The invention belongs to the technical field of fertilizer preparation, and particularly relates to special fertilizer for grapes and a preparation method of the special fertilizer. The special fertilizer is prepared from raw materials in parts by weight as follows: 30-40 parts of urea, 20-30 parts of ammonium phosphate, 18-25 parts of calcium superphosphate, 20-30 parts of calcium magnesium phosphate, 18-25 parts of monopotassium phosphate, 8-15 parts of potassium sulfate, 18-22 parts of cow and sheep manure, 20-30 parts of biogas residues, 12-18 parts of humic acid, 10-15 parts of tea cakes, 8-12 parts of Chinese medicine residues, 1-3 parts of zinc amino acid chelate, 1-3 parts of boron amino acid chelate, 1-3 parts of manganese amino acid chelate, 1-3 parts of calcium amino acid chelate, 1-3 parts of magnesium amino acid chelate, 6-15 parts of compound bacteria and 5-8 parts of a leavening agent. The special fertilizer for the grapes sufficiently meets requirements for growth and development of the grapes, high quality and high yield, meanwhile, a soil structure is effectively improved, besides, characters such as content of procyanidine, anthocyanidin, resveratrol and pectin of the grapes and the like are remarkably improved, and the produced grapes are qualified non-polluted fruits.