195 results about "Phenacyl" patented technology

The present invention relates to a ternary insecticidal composition of 3-[benzoyl(methyl)amino]-N-[2-bromo-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)- 6-(trifluoromethyl)phenyl]-2-fluorobenzamide (Component A), 4-chloro-5-ethyl-2-methyl-N-[[4-(4-methylphenoxy)phenyl]methyl] pyrazole-3-carboxamide (Component B) and at least one insecticide (Component C) demonstrating an effective and synergistic broad spectrum control of insects-pests and mites with one shot application by developing delay in resistance of hard to kill and resistant towards insects-pests and mites Further, the ternary insecticidal composition provides residual control and increases yield of treated plants due to protection against insect-pests and mites. The ternary insecticidal composition of present invention increases overall health and plant vigor and is environmentally safe.

The invention belongs to the technical field of UV visbreaking polymers, and particularly relates to a UV visbreaking film and a preparation method thereof. Wherein the UV viscosity-reducing film sequentially comprises a base film (1), a first viscosity-reducing adhesive layer (5), a second viscosity-reducing adhesive layer (4) and a release film (3) from bottom to top, the first viscosity-reducing adhesive layer (5) and the second viscosity-reducing adhesive layer (4) both comprise a photoinitiator, the photoinitiator in the first viscosity-reducing adhesive layer (5) is 1-hydroxy-cyclohexyl phenyl ketone, and the content of the photoinitiator in the formula of the adhesive layer is 0.1%-10% by mass; a photoinitiator in the second viscosity-reducing adhesive layer (4) is bis (2, 4, 6-trimethylbenzoyl) phenyl phosphine oxide, and the content of the photoinitiator in the adhesive layer formula is 0.1-10% by mass; in the preparation method, ultraviolet irradiation precuring is carried out, so that the UV viscosity-reducing film has light selectivity and high cohesion strength, and the residual adhesive is remarkably reduced.

A process for manufacturing a polyether ketone ketone, involving: placing an aromatic ether or a mixture of aromatic ethers, including at least 50 mol % of 1,3-bis(4-phenoxybenzoyl)benzene, 1,4-bis(4-phenoxybenzoyl)benzene or a mixture thereof, relative to the total number of moles of aromatic ether(s), in contact with an acyl chloride or a mixture of acyl chlorides, and a Lewis acid, in all or part of a reaction solvent, so as to form a reaction mixture, the 1,3-bis(4-phenoxybenzoyl)benzene and / or 1,4-bis(4-phenoxybenzoyl)benzene essentially not being dissolved in the reaction solvent at the end of the step of placing in contact; and, polymerizing the reaction mixture, the polymerization being performed, at least in part, at a temperature Tp greater than or equal to 50° C.; the process including a step of gradual heating of the reaction mixture until acceleration of the polymerization reaction is achieved.

The invention provides a preparation method of 2, 4, 6-tri (4 '-butoxy-2'-hydroxyphenyl)-triazine, and belongs to the technical field of sun-screening agent preparation. The preparation method of the 2, 4, 6-tri (4 '-butoxy-2'-hydroxyphenyl)-triazine comprises the following steps: carrying out substitution reaction on a compound in a formula I to obtain a compound in a formula II; performing hydrolysis reaction on the compound in the formula II to obtain a compound in a formula III; and carrying out Friedel-Crafts reaction on the compound shown in the formula III and cyanuric chloride to obtain a compound shown in a formula IV. The preparation method comprises the following steps: reacting benzoic acid-3-hydroxyphenyl ester with n-butyl bromide to obtain benzoic acid-3-(butyloxy) phenyl ester, removing benzoyl from the benzoic acid-3-(butyloxy) phenyl ester to obtain 3-(butyloxy) phenol, and reacting 3-(butyloxy) phenol with cyanuric chloride to obtain 2, 4, 6-tri (4 '-butoxy-2'-hydroxyphenyl)-triazine, so that the yield of 2, 4, 6-tri (4 '-butoxy-2'-hydroxyphenyl)-triazine is increased, and the yield of 2, 4, 6-tri (4 '-butoxy-2'-hydroxyphenyl)-triazine is increased. The yield of the 2, 4, 6-tri (4 '-butoxy-2'-hydroxyphenyl)-triazine is increased, and the production cost of the yield of the 2, 4, 6-tri (4 '-butoxy-2'-hydroxyphenyl)-triazine is reduced.

The invention discloses a 1, 4-bis (4-fluorobenzoyl) benzene production waste utilization process, which belongs to the technical field of 1, 4-bis (4-fluorobenzoyl) benzene production, and comprises the following steps: dissolving waste leftovers in a solvent, and adsorbing and removing pigments and solid particles in the leftovers by activated carbon; carrying out dehalogenation and hydrogenation on the pretreated leftovers in the presence of a hydrogenation catalyst and an alkaline substance to produce 1, 4-biphenyl acyl benzene; and carrying out separation and purification on the hydrogenation product in a solution crystallization manner to obtain 1, 4-biphenyl acyl benzene with the purity of more than or equal to 99.75%. The waste leftovers are used for producing the 1, 4-biphenyl acyl benzene, so that the utilization rate of the raw materials is increased, the discharge of hazardous wastes is reduced, and the method is green and environment-friendly.

A process for the preparation of a compound of the sterically hindered alkoxyamine class is described, the process comprises the step of alkylating a sterically hindered hydroxylamine compound to a corresponding sterically hindered alkoxyamine by reacting said sterically hindered nitroxyl compound with a compound capable of producing a carbon-central alkyl radical, typically a territorial or secondary alkyl radical, the compounds capable of generating carbon-center alkyl radicals are selected from thermal radical initiators that form radical species in the temperature range of 40 DEG C to 200 DEG C, and from photoinitiators that undergo light excitation when irradiated with UV light or visible light in the range of 180 to 700 nm, in particular UV light in the range of 180 to 380 nm, the compounds capable of generating carbon center alkyl radicals are typically selected from the class of organic peroxides, azo compounds, benzoyl derivatives, benzophenone derivatives, thioxanthone derivatives, benzoin derivatives, benzoyl phosphine oxide derivatives, and the like. The invention relates to a peroxide, for example, selected from the group consisting of diacyl peroxides of formula (A), peracid esters of this formula (A), and oxalic acid peracid esters of formula (D) R-CO-O-O-Z-R (A), r-Z ''-X-CO-CO-O-O-Z''-R (D) wherein each R independently represents a primary or secondary alkyl or cycloalkyl group, preferably comprising from 1 to 15 carbon atoms, and X is oxygen-O-or peroxy-O-O-, Z represents CO or an alkylene group bonded to a quaternary carbon atom, the quaternary carbon atom being an alkylene group of formula (C) R '-C-R' (C), wherein each R'is selected from alkyl groups having 1 to 15 carbon atoms, and Z "represents the alkylene group bonded to a quaternary carbon atom having the formula (C). The described process produces the corresponding O-alkylated derivatives of the sterically hindered hydroxylamines, typically compounds of the class referred to as N-O-alkyl HALS, with very high selectivity and conversion and without the need for the use of catalysts, in particular metal catalysts.

The application relates to the technical field of organic synthesis, and discloses a synthesis method of a benzoyl modified nucleoside, which comprises the following steps: dissolving or suspending a substrate in a solvent, adding N-chlorosuccinimide, reacting at a certain temperature, generating a corresponding N-chloroamine intermediate, then adding a certain equivalent of benzaldehyde, and generating a final product under the joint action of an oxidant and a catalyst. According to the method, the hydroxyl group on the sugar ring does not need to be protected, and is directly reacted with the amino group on the base, so that the side reaction is less, the obtained product is high in purity, and the yield is high.

The application discloses a trifluoromethyl alkyl quinoline compound, a synthesis method and anti-tumor application in the field of organic synthesis and medicinal chemistry, which is synthesized from trifluoropropylene quinoline or N-benzoyl pyrrole (A) and redox active ester (B) as raw materials, dimethyl sulfoxide as a solvent, dihydropyridine as an electron donor, and under visible light irradiation, a trifluoromethyl alkyl quinoline and analogues (C) are synthesized at a high yield. The specific reaction formula is as follows: The compounds provided by the application all have excellent anti-tumor activity and low toxicity to normal cells, and therefore have application prospects for preparing anti-tumor drugs.

The invention provides a synthetic method of 2-(2-amino-5-bromo-benzoyl) pyridine, and belongs to the technical field of medicine synthesis. A one-pot boiling method is adopted, 2-cyanopyridine and 4-bromaniline are used as raw materials, BCl3 is used as a catalyst, dichloromethane is used as a solvent, a heat preservation reaction is performed for 5-25 hours at the temperature of-10 DEG C to 40 DEG C, and the product 2-(2-amino-5-bromo-benzoyl) pyridine is obtained through ethyl acetate extraction, anhydrous sodium sulfate drying and dichloromethane and petroleum ether recrystallization. According to the preparation method of the 2-(2-amino-5-bromo-benzoyl) pyridine, provided by the invention, butyl lithium with extremely high dangerousness does not need to be used, the reaction steps are simple, the yield is stable, the treatment is easy, and the yield is high.

The invention discloses a production process of a cellulose acetate fiber fabric containing natural fragrance, a solvent formed by mixing a modified polymer, 2, 4, 6-trimethylbenzoyl-diphenyl phosphine oxide, a modified microcapsule and dimethylformamide is subjected to dry spinning to prepare the cellulose acetate fiber fabric, and the weight part ratio of the modified polymer to the modified microcapsule is (70-80): (6-8). The preparation method comprises the following steps: by taking an isocyanate group on excessive hexamethylene diisocyanate as a reaction site, firstly reacting with an intermediate containing dihydroxyl, and then reacting with cellulose acetate containing free hydroxyl, so as to prepare the modified polymer. The halamine structure on the molecular chain can destroy cell membranes, enzyme systems or genetic materials through oxidation. The modified capsule has a lavender essential oil and cinnamon essential oil double-component double-capsule-wall structure, the fragrance durability can be improved, the copper sulfide nanoparticles and quaternized chitosan structures can destroy the bacterial cell structure, and the antibacterial performance of the material is improved.

This invention discloses a photosensitive supramolecular fluorescent polymer, its preparation method, and its anti-counterfeiting application in water, using trifluoroethyl methacrylate, hexafluorobutyl acrylate, 4-(acryloyloxy)butyl4-(2-methyl-3-(2-(2-methylbenzo[b]thiophen-3-yl)-4-oxo-5,6-2H-4H-thiaran[2,3-)b]thiaran-3-yl)benzo[b]thiophen-6-yl)-4-oxobutyrate, 4 This polymer was prepared by a simple one-step free radical copolymerization method using 1,1-(acryloyloxy)butyl3-(3,3,4,4,5,5-hexafluoro-2-(2-methyl-1,1-dioxide benzo[b]thiophene-3-yl)cyclopent-1-en-1-yl)-2-methylbenzo[b]thiophene-6-carboxylate 1,1-dioxide and phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide (photoinitiator-819) as raw materials. The polymer exhibits excellent multicolor light-switching performance, high stretch ratio, high self-healing efficiency, strong substrate adhesion, and antifouling properties, especially demonstrating excellent stability under strong acid, strong alkali, and high salt environments. The synthetic route is simple, and it has great application potential in underwater anti-counterfeiting and encryption technologies.

The invention relates to a calcipotriol nano-composite, difunctional integrated hydrogel for treating psoriasis as well as preparation and application of the difunctional integrated hydrogel. The preparation method comprises the following steps: loading calcipotriol on amino-modified mesoporous silica, and then carrying out a one-pot reaction on the amino-modified mesoporous silica, methacrylated gelatin, dopamine methacrylamide, sodium pirolinate carboxylate and phenyl (2, 4, 6-trimethylbenzoyl) lithium phosphate to obtain the difunctional integrated hydrogel. The hydrogel disclosed by the invention is UV-responsive drug-loaded hydrogel, can be quickly cross-linked and adhered to the surface of skin after being irradiated by UV, has the properties of high light transmission, drug sustained release, moisture retention and stable structure, and meets the clinical requirements of synchronous and integrated drug treatment and UV irradiation while remarkably improving the bioavailability of an externally applied drug; organic combination and mechanism complementation of two treatment modes are realized, so that the psoriasis is treated more efficiently.

The application belongs to the field of pharmaceutical chemistry, and specifically discloses a benzimidazole amine derivative, a preparation method thereof and application of the benzimidazole amine derivative as a beta2-adrenergic receptor allosteric antagonist. In the benzimidazole amine derivative, R1 is a hydrogen atom or a bromine atom; and R2 is a substituted benzoyl group or a substituted benzyl group. Pharmacological results show that the benzimidazole amine derivative has good antagonistic activity on beta2AR and can negatively allosterically regulate the functional activity of isoprenaline (ISO).

The present invention relates to crystals of N-(benzoyl)-phenylalanine-based compounds, pharmaceutical compositions thereof, preparation methods and uses. Specifically, as shown in Formula (I) and Formula (II), the crystals of the compound of Formula (I) have crystal form A, and the crystals of the compound of Formula (II) have crystal form B. The two crystal forms have good stability, high reproducibility of the preparation method, high operability, and important application value in the prevention and / or treatment of diseases related to α4β7 integrin. [Chemical formula 1] TIFF2025518346000014.tif44156

The invention discloses a method for preparing an olaparib key intermediate compound as shown in a formula (1). The method comprises the following steps: (a) reacting a compound as shown in a formula (2) with a compound as shown in a formula (3) to generate a compound as shown in a formula (4); (b) carrying out intramolecular cyclization on the compound as shown in the formula (4) under the catalysis of acid to generate a compound as shown in a formula (5); (c) hydrolyzing the compound as shown in the formula (5) in an alkali solution, and acidifying to obtain a compound as shown in a formula (1); wherein in the compounds as shown in the formula (3), the formula (4) and the formula (5), R is formyl, acetyl, propionyl, butyryl, benzoyl, methoxycarbonyl, ethoxycarbonyl, t-butyloxycarbonyl, methylsulfonyl, benzenesulfonyl or p-toluenesulfonyl. The invention also discloses a compound shown in a formula (4) or a formula (5). The method is high in yield, mild in reaction condition, easy to purify and suitable for industrial large-scale production. # imgabs0 #

The invention discloses a synthesis method of 2-butyl-3-(4-hydroxybenzoyl) benzofuran, and relates to the technical field of amiodarone intermediates.The synthesis method comprises the following steps that 2-bromoanisole and 1-hexene-2-alcohol are dissolved in a first solvent, and a first catalyst is added for a reaction; cooling to 25 DEG C, adjusting the pH value to 9-10, adding a catalyst II for reaction, and removing impurities after the reaction is completed, so as to obtain 2-butylbenzofuran; 2-butylbenzofuran and a catalyst III are added into a solvent II, vacuumizing is performed after nitrogen replacement, carbon dioxide is introduced to 0.02-3 MPa for a reaction, impurity removal treatment is performed after the reaction is completed, and 2-butyl-3-(4-hydroxybenzoyl) benzofuran is obtained; compared with a synthetic route in the prior art, the synthetic method has the advantages that the reaction steps are shortened into two steps, the synthetic steps are simplified, the synthetic efficiency is improved, the process cost is reduced, meanwhile, the conversion efficiency is higher, the total yield reaches 70% or above, and the yield is improved by 15% or above compared with the yield in the prior art.

The invention discloses a pyrimidine derivative containing a thiosemicarbazide structure and application of the pyrimidine derivative, and relates to the technical field of medicines, the compound has good oxidation resistance and alpha-glucosidase resistance activity, and the compound is 2-(4, 4 '-difluorophenyl)-2-(4, 4'-difluorophenyl)-2-(4, 4 '-difluorophenyl)-2-(4, 4' The IC50 values of the compound 2-(4, 6-dimethyl pyrimidine-2-yl)-N-methylhydrazine-1-methylsulfamide on DPPH (1, 1-diphenyl-2-picrylhydrazyl) scavenging activity and ABTS (2, 2, 6-dimethyl pyrimidine-2-yl)-N-methylhydrazine-1-methylsulfamide are 3.96 mu g / mL and 2.01 mu g / mL respectively, the IC50 value of the compound 2-(4, 6-dimethyl pyrimidine-2-yl)-N-methylhydrazine-1-methylsulfamide on alpha-glucosidase inhibitory activity is 38.62 mu g / mL, the effect is best, and the compound 2-(4, 6-dimethyl pyrimidine-2-yl)-N-methylhydrazine-1 The pyrimidine derivative containing the thiosemicarbazide structure has a general formula shown in the specification, and is superior to control medicaments such as vitamin C, vitamin E and acarbose.

The invention provides a continuous synthesis method of 2-(4 '-pentylbenzoyl) benzoic acid, and relates to the field of synthesis of 2-(4'-pentylbenzoyl) benzoic acid. The continuous synthesis method of the 2-(4 '-pentylbenzoyl) benzoic acid comprises the following steps: continuous catalytic reaction and post-treatment. The continuous synthesis method of the 2-(4 '-pentylbenzoyl) benzoic acid can effectively realize continuous and stable synthesis of the 2-(4'-pentylbenzoyl) benzoic acid on the premise of reducing the dosage of the traditional aluminum trichloride catalyst, improves the yield and purity of the continuously prepared 2-(4 '-pentylbenzoyl) benzoic acid, and reduces by-products.

A method for resolving a phenylalanine derivative of formula (I), and an intermediate. The method comprises: a resolving step comprising using a resolving reagent to react with the phenylalanine derivative represented by formula (I) in a reaction solvent to obtain a resolved intermediate, wherein the resolving reagent is selected from N-acetyl-D-phenylalanine and / or (2R,3R)-(−)-dibenzoyl-L-tartaric acid, and the reaction solvent is selected from 90-99% aqueous ethanol, absolute ethyl alcohol, or acetone. The method uses a chiral reagent to perform salt formation and racemate resolution, and has the advantages of being easy to operate, requiring no special production devices, and being easy to scale up production.

A photosensitive resin composition of the invention contains (A) a polyimide precursor having a polymerizable unsaturated bond, (B) a photopolymerization initiator comprising a compound represented by the formula (11), (C) a thermal radical generator, and (D) a solvent containing γ-butyrolactone:wherein in the formula (11), R11 is a substituted or unsubstituted benzoyl group, a substituted or unsubstituted fluorenyl group, or a group comprising a substituted or unsubstituted carbazolyl group; R12 is an alkyl group including 1 to 12 carbon atoms, a group comprising a cycloalkyl group including 4 to 10 carbon atoms, a group comprising a phenyl group, or a group comprising a tolyl group; R13 is a substituted or unsubstituted aromatic hydrocarbon group including 6 to 20 carbon atoms.

The invention relates to pharmaceutical compositions comprising a GLP-1 agonist and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid. The invention further relates to processes for the preparation of such compositions, and their use in medicine.

The application discloses a benzyl benzoyl or fluorinated alkane substituted phenol compound and a synthesis method and application thereof, and belongs to the technical field of drug synthesis. The synthesis method comprises the following steps: step one, 0.3mmol of o-aminobenzamide, 0.3mmol of ketone, 10mol% of I2 and 5mL of anhydrous ethanol are added into a 10mL round-bottom flask at one time, stirring is carried out at 80 DEG C for 24h, after the reaction is completed, the reaction liquid is poured into ice water, the volume ratio of the reaction liquid to the ice water is 1:10, ethyl acetate is extracted, the organic layer is washed with saturated brine, dried with anhydrous Na2SO4, and spin-dried to obtain a crude product. The synthesis method has the advantages of mild reaction condition, few side reactions and simple and convenient operation. And the benzyl benzoyl or fluorinated alkane substituted phenol compound obtained by the application has the effect of resisting colon cancer.

The present invention relates to an oral pharmaceutical composition comprises semaglutide, SNAC (Sodium N-[8-(2-hydroxybenzoyl) amino] caprylate), one or more alkalizing agent and one or more pharmaceutically acceptable excipients.

The invention discloses a preparation method and application of a functional degradable soybean oil-based bionic porous composite bone scaffold. The method comprises the following steps: taking epoxidized soybean oil acrylate as a bio-based base material, compounding isobornyl methacrylate to improve the defects of high viscosity and low photosensitivity of the bio-based base material, adding a photoinitiator containing ethyl 2, 4, 6-trimethylbenzoyl phenyl phosphonate and phenyl bis (2, 4, 6-trimethylbenzoyl) phosphine oxide, compounding, and carrying out aging treatment to obtain base resin; mixing calcium lignosulphonate into the base resin to prepare composite photosensitive resin, and printing a triple-period extremely-small curved surface structure through a digital light processing technology and a 3D printing technology to finally obtain the functional degradable soybean oil-based bionic porous scaffold. The scaffold has calcium lignosulphonate-mediated controllable photo-thermal response behaviors of near-infrared light illumination regulation and bone scaffold component dependence under the condition of simulating the in-vivo environment of a human body, so that a controllable photo-thermal response-mediated remote shape memory function is realized, and meanwhile, a mild, safe and controllable photo-thermal curative effect can also be realized. Besides, calcium lignosulphonate promotes degradation of the composite scaffold by preferentially dissolving and generating a microporous structure on the surface of a matrix while improving the hydrophilic performance of the scaffold, and continuously releases calcium ions, so that the scaffold shows enhanced biomineralization ability and promotes cell proliferation and osteogenic differentiation. The research provides a solution with potential for the soybean oil-based biological photosensitive material in the digital light processing preparation technology and the multi-functional application of the bionic porous bone scaffold so as to deal with complex and irregular bone defects.

The invention relates to the technical field of medicine and chemical industry, and discloses an artemisinin C-16-bit derivative and a preparation method and application thereof, the structural general formula of the artemisinin C-16-bit derivative is as shown in formula (1): # imgabs0 #, R1 is one of 4-(tert-butyl) benzenesulfonyl, 4-chlorobenzenesulfonyl, 4-fluorobenzenesulfonyl, 4-(trifluoromethyl) benzenesulfonyl, 4-methyl benzoyl and cyclopropyl formyl; and n is 1 or 2. According to the artemisinin C-16 site derivative disclosed by the invention, a specific aryl ester group is introduced to the C-16 site, so that the molecular polarity and the pharmacokinetic property are optimized, and the anti-tumor activity is improved. The artemisinin C-16-bit derivative disclosed by the invention provides a new strategy for chemical research and development of novel artemisinin derivatives and cancer treatment.

This invention discloses a high-adhesion optical adhesive for extreme conditions, its preparation method, and its application, belonging to the field of optical adhesive technology. It comprises the following components in parts by weight: 20-30 parts of 2-methyl-6-methylene-1,7-octadien-3-one, 15-25 parts of 1,4-butanediol dimethacrylate, 15-25 parts of tetraethylene glycol dimethacrylate, 5-10 parts of α-methacrylic acid, 5-10 parts of hydroxyethyl methacrylate, 2-5 parts of vinyltriethoxysilane, 0.1-0.5 parts of 1-hydroxycyclohexylphenyl ketone, 0.1-0.5 parts of 2-hydroxy-2-methyl-1-phenyl-1-propanone, and 0.3-0.5 parts of 1-[9-ethyl-6-(2-methylbenzoyl)-9H-carbazole-3-yl]acetone-1-(O-acetyloxime). The optical adhesive of the present invention has excellent bonding performance and can prevent the bonded components from debonding and causing cohesive failure at the bonding joint in humid, steamy, or chemical solvent environments.

Cosmetic composition comprising(i) bemotrizinol (bis-ethylhexyloxyphenol methoxyphenyl triazine),(ii) a water-soluble organic UV filter or a salt thereof,(iii) at least one inorganic UV filter,wherein the cosmetic composition is free of the UV filters from the group consisting of hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate (INCI diethylamino hydroxybenzoyl hexyl benzoate), 2,2′-Methylenbis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol](bisoctrizole), 3,3,5-Trimethylcyclohexyl 2-hydroxybenzoate (INCI Homosalate), polysilicone-15, and 2-hydroxy-4-methoxybenzophenone (INCI benzophenone-3) and a method for increasing the water resistance of a cosmetic composition comprising bis-ethylhexyloxyphenol methoxyphenyl triazine (bemotrizinol), zinc oxide, and titanium dioxide comprising the step of adding a water-soluble organic UV filter or a salt thereof to the cosmetic composition.

The invention belongs to the field of organic synthesis, and provides a thietane indoline heterocyclic compound as well as a preparation method and application thereof. R1 and R2 are respectively and independently selected from one of hydrogen, methyl, methoxyl and halogen, R3 is selected from one of t-butyloxycarboryl and 4-chlorobenzoyl, R4 is selected from one of hydrogen, methyl and phenyl, and R5 is selected from methyl or n-propyl; x represents an oxygen atom or an amino group with a protecting group. The preparation method comprises the following steps: putting an indole derivative compound into an organic solvent containing a photocatalyst, and reacting under the irradiation of visible light to obtain the thietane indoline heterocyclic compound. The preparation method provided by the invention can be used for synthesizing the functionalized thietane indoline heterocyclic compound with high stereoselectivity and high yield, and is low in reaction cost, mild in reaction condition and simple and convenient to operate.

The invention discloses a method for detecting components of a 1, 4-bis (4-phenoxy benzoyl) benzene reaction solution by high performance liquid chromatography, which belongs to the technical field of analysis and detection methods, and the set chromatographic analysis conditions are as follows: separation by adopting a C18 chromatographic column subjected to end capping treatment, detection by adopting a diode array detector, and detection by adopting a chromatographic column subjected to end capping treatment. The contents of paraphthaloyl chloride, diphenyl ether, 1, 4-bis (4-phenoxybenzoyl) benzene (EKKE), EKKE ortho-isomer, 4-(4-phenoxybenzoyl) benzoic acid and 4-(4-phenoxybenzoyl) benzoate are simultaneously determined by using a single-point external standard method, and a determination method is provided for central control analysis and reaction endpoint judgment in a synthesis process of the 1, 4-bis (4-phenoxybenzoyl) benzene. The method is high in separation degree; the accuracy rate of a determination result is high, and the recovery rate of each substance is within the range of 95-105%; result repeatability RSD is less than 2%, and repeatability is good.