

This invention relates to the use of (4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone (NSI-189) or a pharmaceutically acceptable salt thereof in the treatment of a psychiatric condition in which depressive symptoms are prominent, including major depressive disorder (MDD), bipolar disorder, post-traumatic stress disorder, substance use disorder, and depression-related aspects of schizophrenia (e.g. negative symptoms) in select patients who exhibit impaired learning and / or memory. The invention also relates to the use of NSI-189 or a pharmaceutically acceptable salt thereof in the treatment of a psychiatric condition in which depressive symptoms are prominent, including major depressive disorder (MDD), in select patients who exhibit impaired learning and / or memory or certain EEG characteristics.

The invention provides a composition for relieving depression. The composition comprises 10-17 parts of anise, 10-15 parts of fennel, 9-12 parts of balm, 18-25 parts of seville orange flower, 8-15 parts of clove, 12-20 parts of black sesame, 12-16 parts of fingered citron, 5-17 parts of hawthorn, 15-20 parts of turmeric, 5-10 parts of pumpkin, 5-10 parts of red bean, 15-20 parts of dropped citrus fruit, 5-17 parts of walnut and 4-7 parts of medlar. The preparation method comprises the steps of crushing, water distillation, physical field treatment, decoction, vacuum concentration, drying, liposome embedding, spray drying into powder and the like. A multi-aspect anti-depression formula is constructed, and compared with health-care products / medicines with single or few components in the prior art, the anti-depression composition can more effectively recover liver functions and relieve depressive symptoms, and the problem that the effect is not remarkable due to short action time, drug resistance and large side effects of a single component in an existing product is solved.

This invention relates to the field of depression treatment technology, and in particular to the application of Trillium truncatum extract in the preparation of drugs for treating depression. The extraction method of the Trillium truncatum extract includes the following steps: S1, adding ethanol solution to Trillium truncatum at a material-to-liquid ratio of 1:10-12, and refluxing at 80-90℃ to obtain an extract; S2, concentrating the extract once, then adding macroporous resin for elution to obtain an eluent; centrifuging, concentrating a second time, and freeze-drying the eluent to obtain the Trillium truncatum extract. In this invention, the use of Trillium truncatum extract as a drug for treating depression can significantly alleviate symptoms of depression and psychogenic depression in mice. Furthermore, since Trillium truncatum extract is a natural substance, it has no toxic side effects, and its price is far lower than existing Western medicines for treating depression, making it convenient for widespread application in the treatment of depression.

The invention belongs to the technical field of traditional Chinese medicine, and particularly discloses a traditional Chinese medicine composition for treating fibromyalgia syndrome and a preparation method and application thereof.The traditional Chinese medicine composition is prepared from radix polygoni multiflori preparata, fructus citri sarcodactylis, radix pseudostellariae, caulis spatholobi, flos rosae rugosae, rhizoma dioscoreae, semen lablab album, rhizoma curcumae longae, lucid ganoderma, arillus longan, flos albiziae and fructus ziziphi jujubae. The traditional Chinese medicine has the effects of soothing liver and strengthening spleen, nourishing and activating blood, calming heart and tranquilizing mind, and activating meridians Pharmacodynamic experiment research and clinical observation results show that the traditional Chinese medicine composition can significantly relieve pain of patients and improve depressive symptoms, and can be used for treating fibromyalgia syndrome.

The invention relates to the fields of biotechnology, traditional Chinese medicines and nutritional health-care products, in particular to a bifidobacterium breve-containing medicinal and edible composite composition and application thereof in preparation of products for preventing or treating anxiety and depression, improving sleep disorders and assisting in weight management. The composite composition is prepared from bifidobacterium breve and a medicinal and edible composition, and the ratio of the bifidobacterium breve to the medicinal and edible composition is 1 * 10 < 10 > CFU of the bifidobacterium breve and 60 g of the medicinal and edible composition. The composition disclosed by the invention has a remarkable synergistic effect, can effectively prevent or relieve anxiety and depression symptoms, can improve sleep quality, and can assist in reducing body weight and body fat. The action mechanism relates to double targets of'intestine-brain-metabolic axis', and the double targets supplement each other to synergistically promote nerve-immunity-endocrine and metabolic balance. The composition disclosed by the invention can be used for preparing medicines, functional foods or health-care products, and provides a safe and effective brand-new choice for intervention of multiple health problems (emotion, sleep and metabolic disorders).

The invention discloses a depression risk detection model training method, a depression symptom early warning method and related equipment, and belongs to the technical field of depression detection. The problem that errors exist in an existing detection method is solved, the neural network model is constructed, the model is trained through the training samples, and the model capable of automatically detecting the depression risk is obtained; using the optimized neural network model to detect the current patient data, and outputting a depression risk detection result; comparing the depression risk detection result with a depression risk index to obtain a depression risk level of the current patient, thereby generating a depression risk detection report; a set intervention scheme is obtained according to the depression risk level, so that targeted treatment suggestions are provided for patients, and doctors can take more effective measures during clinical intervention; according to the method, the time of doctors is saved, and the medical cost is reduced.

The invention provides a traditional Chinese medicine composition for treating Parkinson's depression and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1-10 parts of radix acanthopanacis semticosi and 1-10 parts of bulbus lilii. The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps: taking the acanthopanax and the lily, adding water to soak, heating, refluxing and extracting, and combining filtrate to obtain the traditional Chinese medicine composition. Animal experiments find that the acanthopanax-lily traditional Chinese medicine composition has a good treatment effect on Parkinson depression for the first time, and can remarkably improve dyskinesia and depression symptoms, regulate neurotransmitter disorder, relieve damage to nigra and hippocampal neurons and reduce the level of inflammatory factors in serum. After being taken for a long time, the traditional Chinese medicine composition disclosed by the invention can improve depression and life quality, slow down the progress of Parkinson disease and reduce the use of Parkinson drugs.

1. A method for training a predetermined subject population that is expected to experience or is experiencing at least one depressive symptom, comprising: selecting a subject population that is expected to experience or is experiencing at least one depressive symptom in the future; and training the selected subject population with a neurofeedback (NF) training protocol for increasing activity of a brain's positive emotional valence system, the training comprising: presenting sensory indicators to each subject of the selected subject population; instructing the subject to modify the presented sensory indicators by performing at least one specific activity; detecting an increase in the brain pleasure response in the subject; and providing the subject with a feedback signal indicative of the increase in the brain pleasure response during the presentation.

The invention relates to corn capable of bidirectionally regulating anxiety and depression symptoms. The mass ratio of campesterol to stigmasterol to beta-sitosterol in the corn is 1: (0.5-5): (1-5). The planted corn can bidirectionally regulate anxiety and depression symptoms, and has the advantages of high yield of planted corn and corn straw, good taste, convenience in use, high bioavailability, safety, effectiveness, high comprehensive utilization rate of resources, environmental friendliness and the like.

A system for remotely determining the potential presence of depression in a user. The system includes a virtual agent that administers one or more tasks to the user. The user performs the tasks and the performance is captured by a camera. The captured audiovisual data is sent to a server that derives objective metrics which are then applied to a classifying algorithm. If certain metrics meet certain thresholds, the system determines that the user is exhibiting depression symptoms. In embodiments, the system can further determine whether a user has been taking depression medication.

The invention provides a traditional Chinese medicine composition for treating yin and blood deficiency type depression. The composition is mainly prepared from the following traditional Chinese medicines in parts by weight: 25 to 400 parts of colla corii asini, 25 to 400 parts of semen ziziphi spinosae, 30 to 500 parts of fructus mori, 30 to 500 parts of fructus citri sarcodactylis, 30 to 600 parts of semen persicae and 30 to 600 parts of poria cocos. The composition has the advantages of nourishing yin and blood, soothing liver-qi stagnation, promoting blood circulation to restore menstrual flow, and clearing away heart fire and soothing nerves. Animal experiments show that the traditional Chinese medicine composition can effectively improve depression-like symptoms of mice with depression, the anti-depression effect of the traditional Chinese medicine composition is equivalent to that of a positive drug fluoxetine, and no obvious adverse drug reaction exists. In addition, the composition also has a remarkable curative effect of nourishing yin and enriching blood, and a positive drug fluoxetine does not have a response effect. The composition is simple, raw materials are easy to obtain, the adaptation specificity is high, the preparation process is simple, and the composition is suitable for industrial production.

The invention discloses application of allyl isothiocyanate in preparation of drugs or health-care foods for improving mental disorder, and belongs to the technical field of medicines. Allyl isothiocyanate shows rapid, convenient and efficient intervention potential for depression, emotional disorder, social difficulty, biphasic emotional fluctuation, anxiety and autism spectrum symptoms when used as a functional component of a medicine or health food. Specific experiments verify that in a depression model constructed by adopting social contusion stress, the component can obviously reverse typical depression-like behaviors such as social avoidance tendency and behavioral despair states shown by mice. In a chronic unpredictable stress induced model, allyl isothiocyanate effectively relieves anxiety and depression symptoms of mice and recovers pleasant sensation experience ability of the mice. In a drug-induced bipolar affective disorder model, the component obviously stabilizes the manic attack and depression alternating behavior of mice. In an autism model mouse, the allyl isothiocyanate effectively relieves the repetitive engraving behavior of the autism model mouse.

The invention relates to the technical field of depression treatment, in particular to application of trillium tschonoskii extract in preparation of a medicine for treating depression. The extraction method of the trillium tschonoskii extract comprises the following steps: S1, adding an ethanol solution into trillium tschonoskii according to a solid-liquid ratio of 1: (10-12), and performing reflux extraction at 80-90 DEG C to obtain an extracting solution; s2, performing primary concentration on the extracting solution, and then adding macroporous resin for elution to obtain eluent; performing centrifugation, secondary concentration and freeze-drying on the eluent to obtain a trillium tschonoskii extract; the trillium tschonoskii extract is adopted as the medicine for treating depression, the symptoms of depression and psychotic depression of mice can be obviously relieved, meanwhile, due to the fact that the trillium tschonoskii extract is a natural substance and has no toxic or side effect, the price of the trillium tschonoskii extract is far lower than that of existing western medicine for treating depression, and the trillium tschonoskii extract can be conveniently and widely applied to treatment of depression.

An object is to accurately predict recurrence and worsening of depression symptoms in advance. An information processing system (100) includes: a clustering unit (52) that inputs behavior record information of a user (U) to a clustering model that classifies behavior patterns into a plurality of clusters, and classifies behavior patterns of the user (U) into any of the plurality of clusters; a first feature amount generation unit (53) that generates a first feature amount indicating an activity state of the user U; and an estimation unit (55) that estimates a magnitude of psychological stress of the user (U) on the basis of object person information including attribute information of an object person, a cluster into which the behavior patterns of the object person are classified, and the first feature amount.

The application discloses application of hippuric acid in preparation of a medicine for preventing and / or treating depression, and belongs to the technical field of biological medicine. The hippuric acid or pharmaceutically acceptable salt thereof has significant and multi-target antidepressant pharmacological activity through chronic mild stress depression animal model experiment. Specifically, in terms of improving core depressive symptoms, the sugar water preference experiment result shows that the hippuric acid can effectively reverse CUMS-induced hedonic deficiency of mice, and significantly improves the sucrose preference rate, and the forced swimming experiment proves that the hippuric acid can significantly shorten the immobility time of mice and relieve behavioral despair; in terms of improving anxiety-like behavior, the mine field experiment data show that after the hippuric acid intervention, the number of times of entering the central area, the residence time and the total activity distance of the depressive model mice are all significantly increased, which indicates that the hippuric acid can effectively improve the spontaneous activity reduction caused by chronic stress.

The invention belongs to the field of chemical medicines, and particularly relates to a combined medicine for treating anxiety and / or depression. The combined medicine disclosed by the invention is a combined medicine of glucosylceramide and a PPAR gamma agonist; the combined medicine improves anxiety and depression symptoms by enhancing the transcriptional activity of PPAR gamma and the target gene level of PPAR gamma, shows a synergistic effect, opens up a new direction for treating anxiety and depression, and has a wide application prospect.

The invention provides a traditional Chinese medicine composition for treating coronary heart disease complicated with depressive state and application of the traditional Chinese medicine composition. Specifically, the invention provides a composition which comprises trichosanthes kirilowii maxim, allium macrostemon, salvia miltiorrhiza and blighted wheat. The composition can effectively cope with the problem that coronary heart disease patients are combined with the depressive state. The traditional Chinese medicine not only has the curative effect of treating qi stagnation and blood stasis, but also can remarkably improve the depressive symptom of a patient, so that the comprehensive treatment effect is realized.

The invention relates to the technical field of traditional Chinese medicine preparation, in particular to a traditional Chinese medicine composition for improving depression and a preparation method and application thereof, and the traditional Chinese medicine composition comprises the following raw materials: a spina date seed modified extract, cortex albiziae, vinegar-processed modified radix bupleuri, angelica sinensis, radix paeoniae alba, polygala tenuifolia, poria cocos and a functional additive. According to the invention, the spina date seed modified extract can tranquilize mind by nourishing the heart, calm the heart and calm palpitation, and effectively improve symptoms such as insomnia and anxiety accompanied by depression; the vinegar-processed modified radix bupleuri can soothe liver-qi stagnation and smooth qi activity, and plays a key role in liver-qi stagnation of the depression core pathogenesis; the pretreated cortex albiziae can relieve depression, calm the nerves, activate blood, diminish swelling and assist in improving accompanying symptoms such as blood stasis and qi stagnation; the traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition, the traditional Chinese medicine extract, the radix angelicae sinensis, the radix paeoniae alba and other traditional Chinese medicinal materials have a synergistic effect, the hypothalamus-pituitary-adrenal axis function is improved through multi-target regulation of central neurotransmitters, the improvement effect on depressive symptoms is obviously improved, the compatibility of the medicinal materials is good, the synergistic effect is higher, and the traditional Chinese medicine composition can be widely applied to preparation of medicines or health care products for improving the depressive symptoms.

The invention discloses application of ergothioneine in the aspect of preventing depression, which is specifically characterized in that the ergothioneine has a remarkable effect in the aspect of regulating nervous system functions and can effectively reduce, prevent and relieve the incidence rate of depression symptoms. The action mechanism of the ergothioneine is that the ergothioneine can effectively remove free radicals in a body and reduce damage of oxidative stress to nerve cells, so that the normal function of a nervous system is protected. In addition, the ergothioneine can also promote the balance of neurotransmitters, improve the emotional state and further improve the anti-depression effect. Experimental results provide powerful support for application of ergothioneine in the field of prevention and treatment of depression.

The invention discloses anti-depression soft sweets and a making method thereof.The method comprises the steps that 1, hericium erinaceus polysaccharide, ganoderma lucidum spore powder and cordycepin are mixed to obtain a mixture A, and then the mixture A is mixed with fruit and vegetable powder to obtain functional components; 2, taking solid sugar alcohol, an acidulant, functional components, a preservative, a coloring agent, a coagulator and water for later use; 3, at the temperature of 50-70 DEG C, solid sugar alcohol and an acidulant are sequentially added into water and stirred to be dissolved, sugar liquid is obtained, then the functional components are added into the sugar liquid and stirred to be uniform, a solution B is obtained, then the preservative is added into the solution B and stirred to be dissolved, a solution C is obtained, then the coloring agent is added into the solution C and stirred to be dissolved, and a solution D is obtained; 4, adding a coagulator into the solution D at 70-90 DEG C, and stirring until the coagulator is dissolved to obtain a solution E; and 5, pouring the solution E into a soft sweet mold, standing at room temperature for 4-5 hours, and demolding to obtain the anti-depression soft sweet which is rich in various active ingredients and can effectively improve anxiety and depression symptoms.

The application discloses application of allyl isothiocyanate in preparation of a medicine for improving mental disorders and belongs to the technical field of medicines. The application of allyl isothiocyanate in preparation of a medicine for improving mental disorders has a rapid, convenient and efficient intervention potential for depression, emotional disorder, social difficulty, bipolar emotional fluctuation, anxiety and autism spectrum symptoms. Specific experimental verification: in a depression model constructed by using social frustration stress, the component can obviously reverse typical depression-like behaviors of the mouse, such as social avoidance tendency and behavior despair state. In a model induced by chronic unpredictable stress, allyl isothiocyanate effectively relieves anxiety and depression symptoms of the mouse and restores the hedonic experience ability of the mouse. In a medicine-induced bipolar affective disorder model, the component significantly suppresses the mania onset and depression alternating behavior of the mouse. In a mouse model of autism, allyl isothiocyanate effectively relieves the repetitive stereotyped behavior of the mouse.