42 results about "Sulfanyl" patented technology

Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF-alpha converting enzyme (TACE), a pro-inflammatory cytokine, catalyzes the formation of TNF-alpha from membrane bound TNF-alpha precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states. The present invention provides low molecular weight, non-peptide inhibitors of matrix metalloproteinases (MMPs) and TNF-alpha converting enzyme (TACE) for the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection having the formulawherein R2 and R3 form a heterocyclic ring and A is S, S(O), or S(O)2, and R1 and R4 are defined herein.

Organic dyes and photoelectric conversion devices are provided. The Organic dye has the structure represented by formula (I), wherein, n is an integral of 2-11; the plurality of X is independent and elected from the group consisting ofand combinations thereof; R, R1, and R2 comprise hydrogen, halogen, C1-18 alkyl group, C1-18 alkoxy group, C3-18 heteroalkyl group, C3-20 aryl group, C3-20 heteroaryl group, C3-20 cycloaliphatic group or C3-20 cycloalkyl group, or R1 is connected to R2 to form a ring having 5-14 members; R3 comprise hydrogen, halogen, nitro group, amino group, C1-18 alkyl group, C1-18 alkoxy group, C1-18 sulfanyl group, C3-18 heteroalkyl group, C3-20 aryl group, C3-20 heteroaryl group, C3-20 cycloaliphatic group or C3-20 cycloalkyl group; and Z is hydrogen, alkali metal, or quaternary ammonium salt.

The invention discloses a preparation method of high-purity vortioxetine hydrobromide. The method comprises the following steps: firstly, synthesizing 2-(2,4-dimethyl phenyl sulfanyl) chlorobenzene from 2-chlorophenol and 2,4-dimethylbenzenethiol; then, adding di(dibenzylideneacetone)palladium, 1,1'-binaphthyl-2,2'-bis(diphenyl phosphine), sodium tert-butoxide, and methylbenzene into a reaction bottle to mix, and adding other materials so as to prepare vortioxetine; and dissolving the prepared vortioxetine by using 14-16 times of ethyl acetate, so that a vortioxetine hydrobromide coarse product is obtained; and finally, purifying the coarse product so as to obtain a vortioxetine hydrobromide fine-product. The method disclosed by the invention is easily-obtained in raw materials, mild in process reaction conditions, high in product yield, high in product purity, and convenient for industrial production. Prepared vortioxetine hydrobromide is white crystalline powder, and the purity is more than 99.5%.

The invention discloses a dual-slurry ammonization granulation compound fertilizer production technology, which is characterized by high nitrogen content and adjustable available nutrients. The technology comprises the following steps: 1, carrying out secondary dechlorination at low temperature; 2, dissolving phosphorus and mixing slurries; 3, cooling and absorbing; 4, melting and dissolving urea; 5, aminating and granulating; 6, drying and cooling; 7, screening and smashing; and 8, packaging. By using the invention, nitrogen content of sulfanyl compound fertilizers rises to 25% from 13%, recycle ratio reduces to 20-30% from 40-50%, yield of single-pass granulation in a granulator is greatly improved, dechlorination time is shortened to 1h from over 2h by adopting the secondary dechlorination technology, the dechlorination is thorough, and the production efficiency is greatly improved.

The invention belongs to the field of axial chiral compounds, and discloses an EBINOL axial chiral compound. The EBINOL axial chiral compound has the following general formula(the formula is shown inthe description), wherein R<1> and R<2> are respectively and independently selected from hydrogen, alkyl, alkynyl, alkenyl, phenyl, alkoxyl, amine, halogen, trifluoromethyl, cyano group, hydroxyl, aldehyde group, carboxy group, acetyl, ester group, nitro group, amide group, sulfonyl group, sulfonic group, sulfydryl and sulfanyl. The invention further discloses a synthesis method and application ofthe EBINOL axial chiral compound. According to the EBINOL axial chiral compound as well as the synthesis method and application thereof, the axial chiral EBINOL compound with a novel structure is designed, and the skeleton of the EBINOL is constructed by the asymmetric hydrogenation and arylation of chiral acid catalyzed aryl alkyne; the synthesis method has good yield, and excellent E / Z selectivity and enantioselectivity; catalysts, such as chiral phosphoric acid and chiral phosphoramidite, used for asymmetric reactions can be derived from the EBINOL compound.

The invention is directed toward non-wild-type organophosphorus acid anhydrolases having three site mutations, method of production, and method of use to effectively degrade toxic chemical compounds such as (Ethyl({2-[bis(propan-2-yl)amino]ethyl}sulfanyl)(methyl)phosphinate (“VX”).

The invention provides a reactive dye at formula(I)with sulfanyls and beta-sulfate radical ethyl sulphonyls; wherein the definitions of D,R,R1,R2,R3,R4,Q, x and y are detailed in the specification. The reactive dye is of high solubility and high alkali solubility to cellulose base fibre when being used to dye cellulose base fibre and is easy to wash with water; therefore, the reactive dye is applicable in cold pressure dyeing, continuous dyeing, printing and dyeing, and digital printing.

A photosensitive monomer of formula.“L1”, “L2”, “L3”, “L4”, “L5”, “L6” are selected from hydrogen, fluorine, chlorine, cyano, alkyl, alkylcarbonyl, alkoxycarbonyl, and alkylcarbonyloxy having 1 to 7 carbon atoms, in which one or more hydrogen atoms may be substituted by fluorine or chlorine.“R1”, “R2”, “R3” and “R4” are selected from hydrogen, fluorine, chlorine, cyano, thiocyanato, pentafluoro sulfanyl, nitrite, straight-chained alkyl / branched alkyl, and a “Z-Sp-P” group. At least one of “R1”, “R2”, “R3” and “R4” is “Z-Sp-P” group. “Z” is selected from oxygen, sulfur, methyoxy, carbonyl, caroboxyl, carbamoyl, methylthio, ethenylcarbonyl, carbonylethenyl, and a single bond. “Sp” is selected from straight-chained alkyl or branched alkyl and a single bond. “P” comprises a polymerizable group.

Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF-alpha converting enzyme (TACE), a pro-inflammatory cytokine, catalyzes the formation of TNF-alpha from membrane bound TNF-alpha precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states. The present invention provides low molecular weight, non-peptide inhibitors of matrix metalloproteinases (MMPs) and TNF-alpha converting enzyme (TACE) for the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection having the formula wherein R2 and R3 form a heterocyclic ring and A is S, S(O), or S(O)2, and R1 and R4 are defined herein.

Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF-alpha converting enzyme (TACE), a pro-inflammatory cytokine, catalyzes the formation of TNF-alpha from membrane bound TNF-alpha precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states. The present invention provides low molecular weight, non-peptide inhibitors of matrix metalloproteinases (MMPs) and TNF-alpha converting enzyme (TACE) for the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection having the formula wherein R2 and R3 form a heterocyclic ring and A is S, S(O), or S(O)2, and R1 and R4 are defined herein.

The present invention is directed to a crystalline compound comprising a hydrobromide acid (HBr) salt of a compound of formula (I) (1-{2-[(2,4-dimethylphenyl)sulfanyl]phenyl}piperazine, INN: vortioxetine), having an XRPD pattern with characteristic peaks (expressed in 2θ±0.2° 2θ (CuKα radiation)) at 5.5°, 14.8°, 16.7° and 20.0° and processes for obtaining the same.

The invention relates to a compound of the 5-acylsulfanyl-histidine type and the derivatives thereof, of general formula (I), wherein R1 to R3=H, alkyl, especially CH3; R4=H, alkyl, especially CH3, alkyle(C=0), substituted alkyl (C═O), aryl (C═O); β-alanyl (H2NCH2CH2 (C═O); α-amino-acyl; R5=alkyl, especially methyl, phenyl. The invention also relates to the use of said compound for producing compounds of the 5-sulfanyl-histidine type and the derivatives thereof, in addition to corresponding disulfides; and to the various methods for the production thereof.

An alkyltin compound of specified formula which has utility as an excellent stabilizer for a halogen-containing resin. The alkyltin compound has from 1-3 terminal thiol groups.

The invention belongs to the field of fine chemical engineering, and relates to a method for preparing N-(substituent) benzothiazine-4-ketone without metal participation. Comprising the following steps: sequentially adding N-(substituted)-2-sulfur alkyl benzamide, 1-chloromethyl-4-fluoro-1, 4-diazabicyclo [2.2. 2] octane bis (tetrafluoroborate) salt, sodium iodide and hydroiodic acid into a sealed tube containing a reaction solvent acetonitrile, heating, violently stirring and reacting to obtain the N-(substituted) benzothiazine-4-ketone. The sulfanyl group in the reaction substrate is subjected to C-S bond breakage firstly, then the chloromethyl group in the additive is transferred into the substrate, construction of C-S and C-N is achieved at the same time, and construction of the benzothiazine-4-ketone is achieved. The method has the characteristics of greenness and high efficiency.

The present invention relates to Pyridin-2-yl sulfanyl acid ester compounds having antiinflammatory properties. The present invention particularly relates to novel anti-inflammatory heterocyclic acid esters of Pyridin-2-yl sulfanyl having the structure of general formula 1 which have been screened for their antiinflammatory activity with respect to inhibition of adhesion of neutrophils, isolated from human peripheral blood, onto the surface of human umbilical vein endothelial cells (HU-VEC) as a result of inhibition of the cytokine-stimulated expression of cell adhesion molecule ICAM-1. The compound RS—Z, 3-(Pyridin-2-yl sulfanyl)-propionic acid pentyl ester (structure 1a, R1=H, R2=H, R3=CH2-COOC5H11) was found to be most effective for ICAM-1 and neutrophil adhesion inhibition and was found to effectively alleviate inflammation mediated by excessive leukocyte infiltration leading to inflammatory disorders or like conditions, such as acute lung injury and acute respiratory distress syndrome in mice.

The invention provides a functionalized zirconium-based metal organic cage as well as a preparation method and application thereof. The preparation method of the functionalized zirconium-based metal organic cage comprises the following steps: S1, dissolving (S, S)-2, 5-bis-(2-hydroxypropyl sulfanyl)-terephthalic acid and zircon salt in an organic solvent to obtain a mixture; s2, the mixture is subjected to a reaction through a solvothermal method, and a reaction mixture is obtained; s3, the reaction mixture is cooled, crystallized, washed and subjected to solvent exchange, and the functionalized zirconium-based metal organic cage is obtained. The functionalized zirconium-based metal organic cage is simple in preparation method, good in stability, high in detection efficiency, high in sensitivity and strong in anti-interference performance, can realize specific recognition of various environmental pollutants including sulfonamides, nitrofurans and toxic heavy metals under different concentrations, and has good universality.

The present invention relates to Pyridin-2-yl sulfanyl acid ester compounds having antiinflammatory properties. The present invention particularly relates to novel anti-inflammatory heterocyclic acid esters of Pyridin-2-yl sulfanyl having the structure of general formula 1 which have been screened for their antiinflammatory activity with respect to inhibition of adhesion of neutrophils, isolated from human peripheral blood, onto the surface of human umbilical vein endothelial cells (HU-VEC) as a result of inhibition of the cytokine-stimulated expression of cell adhesion molecule ICAM-1. The compound RS—Z, 3-(Pyridin-2-yl sulfanyl)-propionic acid pentyl ester (structure 1a, R1=H, R2=H, R3=CH2-COOC5H11) was found to be most effective for ICAM-1 and neutrophil adhesion inhibition and was found to effectively alleviate inflammation mediated by excessive leukocyte infiltration leading to inflammatory disorders or like conditions, such as acute lung injury and acute respiratory distress syndrome in mice.

The invention belongs to the technical field of organic photoelectric materials and particularly relates to an alkyl / sulfanyl N-heterocyclic terminal D (A-Ar) type 2 conjugate compound as well as a preparation method and application thereof. A conjugate organic small molecule photovoltaic donor material with a D (A-Ar) type 2 structure is obtained by taking 3,3'-difluoro-2,2'-bisthiophene donor unit as a center core and carrying out alkylation reaction, electrophilic substitution bromination reaction and stille coupling reaction. The D (A-Ar) type 2 conjugate compound disclosed by the invention has the advantages of good solubility and stability, wide spectral absorption range, high light absorption capacity and proper electrochemical energy level and capability of being expected to be used in donor materials of organic solar cells. The maximum energy conversion efficiency and short-circuit current of a single-layer device body heterojunction solar cell with Fullerene PC71BM as a receptor respectively reach 8.91 percent and 16.75mA cm<-2>.

An alkyltin compound of specified formula which has utility as an excellent stabilizer for a halogen-containing resin. The alkyltin compound has from 1-3 terminal thiol groups.

The present invention is directed to a crystalline compound comprising a hydrobromide acid (HBr) salt of a compound of formula (I) (1-{2[2,4-dimethylphenyl)sulfanyl]phenyl}piperazine, INN: vortioxetine), having an XRPD pattern with characteristic peaks (expressed in 2θ±0.2° 2θ (CuKα radiation)) at 5.5°, 14.8°, 16.7° and 20.0° and processes for obtaining the same.

The present invention provides a crystalline lens hardening inhibitor, containing a compound represented by the formula (I):wherein R1-R4 are the same or different and each is a hydrogen atom, a halogen atom, a hydroxy group, a sulfanyl group, a lower alkyl group, a lower acyl group, a lower alkoxy group, a carboxyl group, a carbamoyl group or a carbonylamino acid group, or a salt thereof, and / or a compound represented by the formula (II):wherein R is a hydrogen atom, or a lower alkyl group optionally substituted by an amino group, a hydroxy group, a sulfanyl group or a carboxyl group, and A is a lower alkylene group, or a salt thereof.

The invention relates to a method for producing 4-pentafluoride-sulfanyl-benzoylguanidines of formula (I) wherein groups from R1 to R4 correspond to meanings given in claims. The compounds of the formula (I) constitute NHE1 inhibitors and can be used for curing cardiovascular diseases.

Process for producing N-[(2S)-sulfanyl-4-(1,5,5-trimethylhydantoinyl) butanoyl]-L-leucyl-L-tert-leucine N-methylamide by forming an intermediate compound N-[(2S)-thiobenzoyl-4-(1,5,5-trimethylhydantoinyl)butanoyl]-L-leucyl-L-tert-leucine N-methylamide by an improved process that substantially reduces the presence of contaminants in the reaction mixture.

A compound represented by formula (I), a metal extractant, and a method for separating and recovering metal ions using the metal extractant. In formula (I), R1 and R2 each represent a substituent having a molecular weight of 100 or more, and at least one of the substituents has a molecular weight of 160 or more. YP represents an oxygen atom or a sulfur atom. Z represents a hydroxyl group, a sulfanyl group, or a hydroxyaryl group. L represents a single bond, but when n is 2 or more, L sandwiched between two adjacent Ps represents a single bond or a linking group. And n is an integer of 1-6. Formula (I)

The invention belongs to the technical field of organic optoelectronic materials, and in particular relates to a D(A-Ar) at the end of a class of alkyl / sulfanyl nitrogen heteroaromatic rings 2 Type conjugated compound and preparation method and application thereof. Taking 3,3'-difluoro-2,2'-bisthiophene donor unit as the central nucleus, through alkylation reaction, electrophilic substitution on bromine reaction and stille coupling reaction, D(A-Ar) was obtained 2 Conjugated Organic Small Molecule Photovoltaic Donor Materials with Type Structure. D(A-Ar) according to the present invention 2 The type conjugated compounds have good solubility and stability, wide spectral absorption range, strong light absorption ability and suitable electrochemical energy level, and are expected to be used as donor materials for organic solar cells. with fullerene PC 71 The maximum energy conversion efficiency and short-circuit current of single-layer device bulk heterojunction solar cells with BM as acceptor are as high as 8.91% and 16.75 mA cm, respectively ‑2 .

The present disclosure relates to crystalline solid forms of {6-[(2-amino-3-chloropyridin-4-yl)sulfanyl]-3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-5-methylpyrazin-2-yl}methanol, or a pharmaceutically acceptable salt thereof, the process of preparing the forms, and pharmaceutical compositions and methods of use thereof.

The present application relates to oil and gas hydrogen sulfide absorption technical field, especially to a kind of for oil and gas exploitation, oil and gas environmental protection gathering and transportation hydrogen sulfide absorbent and preparation method thereof.Add 3-amino pentane and isopropylamine, 3-amino pentane and isopropylamine mixture and hydrogen sulfide reaction to form 3-sulfanyl pentane and 1-sulfanyl isopropylamine, reduce the content of hydrogen sulfide in oil and gas;In the reaction, appropriate solid catalyst is added, the reaction speed is improved, and the generation time is saved;And in the oil and gas of reaction kettle, bactericide propyl trimethyl ammonium chloride 2% to 4% and SAA are added, to avoid bacteria in oil and gas storage, sulfate and sulfur-containing organic compounds in sulfur are reduced to hydrogen sulfide;The use of precipitant adsorbs solid impurities in oil and gas and impurities generated after reaction, and the removal of impurities is facilitated;This scheme not only removes hydrogen sulfide in oil and gas, but also ensures that hydrogen sulfide is not generated again during oil and gas storage.