334 results about "Phenacyl" patented technology

An active energy ray-curable inkjet printing ink composition satisfies requirements A to E below is provided: (A) the content of amine-modified oligomer is 1.0 to 20.0% by mass; (B) alkoxy group-containing (meth)acrylate monomers are contained by 2.0 to 20.0% by mass; (C) (meth)acrylate monomers having an alkyl group with 6 to 20 carbon atoms is contained by 2.0 to 25.0% by mass; (D) at least one type selected from the group that consists of 1,6-hexanediol diacrylate, 3-methyl-1,5-pentanediol diacrylate, dipropylene glycol diacrylate, 1,10-decanediol diacrylate, propoxylated(2)neopentyl glycol diacrylate, and hydroxypivalic acid neopentyl glycol diacrylate is contained by 30.0 to 60.0% by mass; (E) as photopolymerization initiators, ethoxy(2,4,6-trimethylbenzoyl)phenylphosphine oxide is contained by 3.0 to 15.0% by, and oligo(2-hydroxy-2-methyl-1-(4-(1-methylvinyl)phenyl)propanone) and / or 2-hydroxy-1-{4-[4-(2-hydroxy-2-methylpropionyl)phenoxy]phenyl}-2-methylpropanone is / are contained by 2.0 to 10.0% by mass, where the total content of photopolymerization initiators is 6.0 to 25.0% by mass.

The invention relates to a preparation method of 2-(2-amino-5-bromo-benzoyl) pyridine, which comprises the following steps: by taking 1, 2-diphenyl-1H-benzimidazole (I) as a starting material, oxidizing under the action of chromium trioxide and acetic acid to obtain N-[2-(2-pyridinecarbonyl) phenyl] benzamide (II), hydrolyzing the N-[2-(2-pyridinecarbonyl) phenyl] benzamide (II) under the action of sulfuric acid to obtain 2-(2-aminobenzoyl) pyridine (III), and reacting the 2-(2-amino-5-bromo-benzoyl) pyridine (III) with the 2-(2-amino-5-bromo-benzoyl) pyridine (III) to obtain the 2-(2-amino-5-bromo-benzoyl) pyridine. And (III) performing substitution reaction with NBS in DCM to obtain the target product 2-(2-amino-5-bromo-benzoyl) pyridine. The method has the advantages of mild reaction conditions, higher product purity, high yield, simplicity and convenience in operation, low cost and easiness in industrialization.

The invention discloses a process method for preparing a fluopyram key intermediate. The key intermediate is [3-chloro-5-(trifluoromethyl) pyridine-2-yl] ({[2-(trifluoromethyl) benzoyl] amino} methyl) dimethyl malonate, and the process method comprises the following steps: in the presence of a solvent 1, carrying out a reaction on a compound 2-[3-chloro-5-(trifluoromethyl) pyridyl] dimethyl malonate potassium salt and a compound 1-D in a reaction container, and distilling and recovering the solvent 1 to obtain the intermediate compound. Wherein the solvent 1 is selected from acetic ester solvents with the boiling point range of 40-110 DEG C at normal temperature and normal pressure. The process method is simple and convenient, the total yield is high, the solvent is easy to recover, and the product purity is high; the intermediate does not need purification post-treatment, can be directly used for synthesis of fluopyram, can be amplified, and is beneficial to cost reduction, efficiency improvement and commercial mass production.

The invention belongs to the field of medicinal chemistry, and particularly discloses a benzimidazole amine derivative, a preparation method thereof and application of the benzimidazole amine derivative as a beta2-adrenergic receptor allosteric antagonist. According to the benzimidazole amine derivative disclosed by the invention, R1 is a hydrogen atom or a bromine atom; r2 is substituted benzoyl, substituted benzyl and the like. Pharmacological results show that the benzimidazole amine derivative disclosed by the invention has relatively good antagonistic activity on beta2AR, and the functional activity of isoprenaline (ISO) can be subjected to negative allosteric regulation.

The invention relates to a preparation method of 2-(2-amino-5-bromo-benzoyl) pyridine, which comprises the following steps: (1) dissolving 2-amino-5-bromobenzoic acid in an organic solvent A, adding dimethyl hydroxylamine hydrochloride, a condensing agent and organic alkali, and carrying out condensation reaction to obtain 2-amino-5-bromo-N-methoxy-N-methyl benzamide; and (2) in an organic solvent B, enabling 2-bromopyridine to react with the 2-amino-5-bromo-N-methoxy-N-methyl benzamide in the step (1) under the action of an organic strong base, so as to obtain the 2-(2-amino-5-bromo-benzoyl) pyridine. The preparation method provided by the invention has the advantages of easily available synthesis raw materials, low cost, simple synthesis route, safe and controllable synthesis process and simple post-treatment method, has no amplification effect, and is suitable for industrial large-scale production.

The invention discloses a preparation method for green synthesis of 1, 4-bis (4-fluorobenzoyl) benzene, and belongs to the technical field of Friedel-Craft reaction, an ionic liquid is used as a catalyst to catalyze the reaction of fluorobenzene and paraphthaloyl chloride to generate the 1, 4-bis (4-fluorobenzoyl) benzene, and the 1, 4-bis (4-fluorobenzoyl) benzene is used as a catalyst to catalyze the reaction of fluorobenzene and paraphthaloyl chloride to generate the 1, 4-bis (4-fluorobenzoyl) benzene. And the ionic liquid is one or more of [Bmim] Cl / AlCl3, [Bmim] Br / AlCl3, [Emim] Cl / AlCl3, [Emim] Br / AlCl3, C4H9NBr / AlCl3, Et3NHCl / AlCl3, [Emim] Cl-AlCl3-MgCl2, [Bmim] Cl-AlCl3-CuCl and [Moemim] Br / AlC13. The invention further discloses a preparation method of the ionic liquid. According to the ionic liquid, fluorobenzene and paraphthaloyl chloride can be converted into 1, 4-bis (4-fluorobenzoyl) benzene at room temperature, long-time backflow at the boiling point of fluorobenzene is not needed, and the reaction safety is high; after the reaction is finished, the ionic liquid can be separated from a reaction system through standing and layering, and the separation steps are simple; after the reaction is finished, the catalyst does not need to be quenched, can be recycled, does not generate waste salt and is green and environment-friendly; the product yield is 96.48%-99.87%, the product purity is 99.62%-99.92%, and the product yield is high.

The present invention relates to a ternary insecticidal composition of 3-[benzoyl(methyl)amino]-N-[2-bromo-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)- 6-(trifluoromethyl)phenyl]-2-fluorobenzamide (Component A), 4-chloro-5-ethyl-2-methyl-N-[[4-(4-methylphenoxy)phenyl]methyl] pyrazole-3-carboxamide (Component B) and at least one insecticide (Component C) demonstrating an effective and synergistic broad spectrum control of insects-pests and mites with one shot application by developing delay in resistance of hard to kill and resistant towards insects-pests and mites Further, the ternary insecticidal composition provides residual control and increases yield of treated plants due to protection against insect-pests and mites. The ternary insecticidal composition of present invention increases overall health and plant vigor and is environmentally safe.

The invention discloses a benzyl benzoyl or fluoroalkane substituted phenol compound as well as a synthesis method and application thereof, and belongs to the technical field of medicine synthesis. The synthesis method comprises the following steps: step 1, adding 0.3 mmol of anthranilamide, 0.3 mmol of ketone, 10 mol% of I2 and 1M of absolute ethyl alcohol into a 100mL round-bottom flask at one time, stirring at 80 DEG C for 24 hours, after the reaction is completed, placing to room temperature, pouring a reaction solution into ice water according to the volume ratio of the reaction solution to the ice water being 10: 1, extracting with ethyl acetate, washing an organic layer with saturated salt water, drying with anhydrous Na2SO4, and spin-drying to obtain an anthranilamide intermediate; a crude product is obtained. The synthesis method is mild in reaction condition, few in side reaction and simple and convenient to operate. And the benzyl benzoyl or fluoroalkane substituted phenol compound obtained by the invention has the effect of resisting colon cancer.

The invention belongs to the technical field of UV visbreaking polymers, and particularly relates to a UV visbreaking film and a preparation method thereof. Wherein the UV viscosity-reducing film sequentially comprises a base film (1), a first viscosity-reducing adhesive layer (5), a second viscosity-reducing adhesive layer (4) and a release film (3) from bottom to top, the first viscosity-reducing adhesive layer (5) and the second viscosity-reducing adhesive layer (4) both comprise a photoinitiator, the photoinitiator in the first viscosity-reducing adhesive layer (5) is 1-hydroxy-cyclohexyl phenyl ketone, and the content of the photoinitiator in the formula of the adhesive layer is 0.1%-10% by mass; a photoinitiator in the second viscosity-reducing adhesive layer (4) is bis (2, 4, 6-trimethylbenzoyl) phenyl phosphine oxide, and the content of the photoinitiator in the adhesive layer formula is 0.1-10% by mass; in the preparation method, ultraviolet irradiation precuring is carried out, so that the UV viscosity-reducing film has light selectivity and high cohesion strength, and the residual adhesive is remarkably reduced.

The present invention discloses spinosad derivatives or their salts, stereoisomers, and tautomers, which have a structure as shown in Formula I, indicating that the single bond or double bond X is selected from O, S, and N; Y is selected from O, S, and N; A is selected from a covalent bond, hydrogen, substituted alkyl, substituted or unsubstituted heterocycloalkyl, alkoxy, substituted carbonyl, substituted benzoyl, substituted aromatic heteroformyl, and substituted phenylacetyl; and B is selected from hydrogen, substituted alkyl, substituted or unsubstituted heterocycloalkyl, substituted carbonyl, substituted benzoyl, substituted aromatic heteroformyl, and substituted phenylacetyl. The present invention also discloses the use of spinosad derivatives in the preparation of insecticides for controlling plant diseases and insect pests. The spinosad derivatives of the present invention show comparable or higher activity to natural spinosad products against insects of the Noctuidae and Pyralidae families, arachnids, and / or nematodes, and can be used in the agricultural and animal health markets.

A process for manufacturing a polyether ketone ketone, involving: placing an aromatic ether or a mixture of aromatic ethers, including at least 50 mol % of 1,3-bis(4-phenoxybenzoyl)benzene, 1,4-bis(4-phenoxybenzoyl)benzene or a mixture thereof, relative to the total number of moles of aromatic ether(s), in contact with an acyl chloride or a mixture of acyl chlorides, and a Lewis acid, in all or part of a reaction solvent, so as to form a reaction mixture, the 1,3-bis(4-phenoxybenzoyl)benzene and / or 1,4-bis(4-phenoxybenzoyl)benzene essentially not being dissolved in the reaction solvent at the end of the step of placing in contact; and, polymerizing the reaction mixture, the polymerization being performed, at least in part, at a temperature Tp greater than or equal to 50° C.; the process including a step of gradual heating of the reaction mixture until acceleration of the polymerization reaction is achieved.

The invention provides a preparation method of 2, 4, 6-tri (4 '-butoxy-2'-hydroxyphenyl)-triazine, and belongs to the technical field of sun-screening agent preparation. The preparation method of the 2, 4, 6-tri (4 '-butoxy-2'-hydroxyphenyl)-triazine comprises the following steps: carrying out substitution reaction on a compound in a formula I to obtain a compound in a formula II; performing hydrolysis reaction on the compound in the formula II to obtain a compound in a formula III; and carrying out Friedel-Crafts reaction on the compound shown in the formula III and cyanuric chloride to obtain a compound shown in a formula IV. The preparation method comprises the following steps: reacting benzoic acid-3-hydroxyphenyl ester with n-butyl bromide to obtain benzoic acid-3-(butyloxy) phenyl ester, removing benzoyl from the benzoic acid-3-(butyloxy) phenyl ester to obtain 3-(butyloxy) phenol, and reacting 3-(butyloxy) phenol with cyanuric chloride to obtain 2, 4, 6-tri (4 '-butoxy-2'-hydroxyphenyl)-triazine, so that the yield of 2, 4, 6-tri (4 '-butoxy-2'-hydroxyphenyl)-triazine is increased, and the yield of 2, 4, 6-tri (4 '-butoxy-2'-hydroxyphenyl)-triazine is increased. The yield of the 2, 4, 6-tri (4 '-butoxy-2'-hydroxyphenyl)-triazine is increased, and the production cost of the yield of the 2, 4, 6-tri (4 '-butoxy-2'-hydroxyphenyl)-triazine is reduced.

The invention discloses a 1, 4-bis (4-fluorobenzoyl) benzene production waste utilization process, which belongs to the technical field of 1, 4-bis (4-fluorobenzoyl) benzene production, and comprises the following steps: dissolving waste leftovers in a solvent, and adsorbing and removing pigments and solid particles in the leftovers by activated carbon; carrying out dehalogenation and hydrogenation on the pretreated leftovers in the presence of a hydrogenation catalyst and an alkaline substance to produce 1, 4-biphenyl acyl benzene; and carrying out separation and purification on the hydrogenation product in a solution crystallization manner to obtain 1, 4-biphenyl acyl benzene with the purity of more than or equal to 99.75%. The waste leftovers are used for producing the 1, 4-biphenyl acyl benzene, so that the utilization rate of the raw materials is increased, the discharge of hazardous wastes is reduced, and the method is green and environment-friendly.

The present invention belongs to the technical field of organic synthesis, and specifically relates to a synthesis process of high-yield 1,4-bis(4-phenoxybenzoyl)benzene. The process is mainly prepared by using excess diphenyl ether and terephthaloyl chloride as reaction raw materials, using o-dichlorobenzene as reaction solvent, and under the catalytic action of aluminum chloride. The synthesis process of 1,4-bis(4-phenoxybenzoyl)benzene provided by the present invention successfully overcomes many challenges existing in traditional synthesis methods, such as many side reactions, low yield, and purification difficulties, by optimizing key parameters such as reaction conditions, solvent selection, catalyst dosage, and sample addition order. It is not only easy to operate, but also significantly improves the yield of the target compound, and also ensures the high purity and low impurity content of the product.

To provide inkjet ink which contains an amine-modified polymerizable compound and can form a cured film having both characteristics of high abrasion resistance and high folding crack resistance. An actinic radiation-curable inkjet ink provided herein contains a polymerizable compound (A) that polymerizes upon irradiation with actinic radiation, a photopolymerization initiator (B), and a gelling agent (C). The polymerizable compound (A) contains an amine-modified polymerizable compound (A1), and the photopolymerization initiator (B) contains ethoxy(2,4,6-trimethylbenzoyl)phenylphosphine oxide.

The invention discloses a method for preparing high-purity estra-1, 3, 5 (10)-triene-3, 15 alpha, 16 alpha, 17 beta-tetrol (abbreviated as estratrol), which is characterized in that 3-hydroxy-17 beta-hydroxyestra-1, 3, 5 (10), 15-tetraene is used as a raw material, and the estratrol is prepared by three steps of phenolic hydroxyl group protection, asymmetric dihydroxylation and hydrolysis. According to the preparation method, 3-hydroxy-17beta-hydroxyestra-1, 3, 5 (10), 15-tetraene is taken as a raw material, 3-hydroxyl is protected by alkoxy-substituted benzoyl, asymmetric dihydroxyl reaction is carried out through catalytic oxidation of potassium osmate, double alpha-hydroxyl is introduced to 15, 16-positions, chemical reagents and catalysts with high cost are not needed in the preparation method, and the preparation method is simple and easy to implement. The dihydroxylation has the advantages of high stereoselectivity, easiness in purification and separation, mild reaction conditions and simplicity and convenience in operation, and high-efficiency preparation of high-purity estetrol (more than or equal to 99.5%) can be realized.

The invention relates to a process for the manufacture of polyetherketoneketones, comprising:-reacting an aromatic ether or a mixture of aromatic ethers, which comprises at least 50 mol% of 1, 3-bis (4-phenoxybenzoyl) benzene, 1, 4-bis (4-phenoxybenzoyl) benzene, or a mixture thereof, and-reacting the aromatic ether or the mixture of aromatic ethers, which comprises at least 50 mol% of 1, 3-bis (4-phenoxybenzoyl) benzene, 1, 4-bis (4-phenoxybenzoyl) benzene, or a mixture thereof; in some embodiments, 1, 3-bis (4-phenoxybenzoyl) benzene and / or 1, 3-bis (4-phenoxybenzoyl) benzene are contacted with acyl chloride or a mixture of acyl chloride and a Lewis acid in all or a portion of a reaction solvent, with respect to the total moles of aromatic ether (s), to form a reaction mixture, 1, 3-bis (4-phenoxybenzoyl) benzene and / or 1, 3-bis (4-phenoxybenzoyl) benzene and / or 1, 3-bis (4-phenoxybenzoyl) benzene. The 1, 4-bis (4-phenoxybenzoyl) benzene is substantially insoluble in the reaction solvent at the end of the contacting step; and-polymerizing the reaction mixture, the polymerization being carried out at least partially at a temperature Tp greater than or equal to 50 DEG C; said method is characterized in that it comprises a step-by-step heating of the reaction mixture until an acceleration of the polymerization reaction is achieved, the step-by-step heating step being carried out at an average heating rate selected from the range from 0.65 DEG C / min to 2.5 DEG C / min; one or more chain terminators are optionally added during the process.

The invention provides a synthesis method of saflufenacil, and belongs to the field of chemical synthesis. The preparation method comprises the following steps: reacting N-(2-chloro-4-fluoro-5-aminobenzoyl)-N '-isopropyl-N'-methyl sulfonamide serving as a raw material with chloroformate in a strong polar solvent, then directly adding alkali and ethyl 3-amino-4, 4, 4-trifluoro-2-butenoate into the reaction material, and carrying out cyclization reaction, so as to obtain the N-(2-chloro-4-fluoro-5-aminobenzoyl)-N '-isopropyl-N'-methyl sulfonamide. And carrying out methylation reaction on the cyclization reaction material and a methylation reagent to obtain saflufenacil. The selected reaction solvent is relatively single and easy to recover, so that the reaction operation is simple, the product yield is improved, and the method is suitable for industrial large-scale production and has a wide application prospect.

A system (100) for the synthesis of hydrazinyl thiazoles from furfural obtained from biomass, wherein the system (100) comprises: configured to deliver 5.0 mmol of hydroxylmethylfurfural (HMF), 5.0 mmol of thiosemicarbazide, and 5.0 mmol of phenacyl tosylate; a grinding unit (104) connected to the reactant delivery unit (102) and configured to grind the reactants under ambient conditions for 5 minutes; a reaction monitoring unit (106) comprising thin-layer chromatography (TLC) and connected to the milling unit (104) and configured to monitor the reaction of the reactants during milling; and a purification unit (108) connected to the reaction monitoring unit (106) and configured to isolate the crude compound, followed by recrystallization using a mixture of ethyl acetate and ethanol.

A process for the preparation of a compound of the sterically hindered alkoxyamine class is described, the process comprises the step of alkylating a sterically hindered hydroxylamine compound to a corresponding sterically hindered alkoxyamine by reacting said sterically hindered nitroxyl compound with a compound capable of producing a carbon-central alkyl radical, typically a territorial or secondary alkyl radical, the compounds capable of generating carbon-center alkyl radicals are selected from thermal radical initiators that form radical species in the temperature range of 40 DEG C to 200 DEG C, and from photoinitiators that undergo light excitation when irradiated with UV light or visible light in the range of 180 to 700 nm, in particular UV light in the range of 180 to 380 nm, the compounds capable of generating carbon center alkyl radicals are typically selected from the class of organic peroxides, azo compounds, benzoyl derivatives, benzophenone derivatives, thioxanthone derivatives, benzoin derivatives, benzoyl phosphine oxide derivatives, and the like. The invention relates to a peroxide, for example, selected from the group consisting of diacyl peroxides of formula (A), peracid esters of this formula (A), and oxalic acid peracid esters of formula (D) R-CO-O-O-Z-R (A), r-Z ''-X-CO-CO-O-O-Z''-R (D) wherein each R independently represents a primary or secondary alkyl or cycloalkyl group, preferably comprising from 1 to 15 carbon atoms, and X is oxygen-O-or peroxy-O-O-, Z represents CO or an alkylene group bonded to a quaternary carbon atom, the quaternary carbon atom being an alkylene group of formula (C) R '-C-R' (C), wherein each R'is selected from alkyl groups having 1 to 15 carbon atoms, and Z "represents the alkylene group bonded to a quaternary carbon atom having the formula (C). The described process produces the corresponding O-alkylated derivatives of the sterically hindered hydroxylamines, typically compounds of the class referred to as N-O-alkyl HALS, with very high selectivity and conversion and without the need for the use of catalysts, in particular metal catalysts.

The present invention relates to a sunscreen or daily care composition comprising(i) bis-ethylhexyloxyphenol methoxyphenyl triazine (bemotrizinol),(ii) 1-(4-(1,1-dimethylethyl)phenyl)-3-(4-methoxyphenyl)propane-1,3-dione (avobenzone), and(iii) titanium dioxide;wherein the sunscreen or daily care composition is free of the UV filters from the group consisting of 4,4′,4″-(1,3,5-triazin-2,4,6-triyltriimino)tris-benzoic acid-tris(2-ethylhexyl)ester (octyl triazone), hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate (INCI diethylamino hydroxybenzoyl hexyl benzoate), 2,2′-Methylenbis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol] (bisoctrizole), 3,3,5-Trimethylcyclohexyl 2-hydroxybenzoate (INCI Homosalate), (RS)-2-Ethylhexyl (2E)-3-(4-methoxyphenyl)prop-2-enoate (octinoxate), 2-ethylhexyl 2-cyano-3,3-diphenylprop-2-enoate (INCI octocrylene), and 2-hydroxy-4-methoxybenzophenone (oxybenzone).

The application relates to the technical field of organic synthesis, and discloses a synthesis method of a benzoyl modified nucleoside, which comprises the following steps: dissolving or suspending a substrate in a solvent, adding N-chlorosuccinimide, reacting at a certain temperature, generating a corresponding N-chloroamine intermediate, then adding a certain equivalent of benzaldehyde, and generating a final product under the joint action of an oxidant and a catalyst. According to the method, the hydroxyl group on the sugar ring does not need to be protected, and is directly reacted with the amino group on the base, so that the side reaction is less, the obtained product is high in purity, and the yield is high.

The application discloses a trifluoromethyl alkyl quinoline compound, a synthesis method and anti-tumor application in the field of organic synthesis and medicinal chemistry, which is synthesized from trifluoropropylene quinoline or N-benzoyl pyrrole (A) and redox active ester (B) as raw materials, dimethyl sulfoxide as a solvent, dihydropyridine as an electron donor, and under visible light irradiation, a trifluoromethyl alkyl quinoline and analogues (C) are synthesized at a high yield. The specific reaction formula is as follows: The compounds provided by the application all have excellent anti-tumor activity and low toxicity to normal cells, and therefore have application prospects for preparing anti-tumor drugs.

The invention provides a synthetic method of 2-(2-amino-5-bromo-benzoyl) pyridine, and belongs to the technical field of medicine synthesis. A one-pot boiling method is adopted, 2-cyanopyridine and 4-bromaniline are used as raw materials, BCl3 is used as a catalyst, dichloromethane is used as a solvent, a heat preservation reaction is performed for 5-25 hours at the temperature of-10 DEG C to 40 DEG C, and the product 2-(2-amino-5-bromo-benzoyl) pyridine is obtained through ethyl acetate extraction, anhydrous sodium sulfate drying and dichloromethane and petroleum ether recrystallization. According to the preparation method of the 2-(2-amino-5-bromo-benzoyl) pyridine, provided by the invention, butyl lithium with extremely high dangerousness does not need to be used, the reaction steps are simple, the yield is stable, the treatment is easy, and the yield is high.

The invention discloses a production process of a cellulose acetate fiber fabric containing natural fragrance, a solvent formed by mixing a modified polymer, 2, 4, 6-trimethylbenzoyl-diphenyl phosphine oxide, a modified microcapsule and dimethylformamide is subjected to dry spinning to prepare the cellulose acetate fiber fabric, and the weight part ratio of the modified polymer to the modified microcapsule is (70-80): (6-8). The preparation method comprises the following steps: by taking an isocyanate group on excessive hexamethylene diisocyanate as a reaction site, firstly reacting with an intermediate containing dihydroxyl, and then reacting with cellulose acetate containing free hydroxyl, so as to prepare the modified polymer. The halamine structure on the molecular chain can destroy cell membranes, enzyme systems or genetic materials through oxidation. The modified capsule has a lavender essential oil and cinnamon essential oil double-component double-capsule-wall structure, the fragrance durability can be improved, the copper sulfide nanoparticles and quaternized chitosan structures can destroy the bacterial cell structure, and the antibacterial performance of the material is improved.

This invention discloses a photosensitive supramolecular fluorescent polymer, its preparation method, and its anti-counterfeiting application in water, using trifluoroethyl methacrylate, hexafluorobutyl acrylate, 4-(acryloyloxy)butyl4-(2-methyl-3-(2-(2-methylbenzo[b]thiophen-3-yl)-4-oxo-5,6-2H-4H-thiaran[2,3-)b]thiaran-3-yl)benzo[b]thiophen-6-yl)-4-oxobutyrate, 4 This polymer was prepared by a simple one-step free radical copolymerization method using 1,1-(acryloyloxy)butyl3-(3,3,4,4,5,5-hexafluoro-2-(2-methyl-1,1-dioxide benzo[b]thiophene-3-yl)cyclopent-1-en-1-yl)-2-methylbenzo[b]thiophene-6-carboxylate 1,1-dioxide and phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide (photoinitiator-819) as raw materials. The polymer exhibits excellent multicolor light-switching performance, high stretch ratio, high self-healing efficiency, strong substrate adhesion, and antifouling properties, especially demonstrating excellent stability under strong acid, strong alkali, and high salt environments. The synthetic route is simple, and it has great application potential in underwater anti-counterfeiting and encryption technologies.

The invention relates to a calcipotriol nano-composite, difunctional integrated hydrogel for treating psoriasis as well as preparation and application of the difunctional integrated hydrogel. The preparation method comprises the following steps: loading calcipotriol on amino-modified mesoporous silica, and then carrying out a one-pot reaction on the amino-modified mesoporous silica, methacrylated gelatin, dopamine methacrylamide, sodium pirolinate carboxylate and phenyl (2, 4, 6-trimethylbenzoyl) lithium phosphate to obtain the difunctional integrated hydrogel. The hydrogel disclosed by the invention is UV-responsive drug-loaded hydrogel, can be quickly cross-linked and adhered to the surface of skin after being irradiated by UV, has the properties of high light transmission, drug sustained release, moisture retention and stable structure, and meets the clinical requirements of synchronous and integrated drug treatment and UV irradiation while remarkably improving the bioavailability of an externally applied drug; organic combination and mechanism complementation of two treatment modes are realized, so that the psoriasis is treated more efficiently.

The invention discloses a small molecular probe based on an imidazo [1, 5-a] pyridine skeleton, a preparation method and application, and belongs to the field of activatable small molecular fluorescent probes. The preparation method of the small molecular probe based on the imidazo [1, 5-a] pyridine skeleton comprises the following steps: dissolving 2-benzoylpyridine and ammonium acetate in acetic acid, adding salicylaldehyde, heating and stirring to generate a compound 3; and dissolving the compound 3 in dichloromethane, adding pyridine, stirring, adding 4-bromobutyryl chloride, and continuously stirring to obtain a compound 1, namely the small molecule probe. The small molecule probe can be used for detecting hydrazine in a biological system or drinking water.

Disclosed are a method for producing pladienolide D that includes a step that reacts a compound represented by formula (A1) with a compound represented by formula (B1) in the presence of a metal catalyst to obtain a compound represented by formula (C1) (in the formulas, X means hydrogen, optionally substituted boryl, optionally substituted stannyl, or optionally substituted silyl, R4 is hydrogen, etc., R5 is optionally substituted benzoyl, etc., and R1 and R2 each independently are hydrogen, etc.) and crystals of a solvate of pladienolide D.

The application belongs to the field of pharmaceutical chemistry, and specifically discloses a benzimidazole amine derivative, a preparation method thereof and application of the benzimidazole amine derivative as a beta2-adrenergic receptor allosteric antagonist. In the benzimidazole amine derivative, R1 is a hydrogen atom or a bromine atom; and R2 is a substituted benzoyl group or a substituted benzyl group. Pharmacological results show that the benzimidazole amine derivative has good antagonistic activity on beta2AR and can negatively allosterically regulate the functional activity of isoprenaline (ISO).