143 results about "Phenacyl" patented technology

The invention belongs to the technical field of UV visbreaking polymers, and particularly relates to a UV visbreaking film and a preparation method thereof. Wherein the UV viscosity-reducing film sequentially comprises a base film (1), a first viscosity-reducing adhesive layer (5), a second viscosity-reducing adhesive layer (4) and a release film (3) from bottom to top, the first viscosity-reducing adhesive layer (5) and the second viscosity-reducing adhesive layer (4) both comprise a photoinitiator, the photoinitiator in the first viscosity-reducing adhesive layer (5) is 1-hydroxy-cyclohexyl phenyl ketone, and the content of the photoinitiator in the formula of the adhesive layer is 0.1%-10% by mass; a photoinitiator in the second viscosity-reducing adhesive layer (4) is bis (2, 4, 6-trimethylbenzoyl) phenyl phosphine oxide, and the content of the photoinitiator in the adhesive layer formula is 0.1-10% by mass; in the preparation method, ultraviolet irradiation precuring is carried out, so that the UV viscosity-reducing film has light selectivity and high cohesion strength, and the residual adhesive is remarkably reduced.

The invention discloses a 1, 4-bis (4-fluorobenzoyl) benzene production waste utilization process, which belongs to the technical field of 1, 4-bis (4-fluorobenzoyl) benzene production, and comprises the following steps: dissolving waste leftovers in a solvent, and adsorbing and removing pigments and solid particles in the leftovers by activated carbon; carrying out dehalogenation and hydrogenation on the pretreated leftovers in the presence of a hydrogenation catalyst and an alkaline substance to produce 1, 4-biphenyl acyl benzene; and carrying out separation and purification on the hydrogenation product in a solution crystallization manner to obtain 1, 4-biphenyl acyl benzene with the purity of more than or equal to 99.75%. The waste leftovers are used for producing the 1, 4-biphenyl acyl benzene, so that the utilization rate of the raw materials is increased, the discharge of hazardous wastes is reduced, and the method is green and environment-friendly.

A process for the preparation of a compound of the sterically hindered alkoxyamine class is described, the process comprises the step of alkylating a sterically hindered hydroxylamine compound to a corresponding sterically hindered alkoxyamine by reacting said sterically hindered nitroxyl compound with a compound capable of producing a carbon-central alkyl radical, typically a territorial or secondary alkyl radical, the compounds capable of generating carbon-center alkyl radicals are selected from thermal radical initiators that form radical species in the temperature range of 40 DEG C to 200 DEG C, and from photoinitiators that undergo light excitation when irradiated with UV light or visible light in the range of 180 to 700 nm, in particular UV light in the range of 180 to 380 nm, the compounds capable of generating carbon center alkyl radicals are typically selected from the class of organic peroxides, azo compounds, benzoyl derivatives, benzophenone derivatives, thioxanthone derivatives, benzoin derivatives, benzoyl phosphine oxide derivatives, and the like. The invention relates to a peroxide, for example, selected from the group consisting of diacyl peroxides of formula (A), peracid esters of this formula (A), and oxalic acid peracid esters of formula (D) R-CO-O-O-Z-R (A), r-Z ''-X-CO-CO-O-O-Z''-R (D) wherein each R independently represents a primary or secondary alkyl or cycloalkyl group, preferably comprising from 1 to 15 carbon atoms, and X is oxygen-O-or peroxy-O-O-, Z represents CO or an alkylene group bonded to a quaternary carbon atom, the quaternary carbon atom being an alkylene group of formula (C) R '-C-R' (C), wherein each R'is selected from alkyl groups having 1 to 15 carbon atoms, and Z "represents the alkylene group bonded to a quaternary carbon atom having the formula (C). The described process produces the corresponding O-alkylated derivatives of the sterically hindered hydroxylamines, typically compounds of the class referred to as N-O-alkyl HALS, with very high selectivity and conversion and without the need for the use of catalysts, in particular metal catalysts.

The invention provides a synthetic method of 2-(2-amino-5-bromo-benzoyl) pyridine, and belongs to the technical field of medicine synthesis. A one-pot boiling method is adopted, 2-cyanopyridine and 4-bromaniline are used as raw materials, BCl3 is used as a catalyst, dichloromethane is used as a solvent, a heat preservation reaction is performed for 5-25 hours at the temperature of-10 DEG C to 40 DEG C, and the product 2-(2-amino-5-bromo-benzoyl) pyridine is obtained through ethyl acetate extraction, anhydrous sodium sulfate drying and dichloromethane and petroleum ether recrystallization. According to the preparation method of the 2-(2-amino-5-bromo-benzoyl) pyridine, provided by the invention, butyl lithium with extremely high dangerousness does not need to be used, the reaction steps are simple, the yield is stable, the treatment is easy, and the yield is high.

The invention discloses a production process of a cellulose acetate fiber fabric containing natural fragrance, a solvent formed by mixing a modified polymer, 2, 4, 6-trimethylbenzoyl-diphenyl phosphine oxide, a modified microcapsule and dimethylformamide is subjected to dry spinning to prepare the cellulose acetate fiber fabric, and the weight part ratio of the modified polymer to the modified microcapsule is (70-80): (6-8). The preparation method comprises the following steps: by taking an isocyanate group on excessive hexamethylene diisocyanate as a reaction site, firstly reacting with an intermediate containing dihydroxyl, and then reacting with cellulose acetate containing free hydroxyl, so as to prepare the modified polymer. The halamine structure on the molecular chain can destroy cell membranes, enzyme systems or genetic materials through oxidation. The modified capsule has a lavender essential oil and cinnamon essential oil double-component double-capsule-wall structure, the fragrance durability can be improved, the copper sulfide nanoparticles and quaternized chitosan structures can destroy the bacterial cell structure, and the antibacterial performance of the material is improved.

This invention discloses a photosensitive supramolecular fluorescent polymer, its preparation method, and its anti-counterfeiting application in water, using trifluoroethyl methacrylate, hexafluorobutyl acrylate, 4-(acryloyloxy)butyl4-(2-methyl-3-(2-(2-methylbenzo[b]thiophen-3-yl)-4-oxo-5,6-2H-4H-thiaran[2,3-)b]thiaran-3-yl)benzo[b]thiophen-6-yl)-4-oxobutyrate, 4 This polymer was prepared by a simple one-step free radical copolymerization method using 1,1-(acryloyloxy)butyl3-(3,3,4,4,5,5-hexafluoro-2-(2-methyl-1,1-dioxide benzo[b]thiophene-3-yl)cyclopent-1-en-1-yl)-2-methylbenzo[b]thiophene-6-carboxylate 1,1-dioxide and phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide (photoinitiator-819) as raw materials. The polymer exhibits excellent multicolor light-switching performance, high stretch ratio, high self-healing efficiency, strong substrate adhesion, and antifouling properties, especially demonstrating excellent stability under strong acid, strong alkali, and high salt environments. The synthetic route is simple, and it has great application potential in underwater anti-counterfeiting and encryption technologies.

The invention relates to a calcipotriol nano-composite, difunctional integrated hydrogel for treating psoriasis as well as preparation and application of the difunctional integrated hydrogel. The preparation method comprises the following steps: loading calcipotriol on amino-modified mesoporous silica, and then carrying out a one-pot reaction on the amino-modified mesoporous silica, methacrylated gelatin, dopamine methacrylamide, sodium pirolinate carboxylate and phenyl (2, 4, 6-trimethylbenzoyl) lithium phosphate to obtain the difunctional integrated hydrogel. The hydrogel disclosed by the invention is UV-responsive drug-loaded hydrogel, can be quickly cross-linked and adhered to the surface of skin after being irradiated by UV, has the properties of high light transmission, drug sustained release, moisture retention and stable structure, and meets the clinical requirements of synchronous and integrated drug treatment and UV irradiation while remarkably improving the bioavailability of an externally applied drug; organic combination and mechanism complementation of two treatment modes are realized, so that the psoriasis is treated more efficiently.

The application belongs to the field of pharmaceutical chemistry, and specifically discloses a benzimidazole amine derivative, a preparation method thereof and application of the benzimidazole amine derivative as a beta2-adrenergic receptor allosteric antagonist. In the benzimidazole amine derivative, R1 is a hydrogen atom or a bromine atom; and R2 is a substituted benzoyl group or a substituted benzyl group. Pharmacological results show that the benzimidazole amine derivative has good antagonistic activity on beta2AR and can negatively allosterically regulate the functional activity of isoprenaline (ISO).

The present invention relates to crystals of N-(benzoyl)-phenylalanine-based compounds, pharmaceutical compositions thereof, preparation methods and uses. Specifically, as shown in Formula (I) and Formula (II), the crystals of the compound of Formula (I) have crystal form A, and the crystals of the compound of Formula (II) have crystal form B. The two crystal forms have good stability, high reproducibility of the preparation method, high operability, and important application value in the prevention and / or treatment of diseases related to α4β7 integrin. [Chemical formula 1] TIFF2025518346000014.tif44156

The invention discloses a pyrimidine derivative containing a thiosemicarbazide structure and application of the pyrimidine derivative, and relates to the technical field of medicines, the compound has good oxidation resistance and alpha-glucosidase resistance activity, and the compound is 2-(4, 4 '-difluorophenyl)-2-(4, 4'-difluorophenyl)-2-(4, 4 '-difluorophenyl)-2-(4, 4' The IC50 values of the compound 2-(4, 6-dimethyl pyrimidine-2-yl)-N-methylhydrazine-1-methylsulfamide on DPPH (1, 1-diphenyl-2-picrylhydrazyl) scavenging activity and ABTS (2, 2, 6-dimethyl pyrimidine-2-yl)-N-methylhydrazine-1-methylsulfamide are 3.96 mu g / mL and 2.01 mu g / mL respectively, the IC50 value of the compound 2-(4, 6-dimethyl pyrimidine-2-yl)-N-methylhydrazine-1-methylsulfamide on alpha-glucosidase inhibitory activity is 38.62 mu g / mL, the effect is best, and the compound 2-(4, 6-dimethyl pyrimidine-2-yl)-N-methylhydrazine-1 The pyrimidine derivative containing the thiosemicarbazide structure has a general formula shown in the specification, and is superior to control medicaments such as vitamin C, vitamin E and acarbose.

The invention provides a continuous synthesis method of 2-(4 '-pentylbenzoyl) benzoic acid, and relates to the field of synthesis of 2-(4'-pentylbenzoyl) benzoic acid. The continuous synthesis method of the 2-(4 '-pentylbenzoyl) benzoic acid comprises the following steps: continuous catalytic reaction and post-treatment. The continuous synthesis method of the 2-(4 '-pentylbenzoyl) benzoic acid can effectively realize continuous and stable synthesis of the 2-(4'-pentylbenzoyl) benzoic acid on the premise of reducing the dosage of the traditional aluminum trichloride catalyst, improves the yield and purity of the continuously prepared 2-(4 '-pentylbenzoyl) benzoic acid, and reduces by-products.

A method for resolving a phenylalanine derivative of formula (I), and an intermediate. The method comprises: a resolving step comprising using a resolving reagent to react with the phenylalanine derivative represented by formula (I) in a reaction solvent to obtain a resolved intermediate, wherein the resolving reagent is selected from N-acetyl-D-phenylalanine and / or (2R,3R)-(−)-dibenzoyl-L-tartaric acid, and the reaction solvent is selected from 90-99% aqueous ethanol, absolute ethyl alcohol, or acetone. The method uses a chiral reagent to perform salt formation and racemate resolution, and has the advantages of being easy to operate, requiring no special production devices, and being easy to scale up production.

A photosensitive resin composition of the invention contains (A) a polyimide precursor having a polymerizable unsaturated bond, (B) a photopolymerization initiator comprising a compound represented by the formula (11), (C) a thermal radical generator, and (D) a solvent containing γ-butyrolactone:wherein in the formula (11), R11 is a substituted or unsubstituted benzoyl group, a substituted or unsubstituted fluorenyl group, or a group comprising a substituted or unsubstituted carbazolyl group; R12 is an alkyl group including 1 to 12 carbon atoms, a group comprising a cycloalkyl group including 4 to 10 carbon atoms, a group comprising a phenyl group, or a group comprising a tolyl group; R13 is a substituted or unsubstituted aromatic hydrocarbon group including 6 to 20 carbon atoms.

The invention relates to pharmaceutical compositions comprising a GLP-1 agonist and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid. The invention further relates to processes for the preparation of such compositions, and their use in medicine.

The application discloses a benzyl benzoyl or fluorinated alkane substituted phenol compound and a synthesis method and application thereof, and belongs to the technical field of drug synthesis. The synthesis method comprises the following steps: step one, 0.3mmol of o-aminobenzamide, 0.3mmol of ketone, 10mol% of I2 and 5mL of anhydrous ethanol are added into a 10mL round-bottom flask at one time, stirring is carried out at 80 DEG C for 24h, after the reaction is completed, the reaction liquid is poured into ice water, the volume ratio of the reaction liquid to the ice water is 1:10, ethyl acetate is extracted, the organic layer is washed with saturated brine, dried with anhydrous Na2SO4, and spin-dried to obtain a crude product. The synthesis method has the advantages of mild reaction condition, few side reactions and simple and convenient operation. And the benzyl benzoyl or fluorinated alkane substituted phenol compound obtained by the application has the effect of resisting colon cancer.

The present invention relates to an oral pharmaceutical composition comprises semaglutide, SNAC (Sodium N-[8-(2-hydroxybenzoyl) amino] caprylate), one or more alkalizing agent and one or more pharmaceutically acceptable excipients.

The invention discloses a preparation method and application of a functional degradable soybean oil-based bionic porous composite bone scaffold. The method comprises the following steps: taking epoxidized soybean oil acrylate as a bio-based base material, compounding isobornyl methacrylate to improve the defects of high viscosity and low photosensitivity of the bio-based base material, adding a photoinitiator containing ethyl 2, 4, 6-trimethylbenzoyl phenyl phosphonate and phenyl bis (2, 4, 6-trimethylbenzoyl) phosphine oxide, compounding, and carrying out aging treatment to obtain base resin; mixing calcium lignosulphonate into the base resin to prepare composite photosensitive resin, and printing a triple-period extremely-small curved surface structure through a digital light processing technology and a 3D printing technology to finally obtain the functional degradable soybean oil-based bionic porous scaffold. The scaffold has calcium lignosulphonate-mediated controllable photo-thermal response behaviors of near-infrared light illumination regulation and bone scaffold component dependence under the condition of simulating the in-vivo environment of a human body, so that a controllable photo-thermal response-mediated remote shape memory function is realized, and meanwhile, a mild, safe and controllable photo-thermal curative effect can also be realized. Besides, calcium lignosulphonate promotes degradation of the composite scaffold by preferentially dissolving and generating a microporous structure on the surface of a matrix while improving the hydrophilic performance of the scaffold, and continuously releases calcium ions, so that the scaffold shows enhanced biomineralization ability and promotes cell proliferation and osteogenic differentiation. The research provides a solution with potential for the soybean oil-based biological photosensitive material in the digital light processing preparation technology and the multi-functional application of the bionic porous bone scaffold so as to deal with complex and irregular bone defects.

This invention discloses a high-adhesion optical adhesive for extreme conditions, its preparation method, and its application, belonging to the field of optical adhesive technology. It comprises the following components in parts by weight: 20-30 parts of 2-methyl-6-methylene-1,7-octadien-3-one, 15-25 parts of 1,4-butanediol dimethacrylate, 15-25 parts of tetraethylene glycol dimethacrylate, 5-10 parts of α-methacrylic acid, 5-10 parts of hydroxyethyl methacrylate, 2-5 parts of vinyltriethoxysilane, 0.1-0.5 parts of 1-hydroxycyclohexylphenyl ketone, 0.1-0.5 parts of 2-hydroxy-2-methyl-1-phenyl-1-propanone, and 0.3-0.5 parts of 1-[9-ethyl-6-(2-methylbenzoyl)-9H-carbazole-3-yl]acetone-1-(O-acetyloxime). The optical adhesive of the present invention has excellent bonding performance and can prevent the bonded components from debonding and causing cohesive failure at the bonding joint in humid, steamy, or chemical solvent environments.

The invention belongs to the field of organic synthesis, and provides a thietane indoline heterocyclic compound as well as a preparation method and application thereof. R1 and R2 are respectively and independently selected from one of hydrogen, methyl, methoxyl and halogen, R3 is selected from one of t-butyloxycarboryl and 4-chlorobenzoyl, R4 is selected from one of hydrogen, methyl and phenyl, and R5 is selected from methyl or n-propyl; x represents an oxygen atom or an amino group with a protecting group. The preparation method comprises the following steps: putting an indole derivative compound into an organic solvent containing a photocatalyst, and reacting under the irradiation of visible light to obtain the thietane indoline heterocyclic compound. The preparation method provided by the invention can be used for synthesizing the functionalized thietane indoline heterocyclic compound with high stereoselectivity and high yield, and is low in reaction cost, mild in reaction condition and simple and convenient to operate.

The application provides a synthesis method and application of an N-phenyl carbazole fluorescent compound for alcohol compound labeling, and belongs to the technical field of fluorescent labeling of organic small-molecule alcohol compounds. The application takes N-phenyl carbazole as a fluorescent parent ring, and imidazole as a reactive group, and the chemical name is 4-(9-carbazole)-benzoylimidazole. The specific preparation method is as follows: (1) reacting carbazole with p-iodobenzoate to obtain 4-(9-carbazolyl)-benzoic acid methyl ester a; (2) reacting a with a potassium hydroxide aqueous solution to obtain 4-(9-carbazolyl)-benzoic acid b; and (3) reacting b with N,N'-carbonyldiimidazole to obtain a target product. The fluorescent labeling reagent can accurately and sensitively label twelve kinds of fatty alcohols, so that the separation and detection of trace fatty alcohols in a complex system can be realized, and the fluorescent labeling and analysis of various fatty alcohols in the research fields of life and food can be carried out, and the application prospect is wide.

The application belongs to the technical field of pharmaceutical chemistry, and relates to a preparation method of a natural product embeloside A. The application takes 2,3,4,6-tetra-benzoyl-alpha-bromoglucose as raw material, and linear 4-step reaction is used to prepare the embeloside A. The application has the advantages of short reaction steps, high yield, mild reaction conditions, easy operation and good application development prospect.

The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical composition for preventing and treating ulcerative colitis as well as a preparation method and application thereof. The pharmaceutical composition disclosed by the invention comprises anhydroicaritin or a pharmaceutically acceptable salt of the anhydroicaritin and N-(3-chlorphenyl)-1-(3-hydroxybenzoyl) piperidine-4-formamide or a pharmaceutically acceptable salt of the N-(3-chlorphenyl)-1-(3-hydroxybenzoyl) piperidine-4-formamide, wherein the weight ratio of the anhydroicaritin to the N-(3-chlorphenyl)-1-(3-hydroxybenzoyl) piperidine-4-formamide is (0.1-3.0): 1. The anhydroicaritin or the pharmaceutically acceptable salt of the anhydroicaritin and the N-(3-chlorphenyl)-1-(3-hydroxybenzoyl) piperidine-4-formamide or the pharmaceutically acceptable salt of the N-(3-chlorphenyl)-1-(3-hydroxybenzoyl) piperidine-4-formamide in the pharmaceutical composition disclosed by the invention have a remarkable synergistic interaction effect in the aspect of preventing or treating ulcerative colitis. The pharmaceutical composition disclosed by the invention has a remarkable treatment effect on ulcerative colitis and has important social benefits and economic values.

The application belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of a hydrochloric acid dinedarone intermediate N-(2-n-butyl-3-(4-halogenated benzoyl) benzofuran-5-yl) methanesulfonamide. The preparation method of the hydrochloric acid dinedarone intermediate provided by the application is safe, simple and convenient in operation process, high in product yield and purity, green and environment-friendly, and suitable for industrialized production.

A radiation curable ink jet composition includes polymerizable compounds and a photopolymerization initiator, the polymerizable compounds include a monofunctional monomer, a content of the monofunctional monomer with respect to a total mass of the polymerizable compounds is 90 percent by mass or more, and the photopolymerization initiator includes ethyl (2,4,6-trimethylbenzoyl)phenylphosphinate.

The application relates to the technical field of compound synthesis, and discloses an aromatic dipeptide functionalized mercapto compound, 3,5-di(triphenylmethylthio)benzoic acid is obtained by adding 3,5-di(methylmercapto)benzoic acid and pyridine into a solution of chloromethyl triphenylphosphonium, purifying after sufficient reaction; then the 3,5-di(triphenylmethylthio)benzoic acid is mixed with N-hydroxysuccinimide and dissolved in an organic solvent, EDC.HCl is added, purifying after sufficient reaction; then 2,5-dioxopyrrolidin-1-yl 3,5-bis(triphenylmethylthiomethyl)benzoate is obtained; then phenylalanine-tryptophan and triethylamine are added, purifying after sufficient reaction; then (3,5-bis(triphenylmethylthiomethyl)benzoyl)tryptophylphenylalanine is obtained; then trifluoroacetic acid and triethylsilane are added, purifying after sufficient reaction; and finally the aromatic dipeptide functionalized mercapto compound is obtained. The aromatic dipeptide functionalized mercapto compound can quickly and effectively identify sodium and potassium ions, and has relatively low detection limit and relatively loose detection condition.

A composition for encapsulation, which contains a photopolymerizable compound and a photopolymerization initiator, and wherein the photopolymerization initiator comprises one or two selected from the group consisting of ethyl (2, 4, 6-trimethylbenzoyl) phenylphosphonate and phenyl bis (2, 4, 6-trimethylbenzoyl) phosphine oxide.

The present invention provides a radiation-curable inkjet ink that has low odor and suitable viscosity and curability for use as an inkjet ink. [Solution] A radiation-curable inkjet ink composition comprising a polymerizable compound, a polymer thioxanthone polymerization initiator, and bis(2,4,6-trimethylbenzoyl)-phenylphosphine oxide, wherein the polymerizable compound does not contain an amine-modified oligomer, or the polymerizable compound contains an amine-modified oligomer, and the content of the amine-modified oligomer is less than 5% by mass of the total amount of the ink composition.

The application discloses a cannabidiol derivative and application thereof, and belongs to the technical field of medicinal chemistry. The structural general formula of the cannabidiol derivative is shown as formula (I): (I) R1 is selected from one of hydrogen, chlorine, bromine, a hydroxyl group, a cyano group, an acetoxy group, an acryloyloxy group, a benzoyl group, an acetamide group, an acrylamide group, a propiolamide group, an ethyl thiourea group, a 3-chloro-2,2-dimethylpropionyl group, a 2-ethylsulfonamide acetyl group, a 2-ethylsulfonamide-N-(2-amino-2-oxoethyl) acetyl group, a methylsulfonyl group, an ethylsulfonyl group, a vinylsulfonyl group, an alkyne propylsulfonyl group, a phenylsulfonyl group and a styrylsulfonyl group; and R2 is selected from one of C2-C5 alkyl groups. The cannabidiol derivative disclosed by the application has significantly improved anti-neuroinflammatory activity, significantly reduced cytotoxicity, and a generally improved treatment index of more than 10 times, or even more than 260 times, compared with cannabidiol.

The invention relates to the technical field of pharmaceutical chemical synthesis, in particular to a synthesis method of a 2, 5-diphenylfuran compound, which comprises the following steps: adding a compound 1, a compound 2, acid and a catalyst into a reactor, stirring for 4 hours under the air condition of 80 DEG C, cooling to room temperature after the reaction is finished, and carrying out reduced pressure distillation to obtain a crude product, namely the 2, 5-diphenylfuran compound. And purifying through column chromatography and thin-layer chromatography to obtain the 2, 5-diphenylfuran compound. A benzoyl sulfoxide ylide compound and a phenylacetylene compound are used as raw materials, and the 2, 5-diphenyl furan compound is synthesized through metal catalysis. The method has the advantages of simple synthesis steps, easily available raw materials, safe synthesis operation, good functional group compatibility and the like; reaction conversion is high, cost is low, and industrial production is facilitated.