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63 results about "Anthocyanidin" patented technology

Anthocyanidins are common plant pigments. They are the sugar-free counterparts of anthocyanins based on the flavylium ion or 2-phenylchromenylium, which is a type of oxonium ion (chromenylium is referred also to as benzopyrylium). They form a large group of polymethine dye. In particular anthocyanidins are salt derivatives of the 2-phenylchromenylium cation, also known as flavylium cation. As shown in the figure below, the phenyl group at the 2-position can carry different substituents. The counterion of the flavylium cation is mostly chloride. With this positive charge, the anthocyanidins differ from other flavonoids. 31 monomeric anthocyanidins have been properly identified, most of the anthocyanins are based on cyanidin (30%), delphinidin (22%), and pelargonidin (18%), respectively. Altogether 20% of the anthocyanins are based on the three common anthocyanidins (peonidin, malvidin, and petunidin) that are methylated. Around 3%, 3%, and 2% of the anthocyanins or anthocyanidins are respectively labeled as 3-desoxyanthocyanidins, rare methylatedanthocyanidins, and 6-hydroxyanthocyanidins, respectively.

Ginseng exosome anti-aging and anti-oxidation composition and preparation method thereof

The invention provides a ginseng exosome anti-aging and anti-oxidation composition and a preparation method thereof, and relates to the field of nursing materials, the ginseng exosome anti-aging and anti-oxidation composition comprises Exo nano-vesicles, procyanidine and cationic liposome, the Exo nano-vesicles are derived from ginseng extracellular fluid, the procyanidine is derived from the cationic liposome, and the cationic liposome is derived from the procyanidine. The ginseng exosome anti-aging and anti-oxidation composition provided by the invention can effectively improve skin wrinkles, enhance skin elasticity, promote collagen synthesis, inhibit collagen degradation and inhibit elastin degradation through the combined action of the Exo nano-vesicles, Pro and cationic lipidosome; degradation of elastin can cause skin to lose resilience, formation of wrinkles is accelerated, and facial skin can be effectively improved and wrinkles can be reduced by promoting synthesis of collagen and inhibiting degradation of elastin.
Owner:XINGFU GLOBAL CO LTD

Skin care composition based on saccharomycetes fermentation lysate filtrate and preparation method

The invention relates to the technical field of cosmetic raw materials, in particular to a skin care composition based on saccharomycetes fermentation lysate filtrate and a preparation method. The quaternary ammonium salt antibacterial product is obtained by adding potassium carbonate, a 1, 4-dibromobutane solution, a bio-phenol solution and trimethylamine. And taking absolute ethyl alcohol, a paeonol solution, a sodium hydroxide solution, a p-hydroxybenzaldehyde solution, absolute ethyl alcohol and an iodine elementary substance as raw materials to obtain a flavone product. And adding the flavonoid product, the quaternary ammonium salt antibacterial product and the anti-inflammatory chalcone into the embedding liquid to obtain the composite embedding product. And finally, adding the yeast fermentation lysate filtrate, the composite embedding product, hydrolyzed procyanidine, sodium hyaluronate, allantoin, butanediol, a preservative and deionized water to obtain a finished product. The finished product prepared by the invention has good antibacterial performance and anti-inflammatory performance, so that the finished product has a wide application prospect in the field of cosmetic raw materials.
Owner:LANKE YIMEI SCI & TECH (JILIN) CO LTD

Protein-based nanoparticle gel double-nozzle 3D printing method and equipment

The invention relates to the technical field of 3D printing of easy-to-swallow food, in particular to a protein-based nanoparticle gel double-nozzle 3D printing method and equipment, aiming at the nutritional requirements of old people with dysphagia, procyanidine is loaded on protein-based nanoparticles, corn starch, gelatin and the like are combined to construct a composite gel system as a printing wall material, and the printing wall material is used as a printing wall material. Protein, citrus juice and peony seed oil emulsion are used as core materials, and a double-nozzle 3D printing technology is utilized to realize accurate texture regulation and control and personalized nutrition design; the method comprises the steps of protein solution preparation, composite nanoparticle synthesis, procyanidine loading, wall material and core material preparation, double-nozzle printing and the like, the technology breaks through the bottleneck that traditional swallowing food is insufficient in protein strengthening and lacks active ingredients, and the antioxidant functional components and the 3D printing technology are integrated; innovative food with swallowing safety and nutrition targeting is provided for the elderly, and application of protein-based materials in intelligent food manufacturing is promoted.
Owner:HENAN UNIV OF SCI & TECH

A cell culture medium for the mantle of Mytilus coruscus and its application

The invention relates to the field of cell culture and discloses a culture medium for thick-shelled mussel mantle cells and an application thereof. The culture medium comprises a basal culture medium and additives, wherein the additives comprise thick-shelled mussel serum, proanthocyanidins, bovine insulin, growth factors, antibiotics, defensins, mussel mucin and a buffer. The culture medium can be used for in vitro culture of thick-shelled mussel mantle cells and can better maintain the survival and growth of in vitro cultured thick-shelled mussel mantle cells. Defensins in a specific proportion are added to the culture medium, and the best growth and reproduction state can be achieved when the thick-shelled mussel mantle cells are cultured using the culture medium in the specific proportion. The application also provides an application method of the culture medium, which is simple to operate and can produce cultured thick-shelled mussel mantle cells with high cell density, good morphology and high wall adhesion.
Owner:ZHEJIANG OCEAN UNIV

Crosslinked graft copolymer and preparation method and application thereof

The invention relates to the technical field of drilling fluid treating agents, and discloses a cross-linked grafted copolymer as well as a preparation method and application thereof. The cross-linked grafted copolymer contains a molecular chain A from lignosulfonate, a molecular chain B from procyanidine, a linking group C from an aldehyde cross-linking agent, a structural unit D as shown in a formula (1) and a structural unit E as shown in a formula (2), wherein the molecular chain A and the molecular chain B are connected through a linking group C, and the linking group C is bonded with carbon atoms on benzene rings respectively contained in the molecular chain A and the molecular chain B; the structural unit D and the structural unit E are grafted on hydroxyl groups of the molecular chain A and the molecular chain B. The cross-linked grafted copolymer disclosed by the invention can keep excellent viscosity reduction performance in a high-temperature environment of 180 DEG C, is non-toxic and easy to degrade, and does not cause environmental harm. # imgabs0 #
Owner:CHINA PETROLEUM & CHEMICAL CORP +1

Honeysuckle flower pigment synthesis gene and application thereof in regulating and controlling content and resistance of plant flower pigment

The invention discloses a honeysuckle flower pigment synthesis gene and application thereof in regulating and controlling the content and resistance of plant anthocyanidin, and belongs to the technical field of gene engineering. The nucleotide sequence of the honeysuckle flower pigment synthesis gene is as shown in SEQ ID NO. 6. The invention provides a honeysuckle flower pigment synthesis gene. The gene has the effects of regulating and controlling the content of anthocyanidin in plants and regulating and controlling the stress resistance of the plants. The gene is introduced into a plant body by constructing an overexpression vector, so that the gene is stably overexpressed, the anthocyanidin content in the plant is remarkably increased, and the petal color and seed coat color of the plant are darkened; the resistance of the plant to drought stress and salt stress is also remarkably enhanced, so that the plant can adapt to a severe environment more easily, and a new gene resource and a theoretical support are provided for breeding of high-resistance plant varieties.
Owner:INST OF TRADITIONAL CHINESE MEDICINE HENAN ACAD OF AGRI SCI

Intestinal tract hemostasis composition as well as preparation method and application thereof

The invention discloses an intestinal tract hemostatic composition as well as a preparation method and application thereof, and relates to the field of hemostatic drugs. Wherein the catechin, the hyperoside, the isoquercitrin, the quercetin-3-O-glucuronide, the gallocatechin, the myricetin-3-O-galactoside, the proanthocyanidin B1, the proanthocyanidin B3, the syringe-3-O-glucoside and the astragalus smicus glycoside are flavonoid compounds; nuciferine, higenamine, N-methyl-higenamine and N-trans-feruloyl tyramine are taken as alkaloid compounds, and the compound is selected from the group consisting of higenamine, nuciferine, higenamine The composition has the advantages of simple preparation process, good hemostatic effect and the like, and provides a new raw material choice for the development of intestinal bleeding treatment medicines.
Owner:INSTITUTE OF TCM HEALTH INDUSTRY CACMS

Method for preparing animal globin polypeptide powder

The application relates to the technical field of polypeptide preparation, and particularly discloses a preparation method of animal blood globin polypeptide powder. The preparation method of the animal blood globin polypeptide powder comprises the following steps: adding trisodium citrate into fresh animal blood, stirring for 10-30 min, adding cyanidin and polylysine, stirring uniformly, placing in a temperature-10 to-20 DEG C environment for 1-2 h, increasing to room temperature, homogenizing for 1-5 min, centrifuging, removing supernatant, and obtaining animal blood globin solution; adding the animal blood globin solution and rare earth lanthanum chitosan amine chelate salt into a glycine-sodium hydroxide buffer solution, stirring at 40-50 DEG C for 10-30 min, adding compound protease, and continuing to stir for 10-20 h to obtain an enzymatic solution; adjusting the pH value of the enzymatic solution to 5-6, increasing the temperature to 90-100 DEG C for 5-10 min, decreasing to room temperature, centrifuging for 5-10 min, and taking supernatant for low-temperature spray drying.
Owner:SHANDONG TAIAI PEPTIDE BIOTECHNOLOGY CO LTD

Comprehensive separation process for multiple active components in peanut coat

The invention relates to the field of separation and extraction of active ingredients of natural products, in particular to a comprehensive separation process of various active ingredients in peanut coats. Through reasonable matching of all the steps, various peanut coat active ingredients including peanut coat total sterol, peanut coat saturated fatty acid, peanut coat unsaturated fatty acid, peanut coat total flavonoid compounds and peanut coat procyanidine can be obtained with high yield through a set of process, the yield is high, and the method is a method capable of effectively and comprehensively utilizing peanut coat resources and improving the production efficiency. And the method is suitable for industrial technological processes.
Owner:HUNAN HUACHENG BIOTECH INC

Deep eutectic solvent as well as preparation method and application thereof

The invention provides a deep eutectic solvent and a preparation method and application thereof, the effective components of the deep eutectic solvent are composed of choline chloride and ethylene glycol, the molar ratio of choline chloride to ethylene glycol is 1: 4, the water content of the effective components is 30%, and the deep eutectic solvent can replace an organic solvent to extract total flavonoids from fructus amomi; chemical components capable of distinguishing the varieties of the fructus amomi are determined through quantitative experiments on the fructus amomi flavonoid compounds, serve as differential markers epicatechin, procyanidine B2 and procyanidine B4 for distinguishing the varieties of the fructus amomi and have very high antioxidant activity, and H2O2-induced GES-1 cell oxidative stress is relieved by removing ROS in cells and up-regulating the level of SOD and GSH-Px.
Owner:TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE +1

Cell-sized liposomes, method for estimating procyanidin concentration, and method for measuring procyanidin concentration

To provide a simple procyanidin analysis method that can be performed at a low cost, and in the form of preliminary analysis for selecting a sample for precision analysis in HPLC, that is, screening.SOLUTION: Cell size liposomes 10, 10' are composed of a lipid component system in which one or more phospholipids 2, 3 and one or more sterol-based lipids 5 are used in a constant composition, and procyanidin 8, where different phase separation domain generation patterns are generated depending on the concentration of procyanidin 8, which can be used for estimating the procyanidin concentration from the phase separation domain generation pattern. The phospholipids 2, 3 are unsaturated phospholipid or saturated phospholipid.SELECTED DRAWING: Figure 1
Owner:AOMORI PREFECTURAL IND TECH RES CENT

Preparation method of diclofenac sodium eye drops

The present invention belongs to the field of eye drops. In view of the problem that the existing diclofenac sodium ophthalmic preparations have poor efficacy and strong irritation on corneal neovascularization, the present invention provides a method for preparing diclofenac sodium eye drops. First, under ice bath conditions, a diclofenac solution is added to a ferrous sulfate solution. Subsequently, proanthocyanidins are coordinated with ferrous sulfate and diclofenac sodium to obtain an iron-based proanthocyanidin-diclofenac sodium nanozyme. The present invention obtains an iron-based proanthocyanidin-diclofenac sodium nanozyme by coordinating proanthocyanidins, ferrous sulfate and diclofenac sodium. The nanozyme is used for eye drops, which improves the inhibitory effect of diclofenac eye drops on corneal neovascularization, and can improve corneal sensitivity and maintain normal intraocular pressure.
Owner:EYE INST OF SHANDONG FIRST MEDICAL UNIV

Cell-sized liposome, estimating method of relative procyanidin concentration using cell-sized liposome, and procyanidin concentration measurement method

To provide a simple method for analyzing procyanidins like screening, which is a preliminary analysis to select samples for further analysis by HPLC (High-Performance Liquid Chromatography) capable of performing at a low cost.SOLUTION: A cell-sized liposome 110 is a cell-sized liposome that is composed of a lipid component system comprising one or more unsaturated phospholipids 12 and one or more saturated phospholipids 13 and a sample for which the procyanidin concentration is to be estimated or procyanidin 18, generates phase separation domain formation patterns varying according to the concentration of procyanidin 18, and is used to estimate the procyanidin concentration from the phase-separated domain formation patterns. The lipid component system of the cell-sized liposome 110 may include sterol lipids such as cholesterol.SELECTED DRAWING: Figure 1-3
Owner:AOMORI PREFECTURAL IND TECH RES CENT

Health wine capable of delaying senescence as well as preparation method and application of health wine

The invention discloses health wine capable of delaying senescence as well as a preparation method and application of the health wine, and belongs to the technical field of health food. According to the health-preserving wine, mulberries and sea-buckthorn are used as monarch materials, rhizoma polygonati and radix puerariae are used as ministerial materials, lophatherum gracile, fructus lycii and Chinese yam are used as assistants and guides, and all the raw materials are medicinal and edible substances. According to the invention, through an optimized'warm soaking-cold soaking 'two-step extraction process, synergistic interaction is realized, and active ingredients such as anthocyanin, flavone, polysaccharide and puerarin are extracted to the greatest extent. The health-preserving wine disclosed by the invention not only has good antioxidant capacity, but also can be used for remarkably removing free radicals such as DPPH (1, 1-diphenyl-2-picrylhydrazyl) and hydroxyl, improving the activity of serum SOD (superoxide dismutase) and GSH-Px (glutathione The formation of advanced glycosylation end products can be effectively inhibited, and the obvious anti-aging and anti-saccharification dual effects are achieved. The health-preserving wine disclosed by the invention is simple in preparation process, mellow in taste and suitable for daily health-preserving drinking.
Owner:SHANXI ZHENDONG WUHE HEALTH WINE CO LTD

Coreopsis tinctoria refined component as well as preparation method and application thereof

The invention relates to the technical field of coreopsis tinctoria refined components and preparation and application, and provides a coreopsis tinctoria refined component and a preparation method and application thereof.The coreopsis tinctoria refined component comprises, by mass, 11 specific components of phenolic acids, flavonol, flavanol and flavonoid, and the 11 specific components comprise, by mass, 2 parts of gallic acid, 1 part of potassium sorbate, 1 part of potassium sorbate, 1 part of potassium sorbate and 1 part of potassium sorbate. The health-care food is prepared from the following raw materials in parts by weight: 3 parts of chlorogenic acid, 14 parts of quercetin, 18 parts of catechin, 5 parts of citric acid, 2-3 parts of procyanidine B, 3 parts of (+)-epicatechin, 1-31 parts of 31 parts of procyanidine C, 14 parts of rutin, 4 parts of camphanol-3-O-rutinoside and 2 parts of isorhamnetin-3-O-rutinoside. The snow chrysanthemum is Changbai Mountain snow chrysanthemum. Animal experiments show that the refined component can significantly reduce the content of total cholesterol and triglyceride in serum of a high-fat model rat, the specific component with blood fat regulating activity is prepared from Changbai Mountain snow chrysanthemum, and a new choice is provided for non-drug intervention of dyslipidemia.
Owner:CHANGCHUN UNIV OF CHINESE MEDICINE

AU, AG and rich phytochemical payload nanomaterials, antiviral / antibacterial products and synthesis methods

A nanomaterial is gold or silver nanoparticle having a nanoparticle surface that consists of one or more of the following extracts from sweet gum leaves: shikimic acid, sweet gum leaf family of Catechins, sweet gum leaf family of Quercetin, Sweroside, Afzelechin, p-Coumaric Acid, Epiafzelechin Trimethyl Ether, Myricetin, Naringenin, Phloretin, Procyanidin B1 and related polyphenols, flavonoids and alkaloids. An antiviral / antibacterial agent includes sweet gum mediated silver nanoparticles having a core size and in a concentration having efficacy as an antiviral / antibacterial exceeding a 3 log 10 reduction in viral titer.
Owner:THE CURATORS OF THE UNIVERSITY OF MISSOURI

A fluorescent photonic neural network, a construction method thereof and an image recognition system

The present application relates to the technical field of photonic neural network, and discloses a fluorescent photonic neural network, a construction method thereof and an image recognition system.The construction method comprises the following steps: providing a single-layer photochromic spiropyran film; using a neural network based on a Keras framework to perform simulation training to obtain a weight matrix of a to-be-identified task; writing the weight matrix of the to-be-identified task into the single-layer photochromic spiropyran film, so that the concentration distribution of cyanine on the single-layer photochromic spiropyran film conforms to the weight matrix, and the fluorescent photonic neural network is obtained; and the fluorescent photonic neural network uses the spontaneous fluorescence of the spiropyran film as the signal output of the to-be-identified task.The present application can realize the storage of the computer fitting weight by the spiropyran film by using the mutual conversion of spiropyran and cyanine under the action of ultraviolet light and visible light, and can automatically sense ultraviolet signals and visible light signals.
Owner:SHENZHEN UNIV

Establishment method and application of peritoneal adhesion tissue model

The invention discloses an establishment method and application of a peritoneal adhesion tissue model, and belongs to the technical field of drug screening model construction. The establishment method comprises the following steps: (1) flushing animal abdominal wall muscle tissue strips with a sterile buffer solution for later use; (2) scraping the peritoneal tissue of the abdominal wall muscle tissue strip by using a tool for 10-40 times; (3) dropwise adding absolute ethyl alcohol at the peritoneal injury tissue, and standing for 2-10 minutes; (4) dripping animal blood to the peritoneal injury tissue; (5) after the blood is coagulated, folding the abdominal wall muscle strip to fit the peritoneal surface; (6) binding up abdominal wall muscle strip tissues; (7) soaking the bound abdominal wall muscle strips in a tissue culture medium for culturing; and (8) culturing for 60-80 hours to obtain the peritoneal adhesion tissue model. The procyanidine substance capable of remarkably preventing postoperative peritoneal adhesion is screened out through the model, so that the peritoneal adhesion tissue model provides a new way for research and development of drugs for preventing postoperative peritoneal adhesion.
Owner:THE SECOND AFFILIATED HOSPITAL TO NANCHANG UNIV

Copolymer and preparation method and application thereof

PendingCN119144021AGood viscosity reduction effectImprove adsorption capacityDrilling compositionPolymer scienceCopolymer
The invention relates to the technical field of drilling fluid treating agents, in particular to a copolymer and a preparation method and application thereof. The copolymer contains a molecular chain A from humate, a molecular chain B from lignosulfonate, a molecular chain C from procyanidine, a linking group D from an aldehyde cross-linking agent and a cross-linking point M from a metal salt cross-linking agent, wherein the molecular chain A, the molecular chain B and the molecular chain C are connected through a linking group D and / or a crosslinking point M, and the linking group D is bonded with carbon atoms on benzene rings contained in the molecular chain A, the molecular chain B and the molecular chain C respectively; the cross-linking point M and oxygen atoms on hydroxyl groups or carbonyl groups contained in the molecular chain A, the molecular chain B and the molecular chain C form a multi-element cyclic structure through coordinate bonds. The copolymer disclosed by the invention has temperature resistance, adsorbability, dispersity and environmental protection property at the same time, and can be used as a high-temperature-resistant environment-friendly viscosity reducer for water-based drilling fluid.
Owner:CHINA PETROLEUM & CHEMICAL CORP +1

Stem cell-loaded drug-loaded nano-vesicle-sericin-based hydrogel and application thereof

The invention relates to the technical field of medicines, in particular to a stem cell-loaded drug-loaded nano-vesicle-sericin-based hydrogel and application thereof. According to the preparation method, sericin is taken as a base material, sericin is chemically grafted through methacrylic anhydride to obtain photo-crosslinked sericin (SerMA), then procyanidine (PC) loaded acrylate-polyethylene glycol-succinimide ester (AC-PEG-NHS) modified cell membrane nano-vesicles are grafted to a molecular skeleton of the cell membrane nano-vesicles through photo-crosslinking reaction, and the SerMA-PC-coated PNVs hydrogel is successfully prepared. In-vitro and in-vivo experimental studies of the hydrogel show that the SerMA-PC-coated PNVs / PDLSCs hydrogel can regulate the polarization state of microglial cells through oxidation resistance, so that the survival of damaged retinal ganglion cells (RGCs) is promoted, and the SerMA-PC-coated PNVs / PDLSCs hydrogel can be used for treating eye diseases such as glaucoma.
Owner:AIER EYE HOSPITAL GRP CO LTD CHANGSHA AIER EYE HOSPITAL

Compound melanterite pill specific chromatogram and construction method and quality detection method thereof

The invention discloses a compound melanterite pill specific chromatogram and a construction method and a quality detection method thereof, and belongs to the field of Chinese patent medicine detection. Taking different batches of compound melanterite pills as test articles to prepare a compound melanterite pill test article solution; the method comprises the following steps: taking gallic acid, ginsenoside Rg1, procyanidine B2, cinnamic acid, coumarin, ginsenoside Rh1, cinnamyl alcohol, cinnamaldehyde, arachidonic acid, epicatechin, 2-methoxycinnamic acid, ginsenoside Rb1, ginsenoside Rd, betulinic acid and 5-hydroxymethylfurfural as reference substances to prepare a single reference substance solution; performing chromatographic analysis on the compound melanterite pill test solution and the single reference substance solution, and recording chromatograms; carrying out similarity analysis; and constructing the characteristic chromatogram of the compound melanterite pill according to the chromatogram of the test solution of the compound melanterite pill and the chromatogram of the single reference substance solution in combination with the total ion chromatogram obtained by the high-resolution mass spectrum and the mass spectrum result map of the chemical components. The method can accurately, clearly and objectively evaluate the quality of the compound melanterite pill.
Owner:SHAANXI UNIV OF SCI & TECH

Lipid droplet detection kit based on double-response water-soluble fluorescent dye and application of lipid droplet detection kit

The invention relates to the technical field of nano material imaging diagnosis, in particular to a lipid droplet detection kit based on double-response water-soluble fluorescent dye and application of the lipid droplet detection kit. The invention provides the lipid droplet detection kit, the lipid droplet detection kit comprises a component A, the component A is a composite fluorescent dye of an anthocyanin derivative fluorescent dye and a metal frame material, the dual response of polarity and RNS can be realized, the lipid droplet imaging effect is good, the dyeing step is simple, the water solubility is better, the lipid droplet is easy to rinse and clean, the experimental result is reliable, and the lipid droplet detection kit has great commercial value.
Owner:WUHAN UNIV OF TECH

Bionic hybrid membrane coating baicalein-loaded procyanidine nano preparation as well as preparation method and application thereof

The invention belongs to the technical field of biological medicine, and particularly relates to a bionic hybrid membrane coating baicalein-loaded procyanidine nano preparation as well as a preparation method and application thereof. The procyanidine nano preparation is prepared from procyanidine, baicalein, an erythrocyte membrane, a microglial cell membrane, an RVG targeting peptide and an MG1 targeting peptide. Baicalein is entrapped in nanoparticles PC (at) BAI formed by self-assembly of procyanidine, a bionic hybrid membrane is used as an outer layer to coat the surface of the nanoparticles PC (at) BAI to obtain a nano material M (at) PC (at) BAI, and an RVG targeting peptide and an MG1 targeting peptide are modified on the surface of the nano material M (at) PC (at) BAI to obtain the nano preparation RVG / MG1-M (at) PC (at) BAI. The biomimetic hybrid membrane coating is combined with the biological function of a natural cell membrane and the stability of synthetic lipid, so that the nano preparation is endowed with excellent long-acting blood circulation capacity and active targeting capacity to a brain lesion area, and the enrichment of the drug in the brain is remarkably improved.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY

Visual hydrogel based on multiple response mechanism and preparation method and application thereof

The present application relates to the technical field of biological medicine, and specifically provides a visual hydrogel based on multiple response mechanisms and a preparation method and application thereof.The preparation method comprises the following steps: (1) preparing an inclusion compound by using beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin and cyanidin; (2) respectively preparing a polyvinyl alcohol / rhein solution and a mixed solution of quaternary ammonium salt chitosan / hyaluronic acid / κ-carrageenan; (3) initiating dynamic crosslinking by using phenylboronic acid, and constructing a multiple network structure in cooperation with tannic acid, the inclusion compound and genipin, and then curing the hydrogel through gradient temperature control.The hydrogel has pH / temperature / ROS response characteristics, and can use the color change of cyanidin to feed back the wound microenvironment state in real time, and meanwhile, hyaluronic acid / polyvinyl alcohol can construct a 3D microchannel structure, promote the ordered arrangement of collagen, and accelerate wound healing, thereby solving the problems of unstable direct loading of cyanidin and difficulty of a single response mechanism in adapting to the complex microenvironment of a diabetic wound.
Owner:YANTAI UNIV

Application of procyanidine A1 in preparation of medicine for inhibiting porcine epidemic diarrhea virus

The invention belongs to the technical field of antiviral drugs, and in particular relates to a novel application of procyanidine A1 in preparation of a drug for inhibiting porcine epidemic diarrhea virus (PEDV). The porcine epidemic diarrhea (PED) is a high-contact intestinal infectious disease caused by the PEDV (porcine epidemic diarrhea virus), so that huge economic loss is caused to the global pig breeding industry. Currently, PEDV serving as an RNA virus is extremely easy to mutate, so that the protection effect of the existing vaccine is limited, and a special-effect antiviral therapeutic drug is lacked clinically. It is found for the first time that the natural compound procyanidine A1 has remarkable inhibitory activity on the porcine epidemic diarrhea virus and can effectively inhibit replication of the virus in cells. In-vitro experiments prove that the procyanidine A1 has no obvious toxicity to cells at an effective antiviral concentration and has high safety. The invention provides a brand new and effective drug choice for prevention and control of PEDV, and has important application value and wide market prospect.
Owner:CHINA AGRI UNIV

Injectable hierarchical controlled-release double-drug-loading hydrogel coupled with MOF (Metal Organic Framework) and preparation method thereof

PendingCN121371296AProsthesisProcyanidin B2Control release
The invention discloses injectable hierarchical controlled-release double-drug-loading hydrogel coupled with MOF and a preparation method of the injectable hierarchical controlled-release double-drug-loading hydrogel. The injectable hierarchical controlled-release double-drug-loading hydrogel can be used for combined delivery of drugs including procyanidine B2 and melatonin. The drug PC2 is used as a crosslinking point, the hydrophobic drug MT is encapsulated in the MOF, and the hydrophilic drug PC2 is used as a bridge to connect the MOF and the hydrogel, so that slow and controllable release of the drug is realized, and injectability and self-repairing performance of the hydrogel are maintained. And finally, efficient sequential delivery of the procyanidine B2 and the melatonin in the intervertebral disc is realized.
Owner:UNIVERSITY OF HEALTH & REHABILITATION SCIENCES

Assistant for enhancing physical ability due to plateau hypoxia as well as preparation method and application thereof

The invention discloses an additive for enhancing physical ability for plateau hypoxia as well as a preparation method and application of the additive, and belongs to the technical field of biological medicines. The invention relates to an auxiliary agent for enhancing physical ability due to plateau hypoxia. The auxiliary agent is formed by wrapping a flavonoid compound and a carrier, the molecular weight of a flavonoid compound in the auxiliary agent is not higher than 1500Da; the carrier in the auxiliary agent is a pharmaceutically acceptable carrier. The invention also provides a preparation method and application of the auxiliary agent. Based on a procyanidine core and a synergistic anti-oxidation carrier, the aid for enhancing physical ability due to plateau hypoxia can inhibit reduction of myocardial cell mitochondrial membrane potential caused by hypoxia and reduce physical ability loss caused by hypoxia.
Owner:ACADEMY OF MILITARY MEDICAL SCIENCES

A method for establishing UPLC fingerprint of Weimaining capsules

The present invention discloses a method for establishing a UPLC fingerprint of Weimaining capsules, comprising the following steps: (1) preparing a test solution; (2) respectively examining the precision of an ultra-high performance liquid chromatograph, the repeatability of a test solution preparation method, and the stability of the test solution; (3) subjecting the test solution to gradient elution in a chromatographic column, and scanning the test solution using an ultra-high performance liquid chromatograph to obtain a chromatogram of the test solution; (4) identifying the common peak components of the chromatogram using reference substances such as gallic acid, protocatechuic acid, protocatechuic aldehyde, proanthocyanidin B2, epicatechin, and rutin. (5) establishing a fingerprint. The ultra-high performance liquid chromatograph used in the present invention has high precision, and the test solution preparation method provided has good repeatability. The fingerprint established based on the above two points has strong stability, and the speed of establishing the fingerprint is fast, the sensitivity is high, and the separation of the chromatographic peaks is good.
Owner:BEIJING HUAMIAO TRADITIONAL CHINESE MEDICINE ENG TECH DEV CENT

Method for constructing characteristic map of Fagopyrum serrata

The present invention discloses a method for constructing a characteristic spectrum of golden buckwheat. The characteristic spectrum has gallic acid, protocatechuic acid, protocatechuic aldehyde, catechin, epicatechin, 4-coumaric acid, and procyanidin B2 as characteristic components. By using an efficient detection method, the common peaks of golden buckwheat samples of different origins are confirmed to construct a characteristic spectrum. The method can distinguish the counterfeit products of golden buckwheat, Smilax glabra and Smilax china, and with the flavonoids contained in golden buckwheat as representative components, it can more comprehensively reflect the product quality. The method is suitable for rapid and comprehensive quality control of golden buckwheat medicinal materials, decoction pieces, extracts, standard decoctions, formula granules, and benchmark samples, preparation intermediates, and finished products of golden buckwheat classic prescriptions. The method is efficient, easy to operate, and suitable for quality monitoring of continuous production.
Owner:JIANGYIN TIANJIANG PHARMA

Composition for resisting oxidation and relieving chronic inflammation, product and application

The invention relates to the technical field of antioxidant products, in particular to a composition for resisting oxidation and relieving chronic inflammation, a product and application. The composition for resisting oxidation and relieving chronic inflammation comprises a first antioxidant, a second antioxidant and a third antioxidant, the first antioxidant comprises sheep lung peptide and amino acid; the second antioxidant comprises B vitamins and a yeast extract; the third antioxidant comprises vitamin C, vitamin E, trace elements and components containing bioactive substances; the bioactive substances at least comprise phenols and flavonoids, the phenols at least comprise procyanidine, the flavonoids at least comprise dihydromyricetin, and the components containing the bioactive substances at least comprise a grape seed extract and an ampelopsis grossedentata extract; the procyanidine content in the grape seed extract is greater than or equal to 95%, and the dihydromyricetin content in the ampelopsis grossedentata extract is greater than or equal to 40%. The composition disclosed by the invention has the advantages of better anti-oxidation effect and chronic inflammation relieving effect.
Owner:BEIJING DONGFANG BEILI NUTRITION TECH CO LTD