235 results about "Flavanone" patented technology

Pharmaceutical compositions, and methods of using the same, are provided utilizing effective amounts of one or more flavones, flavonols, flavanones, isoflavanones and isoflavones to increase cell proliferation in various tissues and cell lines. As examples, the composition and methods of the present invention can be used to increase proliferation of fibroblast cells and, more particularly, in the treatment of wounds as well as strengthening of the skin.

The invention relates to a high temperature and salt resistant polymer fluid loss additive for a drilling fluid and a preparing method of the high temperature and salt resistant polymer fluid loss additive. The fluid loss additive is a copolymer generated during the reaction of alkenyl amide, alkenyl benzene sulfuric acid, alkenyl flavanone and alkenyl sulfuric acid. The preparing method comprises the following steps: (1), weighing the four materials; (2) mixing the alkenyl sulfuric acid liquor with the alkenyl amide, the alkenyl flavanone and the alkenyl benzene sulfuric acid in a reactor, mixing, stirring, and adding nitrogen while discharging oxygen; (3) reacting at the temperature of 30 to 90 DEG C, adding initiating agents (namely, potassium persulfate and sodium hydrosulfite) with the contents of 15 to 30 percent by weight respectively, and reacting for 2 to 12 h so as to obtain a viscous-elastic jelly; and (4) pelletizing the jelly, and drying and crashing at high temperature to obtain the fluid loss additive. At high temperature, the oxydrolysis degree is low, and the action effect between functional groups on a lateral chain and clay particles is remarkable, the quality of a mud cake formed according to the method is better, and the fluid loss effect is favorable in both fresh water and a composite salt water drilling fluid.

The present invention has an object to provide an agent for strengthening calcium-containing tissues, which can be safely applied; and its use: The present invention solves the object by providing an agent for strengthening calcium-containing tissues, which comprises one or more flavones, flavonols, flavanones, flavanonols, anthocyanidins, flavanols, chalcones, and aurones.

The invention discloses a preparation method of a material with nitric oxide (NO) catalytic activity. The preparation method is implemented through the steps that a selenium-containing compound with nitric oxide catalytic activity, a sulfur-containing compound, a soluble copper salt, a compound with an o-phenol structure, a flavonoid compound, and a flavonol compound or a flavanone compound are mixed in a buffer solution and then polymerized. The material with NO catalytic activity not only can be applied to the surface modification of materials which are different in material, geometrical shape and topological structure, and also can be used as a filling material for a controlled release system. Double selenium bonds, double sulfur bonds, copper ions and phenolic hydroxyl groups, which are contained in the prepared material with nitric oxide (NO) catalytic activity, have an excellent free radical removal function; the selenium bonds, the sulfur bonds and the chelate copper ions, which are contained in the material, also have a reduced glutathione (GSH) response function; in addition, the copper ions containing in the material also have an antibacterial function; and the material, besides being used for catalyzing NO release, also can be applied to all related fields of free radical removal and GSH response function.

A method useful for inhibiting moisture loss from skin comprises the step of administering a composition to a subject's skin. The composition comprises a first humectant and a second humectant different from the first humectant. The humectants are useful for increasing moisture content of the subject's skin, specifically the subject's epidermis. The first humectant may comprise a conventional humectant, e.g. glycerol. The second humectant generally comprises certain types of honey. The honey is capable of inhibiting moisture loss from the subject's epidermis and/or moisture loss from the first humectant when the subject is exposed to dry air conditions, e.g. wintertime air having a relative humidity of about 50% or less. Specifically, the second humectant is useful for mitigating adverse effects of the first humectant under certain conditions. Examples of suitable honeys generally include those comprising the flavanone hesperidin, such as orange blossom honey, buckwheat (blossom) honey, or a combination thereof.

The invention discloses a flavone extracting technology of plant effective component based on discarded bamboo, which comprises the following steps: predisposing bamboo leaf; extracting through heating in the water; condensing; extracting through positive butanol liquid; recycling solvent; removing metal through flocculation; spraying; drying.

The present invention refers to the technical field of flavone component extraction, and provides an extraction separation method of a flavone component based on amination graphene. The flavone components comprise flavones, flavanols, isoflavones, flavanones, flavanonols, flavanones, anthocyanidins, chalcones, and chromones etc. The extraction separation method is adsorption extraction, and amination graphene is taken as a medium of adsorption extraction. The extraction separation method of the flavone components based on amination graphene is superior in separation speed and product purity, low cost and convenient operation.

Soybean and Medicago truncatula CYP93C genes have been isolated which encode a cytochrome P450 that can catalyze the aryl migration of a flavanone to yield an isoflavanone intermediate or an isoflavone. Plants can now be genetically engineered to produce isoflavones that provide potential human health benefits and increase disease resistance in plants. Isoflavones can now be produced in transgenic plants species in which isoflavones do not naturally occur, i.e., in species other than legumes. Alternatively, introducing infection-inducible isoflavonoid biosynthesis into non-legumes qualitatively complements these plants phytoalexin defenses against microbial pathogens, whereas over-expression of the isoflavonoid pathway in legumes quantitatively increases this defense response. Finally, modifying the extend of production of isoflavonoids in legume roots positively impacts nodulation efficiency and therefore plant yield.

The invention discloses an oily composition which is extracted from Litsea lancilimba and Blumea mollis and contains 1, 8-eudesmin and blumeatin. The oily composition is oily substance extracted from the Litsea lancilimba and the Blumea mollis. The main compositions by weight percentage of the oily composition are: 2.01 to 19.61 percent of the 1, 8-eudesmin, 0.2 to 9.40 percent of sabinene, 0.40 to 4.71 percent of alpha-pinene, 0.40 to 7.84 percent of lemonene, 0.21 to 8.27 percent of the blumeatin, 1.66 to 23.95 percent of L-camphol and 0.64 to 7.98 percent of beta-caryophyllene. The oily composition is definite in main active ingredients, small in content variation, stable in quality which can be effectively controlled, and reliable in healing effect. The invention also discloses use of the oily composition.

The invention provides a general flavanone capsule of desmodium styracifolium and a preparation method and application thereof, wherein the general flavanone capsule of the desmodium styracifolium comprises total flavanone of the desmodium styracifolium, which is an alcohol extract of the desmodium styracifolium, and pharmaceutically acceptable medicinal excipients. The general flavanone capsule of the desmodium styracifolium disclosed by the invention has the characteristics of being explicit in effective material basis, controllable in quality standard, good in drug dissolution degree, good in quality stability, significant in pharmacology and drug efficacy, less in dosage, safe and convenient to take, and completely applicable to industrial massive production.

The invention discloses a desensitization cosmetic composition. The desensitization cosmetic composition comprises the following components in percentage by weight: 0.79%-55% of cosmetic substrate and 0.21%-0.45% of a natural Chinese herb extract, wherein the natural Chinese herb extract comprises glucan, flavanone and aloe extract. The composition disclosed by the invention has the advantages of adopting natural plant without side effect, being anti-sensitization diminishing inflammation, not causing acnes and stimulus and being safe to sensitive skin. The desensitization cosmetic composition can be used for skin care products such as face cream, cream, mask, various water products (such as astringent, smoothing toner, toner, nutritive water and balancing lotion).

The present invention relates to a composition for increasing testosterone physiological levels comprising: a) a sufficient amount of at least one aromatase inhibitor chosen from a flavone substituted with at least one methoxy group at position 3′,4′,5 or 7, any combinations thereof, and any di, tri or tetra combinations thereof; and a flavanone substituted with at least one methoxy group at position 3′,4′,5 or 7, any combinations thereof, and any di, tri or tetra combinations thereof; and b) a sufficient amount of at least one 5α-reductase inhibitor that inhibit testosterone conversion to DHT, such as beta-sitosterols; in association with a pharmaceutically acceptable carrier.

A synthetic composition is provided comprising (a) one or more compounds selected from the group consisting of flavanols and hydroxystilbenes; and (b) one or more compounds selected from the group consisting of flavanones, flavones, flavonols, proanthocyanidins and anthocyanidins. Also provided is a method of reducing neuronal degeneration in an individual which method comprises administering to the individual said composition.

The invention discloses a method for preparing a fermented type blood orange fruit wine. The method includes the steps of crushing, pulping and color protection; enzymatic hydrolysis; sugar degree adjustment; color protection before fermentation; fruit wine fermentation; filtering; cold shocking; low temperature afterripening color protection; blending and color protection and the like. The production cost is low, the conversion rate is high, about 0.5 ton of the blood orange fruit wine can be produced with 1 ton of raw materials, the alcohol content can reach 10.0-14.0%, and original rich anthocyanins, flavanone, vitamins, polysaccharides and other multi-active components in blood oranges are kept; and the blood orange fruit wine is a novel fruit wine integrated with nutrition, health care, diet therapy and other functions, and has the room-temperature shelf life of 24 months.

The invention provides specificity probe zymolyte of glucuronic acid transferase UGT1A1 and application. The specificity probe zymolyte includes dihydro flavonoids compounds of C-4' hydroxyl. Procedures of enzymatic determination are that C-4' hydroxyl-glucose aldehyde acid of bavachinin is selected to be metabolized to a probe reaction. Activity of UGT1A1 enzyme of each biological sample, cell, in vivo and whole organ is measured by quantitative determining of removing quantity of fructus psoraleae flavanone methyl ether in unit time or generation quantity of glucose aldehyde acidize metabolite of the fructus psoraleae flavanone methyl ether. The specificity probe zymolyte of glucuronic acid transferase UGT1A1 can be used for quantitative evaluating of the activity of the UGT1A1 enzyme of different species, different individual source biology samples and quantitative evaluating of the activity of the UGT1A1 enzyme of animal tissue cell culture fluid of different sources and cell prepared products so as to assess ability of handling drugs on important drug metabolic enzyme UGT1A1.

The invention relates to a method for detecting the flavonoid components in peony leaves. The method comprises the following steps of preparing a flavonoid extracting solution; setting chromatographicconditions, mass spectrum conditions and the detection wavelength of a diode array detector; adopting the super-efficient liquid chromatogram-diode array detector-triple quadrupole rod flight time tandem mass spectrum linkage technology for detecting the flavonoid extracting solution, and obtaining a detecting result; performing structure identification on flavonoid substances by analyzing the detecting result, and speculating the structure of the flavonoid compound. The method is simplified in operation steps, rapid in detection and high in accuracy and sensitivity, the micro content of theflavonoid components can be detected, the identification variety is comprehensive, 45 main flavone, flavonol, flavanone and flavanol compounds are identified in the peony leaves, a gap for flavonoid component identification in the peony leaves is filled up, and the method is of great significance in analysis of different varieties of peony leaf nutrient contents.

An isolated polynucleotide comprising a nucleotide sequence encoding a polypeptide having a flavanone-7-O-glucoside-2''-O-rhamnosyl-transferase catalytic activity and its uses.

The invention provides a method for synthesizing 1-Chloro-formyl-3-methyl sulfonyl-2-imidazo flavanone, which comprises the steps of: (1) reacting methyl chloride and 2 - imidazo flavanone to produce methylsulfonyl-2-imidazo flavanone under the action of a catalyst; and (2) carrying out acylation reaction on the methylsulfonyl-2-imidazo flavanone and triphosgene in an organic solvent in the presence of a catalyst. The invention is technically characterized in that a catalyst is introduced in the step (1), thereby improving the reaction yield, wherein the catalyst can be triethylamine, pyridine, or N,N-dimethylformamide; and the reaction temperature and the dose of the solvent are adjusted in the step (2), thereby shortening the reaction time and reducing energy consumption, wherein the reaction temperature is between 15 DEG C and 25 DEG C, and the dose of the solvent is adjusted according to the ratio of the methylsulfonyl-2-imidazo flavanone to the organic solvent being 1g:5-10 ml.

The present invention relates to food products comprising flavanones. In particular, it relates to food products comprising hesperidin having improved stability. The present invention also concerns processes for the manufacturing of food products comprising said flavanones, especially hesperidin and to the use of the food products in the manufacture of compositions for the improvement of bone and skin health. Said flavanones are subjected to heating in water to a temperature of at least 138° C.

The invention relates to a chemical composition separation method of a traditional Chinese medicine smilax composition and a clinical application thereof. The method comprises the preparation of the water extractive extractum of the traditional Chinese medicine smilax composition, the ethyl acetate extraction of the water extractive material of the traditional Chinese medicine smilax composition,and the separation and measurement of the ethyl acetate extract by silicagel column chromatography. By the method, dihydro-kaempferol, dihydro-kaempferol 3-O-alpha-L-rhamnoside, and 3,3,5,5,7-pentahydroxy-flavanone 3-O-alpha-L-rhamnoside can be obtained, wherein the 3,3,5,5,7-pentahydroxy-flavanone 3-O-alpha-L-rhamnoside is separated from the smilax composition for the first time.

The invention discloses a method for extracting high-purity total flavanone from stragalus membranaceus. The method comprises the following steps that the stragalus membranaceus is smashed after being dried, then ethyl alcohol with the weight ratio of 1:4-6 is added into the smashed stragalus membranaceus to be stirred in an ultrasonic stirrer for 30-40 min, and a mixed solution is obtained; then the mixed solution is transferred to a reflux device for reflux extraction, and an extracting solution is obtained; diluted hydrochloric acid is used to adjust the pH value of the extracting solution to be 2-3 through decompressing condensing, and a total flavanone crude product is obtained after drying; then silica gelcolumn chromatography is conducted on the crude product, the dried solid substance is dissolved by methyl alcohol, and the total flavanone can be obtained through recrystallizing, filtering and drying. Be means of the method for extracting the high-purity total flavanone from the stragalus membranaceus, the extraction ratio of the total flavanone reaches 80%, and the purity reaches above 90%. The method for extracting the total flavanone from the stragalus membranaceus has the advantages that the operation is simple, the energy consumption is low, the extracting time is short, the extracting ratio is high, the purity is high, and the cost is low. The industrial production is easy to achieve.