The invention discloses an abrasion destroy failure quantitative prediction method, based on flow-solid couple analysis, comprising abrasion product protective film character analysis and failure prediction analysis under flow function. Based on the real condition of tube, via flow mechanics similar theory, the invention finds the standard, test condition and flow medium of object tube, via electrochemical test method, processes instant character test of abrasion destroy, builds flow-solid couple model to set characteristic parameter values of abrasion product protective film, uses finite element analysis software to process flow-solid couple simulation, combined with test, corrects the characteristic parameter values of the abrasion product protective film, based on real tube system typical tube, processes flow-solid couple simulation, to realize abrasion destroy failure quantitative prediction of tube system, which can accurately predict the failure points of whole tube system, to support the safe protection technique of pressure tube system.