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35results about How to "Implement the build" patented technology

Method and device for constructing hydraulic simulation data

ActiveCN121682942BImprove conversion efficiencyimplement the build
The application discloses a method and device for constructing hydraulic simulation data. The method comprises: determining a hydraulic role corresponding to each visible component in a BIM model; determining a first face dictionary, a connection element dictionary and a connection face list based on the determination result of the hydraulic role; processing bottom surface data and top surface data of the visible component whose corresponding hydraulic role is a connection element based on the connection element dictionary to determine a receiving area set and a centroid point set; determining a support DEM dictionary and a blocking DEM dictionary based on the first face dictionary, and determining a final support DEM dictionary based on the determined support DEM dictionary and the determined blocking DEM dictionary; and determining a connection DEM dictionary based on the first face dictionary and the connection face list. Thus, the conversion efficiency from the BIM model to the hydraulic simulation is improved.
Owner:BEIJING GENERAL MUNICIPAL ENG DESIGN & RES INST

Sequential slow-release hydrogen sulfide nerve repair conduit and preparation method thereof

The invention provides a sequential slow-release hydrogen sulfide nerve repair conduit and a preparation method thereof, and belongs to the technical field of biological materials. The sequential slow-release hydrogen sulfide nerve repair conduit comprises degradable temperature-sensitive polyethylene glycol monomethyl ether-poly (cysteine-glycolic acid) hydrogel and a pH response hydrogen sulfide donor, wherein the degradable polymer conduit is filled with the degradable temperature-sensitive polyethylene glycol monomethyl ether-poly (cysteine-glycolic acid) hydrogel, and the pH response hydrogen sulfide donor is loaded on the hydrogel. In the application, the pH response donor can respond to an acidic microenvironment of degradation of polyethylene glycol monomethyl ether-poly (cysteine-glycolic acid) hydrogel, release hydrogen sulfide and relieve the acidic environment generated by degradation of the hydrogel at the same time, and form a dual supply mechanism with cysteine (endogenous hydrogen sulfide precursor) obtained by degradation of the hydrogel; nerve regeneration and angiogenesis are synergistically promoted, and oxidative stress is regulated; and the hydrogel is accelerated to degrade during excessive oxidative stress, so that hydrogen sulfide is released as required, and the core problems of insufficient blood supply, unbalanced acidic microenvironment and slow nerve regeneration are synchronously solved.
Owner:湖北江夏实验室 +1

A metadata intelligent identification method and device based on semi-supervised learning

The application provides a metadata intelligent identification method and device based on semi-supervised learning, and the method comprises the following steps: generating a metadata keyword identifier according to a conditional random field, wherein the metadata keyword identifier is used for extracting metadata features corresponding to any identification; acquiring an initial labeled data set, training the metadata keyword identifier according to the initial labeled data set to generate a metadata classifier; acquiring an unlabeled data set, predicting the unlabeled data set according to the metadata classifier to generate a prediction result; generating an intermediate training data set according to the prediction result; cyclically self-training the metadata keyword identifier and the metadata classifier according to the intermediate training data set to obtain a cyclically self-trained metadata classifier; and identifying metadata intelligently according to the cyclically self-trained metadata classifier. Through the application, the problem of low metadata identification construction efficiency in the related art is solved.
Owner:GLOBAL ENERGY INTERCONNECTION RES INST CO LTD +2

A method and system for three-dimensional reconstruction of coronary angiograms

PendingCN122597712Areduce offsetreduce mistakes
The application discloses a kind of coronary angiography three-dimensional reconstruction method and system, it is related to medical image processing technical field, including: obtaining multi-angle coronary DSA angiography projection image and executing pre-processing, extract blood vessel initial center line and both sides initial contour, calculate each section contrast agent relative concentration, combined with blood vessel local curvature, concentration difference sign change and anatomical feature adaptive segmentation blood vessel section, filter reliable reference side and generate mirror virtual contour, calculate three kinds of contour deviation, construct multi-constraint objective function and correct center line section by section, integrate corrected center line and fit lumen parameter, solve blood vessel feature point three-dimensional coordinate and complete three-dimensional reconstruction.The application has the advantages that: effectively suppress the center line deviation caused by contrast agent concentration uneven, consider correction accuracy and blood vessel form continuity, the size of three-dimensional model output is accurate, topological correct, can be directly used for clinical quantitative diagnosis and interventional operation planning.
Owner:张峰 +1

A method for physically estimating microwave soil equivalent temperature considering thermal sampling depth

PendingCN122508796Aimplement the buildBe physically explainable
The present application relates to the technical field of soil parameter remote sensing estimation, and particularly relates to a microwave soil equivalent temperature physical estimation method considering thermal sampling depth, comprising: obtaining soil temperature and humidity profile, surface temperature and soil texture data; combining dielectric constant model to calculate attenuation coefficients at different depths; determining thermal sampling depth based on the attenuation coefficients and dividing into multiple discrete layers; calculating average temperature using top and bottom temperatures of each layer according to soil heat conduction characteristics; calculating contribution weight of each layer to equivalent temperature based on attenuation coefficients and thickness of each layer; and obtaining microwave soil equivalent temperature by weighted sum of average temperature and weight of each layer. The present application has clear physical meaning, high estimation precision and is suitable for multiple frequencies, and overcomes the problem of limited precision or unclear physical meaning in the prior art.
Owner:KUNMING UNIV OF SCI & TECH

A new as-cast aluminum alloy and a preparation method thereof

PendingCN122503701ANo complex heat treatment requiredNot prone to solubility
This invention provides a novel as-cast aluminum alloy and its preparation method, belonging to the technical field of aluminum-based high-temperature materials. The method uses Al, Nb, and W metal blocks with a purity of 99.95% as raw materials, and designs the composition based on an Al-Nb-W ternary system, comprising Al 49–88 at.%, Nb 3–44 at.%, and W 2–14 at.% by atomic percentage, with the balance being unavoidable impurities. By selecting compositional combinations corresponding to different stable phase regions, two-phase structures (Al3Nb+AlNb2), three-phase structures (Al3Nb+AlNb2+Al4W), or three-phase structures (Al3Nb+AlNb2+bcc(Nb,W)) are formed under as-cast conditions. During the preparation process, vacuum arc melting is performed under argon protection, followed by 10–15 ingot-turning melting cycles, and cooling in a water-cooled copper crucible to obtain the as-cast alloy ingot. Characterization analysis confirms the phase regions corresponding to different compositions, and the Al, Nb, and W contents are optimized accordingly to achieve a stable intermetallic compound multiphase structure in the as-cast state. The as-cast structure of this invention exhibits good thermal stability under high-temperature conditions, making it suitable for applications such as high-temperature wear-resistant parts, corrosion-resistant parts, and coating substrates.
Owner:JILIN INST OF CHEM TECH

End-to-end oil business knowledge graph construction method based on large language model

The application relates to an end-to-end petroleum business knowledge graph construction method based on a large language model, which comprises the following steps: acquiring multi-source data in a petroleum business field to form rich corpus information; constructing a knowledge extraction module, designing a petroleum business field special prompt template, extracting and generating input data under instruction prompts by using a large language model, and outputting entity relationship triple knowledge structure; constructing a knowledge consistency verification module, introducing a thinking chain reasoning technology and a self-reflection mechanism, and performing correction and optimization; constructing a knowledge storage and management module, automatically importing triple knowledge data into a graph data system, establishing a multi-dimensional index structure, and completing preliminary establishment of a knowledge graph; and constructing a knowledge updating and feedback learning module, realizing dynamic evolution and self-adaptive updating of the knowledge graph. The application can realize rapid construction and dynamic updating of a petroleum business field knowledge graph at a low cost.
Owner:SANYA MARINE OIL & GAS RESEARCH INSTITUTE NORTHEAST PETROLEUM UNIVERSITY

An active mapping method for unknown underwater environment based on hovering underwater vehicle

ActiveCN116878507BEfficient constructionEfficient dynamic updatesRobot environmentSimulation
The application discloses a kind of based on hovering underwater vehicle's underwater unknown environment active mapping method, belong to robot environment exploration technical field.The underwater unknown environment active mapping method based on hovering underwater vehicle provided by the application utilizes hovering underwater vehicle to obtain the environmental data of unknown area of ocean in cooperation with sensor, determines the best next viewpoint according to information gain value, and determines the safe and feasible path to the best next viewpoint according to the cost of each adjacent node on the current tree as the parent node when the best next viewpoint is reached.Updating grid map in real time in this way, efficiently, quickly and accurately realize the construction and dynamic updating of map, and then assist underwater vehicle to realize the navigation of target area, and has broad application prospect in underwater environment exploration task and underwater structure inspection based on underwater vehicle and similar tasks.
Owner:HARBIN ENG UNIV

Preparation methods and applications of Ni3C / Bi5O7I composite materials

This invention provides a method for preparing Ni3C / Bi5O7I composite material and its application, relating to the field of photocatalysis technology. The preparation method includes: Step 1: Adding KI to a suspension containing Bi(NO3)3·5H2O and NaOH, stirring, and then carrying out a hydrothermal reaction. The resulting product is cooled to room temperature, centrifuged, washed, and dried to obtain Bi5O7I; Step 2: Adding nickel acetate to an oleylamine aqueous solution under a nitrogen atmosphere, carrying out a hydrothermal reaction, cooling to room temperature, and the resulting precipitate is centrifuged, washed, and dried to obtain Ni3C; Step 3: Adding Bi(NO3)3·5H2O solution dropwise to a suspension containing Bi5O7I and Ni3C under vigorous stirring, and then carrying out a hydrothermal reaction. The resulting precipitate is centrifuged, washed, and vacuum dried to obtain Ni3C / Bi5O7I. This invention improves the photocatalytic activity of Bi5O7I by introducing Ni3C into it, and gives the resulting photocatalytic material the ability to efficiently and stably degrade phenol in water, which has potential application value in the field of phenol-containing wastewater purification.
Owner:SHENZHEN KANGHONG INTELLIGENT HEALTH TECH CO LTD

High-efficiency solar water evaporator and preparation method and application thereof

This invention belongs to the field of solar water evaporation technology, and discloses a high-efficiency solar water evaporator, its preparation method, and its application. The preparation method includes the following steps: (1) Clean and dry coconut fibers, take multiple coconut fibers and weave them into a rope, and then cut them into coconut fiber ropes of the same length; (2) Embed the above-mentioned coconut fiber ropes of the same length into a sponge in an m×n array, wherein the lower end of the coconut fiber rope is flush with the bottom surface of the sponge, while its upper end protrudes from the top surface of the sponge by a certain height; (3) Immerse the part of the above-mentioned coconut fiber rope array protruding from the top surface of the sponge in a sodium alginate solution containing carbon black for surface coating treatment, and then take it out and air dry naturally to obtain a high-efficiency solar water evaporator based on a coconut fiber array. This invention has the characteristics of wide material sources, low cost, simple evaporator construction method, and high water evaporation rate, and has better prospects for large-scale preparation and commercial application.
Owner:HAINAN UNIV

Digital-twin-based distributed system performance dynamic simulation test method and platform

ActiveCN121567630Bimplement the buildImplement performance testingDesign optimisation/simulationTransmissionDistributed computingComputer engineering
The application discloses a distributed system performance dynamic simulation test method and platform based on digital twinning, relates to the technical field of digital twinning, and solves the problem of one-sidedness of distributed system performance test, and comprises the following steps: acquiring each physical node in the distributed system, identifying active nodes in the physical nodes, and collecting node static data of the active nodes; setting corresponding virtual nodes according to the node static data of the active nodes, and constructing a virtual twin system of the distributed system based on the virtual nodes and digital twinning technology; collecting node dynamic information of the active nodes in a monitoring period, and constructing a simulation test environment of the virtual twin system according to the node dynamic information; and performing performance test on the virtual twin system based on the simulation test environment, taking the performance test result of the virtual twin system as the performance test result of the distributed system. The application realizes comprehensive test on the performance of the distributed system by performing performance test on the virtual twin system of the distributed system.
Owner:GUOTING INFORMATION TECHNOLOGY (BEIJING) CO LTD

Oil film bidirectional reflection characteristic field measurement device and oil film thickness inversion correction method

The invention discloses an oil film bidirectional reflection characteristic on-site measurement device and an oil film thickness inversion correction method, and belongs to the technical field of image processing, and the oil film bidirectional reflection characteristic on-site measurement device comprises an experiment pool which contains an oil-water mixed sample; the annular guide rail is arranged around the experimental water tank; the camera support is arranged on the annular guide rail in a sliding mode, and a fixing base capable of rotating around a horizontal shaft and a vertical shaft is arranged at the upper end of the camera support; the hyperspectral camera is fixed on the fixed seat and is used for measuring the radiance of the experimental pool; and the irradiance meter is used for measuring the irradiance of the sunlight. The oil film bidirectional reflection characteristic on-site measurement device is simpler in structure and easy to implement, and the spectrum difference caused by different visual angles of the sensor is eliminated. And the accuracy and reliability of oil type identification and thickness inversion are greatly improved.
Owner:OCEAN UNIV OF CHINA

Chlorination furnace and nickel-iron alloy separation device

ActiveCN224302724UReduce corrosion resistance requirementsimplement the buildDispersed particle separationFurnace typesInsulation layerWater chlorination
The utility model provides a kind of chlorination furnace and nickel-iron alloy separation equipment.Chlorination furnace includes furnace body, air inlet, first cooling jacket, lifting mechanism and bottom disc.Furnace body has accommodating cavity inside.Air inlet is communicated with furnace body.First cooling jacket is located outside furnace body.Bottom disc is located at the bottom opening of furnace body and is connected with lifting mechanism, and it forms airtight cooperation with bottom opening to support the material in furnace body, or it separates from bottom opening to realize feeding and discharging of furnace body.In the above-mentioned chlorination furnace, the reaction temperature of furnace body is reduced by first cooling jacket, and the chlorides generated during the reaction process are deposited on the inner wall due to the effect of cooling jacket, and when the deposit reaches a certain thickness, the construction of the furnace insulation layer is realized.Under the condition of lower temperature, the reaction speed of chlorine and steel is slow.Therefore, the requirement for corrosion resistance of steel is reduced, and ordinary boiler steel can be used as the material of furnace body, reducing the production cost of equipment.
Owner:CENT SOUTH UNIV +1

An aerogel protocellular material, its preparation method and application

PendingCN122081302AAchieve dehydration stabilizationimplement the buildHydrolasesTransferasesPtru catalystAcid hydrolysis
This invention discloses an aerogel protocellular material, its preparation method, and its applications. The preparation method includes: under the coexistence of acidic and alkaline catalysts, sequentially subjecting an aqueous solution of a silicon precursor containing bioenzymes and anionic polymers to acid hydrolysis and alkaline condensation reactions to obtain a silica sol; mixing this sol with an oil phase containing cationic compounds for emulsification; and then, through spontaneous film formation and sol-gel conversion, forming a hydrogel protocellular material. Finally, the material undergoes low-temperature solvent replacement and drying. This invention provides the first method to achieve in-situ enzyme immobilization and integration of cell-like structures within a material, realizing the dehydration stabilization of the protocellular system and the construction of aerogel protocellular materials, overcoming the limitation of existing protocellular construction technologies that cannot operate outside of an aqueous environment; furthermore, it endows the bioenzymes with excellent thermal stability, photostability, and resistance to electrical shock, solving the technical problem of easy inactivation of existing bioenzymes under extreme conditions.
Owner:SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI

A sensing yarn, a textile component and a method for producing the same

PendingCN122588746AAchieve deep integrationElectrochemically active
A kind of sensing yarn, textile component and its preparation method belong to medical health monitoring field, sensing yarn includes core layer and coating covering core layer, coating includes biological recognition element and electronic medium body.The textile component includes the textile component main body formed by weft integrated weaving, the textile component main body includes sensing area, non-sensing area and integrated area;At least one sensing component is provided in the sensing area, the sensing component includes at least two conductive fibers, the conductive fibers are introduced into the textile component by laying-in process, and are fixed by covering and fixing of the loop of the textile component, the conductive fibers extend from sensing area to non-sensing area, and converge in the integrated area.The present application fundamentally solves the technical problems of traditional fabric sensor, such as easy to fall off, not durable, uncomfortable to wear and unstable signal, by deep combination of yarn functionalization and structural weaving, and provides a non-invasive, comfortable, reliable and suitable for long-term use of blood glucose trend monitoring solution.
Owner:SINCETECH FUJIAN TECH CO LTD

Hybrid Intermediate Layer and Its Formation Method

PendingCN122094515Aimplement the buildBreak through the size limitSilicon interposerInterconnection density
This application discloses a hybrid interposer and a method for forming the same. The method includes: providing a glass interposer, the glass interposer including a plurality of discrete functional regions and a cut-out region located between adjacent functional regions, the glass interposer including opposing first and second surfaces; forming a first bonding layer on the first surface of the glass interposer; providing a plurality of silicon interposers, each silicon interposer including opposing third and fourth surfaces, the third surface having a second bonding layer; bonding at least one silicon interposer to each functional region of the glass interposer, such that the second bonding layer and the first bonding layer are mixed-bonded; and forming a molding compound covering the silicon interposers on the first surface of the glass interposer, the molding compound exposing the fourth surface of the silicon interposers. This method improves the size and interconnect density of the interposer and reduces the warpage of the interposer.
Owner:JCET GROUP CO LTD

Blasting construction structure for preventing wellhead hole from being blocked

ActiveCN224415914Uimplement the buildPilot holeArchitectural engineering
The application discloses a construction structure of hole plugging prevention for well mouth blasting, which comprises a construction structure for constructing a plugging prevention structure at a pilot hole well mouth. When the blasting area is blasted, the flexible steel wire mesh establishes the first rolling prevention measure for large rolling stones; when the large rolling stones roll down, the wooden pile is moved and clamped in the pilot hole well through the spring A, the large rolling stones are clamped at the pilot hole well mouth against the wooden pile, and the large rolling stones are located at the side of the wooden pile, so that the construction of the plugging prevention structure is realized, and the problem that the existing plugging prevention technology cannot be used for construction due to insufficient construction space for the pilot hole well with a small inner diameter is solved.
Owner:CHINA WATER CONSERVANCY & HYDROPOWER NO 9 ENG BUREAU CO LTD

A method for constructing a digital core based on a rock chip sample

ActiveCN116263514BSolve limited puzzlesimplement the build
A method for constructing a digital core based on a rock sample, the method comprising the steps of: obtaining logging data of an oil and gas well; determining a reservoir section according to the logging data; obtaining logging data of a drill cuttings in the reservoir section; determining a real sample of the drill cuttings according to the logging data and the logging data; and establishing a digital core of the drill cuttings according to the real sample of the drill cuttings. The method for constructing a digital core based on a rock sample provided by the application establishes selection criteria for representative real samples of drill cuttings, and the selection of the real samples of drill cuttings can solve the problem of limited samples when constructing a digital core, thereby realizing the construction of digital cores of all depth sections, and obtaining a brittleness index of the oil and gas well by calculating a core brittleness index, which is beneficial to the development of the oil and gas well.
Owner:PETROCHINA CO LTD

Composite material as well as preparation method and application thereof

PendingCN121950323APrecise activationachieve activationAgriculture tools and machinesOrganic fertilisersOrganic matterIron reduction
The invention discloses a composite material as well as a preparation method and application thereof. The composite material comprises a core, a shell layer and a satellite body, the material of the core comprises an organic matter slow-release material; the material of the shell layer comprises a porous mineral material loaded with an electron shuttle, and the shell layer coats the core; the material of the satellite body comprises a Fe3O4 and iron reducing bacteria compound; and the satellite body is adsorbed on the surface of the shell layer. The composite material provided by the invention realizes integration of positioning, activation and slow release, can be actively anchored on the surface of a soil mineral needing to be activated, can accurately activate the soil mineral in situ and maintain the continuity of an iron reduction process, and releases fixed nutritional ingredients in soil.
Owner:GUANGDONG INST OF ECO ENVIRONMENT & SOIL SCI

Transparent high-precision geological attribute model efficient construction method and system

PendingCN122289580Asave storage spaceEasy dynamic updates
This invention discloses an efficient method for constructing a high-precision geological attribute model for transparent geology, including the steps of constructing a representation method for the geological attribute model; the steps of constructing access operations for the geological attribute model; the steps of constructing an octree operation for the geological attribute model; the steps of constructing the octree structure of the geological attribute model; and the completion of the geological attribute model construction. This invention also discloses a system for implementing the aforementioned efficient method for constructing a high-precision geological attribute model for transparent geology. This invention not only achieves the construction of the geological attribute model, but also boasts higher reliability, better accuracy, and higher efficiency. The construction process consumes less memory, requires less storage space for the constructed model, and facilitates relatively easy dynamic updates.
Owner:CHINA UNIV OF MINING & TECH +1

A method for constructing water-land seamless DEM based on multi-source satellite data fusion

PendingCN122597694Aachieve reconstructionimplement the build
This invention discloses a method for constructing a seamless land-water DEM based on multi-source satellite data fusion. The study area is divided into bare land, drawdown zone, and perennial waterlogged area based on the annual average water frequency of Sentinel-2 imagery. Using the ICESat-2 ATL08 ground point cloud during the dry season and contemporaneous Sentinel-2 imagery, the underwater topography of the drawdown zone is constructed using an XGBoost model. Using the ATL13 water surface elevation and depth during the wet season and contemporaneous Sentinel-2 imagery, the underwater topography of the perennial waterlogged area is constructed. Based on the water frequency, the results from the drawdown zone and the perennial waterlogged area are fused to generate a complete and continuous underwater topography. The elevation of the bare land ALOS DEM is then corrected using the ATL08 point cloud and fused with the topography of the drawdown zone and the perennial waterlogged area, achieving a seamless connection between land and water topography and constructing a high-precision integrated land-water DEM, thus improving the accuracy of the water area and shoreline topography.
Owner:NANJING UNIV OF INFORMATION SCI & TECH

Distributed network architecture construction method and system for port environment monitoring

Embodiments of the present application relate to the technical field of computer, and particularly relate to a distributed network architecture construction method and system for port environment monitoring, which divides multiple monitoring sub-areas according to the port area environment monitoring requirements, and deploys a set of heterogeneous monitoring nodes in each sub-area. Real-time running state sensing processing is performed on the node set to generate a target network topology structure. Based on the topology structure, routing protocol generation and data scheduling strategy formulation are performed to obtain an adaptive routing table and data transmission scheduling rule. Distributed collaborative optimization processing is performed on the nodes according to the table and rule to generate a network resource allocation scheme and node task load adjustment instruction, and finally the port area distributed network architecture is reconstructed through the scheme and instruction to improve the efficiency and accuracy of port environment monitoring.
Owner:CHINA WATERBORNE TRANSPORT RES INST

Satellite communication semi-physical simulation system and method for low-orbit giant satellite base

PendingCN121864148ARealize digital simulation functionimplement the buildRadio transmissionTransmission monitoringChannel simulatorRemote sensing
The invention belongs to the technical field of satellite communication, and provides a satellite communication semi-physical simulation system and method for a low-orbit giant satellite base, and the technical scheme is that the satellite communication semi-physical simulation system comprises a simulation server cluster and a physical test system, and the physical test system comprises a satellite communication load model machine, a ground communication terminal model machine and a satellite channel simulator; the ground communication terminal model machine and the satellite channel simulator are respectively connected to the simulation server cluster through the switch, one end of the satellite communication load model machine is connected to the simulation server cluster through the interface conversion equipment and the switch, and the other end of the satellite communication load model machine is connected with the ground communication terminal model machine through the satellite channel simulator; and the plurality of satellite communication load model machines are connected through the satellite channel simulator. Performance simulation evaluation of the satellite-ground communication network and the inter-satellite communication network can be realized at the same time.
Owner:NAT INNOVATION INST OF DEFENSE TECH PLA ACAD OF MILITARY SCI

Point cloud classification methods, apparatus, computer equipment and storage media

ActiveCN116704254Bimplement the buildImplement codingCharacter and pattern recognitionNeural learning methods
This invention discloses a point cloud classification method. The method includes: acquiring a preset dataset comprising at least one point cloud; determining at least one boundary point based on all points in the point cloud; constructing a graph neural network based on the boundary point and all its neighboring points, and encoding the graph neural network to obtain an encoding vector; extracting features from all non-boundary points in the point cloud using the preset point cloud network to obtain a feature vector; and acquiring a preset classification network to classify the encoding vector and feature vector to obtain a classification result. This invention solves the problem of high computational cost caused by constructing a graph neural network based on all point cloud data by selecting boundary points, thus reducing the computational load. Selecting boundary points improves the prediction accuracy of boundary classification, thereby improving the accuracy of the classification results.
Owner:PING AN TECH (SHENZHEN) CO LTD

Biological 3D printing visual craniocerebral tumor drug in-vitro screening model device and application thereof

PendingCN122012235Aimplement the buildBreakthrough drug type screeningBioreactor/fermenter combinationsBiological substance pretreatments3d printTumor cells
The invention belongs to the technical field of biological equipment, and particularly relates to a biological 3D printing visual craniocerebral tumor drug in-vitro screening model device and application thereof. The visual craniocerebral tumor drug in-vitro screening model device is mainly composed of a liquid inlet, a three-way valve, a bionic blood brain barrier model, a tumor model culture area, a culture container, a container cover, a cell culture bag, a camera and a cell activity detection electrode. The bionic blood brain barrier model and the tumor model can be realized by adopting a biological 3D printing mode; the construction of the in-vitro bionic blood-brain barrier model and the construction of the tumor model are integrated, and the method can be used for assisting in evaluating the type of the craniocerebral tumor treatment medicine and screening and evaluating the dosage of the medicine. Visualization of dynamic progress and drug screening in the rapid growth process of tumor cells is achieved, a stable and high-throughput drug screening chip is preliminarily formed through real-time monitoring of the cell activity detection electrode, and an auxiliary basis is provided for clinical treatment research of craniocerebral tumors.
Owner:THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIV +1

S-N co-doped porous carbon material and preparation method and application thereof

The invention discloses an S-N co-doped porous carbon material as well as a preparation method and application thereof. The preparation method comprises the following steps: A1, synthesizing a porous carbon material GN; a2, preparation of an S-N co-doped material SNGN; weighing GN and an S-N doping source according to a certain mass ratio, grinding and mixing to be uniform; transferring the mixed powder into a calcining furnace, heating to 750-800 DEG C at a certain heating rate in a nitrogen atmosphere, and keeping the temperature; and naturally cooling, washing the product with a hydrochloric acid solution, washing with deionized water until the product is neutral, and carrying out vacuum drying to obtain the S-N co-doped porous carbon material marked as SNGN. Through an S-N co-doping strategy, a porous carbon material (SNGN-1) with a rich microporous structure and multiple active sites is constructed, the adsorption capacity of Na is remarkably enhanced, the specific capacity and the rate capability of a negative electrode material are improved, and then construction of the high-performance all-carbon sodium ion hybrid capacitor is achieved.
Owner:PINGDINGSHAN UNIVERSITY

Ru-based water electrolysis catalyst composite material, and preparation method and application thereof

ActiveCN121161354Bevenly dispersedimplement the buildElectrodesPtru catalystNanoparticle
The application belongs to the technical field of water electrolysis catalysts, and relates to a Ru-based water electrolysis catalyst composite material and a preparation method and application thereof. The composite material takes ZIF-8 derived iron and nitrogen atom doped FeNC nanoparticles as an active carrier, loads sub-nano RuFe alloy particles and Fe elemental nanoparticles, and forms a three-active-site uniformly dispersed multi-level composite structure. Through twice dispersion and calcination, the Fe precursor is dispersed in the ZIF-8 skeleton in situ, the Fe atom and the elemental Fe are uniformly dispersed to construct the Fe / FeNC matrix through the first carbonization, the Ru precursor is adsorbed in the pores of the Fe / FeNC matrix, and the RuFe alloy is constructed and dispersed through the second carbonization, and finally the RuFe / Fe / FeNC composite material is obtained. The composite material provided by the application has high efficient hydrogen evolution and oxygen evolution performance, and has full water splitting industrial application potential in a laboratory electrolytic cell and a commercial PEM electrolytic cell.
Owner:SHANDONG SAIKESAISI HYDROGEN ENERGY +1

Multifunctional natural killer cell as well as preparation method and application thereof

The invention belongs to the technical field of biological medicine, and discloses a multifunctional natural killer cell as well as a preparation method and application thereof. The fused liposome has a core-shell structure, a transforming growth factor beta receptor I inhibitor is loaded in a core of the polylactic acid-glycolic acid copolymer, and phenylboronic acid is covalently connected to a shell layer of the fused liposome. The NK cell is subjected to engineering modification in a membrane fusion mode, a lipid shell layer is inserted into a cell membrane, an internal load is directly released into cytoplasm at the same time, targets on the cell membrane and the cytoplasm are synchronously remodeled in one engineering step, and the obtained multifunctional NK cell can overcome multiple immunosuppression in solid tumor treatment and can be used for treating solid tumors. And efficient adoptive NK cell treatment is realized, and great potential is shown in solid tumor treatment.
Owner:SUN YAT SEN UNIV +1

A knowledge graph construction method based on JERPE

ActiveCN116257637Bimplement the buildSolve the problem of accumulated errorEnergy efficient computingSpecial data processing applicationsSlide windowData source
The application belongs to the technical field of map construction method, and particularly relates to a knowledge map construction method based on JERPE, which comprises the following steps: obtaining data sources required for constructing a knowledge map and performing sliding window processing on text data; initializing primary state features; initializing secondary state features; taking the primary state features and the secondary state features as an environment in which an intelligent agent is located, and maximizing a reward to update parameters of the multi-intelligent agent; obtaining the next time primary state features of the current time from the multi-intelligent update; obtaining the next time secondary state features of the current time; and completing entity relationship attribute extraction to construct a knowledge map. The application can solve the accumulated error problem existing in traditional pipeline extraction, and efficiently and accurately realize construction of a knowledge map. The application can provide strong technical support for information retrieval, intelligent dialogue and many other applications.
Owner:SHANXI INFORMATION IND TECH RES INST CO LTD